{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:15:29Z","timestamp":1760296529100},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2000,9,1]]},"DOI":"10.1038\/sj.gt.3301270","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T16:49:10Z","timestamp":1031158150000},"page":"1584-1592","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Retargeting of adenoviral vectors to neurons using the HC fragment of tetanus toxin"],"prefix":"10.1038","volume":"7","author":[{"given":"H","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Groves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"M\u00fchle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P N","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Knight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Themis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Carvajal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Scaravilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D T","family":"Curiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N F","family":"Fairweather","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Coutelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,9,25]]},"reference":[{"key":"BF3301270_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev.ne.19.030196.001405","volume":"19","author":"DJ Fink","year":"1996","unstructured":"Fink DJ, DeLuca NA, Goins WF, Glorioso JC . Gene transfer to neurons using herpes simplex virus-based vectors Annu Rev Neurosci 1996 19: 265\u2013287","journal-title":"Annu Rev Neurosci"},{"key":"BF3301270_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/exnr.1996.6395","volume":"144","author":"DJ Fink","year":"1997","unstructured":"Fink DJ et al. Development of an HSV-based vector for the treatment of Parkinson's disease Exp Neurol 1997 144: 103\u2013121","journal-title":"Exp Neurol"},{"key":"BF3301270_CR3","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/sj.gt.3300700","volume":"5","author":"MK Howard","year":"1998","unstructured":"Howard MK et al. High efficiency gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5 Gene Therapy 1998 5: 1137\u20131147","journal-title":"Gene Therapy"},{"key":"BF3301270_CR4","first-page":"132","volume":"2","author":"GD Ghadge","year":"1995","unstructured":"Ghadge GD et al. CNS gene delivery by retrograde transport of replication-defective adenoviruses Gene Therapy 1995 2: 132\u2013137","journal-title":"Gene Therapy"},{"key":"BF3301270_CR5","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nm0497-429","volume":"3","author":"G Haase","year":"1997","unstructured":"Haase G et al. Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors Nature Med 1997 3: 429\u2013436","journal-title":"Nature Med"},{"key":"BF3301270_CR6","first-page":"303","volume-title":"Sourcebook of Bacterial Toxins","author":"H Niemann","year":"1991","unstructured":"Niemann H . Molecular biology of clostridial neurotoxins. In: Alouf JE, Freer JH (eds) Sourcebook of Bacterial Toxins Academic Press: London 1991 pp 303\u2013348"},{"key":"BF3301270_CR7","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1126\/science.49080","volume":"188","author":"DL Price","year":"1975","unstructured":"Price DL et al. Tetanus toxin: direct evidence for retrograde intraaxonal transport Science 1975 188: 945\u2013947","journal-title":"Science"},{"key":"BF3301270_CR8","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/0006-8993(77)90457-7","volume":"122","author":"M Schwab","year":"1977","unstructured":"Schwab M, Thoenen H . Selective trans-synaptic migration of tetanus toxin after retrograde axonal transport in peripheral sympathetic nerves: a comparison with nerve growth factor Brain Res 1977 122: 459\u2013474","journal-title":"Brain Res"},{"key":"BF3301270_CR9","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/359832a0","volume":"359","author":"G Schiavo","year":"1992","unstructured":"Schiavo G et al. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin Nature 1992 359: 832\u2013835","journal-title":"Nature"},{"key":"BF3301270_CR10","first-page":"221","volume":"195","author":"JL Halpern","year":"1995","unstructured":"Halpern JL, Neale EA . Neurospecific binding, internalization, and retrograde axonal transport Curr Top Microbiol Immunol 1995 195: 221\u2013241","journal-title":"Curr Top Microbiol Immunol"},{"key":"BF3301270_CR11","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0006-8993(86)90241-6","volume":"380","author":"C Evinger","year":"1986","unstructured":"Evinger C, Erichsen JT . Transsynapic retrograde transport of fragment C of tetanus toxin demonstrated by immunohistochemical localization Brain Res 1986 380: 383\u2013388","journal-title":"Brain