{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:24:23Z","timestamp":1790943863232,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"21","license":[{"start":{"date-parts":[[2004,9,16]],"date-time":"2004-09-16T00:00:00Z","timestamp":1095292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,9,16]],"date-time":"2004-09-16T00:00:00Z","timestamp":1095292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2004,11,1]]},"DOI":"10.1038\/sj.gt.3302319","type":"journal-article","created":{"date-parts":[[2004,9,16]],"date-time":"2004-09-16T09:13:45Z","timestamp":1095326025000},"page":"1579-1589","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Reovirus as an experimental therapeutic for brain and leptomeningeal metastases from breast cancer"],"prefix":"10.1038","volume":"11","author":[{"given":"WQ","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DL","family":"Senger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XQ","family":"Lun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Muzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZQ","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RH","family":"Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PMA","family":"Brasher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NB","family":"Rewcastle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PWK","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PA","family":"Forsyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,9,16]]},"reference":[{"key":"BF3302319_CR1","first-page":"579","volume":"19","author":"JB Posner","year":"1978","unstructured":"Posner JB, Chernik NL . Intracranial metastases from systemic cancer. Adv Neurol 1978; 19: 579\u2013592.","journal-title":"Adv Neurol"},{"key":"BF3302319_CR2","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1002\/1097-0142(19831215)52:12<2349::AID-CNCR2820521231>3.0.CO;2-B","volume":"52","author":"Y Tsukata","year":"1983","unstructured":"Tsukata Y, Fouad A, Pickren JW, Lane WW . Central nervous system metastasis from breast carcinoma: autopsy study. Cancer 1983; 52: 2349\u20132354.","journal-title":"Cancer"},{"key":"BF3302319_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/BF00050693","volume":"4","author":"YTN Lee","year":"1985","unstructured":"Lee YTN . Patterns of metastasis and natural courses of breast carcinoma. Cancer Metast Rev 1985; 4: 153\u2013172.","journal-title":"Cancer Metast Rev"},{"key":"BF3302319_CR4","first-page":"334","volume":"7","author":"YTN Lee","year":"1984","unstructured":"Lee YTN . Breast carcinoma: pattern of recurrence and metastasis after mastestomy. Am J Clin Oncol 1984; 7: 334\u2013344.","journal-title":"Am J Clin Oncol"},{"key":"BF3302319_CR5","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/BF01053937","volume":"15","author":"W Boogerd","year":"1993","unstructured":"Boogerd W, VOs VW, Hart AAM, Baris G . Brain metastases in breast cancer: natural history, prognostic factors and outcome. J Neuro-Oncol 1993; 15: 165\u2013174.","journal-title":"J Neuro-Oncol"},{"key":"BF3302319_CR6","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/89901","volume":"7","author":"D Kirn","year":"2001","unstructured":"Kirn D, Martuza RL, Zwiebel J . Replication-selective virotherapy for cancer: biological principles, risk management and future directions. Nat Med 2001; 7: 781\u2013787.","journal-title":"Nat Med"},{"key":"BF3302319_CR7","first-page":"693","volume":"9","author":"D Makower","year":"2003","unstructured":"Makower D et al. Phase II clinical trial of intralesional administration of the oncolytic adenovirus ONYX-015 in patients with hepatobiliary tumors with correlative p53 studies. Clin Cancer Res 2003; 9: 693\u2013702.","journal-title":"Clin Cancer Res"},{"key":"BF3302319_CR8","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/sj.cgt.7700431","volume":"9","author":"N Habib","year":"2002","unstructured":"Habib N et al. Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma. Cancer Gene Ther 2002; 9: 254\u2013259.","journal-title":"Cancer Gene Ther"},{"key":"BF3302319_CR9","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/sj.gt.3301205","volume":"7","author":"JM Markert","year":"2000","unstructured":"Markert JM et al. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Therapy 2000; 7: 867\u2013874.","journal-title":"Gene Therapy"},{"key":"BF3302319_CR10","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1200\/JCO.2002.08.042","volume":"20","author":"AL Pecora","year":"2002","unstructured":"Pecora AL et al. Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers. J Clin Oncol 2002; 20: 2251\u20132266.","journal-title":"J Clin Oncol"},{"key":"BF3302319_CR11","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1089\/hum.1998.9.15-2177","volume":"9","author":"M Toda","year":"1998","unstructured":"Toda M, Rabkin SD, Martuza RL . Treatment of human breast cancer in a brain metastatic model by G207, a replication-competent multimutated herpes simplex virus 1. Hum Gene Ther 1998; 9: 2177\u20132185.","journal-title":"Hum Gene Ther"},{"key":"BF3302319_CR12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1006\/viro.1995.1382","volume":"211","author":"BP Randazzo","year":"1995","unstructured":"Randazzo BP et al. Treatment of experimental murine melanoma with a neuroattenuated herpes simplex virus 1 mutant. Virology 1995; 211: 94\u2013101.","journal-title":"Virology"},{"key":"BF3302319_CR13","first-page":"1597","volume-title":"Virology","author":"K Tyler","year":"1996","unstructured":"Tyler K, Fields BN . Reoviruses. In: Fields BN, Knipe DM, Howley PM, Chanock RM, Melnick JL, Monath TP (eds). Virology, 3nd edn Lippincott-Raven: Philadelphia, PA, 1996, pp 1597\u20131623."},{"key":"BF3302319_CR14","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1128\/jvi.67.10.6119-6124.1993","volume":"67","author":"B Sherry","year":"1993","unstructured":"Sherry B et al. Lymphocytes protect against and are not required for reovirus-induced myocarditis. J Virol 1993; 67: 6119\u20136124.","journal-title":"J Virol"},{"key":"BF3302319_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/00005072-197301000-00002","volume":"32","author":"CS Raine","year":"1973","unstructured":"Raine CS, Fields BN . Reovirus type III encephalitis \u2013 a virologic and ultrastructural study. J Neropathol Exp Neurol 1973; 32: 19\u201333.","journal-title":"J Neropathol Exp Neurol"},{"key":"BF3302319_CR16","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/0042-6822(89)90146-3","volume":"172","author":"RW Paul","year":"1989","unstructured":"Paul RW, Choi AHC, Lee PWK . The alpha-anomeric form of sialic acid is the minimal receptor determinant recognized by reovirus. Virology 1989; 172: 382\u2013385.","journal-title":"Virology"},{"key":"BF3302319_CR17","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/0042-6822(90)90412-K","volume":"178","author":"AHC Choi","year":"1990","unstructured":"Choi AHC, Paul RW, Lee PWK . Reovirus binds to multiple plasma membrane proteins on mouse L fibroblasts. Virology 1990; 178: 316\u2013320.","journal-title":"Virology"},{"key":"BF3302319_CR18","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0092-8674(01)00231-8","volume":"104","author":"ES Barton","year":"2001","unstructured":"Barton ES et al. Junction adhesion molecule is a receptor for reovirus. Cell 2001; 104: 441\u2013451.","journal-title":"Cell"},{"key":"BF3302319_CR19","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1126\/science.282.5392.1332","volume":"282","author":"MC Coffey","year":"1998","unstructured":"Coffey MC et al. Reovirus therapy of tumors with activated ras pathway. Science 1998; 282: 1332\u20131334.","journal-title":"Science"},{"key":"BF3302319_CR20","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1006\/viro.1993.1602","volume":"197","author":"JE Strong","year":"1993","unstructured":"Strong JE, Tang D, Lee PW . Evidence that the epidermal growth factor receptor on host cells confers reovirus infection efficiency. Virology 1993; 197: 405\u2013411.","journal-title":"Virology"},{"key":"BF3302319_CR21","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1128\/jvi.70.1.612-616.1996","volume":"70","author":"JE Strong","year":"1996","unstructured":"Strong JE, Lee PW . The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection. J Virol 1996; 70: 612\u2013616.","journal-title":"J Virol"},{"key":"BF3302319_CR22","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1093\/emboj\/17.12.3351","volume":"17","author":"J Strong","year":"1998","unstructured":"Strong J et al. The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus. EMBO J 1998; 17: 3351\u20133362.","journal-title":"EMBO J"},{"key":"BF3302319_CR23","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1089\/10430340252837233","volume":"13","author":"KL Norman","year":"2002","unstructured":"Norman KL et al. Reovirus oncolysis of human breast cancer. Hum Gene Ther 2002; 13: 641\u2013652.","journal-title":"Hum Gene Ther"},{"key":"BF3302319_CR24","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1093\/jnci\/93.12.903","volume":"93","author":"ME Wilcox","year":"2001","unstructured":"Wilcox ME et al. Reovirus as an oncolytic agent against experimental human malignant gliomas. J Natl Cancer Inst 2001; 93: 903\u2013912.","journal-title":"J Natl Cancer Inst"},{"key":"BF3302319_CR25","first-page":"3162","volume":"63","author":"WQ Yang","year":"2003","unstructured":"Yang WQ et al. Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma. Cancer Res 2003; 63: 3162\u20133172.","journal-title":"Cancer Res"},{"key":"BF3302319_CR26","first-page":"1696","volume":"62","author":"K Hirasawa","year":"2002","unstructured":"Hirasawa K et al. Oncolytic reovirus against ovarian and colon cancer. Cancer Res 2002; 62: 1696\u20131701.","journal-title":"Cancer Res"},{"key":"BF3302319_CR27","first-page":"348","volume":"63","author":"K Hirasawa","year":"2003","unstructured":"Hirasawa K et al. Systemic reovirus therapy of metastatic cancer in immune-competent mice. Cancer Res 2003; 63: 348\u2013353.","journal-title":"Cancer Res"},{"key":"BF3302319_CR28","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1182\/blood-2002-02-0503","volume":"100","author":"T Alain","year":"2002","unstructured":"Alain T et al. Reovirus therapy of lymphoid malignancies. Blood 2002; 100: 4146\u20134153.","journal-title":"Blood"},{"key":"BF3302319_CR29","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1182\/blood-2002-08-2508","volume":"102","author":"CM Thirukkumaran","year":"2003","unstructured":"Thirukkumaran CM et al. Reovirus oncolysis as a novel purging strategy for autologous stem cell transplantation. Blood 2003; 102: 377\u2013387.","journal-title":"Blood"},{"key":"BF3302319_CR30","first-page":"1218","volume":"9","author":"T Etoh","year":"2003","unstructured":"Etoh T et al. Oncolytic viral therapy for human pancreatic cancer cells by reovirus. Clin Cancer Res 2003; 9: 1218\u20132123.","journal-title":"Clin Cancer Res"},{"key":"BF3302319_CR31","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1126\/science.2470152","volume":"244","author":"DJ Slamon","year":"1989","unstructured":"Slamon DJ et al. Studies of the HER-2\/neu proto-oncogene in human breast and ovarian cancer. Science 1989; 244: 707\u2013712.","journal-title":"Science"},{"key":"BF3302319_CR32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1634\/theoncologist.3-4-237","volume":"3","author":"JS Ross","year":"1998","unstructured":"Ross JS, Fletcher JA . The HER-2\/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Oncologist 1998; 3: 237\u2013252.","journal-title":"Oncologist"},{"key":"BF3302319_CR33","doi-asserted-by":"publisher","first-page":"3302","DOI":"10.1002\/j.1460-2075.1994.tb06632.x","volume":"13","author":"R Ben-levy","year":"1994","unstructured":"Ben-levy R, Paterson HF, Marshall CJ, Yarden YA . A single autophosphorylation site confers oncogenicity to the Neu\/ErbB-2 receptor and enables coupling to the MAP kinase pathway. EMBO J 1994; 13: 3302\u20133311.","journal-title":"EMBO J"},{"key":"BF3302319_CR34","first-page":"4544","volume":"51","author":"PG Koenders","year":"1991","unstructured":"Koenders PG et al. Epidermal growth factor receptor-negative tumors are predominantly confined to the subgroup of estradiol receptor-positive human primary breast cancers. Cancer Res 1991; 51: 4544\u20134548.","journal-title":"Cancer Res"},{"key":"BF3302319_CR35","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/(SICI)1096-9896(199612)180:4<383::AID-PATH686>3.0.CO;2-N","volume":"180","author":"BS Verbeek","year":"1996","unstructured":"Verbeek BS et al. c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis. J Pathol 1996; 180: 383\u2013388.","journal-title":"J Pathol"},{"key":"BF3302319_CR36","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/0014-4886(92)90160-R","volume":"116","author":"EZ Walter","year":"1992","unstructured":"Walter EZ et al. Impaired spatial cognition and synaptic potentiation in a murine model of human immunodeficiency virus type 1 encephalitis. Exp Neurol 1992; 116: 122\u2013132.","journal-title":"Exp Neurol"},{"key":"BF3302319_CR37","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0361-9230(02)00782-7","volume":"58","author":"S Thifault","year":"2001","unstructured":"Thifault S et al. Comparisons between C57BL\/6J and A\/J mice in motor activity and coordination, hole-poking, and spatial learning. Brain Res Bull 2001; 58: 213\u2013218.","journal-title":"Brain Res Bull"},{"key":"BF3302319_CR38","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1037\/h0080832","volume":"38","author":"RJ Sutherland","year":"1984","unstructured":"Sutherland RJ, Richard HD . Place navigation by rats in a swimming pool. Canad J Psychol 1984; 38: 322\u2013347.","journal-title":"Canad J Psychol"},{"key":"BF3302319_CR39","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/297681a0","volume":"297","author":"RGM Morris","year":"1982","unstructured":"Morris RGM, Garrud P, Rawlins JNP, O'Keefe J . Place navigation impaired in rats with heppocampal lesions. Nature 1982; 297: 681\u2013683.","journal-title":"Nature"},{"key":"BF3302319_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/BF01058455","volume":"23","author":"SM Sagar","year":"1995","unstructured":"Sagar SM, Price KJ . An experimental model of leptomeningeal metastases employing rat mammary carcinoma cells. J Neurooncol 1995; 23: 15\u201321.","journal-title":"J Neurooncol"},{"key":"BF3302319_CR41","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1073\/pnas.97.3.1206","volume":"97","author":"M Yang","year":"2000","unstructured":"Yang M et al. Whole-body optical imaging of green flourescent protein-expressing tumors and metastases. Proc Natl Acad Sci USA 2000; 97: 1206\u20131211.