{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:31:48Z","timestamp":1791063108748,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2003,1,1]]},"DOI":"10.1038\/sj.gene.6363900","type":"journal-article","created":{"date-parts":[[2003,2,20]],"date-time":"2003-02-20T15:51:00Z","timestamp":1045756260000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients"],"prefix":"10.1038","volume":"4","author":[{"given":"Y","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Uygar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Pallos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Gorry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Firatli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Cortelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T E","family":"VanDyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P S","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Feingold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T C","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,1,16]]},"reference":[{"key":"BF6363900_CR1","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1016\/0006-291X(81)91962-8","volume":"100","author":"TE Van Dyke","year":"1981","unstructured":"Van Dyke TE, Levine MJ, Tabak LA, Genco RJ . Reduced chemotactic peptide binding in juvenile periodontitis: a model for neutrophil function. Biochem Biophys Res Commun 1981; 100: 1278\u20131284.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF6363900_CR2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1034\/j.1600-051x.2001.028002162.x","volume":"28","author":"B Sigusch","year":"2001","unstructured":"Sigusch B, Eick S, Pfister W, Klinger G, Glockmann E . Altered chemotactic behavior of crevicular PMNs in different forms of periodontitis. J Clin Periodontol 2001; 28: 162\u2013167.","journal-title":"J Clin Periodontol"},{"key":"BF6363900_CR3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1600-0765.1998.tb02202.x","volume":"33","author":"H Hurttia","year":"1998","unstructured":"Hurttia H, Saarinen K, Leino L . Increased adhesion of peripheral blood neutrophils from patients with localized juvenile periodontitis. J Periodontal Res 1998; 33: 292\u2013297.","journal-title":"J Periodontal Res"},{"key":"BF6363900_CR4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1034\/j.1600-051X.1999.260901.x","volume":"26","author":"D Biasi","year":"1999","unstructured":"Biasi D, Bambara LM, Carletto A et al. Neutrophil migration, oxidative metabolism and adhesion in early onset perio-dontitis. J Clin Periodontol 1999; 26: 563\u2013568.","journal-title":"J Clin Periodontol"},{"key":"BF6363900_CR5","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1902\/jop.1993.64.7.617","volume":"64","author":"MA Daniel","year":"1993","unstructured":"Daniel MA, McDonald G, Offenbacher S, Van Dyke TE . Defective chemotaxis and calcium response in localized juvenile periodontitis neutrophils. J Periodontol 1993; 64: 617\u2013621.","journal-title":"J Periodontol"},{"key":"BF6363900_CR6","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1902\/jop.1992.63.6.496","volume":"63","author":"B Sigusch","year":"1992","unstructured":"Sigusch B, Klinger G, Holtz H, Suss J . In vitro phagocytosis by crevicular phagocytes in various forms of periodontitis. J Periodontol 1992; 63: 496\u2013501.","journal-title":"J Periodontol"},{"key":"BF6363900_CR7","unstructured":"Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: {136537}: {6\/21\/00}: {136538}: {3\/20\/01}: {136539}: {7\/2\/98}. World Wide Web URL: http:\/\/www.ncbi.nlm.nih.gov\/omim\/."},{"key":"BF6363900_CR8","first-page":"168","volume":"36","author":"RJ Genco","year":"1986","unstructured":"Genco RJ, Christersson LA, Zambon JJ . Juvenile periodontitis. Int Dent J 1986; 36: 168\u2013176.","journal-title":"Int Dent J"},{"key":"BF6363900_CR9","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1172\/JCI115105","volume":"87","author":"HD Perez","year":"1991","unstructured":"Perez HD, Kelly E, Elfman F, Armitage G, Winkler J . Defective polymorphonuclear leukocyte formyl peptide receptor(s) in juvenile periodontitis. J Clin Invest 1991; 87: 971\u2013976.","journal-title":"J Clin Invest"},{"key":"BF6363900_CR10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1600-0765.1994.tb01101.x","volume":"29","author":"S Agarwal","year":"1994","unstructured":"Agarwal S, Suzuki JB, Riccelli AE . Role of cytokines in the modulation of neutrophil chemotaxis in localized juvenile periodontitis. J Periodontal Res 1994; 29: 127\u2013137.","journal-title":"J Periodontal Res"},{"key":"BF6363900_CR11","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1902\/annals.1996.1.1.821","volume":"1","author":"S Offenbacher","year":"1996","unstructured":"Offenbacher S . Periodontal diseases: pathogenesis. Ann Periodontol 1996; 1: 821\u2013878.","journal-title":"Ann Periodontol"},{"key":"BF6363900_CR12","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1902\/jop.1999.70.10.1194","volume":"70","author":"MR Gwinn","year":"1999","unstructured":"Gwinn MR, Sharma A, De Nardin E . Single nucleotide polymorphisms of the N-formyl peptide receptor in localized juvenile periodontitis. J Periodontol 1999; 70: 1194\u20131201.","journal-title":"J Periodontol"},{"key":"BF6363900_CR13","doi-asserted-by":"crossref","unstructured":"1999 International Workshop for a Classification of Periodontal Diseases and Conditions. Papers. Oak Brook, Illinois, 30 October\u20132 November, 1999. Ann Periodontol 1999; 4: 1\u2013112.","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"BF6363900_CR14","doi-asserted-by":"publisher","first-page":"11123","DOI":"10.1021\/bi00502a016","volume":"29","author":"F Boulay","year":"1990","unstructured":"Boulay F, Tardif M, Brouchon L, Vignais P . The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry 1990; 29: 11123\u201311133.","journal-title":"Biochemistry"},{"key":"BF6363900_CR15","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/0006-291X(90)91143-G","volume":"168","author":"F Boulay","year":"1990","unstructured":"Boulay F, Tardif M, Brouchon L, Vignais P . Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem Biophys Res Commun 1990; 168: 1103\u20131109.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF6363900_CR16","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1016\/S0021-9258(18)42563-X","volume":"267","author":"PM Murphy","year":"1992","unstructured":"Murphy PM, Ozcelik T, Kenney RT, Tiffany HL, McDermott D, Francke U . A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. J Biol Chem 1992; 267: 7637\u20137643.","journal-title":"J Biol Chem"},{"key":"BF6363900_CR17","first-page":"381","volume":"26","author":"E De Nardin","year":"1992","unstructured":"De Nardin E, Radel SJ, Lewis N, Genco RJ, Hammarskjold M . Identification of a gene encoding for the human formyl peptide receptor. Biochem Int 1992; 26: 381\u2013387.","journal-title":"Biochem Int"},{"key":"BF6363900_CR18","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/sj.gene.6363787","volume":"2","author":"A Sahagun-Ruiz","year":"2001","unstructured":"Sahagun-Ruiz A, Colla JS, Juhn J, Gao J-L, Murphy PM, McDermott DH . Contrasting evolution of the human leukocyte N-formylpeptide receptor subtypes FPR and FPRL1R. Genes Immun 2001; 2: 335\u2013342.","journal-title":"Genes Immun"},{"key":"BF6363900_CR19","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1902\/jop.1994.65.6.623","volume":"65","author":"ML Marazita","year":"1994","unstructured":"Marazita ML, Burmeister JA, Gunsolley JC, Koertge TE, Lake K, Schenkein HA . Evidence for autosomal dominant inheritance and race-specific heterogeneity in early-onset perio-dontitis. J Periodontol 1994; 65: 623\u2013630.","journal-title":"J Periodontol"},{"key":"BF6363900_CR20","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1172\/JCI115105","volume":"87","author":"HD Perez","year":"1991","unstructured":"Perez HD, Kelly E, Elfman F, Armitage G, Winkler J . Defective polymorphonuclear leukocyte formyl peptide receptor(s) in juvenile periodontitis. J Clin Invest 1991; 87: 971\u2013976.","journal-title":"J Clin Invest"},{"key":"BF6363900_CR21","first-page":"189","volume":"9","author":"C Mattout","year":"1990","unstructured":"Mattout C, Mege JL, Mattout P, Fourel J, Monnet V . Function of polynuclear neutrophils in patients with juvenile periodontitis and rapidly progressing periodontitis. J Parodontol 1990; 9: 189\u2013193.","journal-title":"J Parodontol"},{"key":"BF6363900_CR22","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/0006-291X(92)90629-Y","volume":"184","author":"RD Ye","year":"1992","unstructured":"Ye RD, Cavanagh SL, Quehenberger O, Prossnitz ER, Cochrane CG . Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem Biophys Res Commun 1992; 184: 582\u2013589.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF6363900_CR23","doi-asserted-by":"crossref","first-page":"18167","DOI":"10.1016\/S0021-9258(17)46825-6","volume":"268","author":"O Quehenberger","year":"1993","unstructured":"Quehenberger O, Prossnitz ER, Cavanagh SL, Cochrane CG, Ye RD . Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J Biol Chem 1993; 268: 18167\u201318175.","journal-title":"J Biol Chem"},{"key":"BF6363900_CR24","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1046\/j.1432-1327.1999.00647.x","volume":"264","author":"A Lala","year":"1999","unstructured":"Lala A, Gwinn M, De Nardin E . Human formyl peptide receptor function role of conserved and nonconserved charged residues. Eur J Biochem 1999; 264: 495\u2013499.","journal-title":"Eur J Biochem"},{"key":"BF6363900_CR25","doi-asserted-by":"publisher","first-page":"42043","DOI":"10.1074\/jbc.M106621200","volume":"276","author":"R Seifert","year":"2001","unstructured":"Seifert R, Wenzel-Seifert K . Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis. J Biol Chem 2001; 276: 42043\u201342049.","journal-title":"J Biol Chem"},{"key":"BF6363900_CR26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1159\/000059337","volume":"95","author":"Y Zhang","year":"2001","unstructured":"Zhang Y, Gorry MC, Hart PS et al. Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p21-p22. Cytogenet Cell Genet 2001; 95: 146\u2013152.","journal-title":"Cytogenet Cell Genet"},{"key":"BF6363900_CR27","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1136\/jmg.37.12.927","volume":"37","author":"PS Hart","year":"2000","unstructured":"Hart PS, Zhang Y, Firatli E et al. Identification of cathepsin C mutations in ethnically diverse Papillon\u2013Lefevre syndrome patients. J Med Genet 2000; 37: 927\u2013932.","journal-title":"J Med Genet"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6363900.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6363900","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6363900.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:27:01Z","timestamp":1704774421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6363900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1,1]]}},"alternative-id":["BF6363900"],"URL":"https:\/\/doi.org\/10.1038\/sj.gene.6363900","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,1]]},"assertion":[{"value":"16 January 2003","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}