{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:18:33Z","timestamp":1773281913237,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T00:00:00Z","timestamp":1171584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1038\/sj.eye.6702734","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T12:53:07Z","timestamp":1171630387000},"page":"869-873","source":"Crossref","is-referenced-by-count":13,"title":["Visual acuity and intraocular pressure after high-dose intravitreal triamcinolone acetonide in selected ocular diseases"],"prefix":"10.1038","volume":"22","author":[{"given":"J B","family":"Jonas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Schlichtenbrede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,2,16]]},"reference":[{"key":"BF6702734_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1001\/archopht.1974.01010010155016","volume":"92","author":"RO Graham","year":"1974","unstructured":"Graham RO, Peyman GA . Intravitreal injection of dexamethasone. Treatment of experimentally induced endophthalmitis. Arch Ophthalmol 1974; 92: 149\u2013154.","journal-title":"Arch Ophthalmol"},{"key":"BF6702734_CR2","first-page":"171","volume":"77","author":"R Machemer","year":"1979","unstructured":"Machemer R, Sugita G, Tano Y . Treatment of intraocular proliferations with intravitreal steroids. Trans Am Ophthalmol Soc 1979; 77: 171\u2013180.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"BF6702734_CR3","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/S0002-9394(14)75196-7","volume":"90","author":"Y Tano","year":"1980","unstructured":"Tano Y, Chandler D, Machemer R . Treatment of intraocular proliferation with intravitreal injection of tramcinolone acetonide. Am J Ophthalmol 1980; 90: 810\u2013816.","journal-title":"Am J Ophthalmol"},{"key":"BF6702734_CR4","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0002-9394(80)90239-1","volume":"89","author":"Y Tano","year":"1980","unstructured":"Tano Y, Sugita G, Abrams G, Machemer R . Inhibition of intraocular proliferation with intravitreal corticosteroid. Am J Ophthalmol 1980; 89: 131\u2013136.","journal-title":"Am J Ophthalmol"},{"key":"BF6702734_CR5","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/00006982-199616020-00017","volume":"16","author":"R Machemer","year":"1996","unstructured":"Machemer R . Five cases in which a depot steroid (hydrocortisone acetate and methylprednisolone acetate) was injected into the eye. Retina 1996; 16: 166\u2013167.","journal-title":"Retina"},{"key":"BF6702734_CR6","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.preteyeres.2005.01.004","volume":"5","author":"JB Jonas","year":"2005","unstructured":"Jonas JB, Kreissig I, Degenring RF . Intravitreal triamcinolone acetonide for treatment of intraocular proliferative, exudative and angiogenic diseases. Prog Ret Eye Res 2005; 5: 587\u2013611.","journal-title":"Prog Ret Eye Res"},{"key":"BF6702734_CR7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1001\/archopht.121.1.57","volume":"121","author":"JB Jonas","year":"2003","unstructured":"Jonas JB, Kreissig I, S\u00f6fker A, Degenring RF . Intravitreal injection of triamcinolone acetonide for diabetic macular oedema. Arch Ophthalmol 2003; 121: 57\u201361.","journal-title":"Arch Ophthalmol"},{"key":"BF6702734_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0002-9394(01)01010-8","volume":"132","author":"JB Jonas","year":"2001","unstructured":"Jonas JB, S\u00f6fker A . Intraocular injection of crystalline cortisone as adjunctive treatment of diabetic macular oedema. Am J Ophthalmol 2001; 132: 425\u2013427.","journal-title":"Am J Ophthalmol"},{"key":"BF6702734_CR9","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/S0161-6420(02)00975-2","volume":"109","author":"A Martidis","year":"2002","unstructured":"Martidis A, Duker JS, Greenberg PB, Rogers AH, Puliafito CA, Reichel E et al. Intravitreal triamcinolone