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3302319_CR42","first-page":"1696","volume":"43","author":"C Jacobs","year":"1983","unstructured":"Jacobs C, Rubsamen H . Expression of pp60c-src protein kinase in adult and fetal human tissue: High activities in some sarcomas and mammary carcinomas. Cancer Res 1983; 43: 1696\u20131702.","journal-title":"Cancer Res"},{"key":"BF3302319_CR43","first-page":"913","volume":"4","author":"SE Shackney","year":"1998","unstructured":"Shackney SE et al. Intracellular coexpression of epidermal growth factor receptor, Her-2\/neu, and p21ras in human breast cancers: evidence for the existence of distinctive patterns of genetic evolution that are common to tumors from different patients. Clin Cancer Res 1998; 4: 913\u2013928.","journal-title":"Clin Cancer Res"},{"key":"BF3302319_CR44","doi-asserted-by":"publisher","first-page":"4285","DOI":"10.1073\/pnas.89.10.4285","volume":"89","author":"P Carter","year":"1992","unstructured":"Carter P et al. Humanization of an antip185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 1992; 89: 4285\u20134289.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3302319_CR45","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/74704","volume":"6","author":"RA Clynes","year":"2000","unstructured":"Clynes RA, Towers TL, Presta LG, Ravetch JV . Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 2000; 6: 443\u2013446.","journal-title":"Nat Med"},{"key":"BF3302319_CR46","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/11320","volume":"5","author":"K Ikeda","year":"1999","unstructured":"Ikeda K et al. Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral response. Nat Med 1999; 5: 881\u2013887.","journal-title":"Nat Med"},{"key":"BF3302319_CR47","doi-asserted-by":"publisher","first-page":"6910","DOI":"10.1038\/sj.onc.1204842","volume":"20","author":"P Clarke","year":"2001","unstructured":"Clarke P et al. Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection. Oncogene 2001; 20: 6910\u20136919.","journal-title":"Oncogene"},{"key":"BF3302319_CR48","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1128\/JVI.74.7.2981-2989.2000","volume":"74","author":"JL Connolly","year":"2000","unstructured":"Connolly JL et al. Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. J Virol 2000; 74: 2981\u20132989.","journal-title":"J Virol"},{"key":"BF3302319_CR49","doi-asserted-by":"publisher","first-page":"8135","DOI":"10.1128\/JVI.74.17.8135-8139.2000","volume":"74","author":"P Clarke","year":"2000","unstructured":"Clarke P et al. Reovirus-induced apoptosis is mediated by TRAIL. J Virol 2000; 74: 8135\u20138139.","journal-title":"J Virol"},{"key":"BF3302319_CR50","doi-asserted-by":"publisher","first-page":"11275","DOI":"10.1128\/JVI.75.23.11275-11283.2001","volume":"75","author":"P Clarke","year":"2001","unstructured":"Clarke P et al. Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun. J Virol 2001; 75: 11275\u201311283.","journal-title":"J Virol"},{"key":"BF3302319_CR51","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/13550280260422677","volume":"8","author":"SM Richardson-Burns","year":"2002","unstructured":"Richardson-Burns SM, Kominsky DJ, Tyler KL . Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol 2002; 8: 365\u2013380.","journal-title":"J Neurovirol"},{"key":"BF3302319_CR52","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/sj.cdd.4401045","volume":"9","author":"DJ Kominsky","year":"2002","unstructured":"Kominsky DJ, Bickel RJ, Tyler KL . Reovirus-induced apoptosis requires both death receptor- and mitochondrial-mediated caspase-dependent pathways of cell death. Cell Death Differ 2002; 9: 926\u2013933.","journal-title":"Cell Death Differ"},{"key":"BF3302319_CR53","unstructured":"Morris D et al. A phase I clinical trial evaluating intralesional Reolysin (reovirus) in histologically confirmed malignancies. Proc Am Soc Clin Oncol 2002; 21:92:24a."}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/3302319.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3302319","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3302319.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T04:16:18Z","timestamp":1648613778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3302319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,16]]},"references-count":53,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2004,11,1]]}},"alternative-id":["BF3302319"],"URL":"https:\/\/doi.org\/10.1038\/sj.gt.3302319","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,16]]},"assertion":[{"value":"1 October 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}