{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:24:34Z","timestamp":1767666274998},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2001,11,1]]},"DOI":"10.1038\/sj.gene.6363801","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T16:27:15Z","timestamp":1032366435000},"page":"388-397","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses"],"prefix":"10.1038","volume":"2","author":[{"given":"RJ","family":"Roper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JJ","family":"Weis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BA","family":"McCracken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CB","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KS","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Fairbairn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RJ","family":"Butterfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MR","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JF","family":"Zachary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RW","family":"Doerge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Teuscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,11,13]]},"reference":[{"key":"BF6363801_CR1","first-page":"1","volume":"49","author":"KA Orloski","year":"2000","unstructured":"Orloski KA, Hayes EB, Campbell GL, Dennis DT Surveillance for Lyme disease\u2014United States Mor Mortal Wkly Rep CDCSurveill Summ 2000 49 1\u201311","journal-title":"Mor Mortal Wkly Rep CDCSurveill Summ"},{"key":"BF6363801_CR2","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1126\/science.7043737","volume":"216","author":"W Burgdorfer","year":"1982","unstructured":"Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP Lyme disease_a tick-borne spirochetosis? Science 1982 216 1317\u20131319","journal-title":"Science"},{"key":"BF6363801_CR3","first-page":"69","volume":"40","author":"JJ Nocton","year":"1995","unstructured":"Nocton JJ, Steere AC Lyme disease Adv Intern Med 1995 40 69\u2013117","journal-title":"Adv Intern Med"},{"key":"BF6363801_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0167-5699(91)90106-4","volume":"12","author":"MM Simon","year":"1991","unstructured":"Simon MM, Schaible UE, Wallich R, Kramer MD A mouse model for Borrelia burgdorferi infection: approach to a vaccine against Lyme disease Immunol Today 1991 12 11\u201316","journal-title":"Immunol Today"},{"key":"BF6363801_CR5","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1128\/iai.62.6.2625-2627.1994","volume":"62","author":"WT Golde","year":"1994","unstructured":"Golde WT, Kappel KJ, Dequesne G et al Tick transmission of Borrelia burgdorferi to inbred strains of mice induces an antibody response to P39 but not to outer surface protein A Infect Immun 1994 62 2625\u20132627","journal-title":"Infect Immun"},{"key":"BF6363801_CR6","doi-asserted-by":"publisher","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","volume":"107","author":"AC Steere","year":"1987","unstructured":"Steere AC, Schoen RT, Taylor E The clinical evolution of Lyme arthritis Ann Intern Med 1987 107 725\u2013731","journal-title":"Ann Intern Med"},{"key":"BF6363801_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1056\/NEJM199401273300401","volume":"330","author":"JJ Nocton","year":"1994","unstructured":"Nocton JJ, Dressler F, Rutledge BJ et al Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis N Engl J Med 1994 330 229\u2013234","journal-title":"N Engl J Med"},{"key":"BF6363801_CR8","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1126\/science.281.5377.703","volume":"281","author":"DM Gross","year":"1998","unstructured":"Gross DM, Forsthuber T, Tary-Lehmann M et al Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis Science 1998 281 703\u2013706","journal-title":"Science"},{"key":"BF6363801_CR9","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/70946","volume":"5","author":"B Hemmer","year":"1999","unstructured":"Hemmer B, Gran B, Zhao Y et al Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease Nat Med 1999 5 1375\u20131382","journal-title":"Nat Med"},{"key":"BF6363801_CR10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/infdis\/162.1.133","volume":"162","author":"SW Barthold","year":"1990","unstructured":"Barthold SW, Beck DS, Hansen GM, Terwilliger GA, Moody KD Lyme borreliosis in selected strains and ages of laboratory mice J Infect Dis 1990 162 133\u2013138","journal-title":"J Infect Dis"},{"key":"BF6363801_CR11","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4049\/jimmunol.162.2.948","volume":"162","author":"JJ Weis","year":"1999","unstructured":"Weis JJ, McCracken BA, Ma Y et al Identification of quantitative trait loci governing arthritis severity and humoral responses in murine model of Lyme disease J