for refractory diabetic macular oedema. Ophthalmology 2002; 109: 920\u2013927.","journal-title":"Ophthalmology"},{"key":"BF6702734_CR10","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ophtha.2003.05.037","volume":"111","author":"P Massin","year":"2004","unstructured":"Massin P, Audren F, Haouchine B, Erginay A, Bergmann JF, Benosman R et al. Intravitreal triamcinolone acetonide for diabetic diffuse macular oedema: preliminary results of a prospective controlled trial. Ophthalmology 2004; 111: 218\u2013224.","journal-title":"Ophthalmology"},{"key":"BF6702734_CR11","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/sj.eye.6701512","volume":"19","author":"M Karacorlu","year":"2005","unstructured":"Karacorlu M, Ozdemir H, Karacorlu S, Alacali N, Mudun B, Burumcek E . Intravitreal triamcinolone as a primary therapy in diabetic macular oedema. Eye 2005; 19: 382\u2013386.","journal-title":"Eye"},{"key":"BF6702734_CR12","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1136\/bjo.2004.062596","volume":"89","author":"UHM Spandau","year":"2005","unstructured":"Spandau UHM, Derse M, Schmitz-Valckenberg P, Papoulis C, Jonas JB . Dosage-dependency of intravitreal triamcinolone acetonide as treatment for diabetic macular oedema. Br J Ophthalmol 2005; 89: 999\u20131003.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR13","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1001\/archopht.123.10.1338","volume":"123","author":"JB Jonas","year":"2005","unstructured":"Jonas JB, Martus P, Degenring RF, Kreissig I, Akkoyun I . Predictive factors for visual acuity change after intravitreal triamcinolone for diabetic macular oedema. Arch Ophthalmol 2005; 123: 1338\u20131343.","journal-title":"Arch Ophthalmol"},{"key":"BF6702734_CR14","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1007\/s00417-002-0529-0","volume":"240","author":"JB Jonas","year":"2002","unstructured":"Jonas JB, Kreissig I, Degenring RF . Intravitreal triamcinolone acetonide as treatment of macular oedema in central retinal vein occlusion. Graef Arch Clin Exp Ophthalmol 2002; 240: 782\u2013783.","journal-title":"Graef Arch Clin Exp Ophthalmol"},{"key":"BF6702734_CR15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1136\/bjo.86.2.247","volume":"86","author":"PB Greenberg","year":"2002","unstructured":"Greenberg PB, Martidis A, Rogers AH, Duker JS, Reichel E . Intravitreal triamcinolone acetonide for macular oedema due to central retinal vein occlusion. Br J Ophthalmol 2002; 86: 247\u2013248.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR16","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1001\/archopht.120.1.29","volume":"120","author":"MS Ip","year":"2002","unstructured":"Ip MS, Kumar KS . Intravitreous triamcinolone acetonide as treatment for macular oedema from central retinal vein occlusion. Arch Ophthalmol 2002; 120: 1217\u20131219.","journal-title":"Arch Ophthalmol"},{"key":"BF6702734_CR17","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0002-9394(03)00228-9","volume":"136","author":"CH Park","year":"2003","unstructured":"Park CH, Jaffe GJ, Fekrat S . Intravitreal triamcinolone acetonide in eyes with cystoid macular oedema associated with central retinal vein occlusion. Am J Ophthalmol 2003; 136: 419\u2013425.","journal-title":"Am J Ophthalmol"},{"key":"BF6702734_CR18","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/sj.eye.6701395","volume":"19","author":"JB Jonas","year":"2005","unstructured":"Jonas JB, Akkoyun I, Kamppeter B, Kreissig I, Degenring RF . Intravitreal triamcinolone acetonide as treatment of branch retinal vein occlusion. Eye 2005; 19: 65\u201371.","journal-title":"Eye"},{"key":"BF6702734_CR19","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1034\/j.1600-0420.2003.00084.x","volume":"81","author":"RF Degenring","year":"2003","unstructured":"Degenring RF, Kamppeter B, Kreissig I, Jonas JB . Morphologic and functional changes after intravitreal triamcinolone acetonide for retinal vein occlusion. Acta Ophthalmol 2003; 81: 399\u2013401.","journal-title":"Acta Ophthalmol"},{"key":"BF6702734_CR20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1136\/bjo.88.1.154","volume":"88","author":"SD Chen","year":"2004","unstructured":"Chen SD, Lochhead J, Patel CK, Frith P . Intravitreal triamcinolone acetonide for ischaemic macular oedema caused by branch retinal vein occlusion. Br J Ophthalmol 2004; 88: 154\u2013155.