{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:39:08Z","timestamp":1777984748857,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T00:00:00Z","timestamp":1180051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1038\/sj.eye.6702867","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T12:10:51Z","timestamp":1180095051000},"page":"1137-1140","source":"Crossref","is-referenced-by-count":18,"title":["Impression cytology of the conjunctival epithelial cells in patients with cystic fibrosis"],"prefix":"10.1038","volume":"22","author":[{"given":"M","family":"Mrugacz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Kasacka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bakunowicz-Lazarczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kaczmarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Kulak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,5,25]]},"reference":[{"key":"BF6702867_CR1","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1126\/science.2475911","volume":"245","author":"JR Riodan","year":"1989","unstructured":"Riodan JR, Rommens JM, Kerem B . Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 1989; 245: 1066\u20131073.","journal-title":"Science"},{"key":"BF6702867_CR2","first-page":"241","volume":"10","author":"J Zielinski","year":"1991","unstructured":"Zielinski J, Rozmahel R, Bozon D . Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator. Genomics 1991; 10: 241\u2013248.","journal-title":"Genomics"},{"key":"BF6702867_CR3","first-page":"29","volume-title":"Lung Biology in Health and Disease","author":"MJ Welsh","year":"1993","unstructured":"Welsh MJ, Anderson MP, Rich DP . Cystic fibrosis, CFTR and abnormal electrolyte transport. In: Davis PB (ed). Lung Biology in Health and Disease. M Dekker: New York, 1993 pp 29\u201332."},{"key":"BF6702867_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/112067210101100103","volume":"11","author":"I Castagna","year":"2001","unstructured":"Castagna I, Roszkowska AM, Fama F, Sinicropi S, Ferreri G . The eye in cystic fibrosis. Eur J Ophthalmol 2001; 11: 9\u201314.","journal-title":"Eur J Ophthalmol"},{"key":"BF6702867_CR5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1076\/ceyr.24.3.182.8297","volume":"24","author":"HC Turner","year":"2002","unstructured":"Turner HC, Bernstein A, Candia OA . Presence of CFTR in the conjunctival epithelium. Curr Eye Res 2002; 24: 182\u2013187.","journal-title":"Curr Eye Res"},{"key":"BF6702867_CR6","first-page":"865","volume":"8","author":"M Mrugacz","year":"2004","unstructured":"Mrugacz M, Minarowska A, Bakunowicz-\u0141azarczyk A, ywalewska N . Dry eye syndrome in children with cystic fibrosis. Med Wieku Rozwoj 2004; 8: 865\u2013870.","journal-title":"Med Wieku Rozwoj"},{"key":"BF6702867_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0039-6257(00)00200-9","volume":"45","author":"C Baudouin","year":"2001","unstructured":"Baudouin C . The pathology of dry eye. Surv Ophthalmol 2001; 45: 211\u2013220.","journal-title":"Surv Ophthalmol"},{"key":"BF6702867_CR8","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.exer.2003.09.009","volume":"78","author":"M Calonge","year":"2004","unstructured":"Calonge M, Diebold Y, Saez V, Enriquez de Salamanca A, Garcia-Vazquez C, Corrales RM et al. Impression cytology of the ocular surface: a review. Exp Eye Res 2004; 78: 457\u2013472.","journal-title":"Exp Eye Res"},{"key":"BF6702867_CR9","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/00125480-200311000-00003","volume":"10","author":"P McKelvie","year":"2003","unstructured":"McKelvie P . Ocular surface impression cytology. Adv Anat Pathol 2003; 10: 328\u2013337.","journal-title":"Adv Anat Pathol"},{"key":"BF6702867_CR10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/00003226-198801000-00012","volume":"7","author":"JD Nelson","year":"1988","unstructured":"Nelson JD . Impression cytology. Cornea 1988; 7: 71\u201381.","journal-title":"Cornea"},{"key":"BF6702867_CR11","first-page":"1818","volume":"36","author":"T Inatomi","year":"1995","unstructured":"Inatomi T, Spurr-Michaud S, Tisdale AS, Gipson IK . Human corneal and conjunctival epithelia express MUC1 mucin. Invest Ophthalmol Vis Sci 1995; 36: 1818\u20131827.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702867_CR12","first-page":"1458","volume":"38","author":"C Baudouin","year":"1997","unstructured":"Baudouin C, Brignole F, Becquet F, Pisella PJ, Goguel A . Flow cytometry in impression cytology specimens. A new method for evaluation of conjunctival inflammation. Invest Ophthalmol Vis Sci 1997; 38: 1458\u20131464.