Immunol 1999 162 948\u2013956","journal-title":"J Immunol"},{"key":"BF6363801_CR12","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/S1369-5274(00)00202-2","volume":"4","author":"RM Wooten","year":"2001","unstructured":"Wooten RM, Weis JJ Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes Curr Opin Microb 2001 4 274\u2013279","journal-title":"Curr Opin Microb"},{"key":"BF6363801_CR13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/IAI.66.1.161-168.1998","volume":"66","author":"Y Ma","year":"1998","unstructured":"Ma Y, Seiler KP, Eichwald EJ, Weis JH, Teuscher C, Weis JJ Distinct characteristics of resistance to Borrelia burgdorferi-induced arthritis in C57BL\/6N mice Infect Immun 1998 66 161\u2013168","journal-title":"Infect Immun"},{"key":"BF6363801_CR14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.4269\/ajtmh.1992.47.249","volume":"47","author":"AL Armstrong","year":"1992","unstructured":"Armstrong AL, Barthold SW, Persing DH, Beck DS Carditis in Lyme disease susceptible and resistant strains of laboratory mice infected with Borrelia burgdorferi Am J Trop Med Hyg 1992 47 249\u2013258","journal-title":"Am J Trop Med Hyg"},{"key":"BF6363801_CR15","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1002\/eji.1830211016","volume":"21","author":"UE Schaible","year":"1991","unstructured":"Schaible UE, Kramer MD, Wallich R, Tran T, Simon MM Experimental Borrelia burgdorferi infection in inbred mouse strains: antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis Eur J Immunol 1991 21 2397\u20132405","journal-title":"Eur J Immunol"},{"key":"BF6363801_CR16","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1128\/iai.60.8.3033-3041.1992","volume":"60","author":"L Yang","year":"1992","unstructured":"Yang L, Ma Y, Schoenfeld R et al Evidence for B-lymphocyte mitogen activity in Borrelia burgdorferi-infected mice Infect Immun 1992 60 3033\u20133041","journal-title":"Infect Immun"},{"key":"BF6363801_CR17","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1084\/jem.181.3.1251","volume":"181","author":"JE Matyniak","year":"1995","unstructured":"Matyniak JE, Reiner SL T helper phenotype and genetic susceptibility in experimental Lyme disease J Exp Med 1995 181 1251\u20131254","journal-title":"J Exp Med"},{"key":"BF6363801_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.4269\/ajtmh.1992.47.605","volume":"47","author":"SW Barthold","year":"1992","unstructured":"Barthold SW, Sidman CL, Smith, AL Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency Am J Trop Med Hyg 1992 47 605\u2013613","journal-title":"Am J Trop Med Hyg"},{"key":"BF6363801_CR19","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1128\/IAI.67.4.1967-1973.1999","volume":"67","author":"CR Brown","year":"1999","unstructured":"Brown CR, Reiner SL Genetic control of experimental Lyme arthritis in the absence of specific immunity Infect Immun 1999 67 1967\u20131973","journal-title":"Infect Immun"},{"key":"BF6363801_CR20","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/genetics\/136.4.1457","volume":"136","author":"ZB Zeng","year":"1994","unstructured":"Zeng ZB Precision mapping of quantitative trait loci Genetics 1994 136 1457\u20131468","journal-title":"Genetics"},{"key":"BF6363801_CR21","doi-asserted-by":"publisher","first-page":"10972","DOI":"10.1073\/pnas.90.23.10972","volume":"90","author":"ZB Zeng","year":"1993","unstructured":"Zeng ZB Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci Proc Natl Acad Sci USA 1993 90 10972\u201310976","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6363801_CR22","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.4049\/jimmunol.163.4.2262","volume":"163","author":"C Teuscher","year":"1999","unstructured":"Teuscher C, Butterfield RJ, Ma RZ, Zachary JF, Doerge RW, Blankenhorn EP Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting\/nonrelapsing experimental allergic encephalomyelitis J Immunol 1999 163 2262\u20132266","journal-title":"J Immunol"},{"key":"BF6363801_CR23","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0002-9440(10)64574-9","volume":"157","author":"RJ Butterfield","year":"2000","unstructured":"Butterfield RJ, Blankenhorn EP, Roper RJ, Zachary JF, Doerge RW, Teuscher C Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis Am J Pathol 2000 157 637\u2013645","journal-title":"Am J Pathol"},{"key":"BF6363801_CR24","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1165\/ajrcmb.23.4.4199","volume":"23","author":"SL Ewart","year":"2000","unstructured":"Ewart SL, Kuperman D, Schadt E et al Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice Am J Respir Cell Mol Biol 2000 23 537\u2013545","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BF6363801_CR25","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1128\/IAI.67.8.4223-4230.1999","volume":"67","author":"GJ Nau","year":"1999","unstructured":"Nau GJ, Liaw L, Chupp GL, Berman JS, Hogan BL, Young RA Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin Infect Immun 1999 67 4223\u20134230","journal-title":"Infect Immun"},{"key":"BF6363801_CR26","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1126\/science.287.5454.860","volume":"287","author":"S Ashkar","year":"2000","unstructured":"Ashkar S, Weber GF, Panoutsakopoulou V et al Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity Science 2000 287 860\u2013864","journal-title":"Science"},{"key":"BF6363801_CR27","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s002510050472","volume":"49","author":"M Kosarova","year":"1999","unstructured":"Kosarova M, Havelkova H, Krulova M, Demant P, Lipoldova M The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively Immunogenetics 1999 49 134\u2013141","journal-title":"Immunogenetics"},{"key":"BF6363801_CR28","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1128\/IAI.67.10.5142-5150.1999","volume":"67","author":"JP Brown","year":"1999","unstructured":"Brown JP, Zachary JF, Teuscher C, Weis JJ, Wooten RM Dual role of interleukin-10 in murine Lyme disease: regulation of arthritis severity and host defense Infect Immun 1999 67 5142\u20135150","journal-title":"Infect Immun"},{"key":"BF6363801_CR29","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.1128\/IAI.68.10.5603-5609.2000","volume":"68","author":"MR Potter","year":"2000","unstructured":"Potter MR, Noben-Trauth N, Weis JH, Teuscher C, Weis JJ Interleukin-4 (IL-4) and IL-13 signaling pathways do not regulate Borrelia burgdorferi-induced arthritis in mice: IgG1 is not required for host control of tissue spirochetes Infect Immun 2000 68 5603\u20135609","journal-title":"Infect Immun"},{"key":"BF6363801_CR30","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1084\/jem.180.5.1705","volume":"180","author":"LS Wicker","year":"1994","unstructured":"Wicker LS, Todd JA, Prins JB, Podolin PL, Renjilian RJ, Peterson LB Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes J Exp Med 1994 180 1705\u20131713","journal-title":"J Exp Med"},{"key":"BF6363801_CR31","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4049\/jimmunol.159.4.1835","volume":"159","author":"PL Podolin","year":"1997","unstructured":"Podolin PL, Denny P, Lord CJ et al Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1 J Immunol 1997 159 1835\u20131843","journal-title":"J Immunol"},{"key":"BF6363801_CR32","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1074-7613(00)00012-1","volume":"13","author":"PA Lyons","year":"2000","unstructured":"Lyons PA, Hancock WW, Denny P et al The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular of Cd30, Tnfr2, and Cd137 Immunity 2000 13 107\u2013115","journal-title":"Immunity"},{"key":"BF6363801_CR33","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/S0952-7915(99)00039-4","volume":"11","author":"EK Wakeland","year":"1999","unstructured":"Wakeland EK, Wandstrat AE, Liu K, Morel L Genetic dissection of systemic lupus erythematosus Curr Opin Immunol 1999 11 701\u2013707","journal-title":"Curr Opin Immunol"},{"key":"BF6363801_CR34","unstructured":"Butterfield RJ, Roper RJ, Rhein DM et al Sex specific QTL govern susceptibility to Theiler\u2019s murine encephalomyelitis virus-induced demyelination (TMEVD) (submitted for publication)"},{"key":"BF6363801_CR35","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.4049\/jimmunol.157.5.2186","volume":"157","author":"JA Encinas","year":"1996","unstructured":"Encinas JA, Lees MB, Sobel RA et al Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL\/J and B10.S mice J Immunol 1996 157 2186\u20132192","journal-title":"J Immunol"},{"key":"BF6363801_CR36","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.4049\/jimmunol.161.4.1860","volume":"161","author":"RJ Butterfield","year":"1998","unstructured":"Butterfield RJ, Sudweeks JD, Blankenhorn EP et al New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice J Immunol 1998 161 1860\u20131867","journal-title":"J Immunol"},{"key":"BF6363801_CR37","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.4049\/jimmunol.164.6.3420","volume":"164","author":"EP Blankenhorn","year":"2000","unstructured":"Blankenhorn EP, Butterfield RJ, Rigby R et al Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints J Immunol 2000 164 3420\u20133425","journal-title":"J Immunol"},{"key":"BF6363801_CR38","doi-asserted-by":"publisher","first-page":"10168","DOI":"10.1073\/pnas.91.21.10168","volume":"91","author":"DH Kono","year":"1994","unstructured":"Kono DH, Burlingame RW, Owens DG et al Lupus susceptibility loci in New Zealand mice Proc Natl