{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:09:25Z","timestamp":1792670965776,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T00:00:00Z","timestamp":1189641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T00:00:00Z","timestamp":1189641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1038\/sj.gt.3303021","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T07:55:45Z","timestamp":1189670145000},"page":"1623-1631","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector"],"prefix":"10.1038","volume":"14","author":[{"given":"K L","family":"Laurie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P","family":"Blundell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H E","family":"Baxendale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Qasim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Brunsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Thrasher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Holmdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,9,13]]},"reference":[{"key":"BF3303021_CR1","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nri1713","volume":"5","author":"C Cunningham-Rundles","year":"2005","unstructured":"Cunningham-Rundles C, Ponda PP . Molecular defects in T- and B-cell primary immunodeficiency diseases. Nat Rev Immunol 2005; 5: 880\u2013892.","journal-title":"Nat Rev Immunol"},{"key":"BF3303021_CR2","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1038\/sj.gt.3302150","volume":"10","author":"HB Gaspar","year":"2003","unstructured":"Gaspar HB, Howe S, Thrasher AJ . Gene therapy progress and prospects: gene therapy for severe combined immunodeficiency. Gene Therapy 2003; 10: 1999\u20132004.","journal-title":"Gene Therapy"},{"key":"BF3303021_CR3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1080\/00313020500402276","volume":"37","author":"SR Larsen","year":"2005","unstructured":"Larsen SR, Rasko JE . Lymphoproliferative disorders: prospects for gene therapy. Pathology 2005; 37: 523\u2013533.","journal-title":"Pathology"},{"key":"BF3303021_CR4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3109\/08830180109045582","volume":"20","author":"ME Melo","year":"2001","unstructured":"Melo ME, El Amine M, Tonnetti L, Fleischman L, Scott DW . Gene therapeutic approaches to induction and maintenance of tolerance. Int Rev Immunol 2001; 20: 627\u2013645.","journal-title":"Int Rev Immunol"},{"key":"BF3303021_CR5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.2174\/1566523043346264","volume":"4","author":"W Wong","year":"2004","unstructured":"Wong W, Wood KJ . Transplantation tolerance by donor MHC gene transfer. Curr Gene Ther 2004; 4: 329\u2013336.","journal-title":"Curr Gene Ther"},{"key":"BF3303021_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/08830180600785827","volume":"25","author":"DJ Laddy","year":"2006","unstructured":"Laddy DJ, Weiner DB . From plasmids to protection: a review of DNA vaccines against infectious diseases. Int Rev Immunol 2006; 25: 99\u2013123.","journal-title":"Int Rev Immunol"},{"key":"BF3303021_CR7","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1126\/science.272.5259.263","volume":"272","author":"L Naldini","year":"1996","unstructured":"Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263\u2013267.","journal-title":"Science"},{"key":"BF3303021_CR8","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.ymthe.2004.03.005","volume":"9","author":"LM Humeau","year":"2004","unstructured":"Humeau LM, Binder GK, Lu X, Slepushkin V, Merling R, Echeagaray P et al. Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load. Mol Ther 2004; 9: 902\u2013913.","journal-title":"Mol Ther"},{"key":"BF3303021_CR9","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1196\/annals.1345.007","volume":"1054","author":"A Bank","year":"2005","unstructured":"Bank A, Dorazio R, Leboulch P . A phase I\/II clinical trial of beta-globin gene therapy for beta-thalassemia. Ann NY Acad Sci 2005; 1054: 308\u2013316.","journal-title":"Ann NY Acad Sci"},{"key":"BF3303021_CR10","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1126\/science.1065806","volume":"294","author":"R Pawliuk","year":"2001","unstructured":"Pawliuk R, Westerman KA, Fabry ME, Payen E, Tighe R, Bouhassira EE et al. Correction of sickle cell disease in transgenic mouse models by gene therapy. Science 2001; 294: 2368\u20132371.","journal-title":"Science"},{"key":"BF3303021_CR11","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1182\/blood.V98.13.3607","volume":"98","author":"S Indraccolo","year":"2001","unstructured":"Indraccolo S, Minuzzo S, Roccaforte F, Zamarchi R, Habeler W, Stievano L et al. Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors. Blood 2001; 98: 3607\u20133617.","journal-title":"Blood"},{"key":"BF3303021_CR12","doi-asserted-by":"publisher","first-page":"3416","DOI":"10.1182\/blood-2002-02-0578","volume":"101","author":"G Marodon","year":"2003","unstructured":"Marodon G, Mouly E, Blair EJ, Frisen C, Lemoine FM, Klatzmann D . Specific transgene expression in human and mouse CD4+ cells using lentiviral vectors with regulatory sequences from the CD4 gene. Blood 2003; 101: 3416\u20133423.","journal-title":"Blood"},{"key":"BF3303021_CR13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1182\/blood.V99.2.399","volume":"99","author":"Y Cui","year":"2002","unstructured":"Cui Y, Golob J, Kelleher E, Ye Z, Pardoll D, Cheng L . Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem\/progenitor cells. Blood 2002; 99: 399\u2013408.","journal-title":"Blood"},{"key":"BF3303021_CR14","doi-asserted-by":"publisher","first-page":"7341","DOI":"10.1128\/JVI.77.13.7341-7351.2003","volume":"77","author":"C Lutzko","year":"2003","unstructured":"Lutzko C, Senadheera D, Skelton D, Petersen D, Kohn DB . Lentivirus vectors incorporating the immunoglobulin heavy chain enhancer and matrix attachment regions provide position-independent expression in B lymphocytes. J Virol 2003; 77: 7341\u20137351.","journal-title":"J Virol"},{"key":"BF3303021_CR15","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/sj.gt.3302255","volume":"11","author":"M Werner","year":"2004","unstructured":"Werner M, Kraunus J, Baum C, Brocker T . B-cell-specific transgene expression using a self-inactivating retroviral vector with human CD19 promoter and viral post-transcriptional regulatory element. Gene Therapy 2004; 11: 992\u20131000.","journal-title":"Gene Therapy"},{"key":"BF3303021_CR16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ymthe.2004.04.005","volume":"10","author":"T Moreau","year":"2004","unstructured":"Moreau T, Bardin F, Imbert J, Chabannon C, Tonnelle C . Restriction of transgene expression to the B-lymphoid progeny of human lentivirally transduced CD34+ cells. Mol Ther 2004; 10: 45\u201356.","journal-title":"Mol Ther"},{"key":"BF3303021_CR17","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1002\/eji.1830270939","volume":"27","author":"CP Kalberer","year":"1997","unstructured":"Kalberer CP, Reininger L, Melchers F, Rolink AG . Priming of helper T cell-dependent antibody responses by hemagglutinin- transgenic B cells. Eur J Immunol 1997; 27: 2400\u20132407.","journal-title":"Eur J Immunol"},{"key":"BF3303021_CR18","doi-asserted-by":"publisher","first-page":"10939","DOI":"10.1093\/nar\/16.22.10939","volume":"16","author":"T Blankenstein","year":"1988","unstructured":"Blankenstein T, Winter E, Muller W . A retroviral expression vector containing murine immunoglobulin heavy chain promoter\/enhancer. Nucleic Acids Res 1988; 16: 10939.","journal-title":"Nucleic Acids Res"},{"key":"BF3303021_CR19","doi-asserted-by":"publisher","first-page":"7041","DOI":"10.1073\/pnas.81.22.7041","volume":"81","author":"Y Bergman","year":"1984","unstructured":"Bergman Y, Rice D, Grosschedl R, Baltimore D . Two regulatory elements for immunoglobulin kappa light chain gene expression. Proc Natl Acad Sci USA 1984; 81: 7041\u20137045.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF3303021_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/344165a0","volume":"344","author":"S Pettersson","year":"1990","unstructured":"Pettersson S, Cook GP, Bruggemann M, Williams GT, Neuberger MS . A second B cell-specific enhancer 3\u2032 of the immunoglobulin heavy-chain locus. Nature 1990; 344: 165\u2013168.","journal-title":"Nature"},{"key":"BF3303021_CR21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/intimm\/7.1.89","volume":"7","author":"GP Cook","year":"1995","unstructured":"Cook GP, Meyer KB, Neuberger MS, Pettersson S . Regulated activity of the IgH intron enhancer (E mu) in the T lymphocyte lineage. Int Immunol 1995; 7: 89\u201395.","journal-title":"Int Immunol"},{"key":"BF3303021_CR22","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1089\/10430340252898984","volume":"13","author":"C Demaison","year":"2002","unstructured":"Demaison C, Parsley K, Brouns G, Scherr M, Battmer K, Kinnon C et al. High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum Gene Ther 2002; 13: 803\u2013813.","journal-title":"Hum Gene Ther"},{"key":"BF3303021_CR23","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1089\/10430340360535814","volume":"14","author":"W Janssens","year":"2003","unstructured":"Janssens W, Chuah MK, Naldini L, Follenzi A, Collen D, Saint-Remy JM et al. Efficiency of onco-retroviral and lentiviral gene transfer into primary mouse and human B-lymphocytes is pseudotype dependent. Hum Gene Ther 2003; 14: 263\u2013276.","journal-title":"Hum Gene Ther"},{"key":"BF3303021_CR24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1089\/104303403321208989","volume":"14","author":"GR Rossi","year":"2003","unstructured":"Rossi GR, Mautino MR, Morgan RA . High-efficiency lentiviral vector-mediated gene transfer into murine macrophages and activated splenic B lymphocytes. Hum Gene Ther 2003; 14: 385\u2013391.","journal-title":"Hum Gene Ther"},{"key":"BF3303021_CR25","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.bbrc.2004.04.057","volume":"318","author":"M Warncke","year":"2004","unstructured":"Warncke M, Vogt B, Ulrich J, von Laer MD, Beyer W, Klump H et al. Efficient in vitro transduction of naive murine B cells with lentiviral vectors. Biochem Biophys Res Commun 2004; 318: 673\u2013679.