{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:58:54Z","timestamp":1698731934373},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T00:00:00Z","timestamp":1158192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T00:00:00Z","timestamp":1158192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"published-print":{"date-parts":[[2006,12,1]]},"DOI":"10.1038\/sj.gene.6364341","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T07:09:50Z","timestamp":1158217790000},"page":"640-646","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases"],"prefix":"10.1038","volume":"7","author":[{"given":"M A","family":"Garcia-Gonzalez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Strunk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Piazuelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Benito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Santolaria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sope\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Sim\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sainz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,9,14]]},"reference":[{"key":"BF6364341_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0140-6736(96)07023-7","volume":"349","author":"CS Goodwin","year":"1997","unstructured":"Goodwin CS, Mendall MM, Northfield TC . Helicobacter pylori infection. Lancet 1997; 349: 265\u2013269.","journal-title":"Lancet"},{"key":"BF6364341_CR2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/oxfordjournals.bmb.a011662","volume":"54","author":"JC Atherton","year":"1998","unstructured":"Atherton JC . H. pylori virulence factors. Br Med Bull 1998; 54: 105\u2013120.","journal-title":"Br Med Bull"},{"key":"BF6364341_CR3","doi-asserted-by":"publisher","first-page":"17771","DOI":"10.1074\/jbc.270.30.17771","volume":"270","author":"JC Atherton","year":"1995","unstructured":"Atherton JC, Cao P, Peek Jr RM, Tummuru MK, Blaser MJ, Cover TL . Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995; 270: 17771\u201317777.","journal-title":"J Biol Chem"},{"key":"BF6364341_CR4","doi-asserted-by":"publisher","first-page":"14648","DOI":"10.1073\/pnas.93.25.14648","volume":"93","author":"S Censini","year":"1996","unstructured":"Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M et al. A. Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996; 93: 14648\u201314653.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6364341_CR5","first-page":"981","volume":"9","author":"H Enroth","year":"2000","unstructured":"Enroth H, Kraaz W, Engstrand L, Nyren O, Rohan T . Helicobacter pylori strain types and risk of gastric cancer: a case\u2013control study. Cancer Epidemiol Biomarkers Prev 2000; 9: 981\u2013985.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BF6364341_CR6","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1046\/j.1523-5378.2000.0050S1003.x","volume":"5","author":"DY Graham","year":"2000","unstructured":"Graham DY, Yamaoka Y . Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. Helicobacter 2000; 5: S3\u2013S9.","journal-title":"Helicobacter"},{"key":"BF6364341_CR7","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1023\/A:1018846723379","volume":"42","author":"S Maeda","year":"1997","unstructured":"Maeda S, Kanai F, Ogura K, Yoshida H, Ikenoue T, Takahashi M et al. High seropositivity of anti-CagA antibody in Helicobacter pylori-infected patients irrelevant to peptic ulcers and normal mucosa in Japan. Dig Dis Sci 1997; 42: 1841\u20131847.","journal-title":"Dig Dis Sci"},{"key":"BF6364341_CR8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1056\/NEJM199607253350404","volume":"335","author":"LE Hansson","year":"1996","unstructured":"Hansson LE, Nyren O, Hsing AW, Bergstrom R, Josefsson S, Chow WH et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med 1996; 335: 242\u2013249.","journal-title":"N Engl J Med"},{"key":"BF6364341_CR9","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1056\/NEJMoa001999","volume":"345","author":"N Uemura","year":"2001","unstructured":"Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784\u2013789.","journal-title":"N Engl J Med"},{"key":"BF6364341_CR10","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1054\/bjoc.1999.1107","volume":"82","author":"MP Ebert","year":"2000","unstructured":"Ebert MP, Yu J, Miehlke S, Fei G, Lendeckel U, Ridwelski K et al. Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer. Br J Cancer 2000; 82: 1795\u20131800.","journal-title":"Br J Cancer"},{"key":"BF6364341_CR11","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/jemt.1104","volume":"53","author":"S Milani","year":"2001","unstructured":"Milani S, Calabro A . Role of growth factors and their receptors in gastric ulcer healing. Microsc Res Tech 2001; 53: 360\u2013371.","journal-title":"Microsc Res Tech"},{"key":"BF6364341_CR12","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3748\/wjg.v11.i1.136","volume":"11","author":"SC Shih","year":"2005","unstructured":"Shih SC, Tseng KW, Lin SC, Kao CR, Chou SY, Wang HY et al. Expression patterns of transforming growth factor-beta and its receptors in gastric mucosa of patients with refractory gastric ulcer. World J Gastroenterol 2005; 11: 136\u2013141.","journal-title":"World J Gastroenterol"},{"key":"BF6364341_CR13","first-page":"443","volume":"47","author":"H Ernst","year":"1996","unstructured":"Ernst H, Konturek PC, Brzozowski T, Konturek SJ, Hahn EG . Subserosal application of transforming growth factor-beta 1 in rats with chronic gastric ulcers: effect on gastric ulcer healing and blood flow. J Physiol Pharmacol 1996; 47: 443\u2013454.","journal-title":"J Physiol Pharmacol"},{"key":"BF6364341_CR14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S1590-8658(03)00165-8","volume":"35","author":"A Perez-Aisa","year":"2003","unstructured":"Perez-Aisa A, Sopena F, Arceiz E, Ortego J, Sainz R, Lanas A . Effect of exogenous administration of transforming growth factor-beta and famotidine on the healing of duodenal ulcer under the impact of indomethacin. Dig Liver Dis 2003; 35: 397\u2013403.","journal-title":"Dig Liver Dis"},{"key":"BF6364341_CR15","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1200\/JCO.1999.17.2.607","volume":"17","author":"Y Maehara","year":"1999","unstructured":"Maehara Y, Kakeji Y, Kabashima A, Emi Y, Watanabe A, Akazawa K et al. Role of transforming growth factor-beta 1 in invasion and metastasis in gastric carcinoma. J Clin Oncol 1999; 17: 607\u2013614.","journal-title":"J Clin Oncol"},{"issue":"Suppl 2","key":"BF6364341_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1365-2036.16.s2.3.x","volume":"16","author":"KB Hahm","year":"2002","unstructured":"Hahm KB, Lee KM, Kim YB, Hong WS, Lee WH, Han SU et al. Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice. Aliment Pharmacol Ther 2002; 16 (Suppl 2): 115\u2013127.","journal-title":"Aliment Pharmacol Ther"},{"key":"BF6364341_CR17","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1101\/gad.181700","volume":"14","author":"K Lehmann","year":"2000","unstructured":"Lehmann K, Janda E, Pierreux CE, Rytomaa M, Schulze A, McMahon M et al. Raf induces TGF beta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev 2000; 14: 2610\u20132622.","journal-title":"Genes Dev"},{"key":"BF6364341_CR18","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1097\/00007890-199810270-00009","volume":"66","author":"MR Awad","year":"1998","unstructured":"Awad MR, El-Gamel A, Hasleton P, Turner DM, Sinnott PJ, Hutchinson IV . Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation 1998; 66: 1014\u20131020.","journal-title":"Transplantation"},{"key":"BF6364341_CR19","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1359\/jbmr.1998.13.10.1569","volume":"13","author":"Y Yamada","year":"1998","unstructured":"Yamada Y, Miyauchi A, Goto J, Takagi Y, Okuizumi H, Kanematsu M et al. Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res 1998; 13: 1569\u20131576.","journal-title":"J Bone Miner Res"},{"key":"BF6364341_CR20","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1161\/01.HYP.28.5.881","volume":"28","author":"F Cambien","year":"1996","unstructured":"Cambien F, Ricard S, Troesch A, Mallet C, Generenaz L, Evans A et al. Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure. The Etude Cas-Temoin de l\u2019Infarctus du Myocarde (ECTIM) Study. Hypertension 1996; 28: 881\u2013887.","journal-title":"Hypertension"},{"key":"BF6364341_CR21","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s002510000211","volume":"51","author":"MA Garcia-Gonzalez","year":"2000","unstructured":"Garcia-Gonzalez MA, Crusius JB, Strunk MH, Bouma G, Perez-Centeno CM, Pals G et al. TGFB1 gene polymorphisms and inflammatory bowel disease. Immunogenetics 2000; 51: 869\u2013872.","journal-title":"Immunogenetics"},{"key":"BF6364341_CR22","first-page":"536","volume":"24","author":"HM Schrijver","year":"2004","unstructured":"Schrijver HM, Crusius JB, Garcia-Gonzalez MA, Polman CH, Pena AS, Barkhof F et al. Gender-related association between the TGFB1+869 polymorphism and multiple sclerosis. J Interferon Cytokine Res 2004; 24: 536\u2013542.","journal-title":"J Interferon Cytokine