{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T08:40:36Z","timestamp":1753519236759},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2006,1,1]]},"DOI":"10.1038\/sj.gene.6364265","type":"journal-article","created":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T14:27:15Z","timestamp":1129818435000},"page":"19-26","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population"],"prefix":"10.1038","volume":"7","author":[{"given":"K","family":"Brophy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A W","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Abuzakouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"McLoughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"O'Morain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N P","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Feighery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kelleher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"McManus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"BF6364265_CR1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/S0016-5085(98)70382-8","volume":"115","author":"A Godkin","year":"1998","unstructured":"Godkin A, Jewell D . The pathogenesis of celiac disease. Gastroenterology 1998; 115: 206\u2013210.","journal-title":"Gastroenterology"},{"issue":"Suppl 3","key":"BF6364265_CR2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1046\/j.1365-2036.18.s3.1.x","volume":"18","author":"R McLoughlin","year":"2003","unstructured":"McLoughlin R, Sebastian SS, Qasim A, McNamara D, O\u2019Connor HJ, Buckley M et al. Coeliac disease in Europe. Aliment Pharmacol Ther 2003; 18 (Suppl 3): 45\u201348.","journal-title":"Aliment Pharmacol Ther"},{"key":"BF6364265_CR3","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nri885","volume":"2","author":"LM Sollid","year":"2002","unstructured":"Sollid LM . Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002; 2: 647\u2013655.","journal-title":"Nat Rev Immunol"},{"key":"BF6364265_CR4","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/0016-5085(93)90912-V","volume":"105","author":"LM Sollid","year":"1993","unstructured":"Sollid LM, Thorsby E . HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993; 105: 910\u2013922.","journal-title":"Gastroenterology"},{"key":"BF6364265_CR5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/0198-8859(95)00144-1","volume":"45","author":"R McManus","year":"1996","unstructured":"McManus R, Moloney M, Borton M, Finch A, Chuan YT, Lawlor E et al. Association of celiac disease with microsatellite polymorphisms close to the tumor necrosis factor genes. Hum Immunol 1996; 45: 24\u201331.","journal-title":"Hum Immunol"},{"key":"BF6364265_CR6","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/j.1572-0241.2004.04109.x","volume":"99","author":"S Gonzalez","year":"2004","unstructured":"Gonzalez S, Rodrigo L, Lopez-Vazquez A, Fuentes D, Agudo-Ibanez L, Rodriguez-Rodero S et al. Association of MHC class I related gene B (MICB) to celiac disease. Am J Gastroenterol 2004; 99: 676\u2013680.","journal-title":"Am J Gastroenterol"},{"issue":"Part 4","key":"BF6364265_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1017\/S0003480097006258","volume":"61","author":"F Petronzelli","year":"1997","unstructured":"Petronzelli F, Bonamico M, Ferrante P, Grillo R, Mora B, Mariani P et al. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum Genet 1997; 61 (Part 4): 307\u2013317.","journal-title":"Ann Hum Genet"},{"key":"BF6364265_CR8","first-page":"687","volume":"36","author":"S Bevan","year":"1999","unstructured":"Bevan S, Popat S, Braegger CP, Busch A, O\u2019Donoghue D, Falth-Magnusson K et al. Contribution of the MHC region to the familial risk of coeliac disease. J Med Genet 1999; 36: 687\u2013690.","journal-title":"J Med Genet"},{"key":"BF6364265_CR9","first-page":"1","volume":"40","author":"N Risch","year":"1987","unstructured":"Risch N . Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 1987; 40: 1\u201314.","journal-title":"Am J Hum Genet"},{"key":"BF6364265_CR10","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1399-0004.1984.tb01100.x","volume":"26","author":"JI Rotter","year":"1984","unstructured":"Rotter JI, Landaw EM . Measuring the genetic contribution of a single locus to a multilocus disease. Clin Genet 1984; 26: 529\u2013542.","journal-title":"Clin Genet"},{"key":"BF6364265_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/ng1196-329","volume":"14","author":"F Zhong","year":"1996","unstructured":"Zhong F, McCombs CC, Olson JM, Elston RC, Stevens FM, McCarthy CF et al. An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland. Nat Genet 1996; 14: 329\u2013333.","journal-title":"Nat Genet"},{"key":"BF6364265_CR12","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1086\/301754","volume":"62","author":"L Greco","year":"1998","unstructured":"Greco L, Corazza G, Babron MC, Clot F, Fulchignoni-Lataud MC, Percopo S et al. Genome search in celiac disease. Am J Hum Genet 1998; 62: 669\u2013675.","journal-title":"Am J Hum Genet"},{"key":"BF6364265_CR13","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1136\/gut.48.5.696","volume":"48","author":"P Holopainen","year":"2001","unstructured":"Holopainen P, Mustalahti K, Uimari P, Collin P, Maki M, Partanen J . Candidate gene regions and genetic heterogeneity in gluten sensitivity. Gut 2001; 48: 696\u2013701.","journal-title":"Gut"},{"key":"BF6364265_CR14","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/sj.ejhg.5200752","volume":"9","author":"AT Naluai","year":"2001","unstructured":"Naluai AT, Nilsson S, Gudjonsdottir AH, Louka AS, Ascher H, Ek J et al. Genome-wide linkage analysis of Scandinavian affected sib-pairs supports presence of susceptibility loci for celiac disease on chromosomes 5 and 11. Eur J Hum Genet 2001; 9: 938\u2013944.","journal-title":"Eur J Hum Genet"},{"key":"BF6364265_CR15","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/sj.ejhg.5201165","volume":"12","author":"MJ van Belzen","year":"2004","unstructured":"van Belzen MJ, Mulder CJ, Zhernakova A, Pearson PL, Houwen RH, Wijmenga C . CTLA4 +49 A\/G and CT60 polymorphisms in Dutch coeliac disease patients. Eur J Hum Genet 2004; 12: 782\u2013785.","journal-title":"Eur J Hum Genet"},{"key":"BF6364265_CR16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/gut.43.2.187","volume":"43","author":"I Djilali-Saiah","year":"1998","unstructured":"Djilali-Saiah I, Schmitz J, Harfouch-Hammoud E, Mougenot JF, Bach JF, Caillat-Zucman S . CTLA-4 gene polymorphism is associated with predisposition to coeliac disease. Gut 1998; 43: 187\u2013189.","journal-title":"Gut"},{"key":"BF6364265_CR17","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1034\/j.1399-0039.2000.560407.x","volume":"56","author":"AT Naluai","year":"2000","unstructured":"Naluai AT, Nilsson S, Samuelsson L, Gudjonsdottir AH, Ascher H, Ek J et al. The CTLA4\/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders. Tissue Antigens 2000; 56: 350\u2013355.","journal-title":"Tissue Antigens"},{"key":"BF6364265_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1080\/003655202753387310","volume":"37","author":"S Popat","year":"2002","unstructured":"Popat S, Hearle N, Wixey J, Hogberg L, Bevan S, Lim W et al. Analysis of the CTLA4 gene in Swedish coeliac disease patients. Scand J Gastroenterol 2002; 37: 28\u201331.","journal-title":"Scand J Gastroenterol"},{"key":"BF6364265_CR19","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0198-8859(02)00782-6","volume":"64","author":"B Mora","year":"2003","unstructured":"Mora B, Bonamico M, Indovina P, Megiorni F, Ferri M, Carbone MC et al. CTLA-4+49 A\/G dimorphism in Italian patients with celiac disease. Hum Immunol 2003; 64: 297\u2013301.","journal-title":"Hum Immunol"},{"key":"BF6364265_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1136\/jmg.39.1.51","volume":"39","author":"AL King","year":"2002","unstructured":"King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM et al. CTLA-4\/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families. J Med Genet 2002; 39: 51\u201354.","journal-title":"J Med Genet"},{"key":"BF6364265_CR21","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1034\/j.1399-0039.1999.530503.x","volume":"53","author":"P Holopainen","year":"1999","unstructured":"Holopainen P, Arvas M, Sistonen P, Mustalahti K, Collin P, Maki M et al. CD28\/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study. Tissue Antigens 1999; 53: 470\u2013475.","journal-title":"Tissue Antigens"},{"key":"BF6364265_CR22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1046\/j.1469-1809.2002.00102.x","volume":"66","author":"S Popat","year":"2002","unstructured":"Popat S, Hearle N, Hogberg L, Braegger CP, O\u2019Donoghue D, Falth-Magnusson K et al. Variation in the CTLA4\/CD28 gene region confers an increased risk of coeliac disease. Ann Hum Genet 2002; 66: 125\u2013137.","journal-title":"Ann Hum Genet"},{"key":"BF6364265_CR23","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/j.1399-0039.2004.00312.x","volume":"64","author":"SS