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR21","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1136\/bjo.87.3.361","volume":"87","author":"RF Degenring","year":"2003","unstructured":"Degenring RF, Jonas JB . Intravitreal injection of triamcinolone acetonide as treatment of chronic uveitis. Br J Ophthalmol 2003; 87: 361.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR22","first-page":"661","volume":"76","author":"JM Benitez Del Castillo Sanchez","year":"2001","unstructured":"Benitez Del Castillo Sanchez JM, Garcia Sanchez J . [Intravitreal injection of triamcinolone acetonide in non infectious uveitis]. Arch Soc Esp Oftalmol 2001; 76: 661\u2013664.","journal-title":"Arch Soc Esp Oftalmol"},{"key":"BF6702734_CR23","first-page":"1380","volume":"119","author":"A Martidis","year":"2001","unstructured":"Martidis A, Duker JS, Puliafito CA . Intravitreal triamcinolone for refractory cystoid macular oedema secondary to birdshot retinochoroidopathy. Arch Ophthalmol 2001; 119: 1380\u20131383.","journal-title":"Arch Ophthalmol"},{"key":"BF6702734_CR24","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1046\/j.1442-9071.2001.00360.x","volume":"29","author":"S Young","year":"2001","unstructured":"Young S, Larkin G, Branley M, Lightman S . Safety and efficacy of intravitreal triamcinolone for cystoid macular oedema in uveitis. Clin Exp Ophthalmol 2001; 29: 2\u20136.","journal-title":"Clin Exp Ophthalmol"},{"key":"BF6702734_CR25","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S0161-6420(00)00658-8","volume":"108","author":"RJ Antcliff","year":"2001","unstructured":"Antcliff RJ, Spalton DJ, Stanford MR, Graham EM, Ffytche TJ, Marshall J . Intravitreal triamcinolone for uveitic cystoid macular oedema: an optical coherence tomography study. Ophthalmology 2001; 108: 765\u2013772.","journal-title":"Ophthalmology"},{"key":"BF6702734_CR26","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/S0002-9394(03)00230-7","volume":"136","author":"JB Jonas","year":"2003","unstructured":"Jonas JB, Kreissig I, Degenring RF . Intravitreal triamcinolone acetonide for pseudophakic cystoid macular oedema. Am J Ophthalmol 2003; 136: 384\u2013386.","journal-title":"Am J Ophthalmol"},{"key":"BF6702734_CR27","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/S0002-9394(02)01938-4","volume":"135","author":"N Benhamou","year":"2003","unstructured":"Benhamou N, Massin P, Haouchine B, Audren F, Tadayoni R, Gaudric A . Intravitreal triamcinolone for refractory pseudophakic macular oedema. Am J Ophthalmol 2003; 135: 246\u2013249.","journal-title":"Am J Ophthalmol"},{"key":"BF6702734_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0886-3350(02)01441-4","volume":"29","author":"MD Conway","year":"2003","unstructured":"Conway MD, Canakis C, Livir-Rallatos C, Peyman GA . Intravitreal triamcinolone acetonide for refractory chronic pseudophakic cystoid macular oedema. J Cataract Refract Surg 2003; 29: 27\u201333.","journal-title":"J Cataract Refract Surg"},{"key":"BF6702734_CR29","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1046\/j.1395-3907.2003.0146.x","volume":"81","author":"M Karacorlu","year":"2003","unstructured":"Karacorlu M, Ozdemir H, Karacorlu S . Intravitreal triamcinolone acetonide for the treatment of chronic pseudophakic cystoid macular oedema. Acta Ophthalmol Scand 2003; 81: 