{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:54:07Z","timestamp":1790870047914,"version":"4.1.0"},"reference-count":110,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2003,5,1]]},"DOI":"10.1038\/sj.gt.3302040","type":"journal-article","created":{"date-parts":[[2003,5,6]],"date-time":"2003-05-06T11:49:51Z","timestamp":1052221791000},"page":"902-911","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Gene therapy for arthritis"],"prefix":"10.1038","volume":"10","author":[{"given":"P D","family":"Robbins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Chernajovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,5,6]]},"reference":[{"key":"BF3302040_CR1","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/1529-0131(199812)41:12<2196::AID-ART15>3.0.CO;2-2","volume":"41","author":"B Bresnihan","year":"1998","unstructured":"Bresnihan B et al. Treatment of rheumatoid arthritis with recombinant human interelukin-1 receptor antagonist. Arthritis Rheum 1998; 41: 2196.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/1529-0131(200005)43:5<1001::AID-ANR7>3.0.CO;2-P","volume":"43","author":"Y Jiang","year":"2000","unstructured":"Jiang Y et al. A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larson scores. Arthritis Rheum 2000; 43: 1001.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1056\/NEJM199707173370301","volume":"337","author":"LW Moreland","year":"1997","unstructured":"Moreland LW et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)\u2013Fc fusion protein. N Engl J Med 1997; 337: 141.","journal-title":"N Engl J Med"},{"key":"BF3302040_CR4","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0140-6736(94)90628-9","volume":"244","author":"MJ Elliott","year":"1994","unstructured":"Elliott MJ et al. Randomized double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor [alpha](cA2) versus placebo in rheumatoid arthritis. Lancet 1994; 244: 1105.","journal-title":"Lancet"},{"key":"BF3302040_CR5","first-page":"283","volume":"10","author":"PD Robbins","year":"1997","unstructured":"Robbins PD, Ghivizzani SC, Evans CH . Gene transfer to joints. Drug News Perspect 1997; 10: 283\u2013292.","journal-title":"Drug News Perspect"},{"key":"BF3302040_CR6","first-page":"2061","volume":"24","author":"CH Evans","year":"1997","unstructured":"Evans CH, Robbins PD . Getting genes into human synovium. J Rheum 1997; 24: 2061\u20132063.","journal-title":"J Rheum"},{"key":"BF3302040_CR7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s11926-001-0054-x","volume":"3","author":"E Gouze","year":"2001","unstructured":"Gouze E, Ghivizzani SC, Robbins PD, Evans CH . Gene therapy for rheumatoid arthritis. Curr Rheumatol Rep 2001; 3: 142\u2013146.","journal-title":"Curr Rheumatol Rep"},{"key":"BF3302040_CR8","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1172\/JCI12037","volume":"107","author":"A Nakajima","year":"2001","unstructured":"Nakajima A et al. Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J Clin Invest 2001; 107: 1293\u20131301.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR9","first-page":"731","volume":"2","author":"Y Chernajovsky","year":"1995","unstructured":"Chernajovsky Y et al. Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor. Gene Therapy 1995; 2: 731\u2013735.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/sj.gt.3300436","volume":"4","author":"Y Chernajovsky","year":"1997","unstructured":"Chernajovsky Y et al. Pathogenic lymphoid cells engineered to express TGF beta 1 ameliorate disease in a collagen-induced arthritis model. Gene Therapy 1997; 4: 553\u2013559.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR11","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.4049\/jimmunol.166.5.3499","volume":"166","author":"SH Kim","year":"2001","unstructured":"Kim SH et al. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol 2001; 166: 3499\u20133505.","journal-title":"J Immunol"},{"key":"BF3302040_CR12","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S1525-0016(02)90712-4","volume":"6","author":"SH Kim","year":"2002","unstructured":"Kim SH, Kim S, Oligino TJ, Robbins PD . Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Mol Ther 2002; 6: 584.","journal-title":"Mol Ther"},{"key":"BF3302040_CR13","first-page":"1051","volume":"12","author":"Y Morita","year":"2001","unstructured":"Morita Y et al. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen induced arthritis J Clin Invest 2001; 12: 1051\u20131061.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jgm.321","volume":"5","author":"N Saidenber-Kermanac'h","year":"2003","unstructured":"Saidenber-Kermanac'h N et al. Efficacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen induced arthritis. J Gene Med 2003; 5: 164\u2013171.","journal-title":"J Gene Med"},{"key":"BF3302040_CR15","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.160.11.5213","volume":"160","author":"F Apparailly","year":"1998","unstructured":"Apparailly F et al. