{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:53:44Z","timestamp":1790798024363,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"20","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2000,10,1]]},"DOI":"10.1038\/sj.gt.3301299","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T16:50:35Z","timestamp":1031158235000},"page":"1761-1767","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Transient depletion of CD4 lymphocyte improves efficacy of repeated administration of recombinant adenovirus in the ornithine transcarbamylase deficient sparse fur mouse"],"prefix":"10.1038","volume":"7","author":[{"given":"X","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Batshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2000,10,25]]},"reference":[{"key":"BF3301299_CR1","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1056\/NEJM199605023341809","volume":"334","author":"JM Wilson","year":"1996","unstructured":"Wilson JM . Adenoviruses as gene-delivery vehicles New Engl J Med 1996 334: 1185\u20131187","journal-title":"New Engl J Med"},{"key":"BF3301299_CR2","first-page":"367","volume":"1","author":"M Ali","year":"1994","unstructured":"Ali M, Lemoine N, Ring C . The use of DNA viruses as vectors for gene therapy Gene Therapy 1994 1: 367\u2013384","journal-title":"Gene Therapy"},{"key":"BF3301299_CR3","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/1074-7613(94)90074-4","volume":"1","author":"Y Yang","year":"1994","unstructured":"Yang Y, Ertl HCJ, Wilson JM . MHC class I restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses Immunity 1994 1: 433\u2013442","journal-title":"Immunity"},{"key":"BF3301299_CR4","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nm0596-545","volume":"2","author":"SK Tripathy","year":"1996","unstructured":"Tripathy SK, Goldwasser BH, Leiden JM . Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors Nature Med 1996 2: 545\u2013550","journal-title":"Nature Med"},{"key":"BF3301299_CR5","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1128\/jvi.70.10.7209-7212.1996","volume":"70","author":"Y Yang","year":"1996","unstructured":"Yang Y, Su Q, Wilson JM . Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs J Virol 1996 70: 7209\u20137212","journal-title":"J Virol"},{"key":"BF3301299_CR6","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1128\/jvi.69.4.2004-2015.1995","volume":"69","author":"Y Yang","year":"1995","unstructured":"Yang Y, Li Q, Ertl HC, Wilson JM . Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses J Virol 1995 69: 2004\u20132015","journal-title":"J Virol"},{"key":"BF3301299_CR7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/sj.gt.3300412","volume":"4","author":"A Michou","year":"1997","unstructured":"Michou A et al. Adenovirus-mediated gene transfer: influence of transgene, mouse strain and type of immune response on persistence of transgene expression Gene Therapy 1997 4: 473\u2013482","journal-title":"Gene Therapy"},{"key":"BF3301299_CR8","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1128\/jvi.62.7.2321-2328.1988","volume":"62","author":"C Wohlfart","year":"1988","unstructured":"Wohlfart C . Neutralization of adenoviruses: kinetics, stoichiometry, and mechanisms J Virol 1988 62: 2321\u20132328","journal-title":"J Virol"},{"key":"BF3301299_CR9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1089\/hum.1997.8.1-99","volume":"8","author":"C Mack","year":"1997","unstructured":"Mack C et al. Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype Hum Gene Ther 1997 8: 99\u2013109","journal-title":"Hum Gene Ther"},{"key":"BF3301299_CR10","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1073\/pnas.92.5.1401","volume":"92","author":"Y Dai","year":"1995","unstructured":"Dai Y et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression Proc Natl Acad Sci USA 1995 92: 1401\u20131405","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301299_CR11","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1089\/hum.1996.7.13-1555","volume":"7","author":"K Jooss","year":"1996","unstructured":"Jooss K, Yang Y, Wilson JM . Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung Hum Gene Ther 1996 7: 1555\u20131566","journal-title":"Hum Gene Ther"},{"key":"BF3301299_CR12","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1089\/hum.1996.7.12-1455","volume":"7","author":"B Guerette","year":"1996","unstructured":"Guerette B et al. Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4Ig Hum Gene Ther 1996 7: 1455\u20131463","journal-title":"Hum Gene Ther"},{"key":"BF3301299_CR13","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1089\/hum.1997.8.8-935","volume":"8","author":"Z Zsengeller","year":"1997","unstructured":"Zsengeller Z et al. Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer Hum Gene Ther 1997 8: 935\u2013941","journal-title":"Hum Gene Ther"},{"key":"BF3301299_CR14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/sj.gt.3300431","volume":"4","author":"A Scaria","year":"1997","unstructured":"Scaria A et al. Antibody to CD40 ligand inhibits both humoral and cellular immune responses to adenoviral vectors and facilitates repeated administration to mouse airway Gene Therapy 1997 4: 611\u2013617","journal-title":"Gene Therapy"},{"key":"BF3301299_CR15","first-page":"412","volume":"3","author":"Y Yang","year":"1996","unstructured":"Yang Y, Greenough K, Wilson JM . Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver Gene Therapy 1996 3: 412\u2013420","journal-title":"Gene Therapy"},{"key":"BF3301299_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1089\/hum.1996.7.4-489","volume":"7","author":"J Kolls","year":"1996","unstructured":"Kolls J et al. Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors Hum Gene Ther 1996 7: 489\u2013497","journal-title":"Hum Gene Ther"},{"key":"BF3301299_CR17","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/nm0995-890","volume":"1","author":"Y Yang","year":"1995","unstructured":"Yang Y, Trinchieri G, Wilson JM . Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung Nature Med 1995 1: 890\u2013893","journal-title":"Nature Med"},{"key":"BF3301299_CR18","first-page":"1187","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"S Brusilow","year":"1996","unstructured":"Brusilow S, Horwich A . Urea cycle enzymes. In: Scriver CR, Beaudet AL, Sly WL, Valle D The Metabolic and Molecular Bases of Inherited Disease McGraw-Hill: New York 1996 pp 1187\u20131232"},{"key":"BF3301299_CR19","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1074\/jbc.271.7.3639","volume":"271","author":"X Ye","year":"1996","unstructured":"Ye X et al. Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectors J Biol Chem 1996 271: 3639\u20133646","journal-title":"J Biol Chem"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/3301299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301299","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T22:04:27Z","timestamp":1648591467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3301299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10,1]]},"references-count":19,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2000,10,1]]}},"alternative-id":["BF3301299"],"URL":"https:\/\/doi.org\/10.1038\/sj.gt.3301299","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10,1]]},"assertion":[{"value":"11 April 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}