648\u2013652.","journal-title":"Acta Ophthalmol Scand"},{"key":"BF6702734_CR30","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/sj.eye.6701438","volume":"19","author":"JB Jonas","year":"2005","unstructured":"Jonas JB, Degenring RF, Kreissig I, Friedemann T, Akkoyun I . Exudative age-related macular degeneration treated by intravitreal triamcinolone acetonide. A prospective comparative non-randomized study. Eye 2005; 19: 163\u2013170.","journal-title":"Eye"},{"key":"BF6702734_CR31","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/j.1442-9071.1995.tb00179.x","volume":"23","author":"PL Penfold","year":"1995","unstructured":"Penfold PL, Gyory JF, Hunyor AB, Billson FA . Exudative macular degeneration and intravitreal triamcinolone. A pilot study. Aust NZ J Ophthalmol 1995; 23: 293\u2013298.","journal-title":"Aust NZ J Ophthalmol"},{"key":"BF6702734_CR32","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1442-9071.1998.tb01330.x","volume":"26","author":"JK Challa","year":"1998","unstructured":"Challa JK, Gillies MC, Penfold PL, Gyory JF, Hunyor AB, Billson FA . Exudative macular degeneration and intravitreal triamcinolone: 18 month follow up. Aust N Z J Ophthalmol 1998; 26: 277\u2013281.","journal-title":"Aust N Z J Ophthalmol"},{"key":"BF6702734_CR33","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/00006982-200003000-00004","volume":"20","author":"RP Danis","year":"2000","unstructured":"Danis RP, Ciulla TA, Pratt LM, Anliker W . Intravitreal triamcinolone acetonide in exudative age-related macular degeneration. Retina 2000; 20: 244\u2013250.","journal-title":"Retina"},{"key":"BF6702734_CR34","first-page":"873","volume":"240","author":"JB Jonas","year":"2002","unstructured":"Jonas JB, Kreissig I, Degenring RF . Repeated intravitreal injections of triamcinolone acetonide as treatment of progressive exudative age-related macular degeneration. Graef Arch Clin Exp Ophthalmol 2002; 240: 873\u2013874.","journal-title":"Graef Arch Clin Exp Ophthalmol"},{"key":"BF6702734_CR35","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1136\/bjo.86.5.527","volume":"86","author":"NT Ranson","year":"2002","unstructured":"Ranson NT, Danis RP, Ciulla TA, Pratt L . Intravitreal triamcinolone in subfoveal recurrence of choroidal neovascularisation after laser treatment in macular degeneration. Br J Ophthalmol 2002; 86: 527\u2013529.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR36","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1136\/bjo.86.6.600","volume":"86","author":"PL Penfold","year":"2002","unstructured":"Penfold PL . Intravitreal triamcinolone in recurrence of choroidal neovascularization. Br J Ophthalmol 2002; 86: 600\u2013601.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR37","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1001\/archopht.121.5.667","volume":"121","author":"MC Gillies","year":"2003","unstructured":"Gillies MC, Simpson JM, Luo W, Penfold P, Hunyor AB, Chua W et al. A randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration: one-year results. Arch Ophthalmol 2003; 121: 667\u2013673.","journal-title":"Arch Ophthalmol"},{"key":"BF6702734_CR38","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1136\/bjo.87.4.462","volume":"87","author":"JB Jonas","year":"2003","unstructured":"Jonas JB, Kreissig I, Hugger P, Sauder G, Panda-Jonas S, Degenring R . Intravitreal triamcinolone acetonide for exudative age-related macular degeneration. Br J Ophthalmol 2003; 87: 462\u2013468.