{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:42:39Z","timestamp":1789767759834,"version":"4.0.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T00:00:00Z","timestamp":1099526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2004,12,1]]},"DOI":"10.1038\/sj.gene.6364143","type":"journal-article","created":{"date-parts":[[2004,11,4]],"date-time":"2004-11-04T10:07:11Z","timestamp":1099562831000},"page":"668-674","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of the divergent eosinophil ribonuclease, mEar 6, and its expression in response to Schistosoma mansoni infection in vivo"],"prefix":"10.1038","volume":"5","author":[{"given":"T","family":"Nitto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K D","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Mejia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bystr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T A","family":"Wynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H F","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"BF6364143_CR1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35057062","volume":"409","author":"ES Lander","year":"2001","unstructured":"Lander ES, Linton LM, Birren B et al. Initial sequencing and analysis of the human genome. Nature 2001; 409: 860\u2013921.","journal-title":"Nature"},{"key":"BF6364143_CR2","volume-title":"Ribonucleases: Structures and Functions","author":"J Riordan","year":"1997","unstructured":"Riordan J, D'Alessio G . Ribonucleases: Structures and Functions. Academic Press: San Diego, 1997."},{"key":"BF6364143_CR3","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s000180050211","volume":"54","author":"JJ Beintema","year":"1998","unstructured":"Beintema JJ, Kleineidam RG . The ribonuclease A superfamily: general discussion. Cell Mol Life Sci 1998; 54: 825\u2013832.","journal-title":"Cell Mol Life Sci"},{"key":"BF6364143_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0079-6107(88)90001-6","volume":"51","author":"JJ Beintema","year":"1988","unstructured":"Beintema JJ, Schuller C, Irie M, Carsana A . Molecular evolution of the ribonuclease superfamily. Prog Biophys Mol Biol 1988; 51: 165\u2013192.","journal-title":"Prog Biophys Mol Biol"},{"key":"BF6364143_CR5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s000180050208","volume":"54","author":"HF Rosenberg","year":"1998","unstructured":"Rosenberg HF . The eosinophil ribonucleases. Cell Mol Life Sci 1998; 54: 795\u2013803.","journal-title":"Cell Mol Life Sci"},{"key":"BF6364143_CR6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/ng0695-219","volume":"10","author":"HF Rosenberg","year":"1995","unstructured":"Rosenberg HF, Dyer KD, Tiffany HL, Gonzalez M . Rapid evolution of a unique family of primate ribonuclease genes. Nat Genet 1995; 10: 219\u2013223.","journal-title":"Nat Genet"},{"key":"BF6364143_CR7","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1073\/pnas.95.7.3708","volume":"95","author":"J Zhang","year":"1998","unstructured":"Zhang J, Rosenberg HF, Nei M . Positive Darwinian selection after gene duplication in primate ribonuclease genes. Proc Natl Acad Sci USA 1998; 95: 3708\u20133713.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6364143_CR8","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1073\/pnas.080071397","volume":"97","author":"J Zhang","year":"2000","unstructured":"Zhang J, Dyer KD, Rosenberg HF . Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selection. Proc Natl Acad Sci USA 2000; 97: 4701\u20134706.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6364143_CR9","doi-asserted-by":"publisher","first-page":"12370","DOI":"10.1073\/pnas.93.22.12370","volume":"93","author":"KA Larson","year":"1996","unstructured":"Larson KA, Olson EV, Madden BJ et al. Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci USA 1996; 93: 12370\u201312375.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6364143_CR10","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/PL00006594","volume":"49","author":"NA Singhania","year":"1999","unstructured":"Singhania NA, Dyer KD, Zhang J et al. Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and mice. J Mol Evol 1999; 49: 721\u2013728.","journal-title":"J Mol Evol"},{"key":"BF6364143_CR11","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1165\/rcmb.4882","volume":"27","author":"SA Cormier","year":"2002","unstructured":"Cormier SA, Yuan S, Crosby JR et al. TH2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages. Am J Respir Cell Mol Biol 2002; 27: 678\u2013687.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BF6364143_CR12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s003350020007","volume":"12","author":"SA Cormier","year":"2001","unstructured":"Cormier SA, Larson KA, Yuan S et al. Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Mamm Genome 2001; 12: 352\u2013361.","journal-title":"Mamm Genome"},{"key":"BF6364143_CR13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S0167-4781(97)00024-9","volume":"1351","author":"T Nittoh","year":"1997","unstructured":"Nittoh T, Hirakata M, Mue S, Ohuchi K . Identification of cDNA encoding rat eosinophil cationic protein\/eosinophil-associated ribonuclease. Biochim Biophys Acta 1997; 1351: 42\u201346.","journal-title":"Biochim Biophys Acta"},{"key":"BF6364143_CR14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0378-1119(01)00392-4","volume":"267","author":"AL McDevitt","year":"2001","unstructured":"McDevitt AL, Deming MS, Rosenberg HF, Dyer KD . Gene structure and enzymatic activity of mouse eosinophil-associated ribonuclease 2. Gene 2001; 267: 23\u201330.","journal-title":"Gene"},{"key":"BF6364143_CR15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0166-3542(03)00111-6","volume":"59","author":"JM Moreau","year":"2003","unstructured":"Moreau JM, Dyer KD, Bonville CA et al. Diminished expression of an antiviral ribonuclease in response to pneumovirus infection in vivo. Antiviral Res 2003; 59: 181\u2013191.","journal-title":"Antiviral Res"},{"key":"BF6364143_CR16","doi-asserted-by":"publisher","first-page":"3396","DOI":"10.1182\/blood-2003-01-0151","volume":"102","author":"D Yang","year":"2003","unstructured":"Yang D, Rosenberg HF, Chen Q et al. Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. Blood 2003; 102: 3396\u20133403.","journal-title":"Blood"},{"key":"BF6364143_CR17","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1084\/jem.184.5.1871","volume":"184","author":"EA Sabin","year":"1996","unstructured":"Sabin EA, Kopf MA, Pearce EJ . Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils. J Exp Med 1996; 184: 1871\u20131878.","journal-title":"J Exp Med"},{"key":"BF6364143_CR18","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1084\/jem.172.5.1425","volume":"172","author":"LA Dent","year":"1990","unstructured":"Dent LA, Strath M, Mellor AL, Sanderson CJ . Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med 1990; 172: 1425\u20131431.","journal-title":"J Exp Med"},{"key":"BF6364143_CR19","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1084\/jem.173.2.429","volume":"173","author":"A Tominaga","year":"1991","unstructured":"Tominaga A, Takaki S, Koyama N et al. Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. J Exp Med 1991; 173: 429\u2013437.","journal-title":"J Exp Med"},{"key":"BF6364143_CR20","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1189\/jlb.70.5.691","volume":"70","author":"HF Rosenberg","year":"2001","unstructured":"Rosenberg HF, Domachowske JB . Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens. J Leukoc Biol 2001; 70: 691\u2013698.","journal-title":"J Leukoc Biol"},{"key":"BF6364143_CR21","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ng852","volume":"30","author":"J Zhang","year":"2002","unstructured":"Zhang J, Zhang YP, Rosenberg HF . Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey. Nat Genet 2002; 30: 411\u2013415.","journal-title":"Nat Genet"},{"key":"BF6364143_CR22","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1096\/fj.01-0306fje","volume":"15","author":"KF Hoffmann","year":"2001","unstructured":"Hoffmann KF, McCarty TC, Segal DH et al. Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions. FASEB J 2001; 15: 2545\u20132547.","journal-title":"FASEB J"},{"key":"BF6364143_CR23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0076-6879(01)41158-X","volume":"341","author":"HF Rosenberg","year":"2001","unstructured":"Rosenberg HF, Domachowske JB . Eosinophil-derived neurotoxin. Methods Enzymol 2001; 341: 273\u2013286.","journal-title":"Methods Enzymol"},{"key":"BF6364143_CR24","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1182\/blood-2003-08-2778","volume":"103","author":"J Bystrom","year":"2004","unstructured":"Bystrom J, Wynn TA, Domachowske JB, Rosenberg HF . Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow. Blood 2004; 103: 868\u2013877.","journal-title":"Blood"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6364143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6364143","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6364143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T22:55:27Z","timestamp":1682808927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6364143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,4]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,12,1]]}},"alternative-id":["BF6364143"],"URL":"https:\/\/doi.org\/10.1038\/sj.gene.6364143","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,4]]},"assertion":[{"value":"19 July 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2004","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2004","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2004","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}