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702867_CR13","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/j.1365-2303.1993.tb00113.x","volume":"4","author":"MV De Rojas","year":"1993","unstructured":"De Rojas MV, Rodriquez MT, Ces Blanco JA, Salorio MS . Impression cytology in patients with keratoconjunctivitis sicca. Cytopathology 1993; 4: 347\u2013355.","journal-title":"Cytopathology"},{"key":"BF6702867_CR14","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/eye.1988.100","volume":"2","author":"AD Adams","year":"1998","unstructured":"Adams AD, Dilly PN, Kirkenss CM . Monitoring ocular disease by impression cytology. Eye 1998; 2: 506\u2013516.","journal-title":"Eye"},{"key":"BF6702867_CR15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1177\/112067210301300201","volume":"13","author":"J Murube","year":"2003","unstructured":"Murube J, Rivas L . Impression cytology on conjunctiva and cornea in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity. Eur J Ophthalmol 2003; 13: 115\u2013127.","journal-title":"Eur J Ophthalmol"},{"key":"BF6702867_CR16","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/S0161-6420(85)33967-2","volume":"92","author":"SCG Tseng","year":"1985","unstructured":"Tseng SCG . Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology 1985; 92: 728\u2013733.","journal-title":"Ophthalmology"},{"key":"BF6702867_CR17","first-page":"35","volume":"27","author":"JM Albietz","year":"2001","unstructured":"Albietz JM . Conjunctival histologic findings of dry eye and non-dry eye contact lens wearing subjects. CLAO J 2001; 27: 35\u201340.","journal-title":"CLAO J"},{"key":"BF6702867_CR18","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/00003226-199811000-00002","volume":"17","author":"ME Stern","year":"1998","unstructured":"Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC . The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 1998; 17: 584\u2013589.","journal-title":"Cornea"},{"key":"BF6702867_CR19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1076\/ceyr.19.3.201.5309","volume":"19","author":"SC Pflugfelder","year":"1999","unstructured":"Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D . Altered cytokine balance in the tear fluid and conjunctiva of patients with Sj\u00f6gren's syndrome keratoconjunctivitis sicca. Curr Eye Res 1999; 19: 210\u2013211.","journal-title":"Curr Eye Res"},{"key":"BF6702867_CR20","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1136\/bjo.76.9.545","volume":"76","author":"C Baudouin","year":"1992","unstructured":"Baudouin C, Haouat N, Brignole F, Bayle J, Gastaud P . Immunopathological findings in conjunctival cells using immunofluorescence staining of impression cytology specimens. Br J Ophthalmol 1992; 76: 545\u20135498.","journal-title":"Br J Ophthalmol"},{"key":"BF6702867_CR21","first-page":"278","volume":"107","author":"M Mrugacz","year":"2005","unstructured":"Mrugacz M, Zywalewska N . HLA-DR antigen expression on conjunctival epithelial cells in patients with dry eye. Klin Oczna 2005; 107: 278\u2013279.","journal-title":"Klin Oczna"},{"key":"BF6702867_CR22","first-page":"120","volume":"41","author":"T Bourcier","year":"2000","unstructured":"Bourcier T, De Saint-Jean M, Brignole F, Goguel A, Baudouin C . Expression of CD40 and CD40 ligand in the human conjunctival epithelium. Invest Ophthalmol Vis Sci 2000; 41: 120\u2013126.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702867_CR23","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/S0161-6420(00)00347-X","volume":"107","author":"PJ Pisella","year":"2000","unstructured":"Pisella PJ, Brignole F, Debbasch C, Pharm D, Lozato PA, Creuzot-Garcher C et al. Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca. Ophthalmology 2000; 107: 1841\u20131849.","journal-title":"Ophthalmology"},{"key":"BF6702867_CR24","first-page":"1356","volume":"41","author":"F Brignole","year":"2000","unstructured":"Brignole F, Pisella PJ, Goldshild M, De Saint Jean M, Goguel A, Baudouin C . Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Invest Ophthalmol Vis Sci 2000; 41: 1356\u20131363.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702867_CR25","first-page":"90","volume":"42","author":"F Brignole","year":"2001","unstructured":"Brignole F, Pisella PJ, Goldshild M, De Saint Brignole F, Pisella PJ, De Saint Jean M et al. Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A. Invest Ophthalmol Vis Sci 2001; 42: 90\u201395.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702867_CR26","first-page":"3493","volume":"35","author":"DT Jones","year":"1994","unstructured":"Jones DT, Monroy D, Ji Z, Atherton SS, Pflugfelder SC . Sj\u00f6gren's syndrome: cytokine and Epstein\u2013Barr viral gene expression within the conjunctival epithelium. Invest Ophthalmol Vis Sci 1994; 35: 3493\u20133504.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702867_CR27","first-page":"2283","volume":"42","author":"A Solomon","year":"2001","unstructured":"Solomon A, Dilek D, Liu Z, Xie Y, Macri A, Pflugfelder SC . Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva in patients with dry-eye disease. Invest Ophthalmol Vis Sci 2001; 42: 2283\u20132292.","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6702867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6702867","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6702867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:30:12Z","timestamp":1684413012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6702867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,25]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["BF6702867"],"URL":"https:\/\/doi.org\/10.1038\/sj.eye.6702867","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,25]]}}}