Acad Sci USA 1994 91 10168\u201310172","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6363801_CR39","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/1074-7613(94)90100-7","volume":"1","author":"L Morel","year":"1994","unstructured":"Morel L, Rudofsky UH, Longmate JA, Schiffenbauer J, Wakeland EK Polygenic control of susceptibility to murine systemic lupus erythematosus Immunity 1994 1 219\u2013229","journal-title":"Immunity"},{"key":"BF6363801_CR40","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.4049\/jimmunol.157.6.2719","volume":"157","author":"TJ Vyse","year":"1996","unstructured":"Vyse TJ, Morel L, Tanner FJ, Wakeland EK, Kotzin BL Backcross analysis of genes linked to autoantibody production in New Zealand White mice J Immunol 1996 157 2719\u20132727","journal-title":"J Immunol"},{"key":"BF6363801_CR41","doi-asserted-by":"crossref","first-page":"5566","DOI":"10.4049\/jimmunol.158.11.5566","volume":"158","author":"TJ Vyse","year":"1997","unstructured":"Vyse TJ, Rozzo SJ, Drake CG, Izui S, Kotzin BL Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice J Immunol 1997 158 5566\u20135574","journal-title":"J Immunol"},{"key":"BF6363801_CR42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev.immunol.16.1.261","volume":"16","author":"TJ Vyse","year":"1998","unstructured":"Vyse TJ, Kotzin BL Genetic susceptibility to systemic lupus erythematosus Annu Rev Immunol 1998 16 261\u2013292","journal-title":"Annu Rev Immunol"},{"key":"BF6363801_CR43","unstructured":"Festing MFW Inbred strain characteristics(http:\/\/www.informatics.jax.org\/external\/festing\/search_form.cgi)"},{"key":"BF6363801_CR44","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1128\/JCM.37.4.987-992.1999","volume":"37","author":"TB Morrison","year":"1999","unstructured":"Morrison TB, Ma Y, Weis JH, Weis JJ Rapid and sensitive quantification of Borrelia burgdorferi-infected mouse tissues by continuous fluorescent monitoring of PCR J Clin Microbiol 1999 37 987\u2013992","journal-title":"J Clin Microbiol"},{"key":"BF6363801_CR45","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1073\/pnas.90.8.3700","volume":"90","author":"JD Sudweeks","year":"1993","unstructured":"Sudweeks JD, Todd JA, Blankenhorn EP et al Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6 Proc Natl Acad Sci USA 1993 90 3700\u20133704","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6363801_CR46","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/0888-7543(87)90010-3","volume":"1","author":"ES Lander","year":"1987","unstructured":"Lander ES, Green P, Abrahamson J et al MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations Genomics 1987 1 174\u2013181","journal-title":"Genomics"},{"key":"BF6363801_CR47","volume-title":"Constructing Genetic Maps With MAPMAKER\/EXP 3.0. Whitehead Institute Technical Report","author":"S Lincoln","year":"1992","unstructured":"Lincoln S, Daly M, Lander E Constructing Genetic Maps With MAPMAKER\/EXP 3.0. Whitehead Institute Technical Report 3rd edition 1992"},{"key":"BF6363801_CR48","volume-title":"QTL Cartographer: A Reference Manual and Tutorial for QTL Mapping","author":"CJ Basten","year":"1997","unstructured":"Basten CJ, Weir BS, Zeng ZB QTL Cartographer: A Reference Manual and Tutorial for QTL Mapping Department of Statistics, North Carolina State University, Raleigh, NC 1997"},{"key":"BF6363801_CR49","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1214\/ss\/1030037909","volume":"12","author":"RW Doerge","year":"1997","unstructured":"Doerge RW, Zeng ZB, Weir BS Statistical issues in the search for genes affecting quantitative traits in experimental populations Stat Sci 1997 12 195\u2013219","journal-title":"Stat Sci"},{"key":"BF6363801_CR50","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/138.3.963","volume":"138","author":"GA Churchill","year":"1994","unstructured":"Churchill GA, Doerge RW Empirical threshold values for quantitative trait mapping Genetics 1994 138 963\u2013971","journal-title":"Genetics"}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6363801.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6363801","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6363801.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T01:23:10Z","timestamp":1704590590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6363801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,1]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,11,1]]}},"alternative-id":["BF6363801"],"URL":"https:\/\/doi.org\/10.1038\/sj.gene.6363801","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11,1]]},"assertion":[{"value":"25 May 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2001","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}