Amundsen","year":"2004","unstructured":"Amundsen SS, Naluai AT, Ascher H, Ek J, Gudjonsdottir AH, Wahlstrom J et al. Genetic analysis of the CD28\/CTLA4\/ICOS (CELIAC3) region in coeliac disease. Tissue Antigens 2004; 64: 593\u2013599.","journal-title":"Tissue Antigens"},{"key":"BF6364265_CR24","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/sj.ejhg.5201357","volume":"13","author":"KA Hunt","year":"2005","unstructured":"Hunt KA, McGovern DP, Kumar PJ, Ghosh S, Travis SP, Walters JR et al. A common CTLA4 haplotype associated with coeliac disease. Eur J Hum Genet 2005; 13: 440\u2013444.","journal-title":"Eur J Hum Genet"},{"key":"BF6364265_CR25","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/ajmg.a.30072","volume":"130A","author":"JD Rioux","year":"2004","unstructured":"Rioux JD, Karinen H, Kocher K, McMahon SG, Karkkainen P, Janatuinen E et al. Genomewide search and association studies in a Finnish celiac disease population: identification of a novel locus and replication of the HLA and CTLA4 loci. Am J Med Genet 2004; 130A: 345\u2013350.","journal-title":"Am J Med Genet"},{"key":"BF6364265_CR26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1146\/annurev.immunol.20.091101.091806","volume":"20","author":"BM Carreno","year":"2002","unstructured":"Carreno BM, Collins M . The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol 2002; 20: 29\u201353.","journal-title":"Annu Rev Immunol"},{"key":"BF6364265_CR27","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/hmg\/5.7.1075","volume":"5","author":"L Nistico","year":"1996","unstructured":"Nistico L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E et al. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet 1996; 5: 1075\u20131080.","journal-title":"Hum Mol Genet"},{"key":"BF6364265_CR28","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1034\/j.1399-0039.1999.530112.x","volume":"53","author":"HF Harbo","year":"1999","unstructured":"Harbo HF, Celius EG, Vartdal F, Spurkland A . CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis. Tissue Antigens 1999; 53: 106\u2013110.","journal-title":"Tissue Antigens"},{"key":"BF6364265_CR29","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1093\/hmg\/8.7.1195","volume":"8","author":"B Vaidya","year":"1999","unstructured":"Vaidya B, Imrie H, Perros P, Young ET, Kelly WF, Carr D et al. The cytotoxic T lymphocyte antigen-4 is a major Graves\u2019 disease locus. Hum Mol Genet 1999; 8: 1195\u20131199.","journal-title":"Hum Mol Genet"},{"key":"BF6364265_CR30","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1034\/j.1399-0039.1999.540512.x","volume":"54","author":"F Clot","year":"1999","unstructured":"Clot F, Fulchignoni-Lataud MC, Renoux C, Percopo S, Bouguerra F, Babron MC et al. Linkage and association study of the CTLA-4 region in coeliac disease for Italian and Tunisian populations. Tissue Antigens 1999; 54: 527\u2013530.","journal-title":"Tissue Antigens"},{"key":"BF6364265_CR31","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1097\/00005176-200007000-00006","volume":"31","author":"C Wijmenga","year":"2000","unstructured":"Wijmenga C, van Belzen MJ, Oren E . The CTLA-4 gene is not associated with coeliac disease in the Dutch population. J Pediatr Gastroenterol Nutr 2000; 31: S16.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BF6364265_CR32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/00005176-200308000-00011","volume":"37","author":"A Martin-Pagola","year":"2003","unstructured":"Martin-Pagola A, Perez de Nanclares G, Vitoria JC, Bilbao JR, Ortiz L, Zubillaga P et al. No association of CTLA4 gene with celiac disease in the Basque population. J Pediatr Gastroenterol Nutr 2003; 37: 142\u2013145.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BF6364265_CR33","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1365-2370.2003.00430.x","volume":"30","author":"AL King","year":"2003","unstructured":"King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM et al. Coeliac disease: investigation of proposed causal variants in the CTLA4 gene region. Eur J Immunogenet 2003; 30: 427\u2013432.","journal-title":"Eur J Immunogenet"},{"key":"BF6364265_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/sj.gene.6364040","volume":"2","author":"K Haimila","year":"2004","unstructured":"Haimila K, Smedberg T, Mustalahti K, Maki M, Partanen J, Holopainen P . Genetic association of coeliac disease susceptibility to polymorphisms in the ICOS gene on chromosome 2q33. Genes Immun 2004; 2: 85\u201392.","journal-title":"Genes