{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T21:00:54Z","timestamp":1783803654303,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T00:00:00Z","timestamp":1050537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T00:00:00Z","timestamp":1050537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2003,5,1]]},"DOI":"10.1038\/sj.gt.3301949","type":"journal-article","created":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T13:49:28Z","timestamp":1050587368000},"page":"765-773","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Adenovirus-mediated gene transfer of interferon \u03b1 improves dimethylnitrosamine-induced liver cirrhosis in rat model"],"prefix":"10.1038","volume":"10","author":[{"given":"K","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ohnami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kazui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,4,17]]},"reference":[{"key":"BF3301949_CR1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0889-8553(21)00146-1","volume":"23","author":"MJ Alter","year":"1994","unstructured":"Alter MJ, Mast EE . The epidemiology of viral hepatitis in the United States. Gastroenterol Clin North Am 1994; 23: 437\u2013455.","journal-title":"Gastroenterol Clin North Am"},{"key":"BF3301949_CR2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1056\/NEJM199701303360507","volume":"336","author":"JH Hoofnagle","year":"1997","unstructured":"Hoofnagle JH, di Bisceglie AM . The treatment of chronic viral hepatitis. N Engl J Med 1997; 336: 347\u2013356.","journal-title":"N Engl J Med"},{"key":"BF3301949_CR3","doi-asserted-by":"publisher","first-page":"128S","DOI":"10.1002\/hep.510260722","volume":"26","author":"SW Schalm","year":"1997","unstructured":"Schalm SW, Fattovich G, Brouwer JT . Therapy of hepatitis C: patients with cirrhosis. Hepatology 1997; 26: 128S\u2013132S.","journal-title":"Hepatology"},{"key":"BF3301949_CR4","doi-asserted-by":"publisher","first-page":"143S","DOI":"10.1002\/hep.510260725","volume":"26","author":"HL Bonkovsky","year":"1997","unstructured":"Bonkovsky HL . Therapy of hepatitis C: other options. Hepatology 1997; 26: 143S\u2013151S.","journal-title":"Hepatology"},{"key":"BF3301949_CR5","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1056\/NEJM198911303212204","volume":"321","author":"AM Di Bisceglie","year":"1989","unstructured":"Di Bisceglie AM et al. Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med 1989; 321: 1506\u20131510.","journal-title":"N Engl J Med"},{"key":"BF3301949_CR6","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/hep.510240405","volume":"24","author":"T Poynard","year":"1996","unstructured":"Poynard T et al. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: effects of dose and duration. Hepatology 1996; 24: 778\u2013789.","journal-title":"Hepatology"},{"key":"BF3301949_CR7","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0168-8278(98)80012-3","volume":"29","author":"J Fort","year":"1998","unstructured":"Fort J et al. Effects of long-term administration of interferon alpha in two models of liver fibrosis in rats. J Hepatol 1998; 29: 263\u2013270.","journal-title":"J Hepatol"},{"key":"BF3301949_CR8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/S0168-8278(05)80223-5","volume":"17","author":"J Camps","year":"1993","unstructured":"Camps J et al. Randomised trial of lymphoblastoid alpha-interferon in chronic hepatitis C. Effects on inflammation, fibrogenesis and viremia. J Hepatol 1993; 17: 390\u2013396.","journal-title":"J Hepatol"},{"key":"BF3301949_CR9","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1056\/NEJM199104043241401","volume":"324","author":"A Castilla","year":"1991","unstructured":"Castilla A, Prieto J, Fausto N . Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy. N Engl J Med 1991; 324: 933\u2013940.","journal-title":"N Engl J Med"},{"key":"BF3301949_CR10","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1023\/A:1026601904609","volume":"43","author":"JF Dufour","year":"1998","unstructured":"Dufour JF, DeLellis R, Kaplan MM . Regression of hepatic fibrosis in hepatitis C with long-term interferon treatment. Dig Dis Sci 1998; 43: 2573\u20132576.","journal-title":"Dig Dis Sci"},{"key":"BF3301949_CR11","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/S0168-8278(99)80196-2","volume":"30","author":"T Okanoue","year":"1999","unstructured":"Okanoue T et al. Interferon therapy lowers the rate of progression to hepatocellular carcinoma in chronic hepatitis C but not significantly in an advanced stage: a retrospective study in 1148 patients. Viral Hepatitis Therapy Study Group. J Hepatol 1999; 30: 653\u2013659.","journal-title":"J Hepatol"},{"key":"BF3301949_CR12","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1600-0676.1991.tb00487.x","volume":"11","author":"R Schvarcz","year":"1991","unstructured":"Schvarcz R et al. Histological outcome in interferon alpha-2b treated patients with chronic posttransfusion non-A, non-B hepatitis. Liver 1991; 11: 30\u201338.","journal-title":"Liver"},{"key":"BF3301949_CR13","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s005350050022","volume":"35","author":"M Yagura","year":"2000","unstructured":"Yagura M et al. Changes of liver fibrosis in chronic hepatitis C patients with no response to interferon-alpha therapy: including quantitative assessment by a morphometric method. J Gastroenterol 2000; 35: 105\u2013111.","journal-title":"J Gastroenterol"},{"key":"BF3301949_CR14","first-page":"205","volume":"19","author":"I Uemura","year":"1985","unstructured":"Uemura I . Pharmacokinetics of recombinant human interferon alpha in rat. Kiso to Rinsho 1985; 19: 205\u2013212.","journal-title":"Kiso to Rinsho"},{"key":"BF3301949_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0168-8278(99)80013-0","volume":"30","author":"T Nakamura","year":"1999","unstructured":"Nakamura T, Akiyoshi H, Saito I, Sato K . Adenovirus-mediated gene expression in the septal cells of cirrhotic rat livers. J Hepatol 1999; 30: 101\u2013106.","journal-title":"J Hepatol"},{"key":"BF3301949_CR16","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/S0168-8278(87)80570-6","volume":"5","author":"AM Jezequel","year":"1987","unstructured":"Jezequel AM et al. A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat. J Hepatol 1987; 5: 174\u2013181.","journal-title":"J Hepatol"},{"key":"BF3301949_CR17","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1056\/NEJM199304223281620","volume":"328","author":"SL Friedman","year":"1993","unstructured":"Friedman SL . Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993; 328: 1828\u20131835.","journal-title":"N Engl J Med"},{"key":"BF3301949_CR18","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0168-8278(85)80747-9","volume":"1","author":"SA Jenkins","year":"1985","unstructured":"Jenkins SA et al. A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat. J Hepatol 1985; 1: 489\u2013499.","journal-title":"J Hepatol"},{"key":"BF3301949_CR19","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1177\/33.8.2410480","volume":"33","author":"A Lopez-De Leon","year":"1985","unstructured":"Lopez-De Leon A, Rojkind M . A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 1985; 33: 737\u2013743.","journal-title":"J Histochem Cytochem"},{"key":"BF3301949_CR20","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/S0168-8278(01)00163-5","volume":"35","author":"R Bruck","year":"2001","unstructured":"Bruck R et al. Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers. J Hepatol 2001; 35: 457\u2013464.","journal-title":"J Hepatol"},{"key":"BF3301949_CR21","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/0003-9861(61)90291-0","volume":"93","author":"JF Woessner","year":"1961","unstructured":"Woessner JF . The determination of hydroxyproline in tissue and protein samples containing small proportion of imino acid. Arch Biochem Biophys 1961; 93: 440\u2013447.","journal-title":"Arch Biochem Biophys"},{"key":"BF3301949_CR22","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/sj.gt.3300885","volume":"6","author":"J Fujimoto","year":"1999","unstructured":"Fujimoto J, Kaneda Y . Reversing liver cirrhosis: impact of gene therapy for liver cirrhosis. Gene Ther 1999; 6: 305\u2013306.","journal-title":"Gene Ther"},{"key":"BF3301949_CR23","first-page":"1114","volume":"48","author":"HS Lee","year":"2001","unstructured":"Lee HS et al. Expression of matrix metalloproteinases in spontaneous regression of liver fibrosis. Hepatogastroenterology 2001; 48: 1114\u20131117.","journal-title":"Hepatogastroenterology"},{"key":"BF3301949_CR24","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0168-8278(00)80363-3","volume":"33","author":"T Watanabe","year":"2000","unstructured":"Watanabe T et al. Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride. J Hepatol 2000; 33: 224\u2013235.","journal-title":"J Hepatol"},{"key":"BF3301949_CR25","doi-asserted-by":"crossref","first-page":"14064","DOI":"10.1016\/S0021-9258(18)92810-3","volume":"266","author":"CM Overall","year":"1991","unstructured":"Overall CM, Wrana JL, Sodek J . Transcriptional and post-transcriptional regulation of 72-kDa gelatinase\/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. J Biol Chem 1991; 266: 14064\u201314071.","journal-title":"J Biol Chem"},{"key":"BF3301949_CR26","first-page":"F458","volume":"275","author":"AC Poncelet","year":"1998","unstructured":"Poncelet AC, Schnaper HW . Regulation of human mesangial cell collagen expression by transforming growth factor-beta 1. Am J Physiol 1998; 275: F458\u2013F466.","journal-title":"Am J Physiol"},{"key":"BF3301949_CR27","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1002\/hep.510290640","volume":"29","author":"K Ikeda","year":"1999","unstructured":"Ikeda K et al. In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology 1999; 29: 1760\u20131767.","journal-title":"Hepatology"},{"key":"BF3301949_CR28","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/hep.510240129","volume":"24","author":"JP Iredale","year":"1996","unstructured":"Iredale JP et al. Tissue Inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology 1996; 24: 176\u2013184.","journal-title":"Hepatology"},{"key":"BF3301949_CR29","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1073\/pnas.96.5.2345","volume":"96","author":"Z Qi","year":"1999","unstructured":"Qi Z et al. Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci USA 1999; 96: 2345\u20132349.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301949_CR30","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/5593","volume":"5","author":"T Ueki","year":"1999","unstructured":"Ueki T et al. Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med 1999; 5: 226\u2013230.","journal-title":"Nat Med"},{"key":"BF3301949_CR31","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1126\/science.287.5456.1253","volume":"287","author":"KL Rudolph","year":"2000","unstructured":"Rudolph KL et al. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 2000; 287: 1253\u20131258.","journal-title":"Science"},{"key":"BF3301949_CR32","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1006\/mthe.2000.0210","volume":"2","author":"S Salgado","year":"2001","unstructured":"Salgado S et al. Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy. Mol Ther 2001; 2: 545\u2013551.","journal-title":"Mol Ther"},{"key":"BF3301949_CR33","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1073\/pnas.94.2.701","volume":"94","author":"H Takayama","year":"1997","unstructured":"Takayama H et al. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor\/scatter factor. Proc Natl Acad Sci USA 1997; 94: 701\u2013706.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301949_CR34","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/8462","volume":"5","author":"T Eto","year":"1999","unstructured":"Eto T, Takahashi H . Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon. Nat Med 1999; 5: 577\u2013581.","journal-title":"Nat Med"},{"key":"BF3301949_CR35","doi-asserted-by":"publisher","first-page":"10818","DOI":"10.1073\/pnas.96.19.10818","volume":"96","author":"U Protzer","year":"1999","unstructured":"Protzer U et al. Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection. Proc Natl Acad Sci USA 1999; 96: 10818\u201310823.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301949_CR36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/sj.gt.3300362","volume":"4","author":"WK de Roos","year":"1997","unstructured":"de Roos WK et al. Isolated-organ perfusion for local gene delivery: efficient adenovirus-mediated gene transfer into the liver. Gene Ther 1997; 4: 55\u201362.","journal-title":"Gene Ther"},{"key":"BF3301949_CR37","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1089\/hum.1998.9.14-1975","volume":"9","author":"N Ferry","year":"1998","unstructured":"Ferry N, Heard JM . Liver-directed gene transfer vectors. Hum Gene Ther 1998; 9: 1975\u20131981.","journal-title":"Hum Gene Ther"},{"key":"BF3301949_CR38","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/sj.gt.3301647","volume":"9","author":"J Garcia-Banuelos","year":"2002","unstructured":"Garcia-Banuelos J et al. Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion. Gene Ther 2002; 9: 127\u2013134.","journal-title":"Gene Ther"},{"key":"BF3301949_CR39","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1136\/gut.47.4.563","volume":"47","author":"T Nakatani","year":"2000","unstructured":"Nakatani T et al. Assessment of efficiency and safety of adenovirus mediated gene transfer into normal and damaged murine livers. Gut 2000; 47: 563\u2013570.","journal-title":"Gut"},{"key":"BF3301949_CR40","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/ng0393-224","volume":"3","author":"S Akli","year":"1993","unstructured":"Akli S et al. Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet 1993; 3: 224\u2013228.","journal-title":"Nat Genet"},{"key":"BF3301949_CR41","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1089\/hum.1997.8.9-1049","volume":"8","author":"WT Hermens","year":"1997","unstructured":"Hermens WT, Verhaagen J . Adenoviral vector-mediated gene expression in the nervous system of immunocompetent Wistar and T cell-deficient nude rats: preferential survival of transduced astroglial cells in nude rats. Hum Gene Ther 1997; 8: 1049\u20131063.","journal-title":"Hum Gene Ther"},{"key":"BF3301949_CR42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/32801","volume":"392","author":"WF Anderson","year":"1998","unstructured":"Anderson WF . Human gene therapy. Nature 1998; 392: 25\u201330.","journal-title":"Nature"},{"key":"BF3301949_CR43","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1089\/hum.1996.7.15-1907","volume":"7","author":"SE Haecker","year":"1996","unstructured":"Haecker SE et al. In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes. Hum Gene Ther 1996; 7: 1907\u20131914.","journal-title":"Hum Gene Ther"},{"key":"BF3301949_CR44","doi-asserted-by":"crossref","first-page":"8944","DOI":"10.1128\/jvi.70.12.8944-8960.1996","volume":"70","author":"A Lieber","year":"1996","unstructured":"Lieber A, He CY, Kirillova I, Kay MA . Recombinant adenoviruses with large deletions generated by Cre-mediated ex-cision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 1996; 70: 8944\u20138960.","journal-title":"J Virol"},{"key":"BF3301949_CR45","first-page":"5","volume":"392","author":"R Langer","year":"1998","unstructured":"Langer R . Drug delivery and targeting. Nature 1998; 392: 5\u201310.","journal-title":"Nature"},{"key":"BF3301949_CR46","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1073\/pnas.93.3.1320","volume":"93","author":"S Miyake","year":"1996","unstructured":"Miyake S et al. Efficient generation of recombinant adenoviruses using adenovirus DNA\u2013terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci USA 1996; 93: 1320\u20131324.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3301949_CR47","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1006\/mthe.2000.0076","volume":"1","author":"K Aoki","year":"2000","unstructured":"Aoki K et al. Restricted expression of an adenoviral vector encoding Fas ligand (CD95L) enhances safety for cancer gene therapy. Mol Ther 2000; 1: 555\u2013565.","journal-title":"Mol Ther"},{"key":"BF3301949_CR48","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","volume":"108","author":"H Niwa","year":"1991","unstructured":"Niwa H, Yamamura K, Miyazaki J . Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108: 193\u2013199.","journal-title":"Gene"},{"key":"BF3301949_CR49","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/sj.gt.3301435","volume":"8","author":"K Aoki","year":"2001","unstructured":"Aoki K et al. Polyethylenimine-mediated gene transfer into pancreatic tumor dissemination in the murine peritoneal cavity. Gene Ther 2001; 8: 508\u2013514.","journal-title":"Gene Ther"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/3301949.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301949","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3301949.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T02:06:47Z","timestamp":1648606007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3301949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,17]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,5,1]]}},"alternative-id":["BF3301949"],"URL":"https:\/\/doi.org\/10.1038\/sj.gt.3301949","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,17]]},"assertion":[{"value":"15 May 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}