Res"},{"key":"BF6364341_CR23","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1136\/ard.2004.027698","volume":"64","author":"M van der Paardt","year":"2005","unstructured":"van der Paardt M, Crusius JB, Garcia-Gonzalez MA, Dijkmans BA, Pena AS, van der Horst-Bruinsma IE . Susceptibility to ankylosing spondylitis: no evidence for the involvement of transforming growth factor beta 1 (TGFB1) gene polymorphisms. Ann Rheum Dis 2005; 64: 616\u2013619.","journal-title":"Ann Rheum Dis"},{"key":"BF6364341_CR24","first-page":"613","volume":"98","author":"SC Shih","year":"1999","unstructured":"Shih SC, Chien CL, Tseng KW, Lin SC, Kao CR . Immunohistochemical studies of transforming growth factor-beta and its receptors in the gastric mucosa of patients with refractory gastric ulcer. J Formos Med Assoc 1999; 98: 613\u2013620.","journal-title":"J Formos Med Assoc"},{"key":"BF6364341_CR25","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1146\/annurev.cb.06.110190.003121","volume":"6","author":"J Massague","year":"1990","unstructured":"Massague J . The transforming growth factor-beta family. Annu Rev Cell Biol 1990; 6: 597\u2013641.","journal-title":"Annu Rev Cell Biol"},{"key":"BF6364341_CR26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1101\/gad.8.2.133","volume":"8","author":"DM Kingsley","year":"1994","unstructured":"Kingsley DM . The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 1994; 8: 133\u2013146.","journal-title":"Genes Dev"},{"key":"BF6364341_CR27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev.cb.10.110194.000511","volume":"10","author":"P Walter","year":"1994","unstructured":"Walter P, Johnson AE . Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Annu Rev Cell Biol 1994; 10: 87\u2013119.","journal-title":"Annu Rev Cell Biol"},{"key":"BF6364341_CR28","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.radonc.2004.12.012","volume":"75","author":"CN Andreassen","year":"2005","unstructured":"Andreassen CN, Alsner J, Overgaard J, Herskind C, Haviland J, Owen R et al. TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. Radiother Oncol 2005; 75: 18\u201321.","journal-title":"Radiother Oncol"},{"key":"BF6364341_CR29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1158\/1055-9965.759.13.5","volume":"13","author":"A Ewart-Toland","year":"2004","unstructured":"Ewart-Toland A, Chan JM, Yuan J, Balmain A, Ma J . A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer. Cancer Epidemiol Biomarkers Prev 2004; 13: 759\u2013764.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BF6364341_CR30","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/j.1572-0241.2006.00560.x","volume":"101","author":"WK Leung","year":"2006","unstructured":"Leung WK, Chan MC, To KF, Man EP, Ng EK, Chu ES et al. H. pylori genotypes and cytokine gene polymorphisms influence the development of gastric intestinal metaplasia in a Chinese population. Am J Gastroenterol 2006; 101: 714\u2013720.","journal-title":"Am J Gastroenterol"},{"key":"BF6364341_CR31","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1745-7270.2006.00151.x","volume":"38","author":"KS Wang","year":"2006","unstructured":"Wang KS, Hu ZL, Li JH, Xiao DS, Wen JF . Enhancement of metastatic and invasive capacity of gastric cancer cells by transforming growth factor-beta1. Acta Biochim Biophys Sin (Shanghai) 2006; 38: 179\u2013186.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"BF6364341_CR32","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1053\/gast.2002.34156","volume":"123","author":"T Furuta","year":"2002","unstructured":"Furuta T, El-Omar EM, Xiao F, Shirai N, Takashima M, Sugimura H . Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology 2002; 123: 92\u2013105.","journal-title":"Gastroenterology"},{"key":"BF6364341_CR33","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3109\/00365529609094531","volume":"215","author":"KE McColl","year":"1996","unstructured":"McColl KE, el-Omar E . Helicobacter pylori and disturbance of gastric function associated with duodenal ulcer disease and gastric cancer. Scand J Gastroenterol Suppl 1996; 215: 32\u201337.","journal-title":"Scand J Gastroenterol Suppl"},{"key":"BF6364341_CR34","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/j.1349-7006.1996.tb00220.x","volume":"87","author":"T Kai","year":"1996","unstructured":"Kai T, Taketazu F, Kawakami M, Shimanuki K, Yamada S, Miyazono K et al. Distribution of transforming growth factor-beta and its receptors in gastric carcinoma tissue. Jpn J Cancer Res 1996; 87: 296\u2013304.","journal-title":"Jpn J Cancer Res"},{"key":"BF6364341_CR35","first-page":"80","volume":"11","author":"S