Immun"},{"key":"BF6364265_CR35","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1399-0039.2004.00189.x","volume":"63","author":"P Holopainen","year":"2004","unstructured":"Holopainen P, Naluai AT, Moodie S, Percopo S, Coto I, Clot F et al. Candidate gene region 2q33 in European families with coeliac disease. Tissue Antigens 2004; 63: 212\u2013222.","journal-title":"Tissue Antigens"},{"key":"BF6364265_CR36","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature01621","volume":"423","author":"H Ueda","year":"2003","unstructured":"Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003; 423: 506\u2013511.","journal-title":"Nature"},{"key":"BF6364265_CR37","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/ng1001-233","volume":"29","author":"GC Johnson","year":"2001","unstructured":"Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G et al. Haplotype tagging for the identification of common disease genes. Nat Genet 2001; 29: 233\u2013237.","journal-title":"Nat Genet"},{"key":"BF6364265_CR38","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1034\/j.1399-0039.2003.00019.x","volume":"61","author":"AD Haaning Andersen","year":"2003","unstructured":"Haaning Andersen AD, Lange M, Lillevang ST . Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. Tissue Antigens 2003; 61: 276\u2013285.","journal-title":"Tissue Antigens"},{"key":"BF6364265_CR39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrg1270","volume":"5","author":"KT Zondervan","year":"2004","unstructured":"Zondervan KT, Cardon LR . The complex interplay among factors that influence allelic association. Nat Rev Genet 2004; 5: 89\u2013100.","journal-title":"Nat Rev Genet"},{"key":"BF6364265_CR40","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1086\/302114","volume":"63","author":"DM Nielsen","year":"1998","unstructured":"Nielsen DM, Ehm MG, Weir BS . Detecting marker-disease association by testing for Hardy\u2013Weinberg disequilibrium at a marker locus. Am J Hum Genet 1998; 63: 1531\u20131540.","journal-title":"Am J Hum Genet"},{"key":"BF6364265_CR41","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1046\/j.1365-2370.2002.00328.x","volume":"29","author":"JP Wood","year":"2002","unstructured":"Wood JP, Pani MA, Bieda K, Meyer G, Usadel KH, Badenhoop K . A recently described polymorphism in the CD28 gene on chromosome 2q33 is not associated with susceptibility to type 1 diabetes. Eur J Immunogenet 2002; 29: 347\u2013349.","journal-title":"Eur J Immunogenet"},{"key":"BF6364265_CR42","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1093\/bioinformatics\/17.9.838","volume":"17","author":"X Ke","year":"2001","unstructured":"Ke X, Collins A, Ye S . PIRA PCR designer for restriction analysis of single nucleotide polymorphisms. Bioinformatics 2001; 17: 838\u2013839.","journal-title":"Bioinformatics"},{"key":"BF6364265_CR43","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/00124784-199907000-00011","volume":"5","author":"AG Dean","year":"1999","unstructured":"Dean AG . Epi Info and Epi Map: current status and plans for Epi Info 2000. J Public Health Manag Pract 1999; 5: 54\u201357.","journal-title":"J Public Health Manag Pract"},{"key":"BF6364265_CR44","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1086\/338688","volume":"70","author":"DJ Schaid","year":"2002","unstructured":"Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA . Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002; 70: 425\u2013434.","journal-title":"Am J Hum Genet"},{"key":"BF6364265_CR45","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2004","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ . Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2004; 21: 263\u2013265.","journal-title":"Bioinformatics"}],"container-title":["Genes & Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6364265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6364265","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6364265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T20:39:36Z","timestamp":1647981576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6364265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,20]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1,1]]}},"alternative-id":["BF6364265"],"URL":"https:\/\/doi.org\/10.1038\/sj.gene.6364265","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,20]]},"assertion":[{"value":"5 April 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2005","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}