{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:00:59Z","timestamp":1760954459278},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2001,7,1]]},"DOI":"10.1038\/sj.gt.3301479","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:59:08Z","timestamp":1032375548000},"page":"977-986","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Bcl-2 expression by retrograde transport of adenoviral vectors with Cre-loxP recombination system in motor neurons of mutant SOD1 transgenic mice"],"prefix":"10.1038","volume":"8","author":[{"given":"S","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Arima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Okado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Uchino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,7,6]]},"reference":[{"key":"BF3301479_CR1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0025-6196(12)61175-6","volume":"66","author":"DB Williams","year":"1991","unstructured":"Williams DB, Windebank AJ . Motor neuron disease (amyotrophic lateral sclerosis) Mayo Clin Proc 1991 66: 54\u201382","journal-title":"Mayo Clin Proc"},{"key":"BF3301479_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"DR Rosen","year":"1993","unstructured":"Rosen DR et al. Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 1993 362: 59\u201362","journal-title":"Nature"},{"key":"BF3301479_CR3","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1212\/WNL.36.4.511","volume":"36","author":"DW Mulder","year":"1986","unstructured":"Mulder DW, Kurland LT, Offord KP, Beard CM . Familial adult motor neuron disease: amyotrophic lateral sclerosis Neurology 1986 36: 511\u2013517","journal-title":"Neurology"},{"key":"BF3301479_CR4","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1126\/science.8209258","volume":"264","author":"ME Gurney","year":"1994","unstructured":"Gurney ME et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation Science 1994 264: 1772\u20131775","journal-title":"Science"},{"key":"BF3301479_CR5","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1073\/pnas.92.3.689","volume":"92","author":"ME Ripps","year":"1995","unstructured":"Ripps ME et al. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis Proc Natl Acad Sci USA 1995 92: 689\u2013693","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301479_CR6","first-page":"1271","volume":"145","author":"MC Dal Canto","year":"1994","unstructured":"Dal Canto MC, Gurney ME . Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis Am J Pathol 1994 145: 1271\u20131279","journal-title":"Am J Pathol"},{"key":"BF3301479_CR7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S0959-4388(96)80103-6","volume":"6","author":"JD Rothstein","year":"1996","unstructured":"Rothstein JD . Therapeutic horizons for amyotrophic lateral sclerosis Curr Opin Neurobiol 1996 6: 679\u2013687","journal-title":"Curr Opin Neurobiol"},{"key":"BF3301479_CR8","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nm0696-696","volume":"2","author":"P Aebischer","year":"1996","unstructured":"Aebischer P et al. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients Nat Med 1996 2: 696\u2013699","journal-title":"Nat Med"},{"key":"BF3301479_CR9","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nm0497-429","volume":"3","author":"G Haase","year":"1997","unstructured":"Haase G et al. Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors Nat Med 1997 3: 429\u2013436","journal-title":"Nat Med"},{"key":"BF3301479_CR10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/hmg\/9.5.803","volume":"9","author":"M Azzouz","year":"2000","unstructured":"Azzouz M et al. Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2 Hum Mol Genet 2000 9: 803\u2013811","journal-title":"Hum Mol Genet"},{"key":"BF3301479_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/sj.gt.3301119","volume":"7","author":"LC Costantini","year":"2000","unstructured":"Costantini LC, Bakowska JC, Breakefield XO, Isacson O . Gene therapy in the CNS Gene Therapy 2000 7: 93\u2013109","journal-title":"Gene Therapy"},{"key":"BF3301479_CR12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/ng0393-224","volume":"3","author":"S Akli","year":"1993","unstructured":"Akli S et al. Transfer of a foreign gene into the brain using adenovirus vectors Nat Genet 1993 3: 224\u2013228","journal-title":"Nat Genet"},{"key":"BF3301479_CR13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/ng0393-219","volume":"3","author":"BL Davidson","year":"1993","unstructured":"Davidson BL et al. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector Nat Genet 1993 3: 219\u2013223","journal-title":"Nat Genet"},{"key":"BF3301479_CR14","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1126\/science.8382374","volume":"259","author":"G Le Gal La Salle","year":"1993","unstructured":"Le Gal La Salle G et al. An adenovirus vector for gene transfer into neurons and glia in the brain Science 1993 259: 988\u2013990","journal-title":"Science"},{"key":"BF3301479_CR15","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/0306-4522(95)00068-T","volume":"66","author":"AP Byrnes","year":"1995","unstructured":"Byrnes AP, Rusby JE, Wood MJ, Charlton HM . Adenovirus gene transfer causes inflammation in the brain Neuroscience 1995 66: 1015\u20131024","journal-title":"Neuroscience"},{"key":"BF3301479_CR16","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/sj.gt.3300851","volume":"6","author":"Y Ohmoto","year":"1999","unstructured":"Ohmoto Y et al. Variation in the immune response to adenoviral vectors in the brain: influence of mouse strain, environmental conditions and priming Gene Therapy 1999 6: 471\u2013481","journal-title":"Gene Therapy"},{"key":"BF3301479_CR17","first-page":"132","volume":"2","author":"GD Ghadge","year":"1995","unstructured":"Ghadge GD et al. CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses Gene Therapy 1995 2: 132\u2013137","journal-title":"Gene Therapy"},{"key":"BF3301479_CR18","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/0169-328X(96)00097-6","volume":"41","author":"DY Ho","year":"1996","unstructured":"Ho DY, McLaughlin JR, Sapolsky RM . Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system Mol Brain Res 1996 41: 200\u2013209","journal-title":"Mol Brain Res"},{"key":"BF3301479_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/sj.gt.3300612","volume":"5","author":"T Oligino","year":"1998","unstructured":"Oligino T et al. Drug inducible transgene expression in brain using a herpes simplex virus vector Gene Therapy 1998 5: 491\u2013496","journal-title":"Gene Therapy"},{"key":"BF3301479_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1006\/mcne.1998.0703","volume":"12","author":"N Sato","year":"1998","unstructured":"Sato N et al. A novel strategy for introducing exogenous bcl-2 into neuronal cells: the Cre\/loxP system-mediated activation of bcl-2 for preventing programmed cell death using recombinant adenoviruses Mol Cell Neurosci 1998 12: 65\u201378","journal-title":"Mol Cell Neurosci"},{"key":"BF3301479_CR21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0304-3940(98)00245-6","volume":"246","author":"H Warita","year":"1998","unstructured":"Warita H, Abe K, Setoguchi Y, Itoyama Y . Expression of adenovirus-mediated E. coli lacZ gene in skeletal muscles and spinal motor neurons of transgenic mice with a mutant superoxide dismutase gene Neurosci Lett 1998 246: 153\u2013156","journal-title":"Neurosci Lett"},{"key":"BF3301479_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S0006-8993(98)01351-1","volume":"819","author":"H Warita","year":"1999","unstructured":"Warita H, Itoyama Y, Abe K . Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene Brain Res 1999 819: 120\u2013131","journal-title":"Brain Res"},{"key":"BF3301479_CR23","first-page":"25","volume":"392 (Suppl.)","author":"WF Anderson","year":"1998","unstructured":"Anderson WF . Human gene therapy Nature 1998 392 (Suppl.): 25\u201330","journal-title":"Nature"},{"key":"BF3301479_CR24","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1038\/sj.gt.3301008","volume":"6","author":"V Navarro","year":"1999","unstructured":"Navarro V et al. Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter Gene Therapy 1999 6: 1884\u20131892","journal-title":"Gene Therapy"},{"key":"BF3301479_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","volume":"108","author":"H Niwa","year":"1991","unstructured":"Niwa H, Yamamura K, Miyazaki J . Efficient selection for high-expression transfectants with a novel eukaryotic vector Gene 1991 108: 193\u2013199","journal-title":"Gene"},{"key":"BF3301479_CR26","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1073\/pnas.92.7.3024","volume":"92","author":"S Rabizadeh","year":"1995","unstructured":"Rabizadeh S et al. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells Proc Natl Acad Sci USA 1995 92: 3024\u20133028","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301479_CR27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1126\/science.277.5325.559","volume":"277","author":"V Kostic","year":"1997","unstructured":"Kostic V et al. Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis Science 1997 277: 559\u2013562","journal-title":"Science"},{"key":"BF3301479_CR28","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0378-1119(96)00516-1","volume":"181","author":"Y Kanegae","year":"1996","unstructured":"Kanegae Y et al. Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase Gene 1996 181: 207\u2013212","journal-title":"Gene"},{"key":"BF3301479_CR29","doi-asserted-by":"publisher","first-page":"3816","DOI":"10.1093\/nar\/23.19.3816","volume":"23","author":"Y Kanegae","year":"1995","unstructured":"Kanegae Y et al. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase Nucleic Acids Res 1995 23: 3816\u20133821","journal-title":"Nucleic Acids Res"},{"key":"BF3301479_CR30","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1182\/blood.V80.4.879.879","volume":"80","author":"SJ Korsmeyer","year":"1992","unstructured":"Korsmeyer SJ . Bcl-2 initiates a new category of oncogenes: regulators of cell death Blood 1992 80: 879\u2013886","journal-title":"Blood"},{"key":"BF3301479_CR31","doi-asserted-by":"publisher","first-page":"8756","DOI":"10.1523\/JNEUROSCI.17-22-08756.1997","volume":"17","author":"GD Ghadge","year":"1997","unstructured":"Ghadge GD et al. Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection J Neurosci 1997 17: 8756\u20138766","journal-title":"J Neurosci"},{"key":"BF3301479_CR32","doi-asserted-by":"publisher","first-page":"15763","DOI":"10.1073\/pnas.95.26.15763","volume":"95","author":"P Pasinelli","year":"1998","unstructured":"Pasinelli P et al. Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase Proc Natl Acad Sci USA 1998 95: 15763\u201315768","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301479_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1046\/j.1471-4159.1997.69010021.x","volume":"69","author":"MA Mena","year":"1997","unstructured":"Mena MA et al. Effects of wild-type and mutated copper\/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture J Neurochem 1997 69: 21\u201333","journal-title":"J Neurochem"},{"key":"BF3301479_CR34","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/00001756-199512290-00088","volume":"7","author":"F Finiels","year":"1995","unstructured":"Finiels F et al. Specific and efficient gene transfer strategy offers new potentialities for the treatment of motor neurone diseases Neuroreport 1995 7: 373\u2013378","journal-title":"Neuroreport"},{"key":"BF3301479_CR35","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1523\/JNEUROSCI.20-08-02875.2000","volume":"20","author":"K Namikawa","year":"2000","unstructured":"Namikawa K et al. Akt\/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration J Neurosci 2000 20: 2875\u20132886","journal-title":"J Neurosci"},{"key":"BF3301479_CR36","doi-asserted-by":"publisher","first-page":"8531","DOI":"10.1074\/jbc.274.13.8531","volume":"274","author":"M Tamatani","year":"1999","unstructured":"Tamatani M et al. Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons J Biol Chem 1999 274: 8531\u20138538","journal-title":"J Biol Chem"},{"key":"BF3301479_CR37","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1172\/JCI116739","volume":"92","author":"MA Morsy","year":"1993","unstructured":"Morsy MA et al. Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes J Clin Invest 1993 92: 1580\u20131586","journal-title":"J Clin Invest"},{"key":"BF3301479_CR38","doi-asserted-by":"publisher","first-page":"9509","DOI":"10.1073\/pnas.86.23.9509","volume":"86","author":"S Mita","year":"1989","unstructured":"Mita S et al. Detection of \u2018deleted\u2019 mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns\u2013Sayre syndrome Proc Natl Acad Sci USA 1989 86: 9509\u20139513","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301479_CR39","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/(SICI)1097-4598(199804)21:4<490::AID-MUS7>3.0.CO;2-4","volume":"21","author":"S Mita","year":"1998","unstructured":"Mita S et al. Single muscle fiber analysis of myoclonus epilepsy with ragged-red fibers Muscle Nerve 1998 21: 490\u2013497","journal-title":"Muscle Nerve"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/3301479.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301479","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301479.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T01:09:12Z","timestamp":1648602552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3301479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,1]]},"references-count":39,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2001,7,1]]}},"alternative-id":["BF3301479"],"URL":"https:\/\/doi.org\/10.1038\/sj.gt.3301479","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,1]]},"assertion":[{"value":"27 September 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}