Beckert","year":"2005","unstructured":"Beckert S, Wolf SC, Farrahi F, Zittel TT, Coerper S . TGF-beta inhibits pentagastrin-stimulated gastric acid secretion in rats. Med Sci Monit 2005; 11: 80\u201383.","journal-title":"Med Sci Monit"},{"key":"BF6364341_CR36","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0016-5085(89)90071-1","volume":"97","author":"GM Sobala","year":"1989","unstructured":"Sobala GM, Schorah CJ, Sanderson M, Dixon MF, Tompkins DS, Godwin P et al. Ascorbic acid in the human stomach. Gastroenterology 1989; 97: 357\u2013363.","journal-title":"Gastroenterology"},{"key":"BF6364341_CR37","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0027-5107(88)90194-7","volume":"202","author":"H Bartsch","year":"1988","unstructured":"Bartsch H, Ohshima H, Pignatelli B . Inhibitors of endogenous nitrosation. Mechanisms and implications in human cancer prevention. Mutat Res 1988; 202: 307\u2013324.","journal-title":"Mutat Res"},{"key":"BF6364341_CR38","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0016-5085(90)91028-5","volume":"99","author":"MF Graham","year":"1990","unstructured":"Graham MF, Bryson GR, Diegelmann RF . Transforming growth factor beta 1 selectively augments collagen synthesis by human intestinal smooth muscle cells. Gastroenterology 1990; 99: 447\u2013453.","journal-title":"Gastroenterology"},{"key":"BF6364341_CR39","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0165-2478(02)00023-8","volume":"82","author":"A Moustakas","year":"2002","unstructured":"Moustakas A, Pardali K, Gaal A, Heldin CH . Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation. Immunol Lett 2002; 82: 85\u201391.","journal-title":"Immunol Lett"},{"key":"BF6364341_CR40","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/386671a0","volume":"386","author":"W Risau","year":"1997","unstructured":"Risau W . Mechanisms of angiogenesis. Nature 1997; 386: 671\u2013674.","journal-title":"Nature"},{"key":"BF6364341_CR41","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0002-9440(10)63853-9","volume":"162","author":"PL Beck","year":"2003","unstructured":"Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK . Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 2003; 162: 597\u2013608.","journal-title":"Am J Pathol"},{"key":"BF6364341_CR42","first-page":"2610","volume":"63","author":"AM Dunning","year":"2003","unstructured":"Dunning AM, Ellis PD, McBride S, Kirschenlohr HL, Healey CS, Kemp PR et al. A transforming growth factor beta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res 2003; 63: 2610\u20132615.","journal-title":"Cancer Res"},{"key":"BF6364341_CR43","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1161\/01.CIR.101.24.2783","volume":"101","author":"M Yokota","year":"2000","unstructured":"Yokota M, Ichihara S, Lin TL, Nakashima N, Yamada Y . Association of a T29\u2212&gt;C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese. Circulation 2000; 101: 2783\u20132787.","journal-title":"Circulation"},{"key":"BF6364341_CR44","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/00004836-199701000-00002","volume":"24","author":"JH Kurata","year":"1997","unstructured":"Kurata JH, Nogawa AN . Meta-analysis of risk factors for peptic ulcer. Nonsteroidal antiinflammatory drugs, Helicobacter pylori, and smoking. J Clin Gastroenterol 1997; 24: 2\u201317.","journal-title":"J Clin Gastroenterol"},{"key":"BF6364341_CR45","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1093\/jnci\/94.22.1680","volume":"94","author":"C Figueiredo","year":"2002","unstructured":"Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R et al. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002; 94: 1680\u20131687.","journal-title":"J Natl Cancer Inst"},{"key":"BF6364341_CR46","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1046\/j.1365-2249.2001.01593.x","volume":"125","author":"MA Garcia-Gonzalez","year":"2001","unstructured":"Garcia-Gonzalez MA, Lanas A, Santolaria S, Crusius JB, Serrano MT, Pena AS . The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer. Clin Exp Immunol 2001; 125: 368\u2013375.","journal-title":"Clin Exp Immunol"},{"key":"BF6364341_CR47","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/sj.gene.6363798","volume":"2","author":"A Lanas","year":"2001","unstructured":"Lanas A, Garcia-Gonzalez MA, Santolaria S, Crusius JB, Serrano MT, Benito R et al. TNF and LTA gene polymorphisms reveal different risk in gastric and duodenal ulcer patients. Genes Immun 2001; 2: 415\u2013421.","journal-title":"Genes Immun"},{"key":"BF6364341_CR48","first-page":"A454","volume":"126","author":"MA