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. J Immunol 1998; 160: 5213\u20135220..","journal-title":"J Immunol"},{"key":"BF3302040_CR16","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1172\/JCI116614","volume":"92","author":"BJ Roessler","year":"1993","unstructured":"Roessler BJ et al. Adenoviral mediated gene transfer to rabbit synovium in vivo. J Clin Invest 1993; 92: 1085\u20131092.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR17","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1073\/pnas.95.8.4613","volume":"95","author":"SC Ghivizzani","year":"1998","unstructured":"Ghivizzani SC et al. Direct adenoviral-mediated gene transfer of IL-1 and TNF-alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc Natl Acad Sci USA 1998; 95: 4613\u20134618.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3302040_CR18","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1172\/JCI119726","volume":"100","author":"H Zhang","year":"1997","unstructured":"Zhang H et al. Amelioration of collagen-induced arthritis by CD95 (Apo-1\/Fas)-ligand gene transfer. J Clin Invest 1997; 100: 1951.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/1529-0131(200002)43:2<289::AID-ANR8>3.0.CO;2-H","volume":"43","author":"RY Pan","year":"2000","unstructured":"Pan RY et al. Therapy and prevention of arthritis by recombinant adeno-associated virus vector in a rat arthritis model. Arthritis Rheum 2000; 43: 289\u2013297.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/mthe.2000.0111","volume":"2","author":"S Watanabe","year":"2000","unstructured":"Watanabe S et al. Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synoviujm. Mol Ther 2000; 2: 147\u2013152.","journal-title":"Mol Ther"},{"key":"BF3302040_CR21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/mthe.2002.0562","volume":"5","author":"E Gouze","year":"2002","unstructured":"Gouze E et al. In vivo gene delivery to synovium by lentiviral vectors. Mol Ther 2002; 5: 397\u2013404.","journal-title":"Mol Ther"},{"key":"BF3302040_CR22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1359-6446(01)01685-3","volume":"6","author":"SC Ghivizanni","year":"2001","unstructured":"Ghivizanni SC, Oligino TJ, Glorioso JC, Robbins PD, Evans CH . Direct gene delivery strategies for the treatment of rheumatoid arthritis. Drug Discov Today 2001; 6: 259\u2013267.","journal-title":"Drug Discov Today"},{"key":"BF3302040_CR23","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1089\/104303401750214285","volume":"12","author":"K Ijimi","year":"2001","unstructured":"Ijimi K et al. Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4Ig in a murine model of type II collagen-induced arthritis. Hum Gene Ther 2001; 12: 1063\u20131077.","journal-title":"Hum Gene Ther"},{"key":"BF3302040_CR24","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.4049\/jimmunol.166.2.1214","volume":"166","author":"JM Woods","year":"2001","unstructured":"Woods JM et al. IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis. J Immunol 2001; 166: 1214\u20131222.","journal-title":"J Immunol"},{"key":"BF3302040_CR25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/10430340252792512","volume":"13","author":"JM Woods","year":"2002","unstructured":"Woods JM et al. Interleukin-13 gene therapy reduces inflammation, vascularization, and bony destruction in rat adjuvant-induced arthritis. Hum Gene Ther 2002; 13: 381\u2013393.","journal-title":"Hum Gene Ther"},{"key":"BF3302040_CR26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/ar104","volume":"2","author":"SH Kim","year":"2000","unstructured":"Kim SH et al. Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4. Arthritis Res 2000; 2: 293.","journal-title":"Arthritis Res"},{"key":"BF3302040_CR27","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1172\/JCI7739","volume":"105","author":"E Lubberts","year":"2000","unstructured":"Lubberts E et al. IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. J Clin Invest 2000; 105: 1697\u20131710.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR28","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.4049\/jimmunol.163.8.4546","volume":"163","author":"E Lubberts","year":"1999","unstructured":"Lubberts E et al. Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. J Immunol 1999; 163: 4546\u20134556.","journal-title":"J Immunol"},{"key":"BF3302040_CR29","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.4049\/jimmunol.162.6.3625","volume":"162","author":"JD Whalen","year":"1999","unstructured":"Whalen JD et al. