{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:55:20Z","timestamp":1773269720578,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2002,9,1]]},"DOI":"10.1038\/sj.gene.6363863","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T16:27:55Z","timestamp":1032366475000},"page":"368-372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["A weak association of HLA-B*2702 with Beh\u00e7et\u2019s disease"],"prefix":"10.1038","volume":"3","author":[{"given":"A","family":"G\u00fcl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F A","family":"Uyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Inan\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Ocal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Aral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Koni\u00e7e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Saruhan-Direskeneli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,9,3]]},"reference":[{"key":"BF6363863_CR1","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","volume":"341","author":"T Sakane","year":"1999","unstructured":"Sakane T, Takeno M, Suzuki N, Inaba G . Beh\u00e7et\u2019s disease N Engl J Med 1999 341: 1284\u20131291","journal-title":"N Engl J Med"},{"key":"BF6363863_CR2","first-page":"S6","volume":"19(Suppl 24)","author":"A G\u00fcl","year":"2001","unstructured":"G\u00fcl A . Beh\u00e7et\u2019s disease: an update on the pathogenesis Clin Exp Rheum 2001 19(Suppl 24): S6\u2013S12","journal-title":"Clin Exp Rheum"},{"key":"BF6363863_CR3","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1001\/archopht.1982.01030040433013","volume":"100","author":"S Ohno","year":"1982","unstructured":"Ohno S, Ohguchi M, Hirose S, Matsuda H, Wakisaka A, Aizawa M . Close association of HLA-Bw51 with Beh\u00e7et\u2019s disease Arch Ophthalmol 1982 100: 1445\u20131458","journal-title":"Arch Ophthalmol"},{"key":"BF6363863_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1399-0039.1992.tb01953.x","volume":"40","author":"N Mizuki","year":"1992","unstructured":"Mizuki N, Ohno S, Tanaka H et al. Association of HLA-B51 and lack of association of class II alleles with Beh\u00e7et\u2019s disease Tissue Antigens 1992 40: 22\u201330","journal-title":"Tissue Antigens"},{"key":"BF6363863_CR5","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1399-0039.1981.tb00687.x","volume":"17","author":"AU M\u00fcft\u00fcoglu","year":"1981","unstructured":"M\u00fcft\u00fcoglu AU, Yazici H, Yurdakul S et al. Beh\u00e7et\u2019s disease: lack of correlation of clinical manifestations with HLA antigens Tissue Antigens 1981 17: 226\u2013230","journal-title":"Tissue Antigens"},{"key":"BF6363863_CR6","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/0002-9343(87)90896-5","volume":"83","author":"T Chajek-Shaul","year":"1987","unstructured":"Chajek-Shaul T, Pisanty S, Knobler H et al. HLA-B51 may serve as an immunogenetic marker for a subgroup of patients with Beh\u00e7et\u2019s syndrome Am J Med 1987 83: 666\u2013672","journal-title":"Am J Med"},{"key":"BF6363863_CR7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/j.1399-0039.1992.tb01925.x","volume":"39","author":"A Balboni","year":"1992","unstructured":"Balboni A, Pivetti-Pezzi P, Orlando P et al. Serological and molecular HLA typing in Italian Beh\u00e7et\u2019s patients: significant association to B51-DR5-DQw3 haplotype Tissue Antigens 1992 39: 141\u2013143","journal-title":"Tissue Antigens"},{"key":"BF6363863_CR8","first-page":"895","volume":"37","author":"T Lehner","year":"1979","unstructured":"Lehner T, Batchelor JR, Challacombe SJ, Kennedy L . An immunogenetic basis for the tissue involvement in Beh\u00e7et\u2019s syndrome Immunology 1979 37: 895\u2013900","journal-title":"Immunology"},{"key":"BF6363863_CR9","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1136\/bjo.81.8.649","volume":"81","author":"DJ Kilmartin","year":"1997","unstructured":"Kilmartin DJ, Finch A, Acheson RW . Primary association of HLA-B51 with Behcet\u2019s disease in Ireland Br J Ophthalmol 1997 81: 649\u2013653","journal-title":"Br J Ophthalmol"},{"key":"BF6363863_CR10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0198-8859(94)00159-N","volume":"43","author":"N Mizuki","year":"1995","unstructured":"Mizuki N, Ohno S, Sato T et al. Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Beh\u00e7et\u2019s disease Hum Immunol 1995 43: 129\u2013135","journal-title":"Hum Immunol"},{"key":"BF6363863_CR11","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1073\/pnas.94.4.1298","volume":"94","author":"N Mizuki","year":"1997","unstructured":"Mizuki N, Ota M, Kimura M et al. Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Beh\u00e7et disease Proc Natl Acad Sci USA 1997 94: 1298\u20131303","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6363863_CR12","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3109\/08830189709116843","volume":"14","author":"N Mizuki","year":"1997","unstructured":"Mizuki N, Inoko H, Ohno S . Pathogenic gene responsible for the predisposition to Beh\u00e7et\u2019s disease Intern Rev Immunol 1997 14: 33\u201348","journal-title":"Intern Rev Immunol"},{"key":"BF6363863_CR13","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1086\/302364","volume":"64","author":"M Ota","year":"1999","unstructured":"Ota M, Mizuki N, Katsuyama Y et al. The critical region for Beh\u00e7et\u2019s disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping Am J Hum Genet 1999 64: 1406\u20131410","journal-title":"Am J Hum Genet"},{"key":"BF6363863_CR14","first-page":"3702","volume":"41","author":"N Mizuki","year":"2000","unstructured":"Mizuki N, Ota M, Yabuki K et al. Localization of the pathogenic gene of Behcet\u2019s disease by microsatellite analysis of three different populations Invest Ophthalmol Vis Sci 2000 41: 3702\u20133708","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6363863_CR15","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1084\/jem.180.2.537","volume":"180","author":"V Litwin","year":"1994","unstructured":"Litwin V, Gumperz J, Parham P, Phillips JH, Lanier LL . NKB1: A natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules J Exp Med 1994 180: 537\u2013543","journal-title":"J Exp Med"},{"key":"BF6363863_CR16","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1084\/jem.180.4.1235","volume":"180","author":"M Cella","year":"1994","unstructured":"Cella M, Longo A, Ferrara GB, Strominger JL, Colonna M . NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80 J Exp Med 1994 180: 1235\u20131242","journal-title":"J Exp Med"},{"key":"BF6363863_CR17","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev.immunol.16.1.359","volume":"16","author":"LL Lanier","year":"1998","unstructured":"Lanier LL . NK cell receptors Annu Rev Immunol 1998 16: 359\u2013393","journal-title":"Annu Rev Immunol"},{"key":"BF6363863_CR18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0167-5699(97)01236-X","volume":"19","author":"MC Mingari","year":"1998","unstructured":"Mingari MC, Moretta A, Moretta L . Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T cell responses Immunol Today 1998 19: 153\u2013157","journal-title":"Immunol Today"},{"key":"BF6363863_CR19","first-page":"541","volume":"45","author":"H Payami","year":"1989","unstructured":"Payami H, Joe S, Farid NR et al. Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease Am J Hum Genet 1989 45: 541\u2013546","journal-title":"Am J Hum Genet"},{"key":"BF6363863_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/gepi.1370060129","volume":"6","author":"G Thomson","year":"1989","unstructured":"Thomson G, Robinson WP, Kuhner MK, Joe S, Klitz W . HLA and insulin gene associations with IDDM Genet Epidemiol 1989 6: 155\u2013160","journal-title":"Genet Epidemiol"},{"key":"BF6363863_CR21","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3109\/10408369509084684","volume":"32","author":"G Thomson","year":"1995","unstructured":"Thomson G . HLA disease associations: models for the study of complex human genetic disorders Crit Rev Clin Lab Sci 1995 32: 183\u2013219","journal-title":"Crit Rev Clin Lab Sci"},{"key":"BF6363863_CR22","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/(SICI)1098-2272(1998)15:2<123::AID-GEPI2>3.0.CO;2-7","volume":"15","author":"H Mu","year":"1998","unstructured":"Mu H, King MC, Criswell LA . Relative predispositional effects and mode of inheritance of HLA-DRB1 alleles among community-based Caucasian females with rheumatoid arthritis Genet Epidemiol 1998 15: 123\u2013134","journal-title":"Genet Epidemiol"},{"key":"BF6363863_CR23","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1399-0039.1996.tb02553.x","volume":"47","author":"L Lin","year":"1996","unstructured":"Lin L, Tokunaga K, Tanaka H et al. Further molecular diversity in the HLA-B15 group Tissue Antigens 1996 47: 265\u2013274","journal-title":"Tissue Antigens"},{"key":"BF6363863_CR24","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1046\/j.1365-2249.2000.01176.x","volume":"120","author":"S Kurhan-Yavuz","year":"2000","unstructured":"Kurhan-Yavuz S, Direskeneli H, Bozkurt N et al. Anti-MHC autoimmunity in Beh\u00e7et\u2019s disease: T cell responses to an HLA-B-derived peptide cross-reactive with retinal-S antigen in patients with uveitis Clin Exp Immunol 2000 120: 162\u2013166","journal-title":"Clin Exp Immunol"},{"key":"BF6363863_CR25","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/art.1780380321","volume":"38","author":"M Takeno","year":"1995","unstructured":"Takeno M, Kariyone A, Yamashita N et al. Excessive function of peripheral blood neutrophils from patients with Beh\u00e7et\u2019s disease and from HLA-B51 transgenic mice Arthritis Rheum 1995 38: 426\u2013433","journal-title":"Arthritis Rheum"},{"key":"BF6363863_CR26","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.4049\/jimmunol.158.11.5237","volume":"158","author":"JE Gumperz","year":"1997","unstructured":"Gumperz JE, Barber LD, Valiante NM et al. Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor J Immunol 1997 158: 5237\u20135241","journal-title":"J Immunol"},{"key":"BF6363863_CR27","first-page":"742","volume":"19","author":"A Kahan","year":"1992","unstructured":"Kahan A, Hamzaoui K, Ayed K . Abnormalities of T lymphocyte subsets in Beh\u00e7et\u2019s disease demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies J Rheumatol 1992 19: 742\u2013746","journal-title":"J Rheumatol"},{"key":"BF6363863_CR28","first-page":"588","volume":"19","author":"Y Suzuki","year":"1992","unstructured":"Suzuki Y, Hoshi K, Matsuda T, Mizushima Y . Increased peripheral blood \u03b3\u03b4+ T cells and natural killer cells in Beh\u00e7et\u2019s disease J Rheumatol 1992 19: 588\u2013592","journal-title":"J Rheumatol"},{"key":"BF6363863_CR29","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S0140-6736(96)90868-5","volume":"347","author":"A Hasan","year":"1996","unstructured":"Hasan A, Fortune F, Wilson A et al. Role of \u03b3\u03b4 T cells in the pathogenesis and diagnosis of Beh\u00e7et\u2019s disease Lancet 1996 347: 789\u2013794","journal-title":"Lancet"},{"key":"BF6363863_CR30","first-page":"6","volume":"73","author":"C Young","year":"1988","unstructured":"Young C, Lehner T, Barnes CG . CD4 and CD8 cell responses to herpes simplex virus in Behcet\u2019s disease Clin Exp Immunol 1988 73: 6\u201310","journal-title":"Clin Exp Immunol"},{"key":"BF6363863_CR31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1365-2249.1990.tb05122.x","volume":"79","author":"K Hamzaoui","year":"1990","unstructured":"Hamzaoui K, Ayed Kh, Slim A, Hamza M, Touraine JL . Natural killer cell activity, interferon-gamma and antibodies to herpes viruses in patients with Beh\u00e7et\u2019s