Garc\u00eda-Gonz\u00e1lez","year":"2004","unstructured":"Garc\u00eda-Gonz\u00e1lez MA, Strunk M, Benito R, Santolaria S, Piazuelo E, Jim\u00e9nez P et al. Lack of association of IL-1 family, TNF and TGFB1 gene polymorphisms with noncardia gastric cancer in a population with high Helicobacter pylori infection rate. Gastroenterology 2004; 126: A454.","journal-title":"Gastroenterology"},{"key":"BF6364341_CR49","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/35006081","volume":"404","author":"EM El-Omar","year":"2000","unstructured":"El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398\u2013402.","journal-title":"Nature"},{"key":"BF6364341_CR50","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/S0016-5085(03)00157-4","volume":"124","author":"EM El-Omar","year":"2003","unstructured":"El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003; 124: 1193\u20131201.","journal-title":"Gastroenterology"},{"key":"BF6364341_CR51","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1053\/gast.2001.28000","volume":"121","author":"JC Machado","year":"2001","unstructured":"Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C et al. Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 2001; 121: 823\u2013829.","journal-title":"Gastroenterology"},{"key":"BF6364341_CR52","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10552-005-0439-7","volume":"17","author":"F Kamangar","year":"2006","unstructured":"Kamangar F, Abnet CC, Hutchinson AA, Newschaffer CJ, Helzlsouer K, Shugart YY et al. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control 2006; 17: 117\u2013125.","journal-title":"Cancer Causes Control"},{"key":"BF6364341_CR53","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cyto.2005.01.011","volume":"30","author":"F Perri","year":"2005","unstructured":"Perri F, Piepoli A, Bonvicini C, Gentile A, Quitadamo M, Di Candia M et al. Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence. Cytokine 2005; 30: 293\u2013302.","journal-title":"Cytokine"},{"key":"BF6364341_CR54","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1053\/j.gastro.2003.08.042","volume":"126","author":"CF Zambon","year":"2004","unstructured":"Zambon CF, Basso D, Navaglia F, Falda A, Belluco C, Fogar P et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2004; 126: 382\u2013384.","journal-title":"Gastroenterology"},{"key":"BF6364341_CR55","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P . The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31\u201349.","journal-title":"Acta Pathol Microbiol Scand"},{"key":"BF6364341_CR56","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1046\/j.1365-2036.1999.00631.x","volume":"13","author":"S Santolaria","year":"1999","unstructured":"Santolaria S, Lanas A, Benito R, Parez-Aisa MA, Montoro M, Sainz R . Helicobacter pylori infection is a protective factor for bleeding gastric ulcers but not for bleeding duodenal ulcers in NSAID users. Aliment Pharmacol Ther 1999; 13: 1511\u20131518.","journal-title":"Aliment Pharmacol Ther"},{"key":"BF6364341_CR57","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0210-5705(01)70136-7","volume":"24","author":"S Santolaria","year":"2001","unstructured":"Santolaria S, Barrios Y, Benito R, Piazuelo E, Quintero E, Lanas A . Helicobacter pylori and immunogenetic factors of the host: relevance of the HLADQA1 *0102 and *0301 alleles in peptic ulcer. Gastroenterol Hepatol 2001; 24: 117\u2013121.","journal-title":"Gastroenterol Hepatol"},{"key":"BF6364341_CR58","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/0016-5085(92)90018-T","volume":"103","author":"A Lanas","year":"1992","unstructured":"Lanas A, Sekar MC, Hirschowitz BI . Objective evidence of aspirin use in both ulcer and nonulcer upper and lower gastrointestinal bleeding. Gastroenterology 1992; 103: 862\u2013869.","journal-title":"Gastroenterology"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6364341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6364341","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6364341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T21:04:34Z","timestamp":1683579874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6364341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,14]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,12,1]]}},"alternative-id":["BF6364341"],"URL":"https:\/\/doi.org\/10.1038\/sj.gene.6364341","relation":{},"ISSN":["1466-4879","1476-5470"],"issn-type":[{"value":"1466-4879","type":"print"},{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,14]]},"assertion":[{"value":"9 June 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}