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. J Immunol 1999; 162: 3625.","journal-title":"J Immunol"},{"key":"BF3302040_CR30","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.4049\/jimmunol.163.4.2202","volume":"163","author":"ER Lechman","year":"1999","unstructured":"Lechman ER et al. Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol 1999; 163: 2202.","journal-title":"J Immunol"},{"key":"BF3302040_CR31","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1172\/JCI0214536","volume":"109","author":"AV Miagkov","year":"2002","unstructured":"Miagkov AV et al. Endogenous regulation of a therapeutic transgene restores homeostasis in arthritic joints. J Clin Invest 2002; 109: 1223\u20131229.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/1529-0131(199904)42:3<498::AID-ANR15>3.0.CO;2-A","volume":"42","author":"A Bendele","year":"1999","unstructured":"Bendele A et al. Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: comparison of efficacy in animal models with human clinical trial data. Arthritis Rheum 1999; 42: 498\u2013506.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR33","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.4049\/jimmunol.156.9.3558","volume":"156","author":"K Otani","year":"1996","unstructured":"Otani K et al. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol 1996; 156: 3558\u20133562.","journal-title":"J Immunol"},{"key":"BF3302040_CR34","doi-asserted-by":"crossref","first-page":"10764","DOI":"10.1073\/pnas.90.22.10764","volume":"90","author":"G Bandara","year":"1993","unstructured":"Bandara G et al. Intraarticular expression of the interleukin-1 receptor antagonist protein by ex-vivo gene transfer. Proc Natl Acad Sci USA 1993; 90: 10764\u201310768.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3302040_CR35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1073\/pnas.93.1.402","volume":"93","author":"SS Markarov","year":"1996","unstructured":"Markarov SS et al. Suppression of experimental arthritis by gene transfer of the interluekin-1 receptor antagonists cDNA. Proc Natl Acad Sci USA 1996; 93: 402\u2013406.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3302040_CR36","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/art.1780400517","volume":"40","author":"AC Bakker","year":"1997","unstructured":"Bakker AC et al. Prevention of murine collagen induced arthritis in the knee and ipsilateral paw by local expression of human interluekin-1 receptor antagonist protein in the knee. Arthritis Rheum 1997; 40: 893\u2013900.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR37","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0002-9440(10)65368-0","volume":"154","author":"J Fernandes","year":"1999","unstructured":"Fernandes J et al. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am J Pathol 1999; 154: 1159\u20131169.","journal-title":"Am J Pathol"},{"key":"BF3302040_CR38","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/art.1780400604","volume":"40","author":"J-P Pelletier","year":"1997","unstructured":"Pelletier J-P et al. In vivo suppression of early experimental osteoarthritis by IL-1Ra using gene therapy. Arthritis Rheum 1997; 40: 1012\u20131019.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/sj.gt.3301608","volume":"9","author":"DD Frisbie","year":"2002","unstructured":"Frisbie DD et al. Treatment of experimental equine osteoarthritis by in vivo delivery of equine interleukin-1 receptor antagonist. Gene Therapy 2002; 9: 12\u201320.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR40","unstructured":"Mi Z et al. Intra-articular effects of TGF-\u00df1 following adenoviral-mediated gene delivery. Arthritis Res., in press."},{"key":"BF3302040_CR41","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1172\/JCI2480","volume":"101","author":"XY Song","year":"1998","unstructured":"Song XY et al. Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. J Clin Invest 1998; 101: 2615\u20132621.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR42","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/sj.gt.3300461","volume":"4","author":"SS Makarov","year":"1997","unstructured":"Makarov SS et al. NF-kappa B as a target for anti-inflammatory gene therapy: suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of I kappa B alpha cDNA. Gene Therapy 1997; 4: 846\u2013852.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR43","doi-asserted-by":"crossref","first-page":"13859","DOI":"10.1073\/pnas.95.23.13859","volume":"95","author":"AV Miagkov","year":"1998","unstructured":"Miagkov AV et al. NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc Natl Acad Sci USA 1998; 95: 13859\u201313864.