disease Clin Exp Immunol 1990 79: 28\u201334","journal-title":"Clin Exp Immunol"},{"key":"BF6363863_CR32","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1097\/00007890-199502270-00001","volume":"59","author":"R Buelow","year":"1995","unstructured":"Buelow R, Veyron P, Clayberger C, Pouletty P, Touraine J-L . Prolongation of skin allograft in mice following administration of allotrap Transplantation 1995 59: 455\u2013460","journal-title":"Transplantation"},{"key":"BF6363863_CR33","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1097\/00007890-199704150-00017","volume":"63","author":"M Giral","year":"1997","unstructured":"Giral M, Cuturi M-C, Nguyen J-M et al. Decreased cytotoxic activity of natural killer cells in kidney allograft recipients treated with human HLA-derived peptide Transplantation 1997 63: 1004\u20131011","journal-title":"Transplantation"},{"key":"BF6363863_CR34","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1084\/jem.184.4.1585","volume":"184","author":"M Peruzzi","year":"1996","unstructured":"Peruzzi M, Wagtmann N, Long EO . A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B*2705 J Exp Med 1996 184: 1585\u20131590","journal-title":"J Exp Med"},{"key":"BF6363863_CR35","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/BF02786393","volume":"16","author":"KD Smith","year":"1997","unstructured":"Smith KD, Kurago ZB, Lutz CT . Corformational changes in MHC class I molecules. Antibody, T-cell receptor, and NK cell recognition in an HLA-B7 model system Immunol Res 1997 16: 243\u2013259","journal-title":"Immunol Res"},{"key":"BF6363863_CR36","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1399-0039.1997.tb02724.x","volume":"49","author":"S Gonzalez-Roces","year":"1997","unstructured":"Gonzalez-Roces S, Alvarez MV, Gonzalez S et al. HLA-B27 polymorphism and worldwide susceptiblity to ankylosing spondylitis Tissue Antigens 1997 49: 116\u2013123","journal-title":"Tissue Antigens"},{"key":"BF6363863_CR37","doi-asserted-by":"crossref","unstructured":"International Study Group for Behcet\u2019s Disease. Criteria for diagnosis of Beh\u00e7et\u2019s disease Lancet 1990 335: 1078\u20131080","DOI":"10.1016\/0140-6736(90)92643-V"},{"key":"BF6363863_CR38","first-page":"216","volume-title":"Genetic Diversity of HLA. Functional and Medical Implication","author":"LJ Kennedy","year":"1997","unstructured":"Kennedy LJ, Poulton KV, Thomson W et al. HLA class I DNA typing using sequence specific oligonucleotide probes (SSOP) In: Charron D (ed) Genetic Diversity of HLA. Functional and Medical Implication EDK: Paris 1997 pp 216\u2013225"},{"key":"BF6363863_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1399-0039.1995.tb02408.x","volume":"45","author":"N Cereb","year":"1995","unstructured":"Cereb N, Maye P, Lee S, Kong Y, Yang SY . Locus-specific amplification of HLA class I genes from genomic DNA: locus-specific sequences in the first and third introns of HLA-A, -B and -C alleles Tissue Antigens 1995 45: 1\u201311","journal-title":"Tissue Antigens"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6363863.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6363863","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6363863.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T01:23:09Z","timestamp":1704590589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6363863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,1]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,9,1]]}},"alternative-id":["BF6363863"],"URL":"https:\/\/doi.org\/10.1038\/sj.gene.6363863","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,1]]},"assertion":[{"value":"23 August 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2002","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2002","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2002","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}