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR39","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/S0161-6420(03)00544-X","volume":"110","author":"RF Spaide","year":"2003","unstructured":"Spaide RF, Sorenson J, Maranan L . Combined photodynamic therapy with verteporfin and intravitreal triamcinolone acetonide for choroidal neovascularization. Ophthalmology 2003; 110: 1517\u20131525.","journal-title":"Ophthalmology"},{"key":"BF6702734_CR40","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1001\/archopht.122.2.218","volume":"122","author":"JB Jonas","year":"2004","unstructured":"Jonas JB, Akkoyun I, Budde WM, Kreissig I, Degenring RF . Intravitreal re-injection of triamcinolone for exudative age-related macular degeneration. Arch Ophthalmol 2004; 122: 218\u2013222.","journal-title":"Arch Ophthalmol"},{"key":"BF6702734_CR41","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/sj.eye.6701438","volume":"19","author":"JB Jonas","year":"2005","unstructured":"Jonas JB, Degenring RF, Kreissig I, Friedemann T, Akkoyun I . Exudative age-related macular degeneration treated by intravitreal triamcinolone acetonide. A prospective comparative non-randomized study. Eye 2005; 19: 163\u2013170.","journal-title":"Eye"},{"key":"BF6702734_CR42","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1136\/bjo.2003.039552","volume":"88","author":"JB Jonas","year":"2004","unstructured":"Jonas JB, Kreissig I, Degenring RF . Factors influencing visual acuity after intravitreal triamcinolone acetonide as treatment of exudative age-related macular degeneration. Br J Ophthalmol 2004; 88: 1557\u20131562.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR43","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1136\/bjo.2003.027177","volume":"88","author":"E Rechtman","year":"2004","unstructured":"Rechtman E, Danis RP, Pratt LM, Harris A . Intravitreal triamcinolone with photodynamic therapy for subfoveal choroidal neovascularisation in age related macular degeneration. Br J Ophthalmol 2004; 88: 344\u2013347.","journal-title":"Br J Ophthalmol"},{"key":"BF6702734_CR44","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.ajo.2005.01.032","volume":"139","author":"JB Jonas","year":"2005","unstructured":"Jonas JB, Spandau UH, Harder B, Vossmerbaeumer U, Kamppeter BA . Inter-eye difference in exudative age-related macular degeneration with minimally classic or occult subfoveal neovascularisation after unilateral intravitreal injection of triamcinolone acetonide. Am J Ophthalmol 2005; 139: 1073\u20131079.","journal-title":"Am J Ophthalmol"},{"key":"BF6702734_CR45","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1001\/archopht.121.11.1663-a","volume":"121","author":"JB Jonas","year":"2003","unstructured":"Jonas JB, Kreissig I, Degenring RF . Endophthalmitis after intravitreal injection of triamcinolone acetonide. Arch Ophthalmol 2003; 121: 1663\u20131664.","journal-title":"Arch Ophthalmol"},{"key":"BF6702734_CR46","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.ajo.2004.09.059","volume":"139","author":"UHM Spandau","year":"2005","unstructured":"Spandau UHM, Derse M, Schmitz-Valckenberg P, Papoulis C, Sagstetter BU, Stiefvater KH et al. Measurement of triamcinolone acetonide concentration after filtering of solvent agent. Am J Ophthalmol 2005; 139: 712\u2013713.","journal-title":"Am J Ophthalmol"},{"key":"BF6702734_CR47","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.ophtha.2004.10.042","volume":"112","author":"JB Jonas","year":"2005","unstructured":"Jonas JB, Degenring RF, Kreissig I, Akkoyun I, Kamppeter BA . Intraocular pressure elevation after intravitreal triamcinolone acetonide injection. Ophthalmology 2005; 112: 593\u2013598.","journal-title":"Ophthalmology"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6702734.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6702734","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6702734.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:28:55Z","timestamp":1684412935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6702734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,16]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["BF6702734"],"URL":"https:\/\/doi.org\/10.1038\/sj.eye.6702734","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,16]]}}}