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3302040_CR44","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/1529-0131(200108)44:8<1897::AID-ART328>3.0.CO;2-4","volume":"44","author":"PP Tak","year":"2001","unstructured":"Tak PP et al. Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation. Arthritis Rheum. 2001; 44: 1897\u20131907.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR45","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1002\/1529-0131(199912)42:12<2532::AID-ANR5>3.0.CO;2-2","volume":"42","author":"T Tomita","year":"1999","unstructured":"Tomita T et al. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotide as a gene therapy. Arthritis Rheum. 1999; 42: 2532\u20132542.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI6093","volume":"104","author":"H Takayanagi","year":"1991","unstructured":"Takayanagi H et al. Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. J Clin Invest 1991; 104: 137\u2013146.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR47","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1172\/JCI13568","volume":"108","author":"T Shouda","year":"2001","unstructured":"Shouda T et al. Induction of cytokine signal regulator SOCS3\/CIS3 as a therapeutic strategy for treating inflammatory arthritis J Clin Invest 2001; 108: 1781\u20131788.","journal-title":"J Clin Invest"},{"key":"BF3302040_CR48","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1089\/hum.1998.9.18-2735","volume":"9","author":"SM Sant","year":"1998","unstructured":"Sant SM et al. Molecular lysis of synovial lining cells by in vivo herpes simplex virus-thymidine kinase gene transfer. Hum Gene Ther 1998; 9: 2735\u20132743.","journal-title":"Hum Gene Ther"},{"key":"BF3302040_CR49","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1089\/10430349950018139","volume":"10","author":"PH Goossens","year":"1999","unstructured":"Goossens PH et al. Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys. Hum Gene Ther 1999; 10: 1139\u20131149.","journal-title":"Hum Gene Ther"},{"key":"BF3302040_CR50","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/(SICI)1521-2254(200005\/06)2:3<210::AID-JGM101>3.0.CO;2-P","volume":"2","author":"Q Yao","year":"2000","unstructured":"Yao Q et al. Adenoviral mediated delivery of Fas ligand to rheumatoid synovium results in extensive apoptosis in the synovial lining. J Gene Med 2000; 2: 210\u2013219.","journal-title":"J Gene Med"},{"key":"BF3302040_CR51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.gt.3300597","volume":"5","author":"K Okamoto","year":"1998","unstructured":"Okamoto K et al. Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer. Gene Therapy 1998; 5: 331\u2013338.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR52","unstructured":"Yao Q et al. TRAIL induced apoptosis in the rabbit synovium. Gene Therapy, in press."},{"key":"BF3302040_CR53","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1006\/mthe.2001.0343","volume":"3","author":"Q Yao","year":"2001","unstructured":"Yao Q et al. Gene transfer of p53 to arthritis joints stimulates synovial apoptosis and inhibits inflammation. Mol Ther 2001; 3: 901\u2013910.","journal-title":"Mol Ther"},{"key":"BF3302040_CR54","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/10480","volume":"5","author":"K Taniguchi","year":"1999","unstructured":"Taniguchi K et al. Induction of the p16IKNK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis. Nat Med 1999; 5: 760\u2013767.","journal-title":"Nat Med"},{"key":"BF3302040_CR55","doi-asserted-by":"crossref","first-page":"7246","DOI":"10.4049\/jimmunol.165.12.7246","volume":"165","author":"K Nasu","year":"2000","unstructured":"Nasu K et al. Adenoviral transfer of cyclin dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice. J Immunol 2000; 165: 7246\u20137252.","journal-title":"J Immunol"},{"key":"BF3302040_CR56","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1006\/mthe.2002.0590","volume":"5","author":"G Yin","year":"2002","unstructured":"Yin G et al. Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis. Mol Ther 2002; 5: 547\u2013554.","journal-title":"Mol Ther"},{"key":"BF3302040_CR57","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/art.10113","volume":"46","author":"JM Kim","year":"2002","unstructured":"Kim JM et al. Angiostatin gene transfer as an effective treatment strategy in murine collagen induced arthritis. Arthritis Rheum 2002; 46: 793\u2013801.