{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:44:45Z","timestamp":1772113485153,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2006,1,1]]},"DOI":"10.1038\/sj.gene.6364276","type":"journal-article","created":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T12:43:51Z","timestamp":1136465031000},"page":"77-80","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The impact of CD14 polymorphisms on the development of soluble CD14 levels during infancy"],"prefix":"10.1038","volume":"7","author":[{"given":"T D","family":"LeVan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Klimecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Vasquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I C","family":"Lohman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F D","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Halonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,1,5]]},"reference":[{"key":"BF6364276_CR1","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1126\/science.1698311","volume":"249","author":"SD Wright","year":"1990","unstructured":"Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC . CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. [comment]. Science 1990; 249: 1431\u20131433.","journal-title":"Science"},{"key":"BF6364276_CR2","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S1074-7613(00)80254-X","volume":"4","author":"A Haziot","year":"1996","unstructured":"Haziot A, Ferrero E, Kontgen F, Hijiya N, Yamamoto S, Silver J et al. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 1996; 4: 407\u2013414.","journal-title":"Immunity"},{"key":"BF6364276_CR3","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1002\/eji.1830161218","volume":"16","author":"V Bazil","year":"1986","unstructured":"Bazil V, Horejsi V, Baudys M, Kristofova H, Strominger JL, Kostka W et al. Biochemical characterization of a soluble form of the 53-kDa monocyte surface antigen. Eur J Immunol 1986; 16: 1583\u20131589.","journal-title":"Eur J Immunol"},{"key":"BF6364276_CR4","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1165\/ajrcmb.20.5.3494","volume":"20","author":"M Baldini","year":"1999","unstructured":"Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD . A polymorphism in the 5\u2032 flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Resp Cell Mol Biol 1999; 20: 976\u2013983.","journal-title":"Am J Resp Cell Mol Biol"},{"key":"BF6364276_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0167-5699(92)90198-G","volume":"13","author":"CA Janeway Jr","year":"1992","unstructured":"Janeway Jr CA . The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 1992; 13: 11\u201316.","journal-title":"Immunol Today"},{"key":"BF6364276_CR6","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1164\/rccm.200304-499OC","volume":"169","author":"S Guerra","year":"2004","unstructured":"Guerra S, Lohman IC, Halonen M, Martinez FD, Wright AL . Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age. Am J Resp Crit Care Med 2004; 169: 70\u201376.","journal-title":"Am J Resp Crit Care Med"},{"key":"BF6364276_CR7","unstructured":"Martinez F . Innate Immunity PGA, NHLBI Program Applications URL http:\/\/oldinnateimmunity.net\/iiPGA\/IIPGASNPs\/CD14\/index,2003."},{"key":"BF6364276_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1034\/j.1600-065X.2002.19002.x","volume":"190","author":"R Lazarus","year":"2002","unstructured":"Lazarus R, Vercelli D, Palmer LJ, Klimecki WJ, Silverman EK, Richter B et al. Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol Rev 2002; 190: 9\u201325.","journal-title":"Immunol Rev"},{"key":"BF6364276_CR9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1086\/381000","volume":"74","author":"CS Carlson","year":"2004","unstructured":"Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA . Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004; 74: 106\u2013120.","journal-title":"Am J Hum Genet"},{"key":"BF6364276_CR10","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.jaci.2003.12.374","volume":"113","author":"W Eder","year":"2004","unstructured":"Eder W, Klimecki W, Yu L, von Mutius E, Reidler J, Braun-Fahrlander C et al. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol 2004; 113: 482\u2013488.","journal-title":"J Allergy Clin Immunol"},{"key":"BF6364276_CR11","volume-title":"Applied Mixed Models in Medicine","author":"H Brown","year":"2001","unstructured":"Brown H, Prescott R . Applied Mixed Models in Medicine. John Wiley & Sons, LTD: Chichester, UK, 2001."},{"key":"BF6364276_CR12","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1600-0897.2004.00207.x","volume":"52","author":"S Guerra","year":"2004","unstructured":"Guerra S, Lohman I, LeVan T, Wright A, Martinez F, Halonen M . The differential effect of genetic variation on soluble CD14 levels in human plasma and milk. Am J Reprod Immunol 2004; 52: 204\u2013211.","journal-title":"Am J Reprod Immunol"},{"key":"BF6364276_CR13","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1398-9995.2004.00439.x","volume":"59","author":"M Kabesch","year":"2004","unstructured":"Kabesch M, Hasemann K, Schickinger V, Tzotcheva I, Bohnert A, Carr D et al. A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases. Allergy 2004; 59: 520\u2013525.","journal-title":"Allergy"},{"key":"BF6364276_CR14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1034\/j.1399-3038.2003.00048.x","volume":"14","author":"TF Leung","year":"2003","unstructured":"Leung TF, Tang NL, Sung YM, Li AM, Wong GW, Chan IH et al. The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children. Pediatric Allergy Immunol 2003; 14: 255\u2013260.","journal-title":"Pediatric Allergy Immunol"},{"key":"BF6364276_CR15","first-page":"A943","volume":"167","author":"W Eder","year":"2003","unstructured":"Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, Braun-Fahrlander C et al. Opposite effects of CD14\/\u2212159 on total serum IgE in children raised in environments with different levels of microbial exposure. Am J Resp Crit Care Med 2003; 167: A943.","journal-title":"Am J Resp Crit Care Med"},{"key":"BF6364276_CR16","doi-asserted-by":"publisher","first-page":"5838","DOI":"10.4049\/jimmunol.167.10.5838","volume":"167","author":"TD LeVan","year":"2001","unstructured":"LeVan TD, Bloom JW, Bailey TJ, Karp CL, Halonen M, Martinez FD et al. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 2001; 167: 5838\u20135844.","journal-title":"J Immunol"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6364276.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6364276","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6364276.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T20:39:20Z","timestamp":1647981560000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6364276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1,1]]}},"alternative-id":["BF6364276"],"URL":"https:\/\/doi.org\/10.1038\/sj.gene.6364276","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,1]]},"assertion":[{"value":"24 August 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}