{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:30:56Z","timestamp":1760027456101},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2000,5,25]],"date-time":"2000-05-25T00:00:00Z","timestamp":959212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,5,25]],"date-time":"2000-05-25T00:00:00Z","timestamp":959212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2000,6,1]]},"DOI":"10.1038\/sj.gt.3301182","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T16:47:26Z","timestamp":1031158046000},"page":"942-949","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adenoviral gene transfer of basic fibroblast growth factor promotes angiogenesis in rat brain"],"prefix":"10.1038","volume":"7","author":[{"given":"H","family":"Yukawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JC","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-I","family":"Miyatake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Akimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Yanamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,5,25]]},"reference":[{"key":"BF3301182_CR1","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1161\/01.CIR.85.3.1197","volume":"85","author":"S Sasayama","year":"1992","unstructured":"Sasayama S, Fujita M . Recent insights into coronary collateral circulation Circulation 1992 85: 1197\u20131204","journal-title":"Circulation"},{"key":"BF3301182_CR2","first-page":"H1588","volume":"266","author":"EF Unger","year":"1994","unstructured":"Unger EF et al. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model Am J Physiol 1994 266: H1588\u2013H1595","journal-title":"Am J Physiol"},{"key":"BF3301182_CR3","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1056\/NEJM198511073131904","volume":"313","author":"stroke Failure of extracranial-intracrania","year":"1985","unstructured":"Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke . Results of an international randomized trial. The EC\/IC Bypass Study Group New Engl J Med 1985 313: 1191\u20131200","journal-title":"New Engl J Med"},{"key":"BF3301182_CR4","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1161\/01.STR.16.3.397","volume":"16","author":"methodology The International Cooperative Study","year":"1985","unstructured":"The International Cooperative Study of Extracranial\/Intracranial Arterial Anastomosis (EC\/IC Bypass Study): methodology and entry characteristics . The EC\/IC Bypass Study group Stroke 1985 16: 397\u2013406","journal-title":"Stroke"},{"key":"BF3301182_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0045-6039(86)90021-7","volume":"19","author":"D Gospodarowicz","year":"1986","unstructured":"Gospodarowicz D, Neufeld G, Schweigerer L . Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells Cell Diff 1986 19: 1\u201317","journal-title":"Cell Diff"},{"key":"BF3301182_CR6","doi-asserted-by":"publisher","first-page":"5459","DOI":"10.1073\/pnas.84.15.5459","volume":"84","author":"K Unsicker","year":"1987","unstructured":"Unsicker K et al. Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons Proc Natl Acad Sci USA 1987 84: 5459\u20135463","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301182_CR7","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1016\/S0021-9258(19)49853-0","volume":"267","author":"J Folkman","year":"1992","unstructured":"Folkman J, Shing Y . Angiogenesis J Biol Chem 1992 267: 10931\u201310934","journal-title":"J Biol Chem"},{"key":"BF3301182_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1242\/jcs.1990.Supplement_13.10","volume":"13","author":"R Westermann","year":"1990","unstructured":"Westermann R, Grothe C, Unsicker K . Basic fibroblast growth factor (bFGF), a multifunctional growth factor for neuroectodermal cells J Cell Sci Suppl 1990 13: 97\u2013117","journal-title":"J Cell Sci Suppl"},{"key":"BF3301182_CR9","first-page":"H1525","volume":"262","author":"Jr Hawker JR","year":"1992","unstructured":"Hawker JR Jr, Granger HJ . Internalized basic fibroblast growth factor translocates to nuclei of venular endothelial cells Am J Physiol 1992 262: H1525\u2013H1537","journal-title":"Am J Physiol"},{"key":"BF3301182_CR10","doi-asserted-by":"crossref","first-page":"25803","DOI":"10.1016\/S0021-9258(18)35681-3","volume":"267","author":"D Moscatelli","year":"1992","unstructured":"Moscatelli D . Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implications for mechanisms of bFGF release from pericellular matrix J Biol Chem 1992 267: 25803\u201325809","journal-title":"J Biol Chem"},{"key":"BF3301182_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/00005344-199401000-00013","volume":"23","author":"EH Boussairi","year":"1994","unstructured":"Boussairi EH, Sassard J . Cardiovascular effects of basic fibroblast growth factor in rats J Cardiovasc Pharmacol 1994 23: 99\u2013102","journal-title":"J Cardiovasc Pharmacol"},{"key":"BF3301182_CR12","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1126\/science.2017680","volume":"252","author":"MA Rosenfeld","year":"1991","unstructured":"Rosenfeld MA et al. Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo Science 1991 252: 431\u2013434","journal-title":"Science"},{"key":"BF3301182_CR13","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1073\/pnas.89.7.2581","volume":"89","author":"B Quantin","year":"1992","unstructured":"Quantin B, Perricaudet LD, Tajbakhsh S, Mandel JL . Adenovirus as an expression vector in muscle cells in vivo Proc Natl Acad Sci USA 1992 89: 2581\u20132584","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301182_CR14","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/ng0393-219","volume":"3","author":"BL Davidson","year":"1993","unstructured":"Davidson BL et al. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector Nat Genet 1993 3: 219\u2013223","journal-title":"Nat Genet"},{"key":"BF3301182_CR15","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/ng0393-224","volume":"3","author":"S Akli","year":"1993","unstructured":"Akli S et al. Transfer of a foreign gene into the brain using adenovirus vectors Nat Genet 1993 3: 224\u2013228","journal-title":"Nat Genet"},{"key":"BF3301182_CR16","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1165\/ajrcmb.10.4.8136153","volume":"10","author":"Y Setoguchi","year":"1994","unstructured":"Setoguchi Y, Jaffe HA, Chu CS, Crystal RG . Intraperitoneal in vivo gene therapy to deliver alpha 1-antitrypsin to the systemic circulation Am J Respir Cell Mol Biol 1994 10: 369\u2013377","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BF3301182_CR17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0021-9150(97)00102-0","volume":"132","author":"JC Takahashi","year":"1997","unstructured":"Takahashi JC et al. Adenovirus-mediated gene transfer of basic fibroblast growth factor induces in vitro angiogenesis Atherosclerosis 1997 132: 199\u2013205","journal-title":"Atherosclerosis"},{"key":"BF3301182_CR18","first-page":"273","volume":"40","author":"M Akimoto","year":"1999","unstructured":"Akimoto M et al. Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats Invest Ophthalmol Vis Sci 1999 40: 273\u2013279","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF3301182_CR19","volume-title":"The Rat Brain in Stereotaxic Coodinates","author":"G Paxinos","year":"1986","unstructured":"Paxinos G, Watson C . The Rat Brain in Stereotaxic Coodinates Academic Press: New York 1986"},{"key":"BF3301182_CR20","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1097\/00000478-198310000-00007","volume":"7","author":"SH Barsky","year":"1983","unstructured":"Barsky SH et al. Use of anti-basement membrane antibodies to distinguish blood vessel capillaries from lymphatic capillaries Am J Surg Pathol 1983 7: 667\u2013677","journal-title":"Am J Surg Pathol"},{"key":"BF3301182_CR21","doi-asserted-by":"publisher","first-page":"13612","DOI":"10.1073\/pnas.94.25.13612","volume":"94","author":"DR Senger","year":"1997","unstructured":"Senger DR et al. Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins Proc Natl Acad Sci USA 1997 94: 13612\u201313617","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301182_CR22","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1126\/science.2432664","volume":"235","author":"J Folkman","year":"1987","unstructured":"Folkman J, Klagsburn M . Angiogenic factors Science 1987 235: 442\u2013447","journal-title":"Science"},{"key":"BF3301182_CR23","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1126\/science.2479986","volume":"246","author":"DW Leung","year":"1989","unstructured":"Leung DW et al. Vascular endothelial growth factor is a secreted angiogenic mitogen Science 1989 246: 1306\u20131309","journal-title":"Science"},{"key":"BF3301182_CR24","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1093\/cvr\/28.8.1176","volume":"28","author":"S Banai","year":"1994","unstructured":"Banai S et al. Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis Cardiovasc Res 1994 28: 1176\u20131179","journal-title":"Cardiovasc Res"},{"key":"BF3301182_CR25","first-page":"II228","volume":"90","author":"S Takeshita","year":"1994","unstructured":"Takeshita S et al. Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia Circulation 1994 90: II228\u2013II234","journal-title":"Circulation"},{"key":"BF3301182_CR26","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1172\/JCI117018","volume":"93","author":"S Takeshita","year":"1994","unstructured":"Takeshita S et al. Therapeutic angiogenesis. A single intra-arterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model J Clin Invest 1994 93: 662\u2013670","journal-title":"J Clin Invest"},{"key":"BF3301182_CR27","doi-asserted-by":"publisher","first-page":"7311","DOI":"10.1073\/pnas.86.19.7311","volume":"86","author":"D Gospodarowicz","year":"1989","unstructured":"Gospodarowicz D, Abraham JA, Schilling J . Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells Proc Natl Acad Sci USA 1989 86: 7311\u20137315","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301182_CR28","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1177\/000331979804900507","volume":"49","author":"M Miyataka","year":"1998","unstructured":"Miyataka M, Ishikawa K, Katori R . Basic fibroblast growth factor increased regional myocardial blood flow and limited infarct size of acutely infarcted myocardium in dogs Angiology 1998 49: 381\u2013390","journal-title":"Angiology"},{"key":"BF3301182_CR29","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1161\/01.CIR.94.8.1927","volume":"94","author":"MC Horrigan","year":"1996","unstructured":"Horrigan MC et al. Reduction in myocardial infarct size by basic fibroblast growth factor after temporary coronary occlusion in a canine model Circulation 1996 94: 1927\u20131933","journal-title":"Circulation"},{"key":"BF3301182_CR30","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/jcbfm.1991.90","volume":"11","author":"K Yamada","year":"1991","unstructured":"Yamada K et al. Basic fibroblast growth factor prevents thalamic degeneration after cortical infarction J Cereb Blood Flow Metab 1991 11: 472\u2013478","journal-title":"J Cereb Blood Flow Metab"},{"key":"BF3301182_CR31","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0022-510X(96)00052-4","volume":"139","author":"N Jiang","year":"1996","unstructured":"Jiang N et al. Delayed intravenous administration of basic fibroblast growth factor (bFGF) reduces infarct volume in a model of focal cerebral ischemia\/reperfusion in the rat J Neurol Sci 1996 139: 173\u2013179","journal-title":"J Neurol Sci"},{"key":"BF3301182_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1161\/01.RES.77.1.7","volume":"77","author":"H Ooboshi","year":"1995","unstructured":"Ooboshi H et al. Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue Circ Res 1995 77: 7\u201313","journal-title":"Circ Res"},{"key":"BF3301182_CR33","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1227\/00006123-199505000-00012","volume":"36","author":"SE Doran","year":"1995","unstructured":"Doran SE et al. Gene expression from recombinant viral vectors in the central nervous system after blood\u2013brain barrier disruption Neurosurgery 1995 36: 965\u2013970","journal-title":"Neurosurgery"},{"key":"BF3301182_CR34","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.1073\/pnas.91.10.4407","volume":"91","author":"Y Yang","year":"1994","unstructured":"Yang Y et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy Proc Natl Acad Sci USA 1994 91: 4407\u20134411","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301182_CR35","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/jcp.1041620311","volume":"162","author":"RZ Florkiewicz","year":"1995","unstructured":"Florkiewicz RZ, Majack RA, Buecheler RD, Florkiewicz E . Quantitative export of FGF-2 occurs through an alternative, energy dependent, non-ER\/Golgi pathway J Cell Phys 1995 162: 388\u2013399","journal-title":"J Cell Phys"},{"key":"BF3301182_CR36","unstructured":"Akimoto M et al. Secretory modification enhances the neurotrophic effect of adenovirally expressed basic fibroblast growth factor Hum Gene Ther (submitted for publication)"},{"key":"BF3301182_CR37","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1089\/hum.1995.6.11-1457","volume":"6","author":"J Muhlhauser","year":"1995","unstructured":"Muhlhauser J et al. In vivo angiogenesis induced by recombinant adenovirus vectors coding either for secreted or nonsecreted forms of acidic fibroblast growth factor Hum Gene Ther 1995 6: 1457\u20131465","journal-title":"Hum Gene Ther"},{"key":"BF3301182_CR38","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.1523\/JNEUROSCI.12-10-03828.1992","volume":"12","author":"A Logan","year":"1992","unstructured":"Logan A, Frautschy SA, Gonzalez AM, Baird A . A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury J Neurosci 1992 12: 3828\u20133837","journal-title":"J Neurosci"},{"key":"BF3301182_CR39","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3171\/jns.1991.75.2.0267","volume":"75","author":"M Hoshimaru","year":"1991","unstructured":"Hoshimaru M et al. Possible roles of basic fibroblast growth factor in the pathogenesis of moyamoya disease: an immunohistochemical study J Neurosurg 1991 75: 267\u2013270","journal-title":"J Neurosurg"},{"key":"BF3301182_CR40","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000121249","volume":"27","author":"AM Malek","year":"1997","unstructured":"Malek AM et al. Elevation of cerebrospinal fluid levels of basic fibroblast growth factor in moyamoya and central nervous system disorders Pediatr Neurosurg 1997 27: 182\u2013189","journal-title":"Pediatr Neurosurg"},{"key":"BF3301182_CR41","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0006-8993(91)90784-S","volume":"558","author":"MK Lyons","year":"1991","unstructured":"Lyons MK, Anderson RE, Meyer FB . Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia Brain Res 1991 558: 315\u2013320","journal-title":"Brain Res"},{"key":"BF3301182_CR42","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1227\/00006123-199510000-00017","volume":"37","author":"S Gately","year":"1995","unstructured":"Gately S, Soff GA, Brem S . The potential role of basic fibroblast growth factor in the transformation of cultured primary human fetal astrocytes and the proliferation of human glioma (U-87) cells Neurosurgery 1995 37: 723\u2013730","journal-title":"Neurosurgery"},{"key":"BF3301182_CR43","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1161\/01.RES.68.1.106","volume":"68","author":"V Lindner","year":"1991","unstructured":"Lindner V et al. Role of basic fibroblast growth factor in vascular lesion formation Circ Res 1991 68: 106\u2013113","journal-title":"Circ Res"},{"key":"BF3301182_CR44","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1089\/hum.1997.8.3-253","volume":"8","author":"K Kajiwara","year":"1997","unstructured":"Kajiwara K et al. Immune responses to adenoviral vectors during gene transfer in the brain Hum Gene Ther 1997 8: 253\u2013265","journal-title":"Hum Gene Ther"},{"key":"BF3301182_CR45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0006-8993(90)90140-7","volume":"534","author":"M Puumala","year":"1990","unstructured":"Puumala M, Anderson RE, Meyer FB . Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat Brain Res 1990 534: 283\u2013286","journal-title":"Brain Res"},{"key":"BF3301182_CR46","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/ana.410350413","volume":"35","author":"N Koketsu","year":"1994","unstructured":"Koketsu N et al. Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats Ann Neurol 1994 35: 451\u2013457","journal-title":"Ann Neurol"},{"key":"BF3301182_CR47","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/jcbfm.1993.27","volume":"13","author":"K Nozaki","year":"1993","unstructured":"Nozaki K, Finkelstein SP, Beal MF . Basic fibroblast groth factor protect against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats J Cereb Blood Flow Metab 1993 13: 221\u2013228","journal-title":"J Cereb Blood Flow Metab"},{"key":"BF3301182_CR48","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1073\/pnas.93.3.1320","volume":"93","author":"S Miyake","year":"1996","unstructured":"Miyake S et al. Efficient generation of recombinant adenovirus using adenovirus DNA\u2013terminal protein complex and a cosmide bearing the full-length virus genome Proc Natl Acad Sci USA 1996 93: 1320\u20131324","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301182_CR49","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0014-5793(87)81489-8","volume":"213","author":"T Kurokawa","year":"1987","unstructured":"Kurokawa T, Sasada R, Iwane M, Igarashi K . Cloning and expression of cDNA encoding human basic fibroblast growth factor FEBS Lett 1987 213: 189\u2013194","journal-title":"FEBS Lett"},{"key":"BF3301182_CR50","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1749-6632.1991.tb49025.x","volume":"638","author":"R Sasada","year":"1991","unstructured":"Sasada R, Seno M, Watanabe T, Igarashi K . Expression of modified bFGF cDNAs in mammalian cells Ann NY Acad Sci 1991 638: 149\u2013160","journal-title":"Ann NY Acad Sci"},{"key":"BF3301182_CR51","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1128\/jvi.54.3.711-719.1985","volume":"54","author":"I Saito","year":"1985","unstructured":"Saito I et al. Construction of nondefective adenovirus type 5 bearing a 2.8-kilobase hepatitis B virus DNA near the right end of its genome J Virol 1985 54: 711\u2013719","journal-title":"J Virol"},{"key":"BF3301182_CR52","doi-asserted-by":"publisher","first-page":"157","DOI":"10.7883\/yoken1952.47.157","volume":"47","author":"Y Kanegae","year":"1994","unstructured":"Kanegae Y, Makimura M, Saito I . A simple and efficient method for purification of infectious recombinant adenovirus Jpn J Med Sci Biol 1994 47: 157\u2013166","journal-title":"Jpn J Med Sci Biol"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/3301182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301182","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T19:26:13Z","timestamp":1648581973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3301182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5,25]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2000,6,1]]}},"alternative-id":["BF3301182"],"URL":"https:\/\/doi.org\/10.1038\/sj.gt.3301182","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5,25]]},"assertion":[{"value":"2 September 1999","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}