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR58","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nbt1097-1002","volume":"15","author":"AW Varley","year":"1997","unstructured":"Varley AW, Geiszler SM, Gaynor RB, Munford RS . A two component expression system that responds to inflammatory stimuli in vivo. Nat Biotechnol 1997; 15: 1002\u20131006.","journal-title":"Nat Biotechnol"},{"key":"BF3302040_CR59","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/art.10481","volume":"46","author":"AC Bakker","year":"2002","unstructured":"Bakker AC et al. C3-Tat\/HIV-regulated intraarticular human interleukin-1 receptor antagonist gene therapy results in efficient inhibition of collagen-induced arthritis superior to cytomegalovirus-regulated expression of the same transgene. Arthritis Rheum 2002; 46: 1661\u20131670.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR60","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1038\/sj.gt.3301354","volume":"7","author":"DJ Gould","year":"2000","unstructured":"Gould DJ et al. A novel doxycycline inducible autoregulatory plasmid which displays \u201con\u201d\/\u201doff\u201d regulation suited to gene therapy applications. Gene Therapy 2000; 7: 2061\u20132070.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR61","first-page":"29","volume":"41","author":"D Gould","year":"2002","unstructured":"Gould D, Bright C, Chernajovsky Y . Inhibition of collagen induced arthritis with dTNF-R expressed from a doxycycline regulatable plasmid. Rheumatology 2002; 41: 29.","journal-title":"Rheumatology"},{"key":"BF3302040_CR62","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/1529-0131(200008)43:8<1698::AID-ANR5>3.0.CO;2-8","volume":"43","author":"H Dreja","year":"2000","unstructured":"Dreja H, Annenkov A, Chernajovsky Y . Soluble complement receptor 1 (CD35) delivered by retrovirally infected syngeneic cells or by naked DNA injection prevents the progression of collagen-induced arthritis. Arthritis Rheum 2000; 43: 1698\u20131709.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR63","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2177\/jsci.23.538","volume":"23","author":"Y Misaki","year":"2000","unstructured":"Misaki Y et al. Antigen-specific T cells transduced with interleukin-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen. Nihon Rinsho Meneki Gakkai Kaishi 2000; 23: 538\u2013541.","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi"},{"key":"BF3302040_CR64","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/oxfordjournals.bmb.a072976","volume":"51","author":"Y Chernajovsky","year":"1995","unstructured":"Chernajovsky Y, Feldmann M, Maini RN . Gene therapy of rheumatoid arthritis via cytokine regulation: future perspectives. Br Med Bull 1995; 51: 503\u2013516.","journal-title":"Br Med Bull"},{"key":"BF3302040_CR65","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/sj.gt.3300785","volume":"5","author":"RA Mageed","year":"1998","unstructured":"Mageed RA et al. Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. Gene Therapy 1998; 5: 1584\u20131592.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR66","doi-asserted-by":"crossref","first-page":"9784","DOI":"10.1073\/pnas.89.20.9784","volume":"89","author":"RO Williams","year":"1992","unstructured":"Williams RO, Feldmann M, Maini RN . Anti-TNF ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 1992; 89: 9784\u20139788.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3302040_CR67","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.4049\/jimmunol.161.12.6604","volume":"161","author":"AE Annenkov","year":"1998","unstructured":"Annenkov AE et al. Loss of original antigenic specificity in T cell hybridomas transduced with a chimeric receptor containing single-chain Fv of an anti-collagen antibody and Fc epsilonRI-signaling gamma subunit. J Immunol 1998; 161: 6604\u20136613.","journal-title":"J Immunol"},{"key":"BF3302040_CR68","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/sj.gt.3301149","volume":"7","author":"A Annenkov","year":"2000","unstructured":"Annenkov A, Chernajovsky Y . Engineering mouse T lymphocytes specific to type II collagen by transduction with a chimeric receptor consisting of a single chain Fv and TCR zeta. Gene Therapy 2000; 7: 714\u2013722.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR69","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1084\/jem.190.3.385","volume":"190","author":"GA Rabinovich","year":"1999","unstructured":"Rabinovich GA et al. Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J Exp Med. 1999; 190: 385\u2013398.","journal-title":"J Exp Med"},{"key":"BF3302040_CR70","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jgm.275","volume":"4","author":"N Bessis","year":"2002","unstructured":"Bessis N et al. Syngeneic fibroblasts transfected with a plasmid encoding interleukin-4 as non-viral vectors for anti-inflammatory gene therapy in collagen- induced arthritis. J Gene Med 2002; 4: 300\u2013307.","journal-title":"J Gene Med"},{"key":"BF3302040_CR71","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.4049\/jimmunol.155.9.4504","volume":"155","author":"EF Rosloniec","year":"1995","unstructured":"Rosloniec EF et al. Vaccination with a recombinant V alpha domain of a TCR prevents the development of collagen-induced arthritis. J Immunol 1995; 155: 4504\u20134511.","journal-title":"J Immunol"},{"key":"BF3302040_CR72","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/1529-0131(200008)43:8<1688::AID-ANR4>3.0.CO;2-C","volume":"43","author":"E Quattrocchi","year":"2000","unstructured":"Quattrocchi E, Dallman MJ and Feldmann M . Adenovirus-mediated gene transfer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis. Arthritis Rheum 2000; 43: 1688\u20131697.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR73","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1038\/sj.gt.3301613","volume":"8","author":"L Guery","year":"2001","unstructured":"Guery L et al. Collagen II-pulsed antigen-presenting cells genetically modified to secrete IL-4 down-regulate collagen-induced arthritis. Gene Therapy 2001; 8: 1855\u20131862.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR74","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.1365-2249.1998.00500.x","volume":"111","author":"N Bessis","year":"1998","unstructured":"Bessis N et al. Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha (TNF-alpha)-transgenic mice by treatment with cells engineered to secrete IL-4, IL-10 or IL-13. Clin Exp Immunol 1998; 111: 391\u2013396.","journal-title":"Clin Exp Immunol"},{"key":"BF3302040_CR75","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1046\/j.1365-2249.1999.00959.x","volume":"117","author":"N Bessis","year":"1999","unstructured":"Bessis N et al. Encapsulation in hollow fibres of xenogeneic cells engineered to secrete IL-4 or IL-13 ameliorates murine collagen-induced arthritis (CIA). Clin Exp Immunol. 1999; 117: 376\u2013382.","journal-title":"Clin Exp Immunol"},{"key":"BF3302040_CR76","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/1529-0131(199901)42:1<90::AID-ANR12>3.0.CO;2-A","volume":"42","author":"KA Triantaphyllopoulos","year":"1999","unstructured":"Triantaphyllopoulos KA et al. Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy. Arthritis Rheum 1999; 42: 90\u201399.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR77","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1006\/cyto.1996.0050","volume":"8","author":"R Neve","year":"1996","unstructured":"Neve R et al. Expression of an efficient small molecular weight tumour necrosis factor\/lymphotoxin antagonist. Cytokine 1996; 8: 365\u2013370.","journal-title":"Cytokine"},{"key":"BF3302040_CR78","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1358\/dot.1999.35.4-5.552210","volume":"35","author":"Y Chernajovsky","year":"1999","unstructured":"Chernajovsky Y . Systemic gene therapy for arthritis. Drugs Today 1999; 35: 361\u2013377.","journal-title":"Drugs Today"},{"key":"BF3302040_CR79","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4049\/jimmunol.169.4.1665","volume":"169","author":"MA Freudenberg","year":"2002","unstructured":"Freudenberg MA et al. A murine, IL-12-independent pathway of IFN-gamma induction by Gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling. J Immunol 2002; 169: 665\u20131668.","journal-title":"J Immunol"},{"key":"BF3302040_CR80","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/76932","volume":"1","author":"JD Farrar","year":"2000","unstructured":"Farrar JD et al. Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat Immunol 2000; 1: 65\u201369.","journal-title":"Nat Immunol"},{"key":"BF3302040_CR81","doi-asserted-by":"crossref","first-page":"S227","DOI":"10.1186\/ar581","volume":"4","author":"H Takayanagi","year":"2002","unstructured":"Takayanagi H, Kim S, Taniguchi T . Signaling crosstalk between RANK-L and interferons in osteoclastogenesis. Arthritis Res 2002; 4: S227\u2013S232.","journal-title":"Arthritis Res"},{"key":"BF3302040_CR82","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/sj.gt.3301165","volume":"7","author":"R Fellowes","year":"2000","unstructured":"Fellowes R et al. Amelioration of established collagen induced arthritis by systemic IL- 10 gene delivery. Gene Therapy 2000; 7: 967\u2013977.","journal-title":"Gene Therapy"},{"key":"BF3302040_CR83","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/1521-4141(200003)30:3<867::AID-IMMU867>3.0.CO;2-M","volume":"30","author":"N Bessis","year":"2000","unstructured":"Bessis N et al. The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis. Eur J Immunol, 2000; 30: 867\u2013875.","journal-title":"Eur J Immunol"},{"key":"BF3302040_CR84","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/rheumatology\/39.7.749","volume":"39","author":"T Tomita","year":"2000","unstructured":"Tomita T et al. Transcription factor decoy for NFkappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis. Rheumatology (Oxford) 2000; 39: 749\u2013757.","journal-title":"Rheumatology"},{"key":"BF3302040_CR85","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/1529-0131(200109)44:9<2160::AID-ART369>3.0.CO;2-0","volume":"44","author":"S Iyama","year":"2001","unstructured":"Iyama S et al. Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transfer. Arthritis Rheum 2001; 44: 2160\u20132167.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR86","unstructured":"Dai L et al. Amelioration of antigen-induced arthritis in rats by transfer of extracellular superoxide dismutase and catalase genes. Gene Therapy, in press."},{"key":"BF3302040_CR87","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1002\/1529-0131(200106)44:6<1444::AID-ART240>3.0.CO;2-Q","volume":"44","author":"F Apparailly","year":"2001","unstructured":"Apparailly F et al. Paradoxical effects of tissue inhibitor of metalloproteinases 1 gene transfer in collagen-induced arthritis. Arthritis Rheum 2001; 44: 1444\u20131454.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR88","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1006\/mthe.2001.0492","volume":"4","author":"JD Whalen","year":"2001","unstructured":"Whalen JD et al. Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages. Mol Ther 2001; 4: 543\u2013550.","journal-title":"Mol Ther"},{"key":"BF3302040_CR89","first-page":"591","volume":"6","author":"SH Kim","year":"2002","unstructured":"Kim SH et al. Intra-articular, ex vivo delivery of the IL-1 receptor antagonist and soluble TNF-alpha receptor confers a therapeutic effect in both the treated and untreated contralateral joints in a rabbit antigen-induced arthritis model. Mol Ther 2002; 6: 591\u2013600.","journal-title":"Mol Ther"},{"key":"BF3302040_CR90","doi-asserted-by":"crossref","unstructured":"Lechman ER et al. The contralateral effect conferred by intra-articular adenovirus mediated gene transfer of vIL-10 is antigen specific. Gene Therapy, in press.","DOI":"10.1038\/sj.gt.3302109"},{"key":"BF3302040_CR91","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00003086-200010001-00039","volume":"379","author":"CH Evans","year":"2000","unstructured":"Evans CH et al. Clinical trials in the gene therapy of arthritis. Clin Ortho 2000; 379: 300\u2013307.","journal-title":"Clin Ortho"},{"key":"BF3302040_CR92","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1089\/hum.1996.7.10-1261","volume":"7","author":"CH Evans","year":"1996","unstructured":"Evans CH et al. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther 1996; 7: 1261\u20131280.","journal-title":"Hum Gene Ther"},{"key":"BF3302040_CR93","unstructured":"Feldmann M, Brennan FM, Abney ER, Hales A, Chernajovsky Y, Katsikis P, Corcoran A, Haworth C, Cope A, Gibbons D, Chu CQ, Field M, Deleuran B, Williams RO, Maini RN . Are imbalances in cytokine function of importance in the pathogenesis of RA? In: Davies E, Dingle JD (eds.), Immunopharmacology of Joints and Connective Tissue. Academic Press: New York, 1994, pp. 119\u2013128."},{"key":"BF3302040_CR94","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.med.51.1.207","volume":"51","author":"RN Maini","year":"2000","unstructured":"Maini RN, Taylor PC . Anti-cytokine therapy for rheumatoid arthritis. Annu Rev Med 2000; 51: 207\u2013229.","journal-title":"Annu Rev Med"},{"key":"BF3302040_CR95","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00002281-199805000-00012","volume":"10","author":"GS Firestein","year":"1998","unstructured":"Firestein GS . Novel therapeutic strategies involving animals, arthritis, and apoptosis. Curr Opin Rheumatol 1998; 10: 236\u2013241.","journal-title":"Curr Opin Rheumatol"},{"key":"BF3302040_CR96","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/1529-0131(199904)42:3<490::AID-ANR14>3.0.CO;2-L","volume":"42","author":"U Muller-Ladner","year":"1999","unstructured":"Muller-Ladner U et al. Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model. Arthritis Rheum 1999; 42: 490\u2013497.","journal-title":"Arthritis Rheum"},{"key":"BF3302040_CR97","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1073\/pnas.94.20.10895","volume":"94","author":"GS Firestein","year":"1997","unstructured":"Firestein GS et al. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc Natl Acad Sci USA 1997; 94: 10895\u201310900.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3302040_CR98","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0167-5699(99)01552-2","volume":"21","author":"PP Tak","year":"2000","unstructured":"Tak PP et al. Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunol Today 2000; 21: 78\u201382.","journal-title":"Immunol Today"},{"key":"BF3302040_CR99","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00129785-200202040-00002","volume":"2","author":"Y Chernajovsky","year":"2003","unstructured":"Chernajovsky Y, Winyard PG, Kabouridis PS . Advances in understanding the genetic basis of rheumatoid arthritis: implications for therapy. Am J Pharmacogenomics. 2003; 2: 223\u2013234.","journal-title":"Am J Pharmacogenomics"},{"key":"BF3302040_CR100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/ar84","volume":"2","author":"U Muller-Ladner","year":"2000","unstructured":"Muller-Ladner U, Nishioka K . p53 in rheumatoid arthritis: friend or foe? Arthritis Res 2000; 2: 175\u2013178.","journal-title":"Arthritis Res"},{"key":"BF3302040_CR101","first-page":"29","volume":"41","author":"G Adams","year":"2002","unstructured":"Adams G, Dreja H, Chernajovsky Y . Targeting cytokines to sites of inflammation. Rheumatology 2002; 41(S1): 29.","journal-title":"Rheumatology"},{"key":"BF3302040_CR102","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/rheumatology\/41.S1.28","volume":"41","author":"Y Gofur","year":"2002","unstructured":"Gofur Y, Chernajovsky Y . The development of immunocytokines for the treatment of rheumatoid arthritis. Rheumatology 2002; 41(S1): 28.","journal-title":"Rheumatology"},{"key":"BF3302040_CR103","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2165\/00002512-199812010-00004","volume":"12","author":"Y Chernajovsky","year":"1998","unstructured":"Chernajovsky Y et al. Gene therapy for rheumatoid arthritis. Theoretical considerations. Drugs Aging 1998; 12: 29\u201341.","journal-title":"Drugs Aging"},{"key":"BF3302040_CR104","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00832007","volume":"20","author":"PD Robbins","year":"1998","unstructured":"Robbins PD, Evans CH, Chernajovsky Y . Gene therapy for rheumatoid arthritis. Springer Semin Immunopathol 1998; 20: 197\u2013209.","journal-title":"Springer Semin Immunopathol"},{"key":"BF3302040_CR105","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.4049\/jimmunol.164.3.1576","volume":"164","author":"KN Kim","year":"2000","unstructured":"Kim KN et al. Viral IL-10 and soluble TNF receptor act synergistically to inhibit collagen-induced arthritis following adenovirus-mediated gene transfer. J Immunol 2000; 164: 1576\u20131581.","journal-title":"J Immunol"},{"key":"BF3302040_CR106","first-page":"a5","volume":"3S 1","author":"U M\u00fcller-Ladner","year":"2001","unstructured":"M\u00fcller-Ladner U et al. Double and triple gene transfer in arthritis. Arthritis Res 2001; 3S 1: a5.","journal-title":"Arthritis Res"},{"key":"BF3302040_CR107","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/87887","volume":"7","author":"M Delgado","year":"2001","unstructured":"Delgado M et al. Vasoactive intestinal peptide prevents experimental arthritis downregulating both autoimmune and inflammatory components of the disease. Nat Med. 2001; 7: 563\u2013568.","journal-title":"Nat Med"},{"key":"BF3302040_CR108","doi-asserted-by":"crossref","first-page":"004","DOI":"10.4049\/jimmunol.167.2.1004","volume":"167","author":"E Lubberts","year":"2001","unstructured":"Lubberts E et al. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J Immunol 2001; 167: 004\u20131013.","journal-title":"J Immunol"},{"key":"BF3302040_CR109","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.immunol.17.1.19","volume":"17","author":"TA Waldmann","year":"1999","unstructured":"Waldmann TA, Tagaya Y . The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 1999; 17: 19\u201349.","journal-title":"Annu Rev Immunol"},{"key":"BF3302040_CR110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/ard.60.4.305","volume":"60","author":"C Jorgensen","year":"2001","unstructured":"Jorgensen C et al. Stem cells for repair of cartilage and bone: the next challenge in osteoarthritis and rheumatoid arthritis. Ann Rheum Dis 2001; 60: 305\u2013309.","journal-title":"Ann Rheum Dis"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/3302040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3302040","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3302040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:04:12Z","timestamp":1704834252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3302040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5,1]]},"references-count":110,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,5,1]]}},"alternative-id":["BF3302040"],"URL":"https:\/\/doi.org\/10.1038\/sj.gt.3302040","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5,1]]},"assertion":[{"value":"6 May 2003","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}