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF3303021_CR26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/BF00915383","volume":"1","author":"MD Cooper","year":"1981","unstructured":"Cooper MD . Pre-B cells; normal and abnormal development. J Clin Immunol 1981; 1: 81\u201389.","journal-title":"J Clin Immunol"},{"key":"BF3303021_CR27","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1182\/blood.V96.4.1309.h8001309_1309_1316","volume":"96","author":"D Chinnasamy","year":"2000","unstructured":"Chinnasamy D, Chinnasamy N, Enriquez MJ, Otsu M, Morgan RA, Candotti F . Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins. Blood 2000; 96: 1309\u20131316.","journal-title":"Blood"},{"key":"BF3303021_CR28","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1126\/science.288.5466.669","volume":"288","author":"M Cavazzana-Calvo","year":"2000","unstructured":"Cavazzana-Calvo M, Hacein-Bey S, de Saint BG, Gross F, Yvon E, Nusbaum P et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 2000; 288: 669\u2013672.","journal-title":"Science"},{"key":"BF3303021_CR29","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1016\/S0140-6736(04)17590-9","volume":"364","author":"HB Gaspar","year":"2004","unstructured":"Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J et al. Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet 2004; 364: 2181\u20132187.","journal-title":"Lancet"},{"key":"BF3303021_CR30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4049\/jimmunol.122.2.549","volume":"122","author":"KJ Kim","year":"1979","unstructured":"Kim KJ, Kanellopoulos-Langevin C, Merwin RM, Sachs DH, Asofsky R . Establishment and characterization of BALB\/c lymphoma lines with B cell properties. J Immunol 1979; 122: 549\u2013554.","journal-title":"J Immunol"},{"key":"BF3303021_CR31","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/jcp.1040720208","volume":"72","author":"SA Aaronson","year":"1968","unstructured":"Aaronson SA, Todaro GJ . Development of 3T3-like lines from Balb-c mouse embryo cultures: transformation susceptibility to SV40. J Cell Physiol 1968; 72: 141\u2013148.","journal-title":"J Cell Physiol"},{"key":"BF3303021_CR32","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2580::AID-IMMU2580>3.0.CO;2-X","volume":"28","author":"A Corthay","year":"1998","unstructured":"Corthay A, Backlund J, Broddefalk J, Michaelsson E, Goldschmidt TJ, Kihlberg J et al. Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis. Eur J Immunol 1998; 28: 2580\u20132590.","journal-title":"Eur J Immunol"},{"key":"BF3303021_CR33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0092-8674(88)90536-3","volume":"52","author":"RL Williams","year":"1988","unstructured":"Williams RL, Courtneidge SA, Wagner EF . Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene. Cell 1988; 52: 121\u2013131.","journal-title":"Cell"},{"key":"BF3303021_CR34","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nbt0997-871","volume":"15","author":"R Zufferey","year":"1997","unstructured":"Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D . Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 1997; 15: 871\u2013875.","journal-title":"Nat Biotechnol"},{"key":"BF3303021_CR35","doi-asserted-by":"publisher","first-page":"5448","DOI":"10.1128\/JVI.75.12.5448-5456.2001","volume":"75","author":"S Neil","year":"2001","unstructured":"Neil S, Martin F, Ikeda Y, Collins M . Postentry restriction to human immunodeficiency virus-based vector transduction in human monocytes. J Virol 2001; 75: 5448\u20135456.","journal-title":"J Virol"},{"key":"BF3303021_CR36","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.4049\/jimmunol.169.5.2361","volume":"169","author":"KL Laurie","year":"2002","unstructured":"Laurie KL, van Driel IR, Zwar TD, Barrett SP, Gleeson PA . Endogenous H\/K ATPase beta-subunit promotes T cell tolerance to the immunodominant gastritogenic determinant. J Immunol 2002; 169: 2361\u20132367.","journal-title":"J Immunol"},{"key":"BF3303021_CR37","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/sj.gt.3302440","volume":"12","author":"S Charrier","year":"2005","unstructured":"Charrier S, Stockholm D, Seye K, Opolon P, Taveau M, Gross DA et al. A lentiviral vector encoding the human Wiskott\u2013Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice. Gene Therapy 2005; 12: 597\u2013606.","journal-title":"Gene Therapy"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/3303021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3303021","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/3303021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T04:03:32Z","timestamp":1684037012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3303021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,13]]},"references-count":37,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["BF3303021"],"URL":"https:\/\/doi.org\/10.1038\/sj.gt.3303021","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,13]]},"assertion":[{"value":"24 October 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}