Res"},{"key":"BF3301270_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0006-8993(87)90792-X","volume":"406","author":"PS Fishman","year":"1987","unstructured":"Fishman PS, Carrigan DR . Retrograde transneuronal transfer of the fragment C of tetanus toxin Brain Res 1987 406: 275\u2013279","journal-title":"Brain Res"},{"key":"BF3301270_CR13","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1128\/iai.63.8.3218-3221.1995","volume":"63","author":"DM Figueiredo","year":"1995","unstructured":"Figueiredo DM et al. Characterization of recombinant tetanus toxin derivatives suitable for vaccine development Infect Immun 1995 63: 3218\u20133221","journal-title":"Infect Immun"},{"key":"BF3301270_CR14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0022-510X(90)90272-O","volume":"98","author":"PS Fishman","year":"1990","unstructured":"Fishman PS, Savitt JM, Farrand DA . Enhanced CNS uptake of systemically administered proteins through conjugation with tetanus C-fragment J Neurol Sci 1990 98: 311\u2013325","journal-title":"J Neurol Sci"},{"key":"BF3301270_CR15","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1073\/pnas.89.6.2297","volume":"89","author":"K Dobrenis","year":"1992","unstructured":"Dobrenis K, Joseph A, Rattazzi MC . Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin Proc Natl Acad Sci USA 1992 89: 2297\u20132301","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301270_CR16","doi-asserted-by":"publisher","first-page":"15434","DOI":"10.1074\/jbc.270.25.15434","volume":"270","author":"JW Francis","year":"1995","unstructured":"Francis JW, Hosler BA, Brown RH, Fishman PS . CuZn superoxide dismutase (SOD-1)\/tetanus toxin fragment C hybrid protein for targeted delivery of SOD-1 to neuronal cells J Biol Chem 1995 270: 15434\u201315442","journal-title":"J Biol Chem"},{"key":"BF3301270_CR17","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1006\/exnr.1997.6490","volume":"145","author":"DM Figueiredo","year":"1997","unstructured":"Figueiredo DM et al. Delivery of recombinant tetanus-superoxide dismutase proteins to central nervous system neurons by retrograde axonal transport Exp Neurol 1997 145: 546\u2013554","journal-title":"Exp Neurol"},{"key":"BF3301270_CR18","doi-asserted-by":"publisher","first-page":"9400","DOI":"10.1073\/pnas.94.17.9400","volume":"94","author":"L Coen","year":"1997","unstructured":"Coen L, Osta R, Maury M, Brulet P . Construction of hybrid proteins that migrate retrogradely and trans-synaptically into the central nervous system Proc Natl Acad Sci USA 1997 94: 9400\u20139405","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301270_CR19","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1046\/j.1432-1327.1999.00108.x","volume":"259","author":"A Knight","year":"1999","unstructured":"Knight A et al. Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin Eur J Biochem 1999 259: 762\u2013769","journal-title":"Eur J Biochem"},{"key":"BF3301270_CR20","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1038\/nbt1196-1570","volume":"14","author":"TJ Wickham","year":"1996","unstructured":"Wickham TJ, Roelvink PW, Brough DE, Kovesdi I . Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types Nat Biotechnol 1996 14: 1570\u20131573","journal-title":"Nat Biotechnol"},{"key":"BF3301270_CR21","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/nbt1196-1574","volume":"14","author":"JT Douglas","year":"1996","unstructured":"Douglas JT et al. Targeted gene delivery by tropism-modified adenoviral vectors Nat Biotechnol 1996 14: 1574\u20131578","journal-title":"Nat Biotechnol"},{"key":"BF3301270_CR22","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1128\/jvi.70.10.6831-6838.1996","volume":"70","author":"TJ Wickham","year":"1996","unstructured":"Wickham TJ et al. Targeted adenovirus-mediated gene transfer to endothelial and smooth muscle cells by using bispecific antibodies J Virol 1996 70: 6831\u20136838","journal-title":"J Virol"},{"key":"BF3301270_CR23","first-page":"1447","volume":"57","author":"CK Goldman","year":"1997","unstructured":"Goldman CK et al. Targeted gene delivery to Karposi's sarcoma cells via the fibroblast growth factor receptor Cancer Res 1997 57: 1447\u20131451","journal-title":"Cancer Res"},{"key":"BF3301270_CR24","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.1128\/jvi.71.11.8221-8229.1997","volume":"71","author":"TJ Wickham","year":"1997","unstructured":"Wickham TJ et al. Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins J Virol 1997 71: 8221\u20138229","journal-title":"J Virol"},{"key":"BF3301270_CR25","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/sj.gt.3300541","volume":"4","author":"BE Rogers","year":"1997","unstructured":"Rogers BE et al. Use of a novel cross-linking method to modify adenoviral tropism Gene Therapy 1997 4: 1387\u20131392","journal-title":"Gene Therapy"},{"key":"BF3301270_CR26","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1128\/JVI.72.3.1844-1852.1998","volume":"72","author":"V Krasnykh","year":"1998","unstructured":"Krasnykh V et al. Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob J Virol 1998 72: 1844\u20131852","journal-title":"J Virol"},{"key":"BF3301270_CR27","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.4049\/jimmunol.162.11.6378","volume":"162","author":"BW Tillman","year":"1999","unstructured":"Tillman BW et al. Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector J Immunol 1999 162: 6378\u20136383","journal-title":"J Immunol"},{"key":"BF3301270_CR28","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nm0995-864","volume":"1","author":"C Coutelle","year":"1995","unstructured":"Coutelle C, Douar AM, Colledge WH, Froster U . The challenge of fetal gene therapy Nature Med 1995 1: 864\u2013866","journal-title":"Nature Med"},{"key":"BF3301270_CR29","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/6458","volume":"5","author":"H Schneider","year":"1999","unstructured":"Schneider H, Coutelle C . In utero gene therapy: the case for Nature Med 1999 5: 256\u2013257","journal-title":"Nature Med"},{"key":"BF3301270_CR30","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1038\/sj.gt.3301008","volume":"6","author":"V Navarro","year":"1999","unstructured":"Navarro V et al. Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter Gene Therapy 1999 6: 1884\u20131892","journal-title":"Gene Therapy"},{"key":"BF3301270_CR31","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1089\/hum.1998.9.18-2709","volume":"9","author":"NP Morral","year":"1998","unstructured":"Morral NP et al. High doses of helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity Hum Gene Ther 1998 9: 2709\u20132716","journal-title":"Hum Gene Ther"},{"key":"BF3301270_CR32","doi-asserted-by":"crossref","first-page":"11188","DOI":"10.1016\/S0021-9258(18)82109-3","volume":"268","author":"JL Halpern","year":"1993","unstructured":"Halpern JL, Loftus A . Characterization of the receptor-binding domain of tetanus toxin J Biol Chem 1993 268: 11188\u201311192","journal-title":"J Biol Chem"},{"key":"BF3301270_CR33","first-page":"337","volume-title":"Culturing Nerve Cells","author":"N Kleitman","year":"1992","unstructured":"Kleitman N, Wood P, Bunge R . Tissue culture methods for the study of myelination. In: Banker G, Goslin K (eds) Culturing Nerve Cells MIT Press: Cambridge 1992 pp 337\u2013377"},{"key":"BF3301270_CR34","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/0042-6822(73)90341-3","volume":"52","author":"FL Graham","year":"1973","unstructured":"Graham FL, Eb AJ . A new technique for the assay of infectivity of human adenovirus 5 DNA Virology 1973 52: 456\u2013457","journal-title":"Virology"},{"key":"BF3301270_CR35","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1128\/jvi.70.7.4805-4810.1996","volume":"70","author":"C Chartier","year":"1996","unstructured":"Chartier C et al. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli J Virol 1996 70: 4805\u20134810","journal-title":"J Virol"},{"key":"BF3301270_CR36","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1099\/0022-1317-36-1-59","volume":"36","author":"FL Graham","year":"1977","unstructured":"Graham FL, Smiley J, Russel WC, Nairn R . Characteristics of a human cell line transformed by DNA from human adenovirus type 5 J Gen Virol 1977 36: 59\u201372","journal-title":"J Gen Virol"},{"key":"BF3301270_CR37","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1093\/nar\/19.7.1461","volume":"19","author":"MA Romanos","year":"1991","unstructured":"Romanos MA et al. Expression of tetanus toxin fragment C in yeast: gene synthesis is required to eliminate fortuitous polyadenylation sites in AT-rich DNA Nucleic Acids Res 1991 19: 1461\u20131467","journal-title":"Nucleic Acids Res"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/3301270.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301270","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301270.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:16:12Z","timestamp":1682036172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3301270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,1]]},"references-count":37,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2000,9,1]]}},"alternative-id":["BF3301270"],"URL":"https:\/\/doi.org\/10.1038\/sj.gt.3301270","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,1]]},"assertion":[{"value":"19 January 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}