{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:46:37Z","timestamp":1792129597901,"version":"4.4.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heredity"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1038\/sj.hdy.6800915","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T10:32:30Z","timestamp":1166092350000},"page":"132-140","source":"Crossref","is-referenced-by-count":191,"title":["Robustness and evolution: concepts, insights and challenges from a developmental model system"],"prefix":"10.1038","volume":"100","author":[{"given":"M-A","family":"F\u00e9lix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,12,13]]},"reference":[{"key":"BF6800915_CR1","first-page":"551","volume":"17","author":"L Ancel Meyers","year":"2002","unstructured":"Ancel Meyers L, Bull JJ (2002). Fighting change with change: adaptive variation in an uncertain world. TREE 17: 551\u2013557.","journal-title":"TREE"},{"key":"BF6800915_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nature04488","volume":"440","author":"RB Azevedo","year":"2006","unstructured":"Azevedo RB, Lohaus R, Srinivasan S, Dang KK, Burch CL (2006). Sexual reproduction selects for robustness and negative epistasis in artificial gene networks. Nature 440: 87\u201390.","journal-title":"Nature"},{"key":"BF6800915_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0025-5564(03)00057-9","volume":"184","author":"H Bagheri-Chaichian","year":"2003","unstructured":"Bagheri-Chaichian H, Hermisson J, Vaisnys JR, Wagner GP (2003). Effects of epistasis on phenotypic robustness in metabolic pathways. Math Biosci 184: 27\u201351.","journal-title":"Math Biosci"},{"key":"BF6800915_CR4","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/43199","volume":"387","author":"N Barkai","year":"1997","unstructured":"Barkai N, Leibler S (1997). Robustness in simple biochemical networks. Nature 387: 913\u2013917.","journal-title":"Nature"},{"key":"BF6800915_CR5","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1126\/science.1055642","volume":"291","author":"T Berset","year":"2001","unstructured":"Berset T, Hoier EF, Battu G, Canevascini S, Hajnal A (2001). Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science 291: 1055\u20131058.","journal-title":"Science"},{"key":"BF6800915_CR6","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1101\/gad.333505","volume":"19","author":"TA Berset","year":"2005","unstructured":"Berset TA, Hoier EF, Hajnal A (2005). The C. elegans homolog of the mammalian tumor suppressor Dep-1\/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions. Genes Dev 19: 1328\u20131340.","journal-title":"Genes Dev"},{"key":"BF6800915_CR7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S1534-5807(04)00021-8","volume":"6","author":"N Chen","year":"2004","unstructured":"Chen N, Greenwald I (2004). The lateral signal for LIN-12\/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Dev Cell 6: 183\u2013192.","journal-title":"Dev Cell"},{"key":"BF6800915_CR8","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1554\/02-750R","volume":"57","author":"JA de Visser","year":"2003","unstructured":"de Visser JA, Hermisson J, Wagner GP, Ancel Meyers L, Bagheri-Chaichian H, Blanchard JL et al. (2003). Perspective: evolution and detection of genetic robustness. Evolution 57: 1959\u20131972.","journal-title":"Evolution"},{"key":"BF6800915_CR9","first-page":"555","volume":"16","author":"V Debat","year":"2001","unstructured":"Debat V, David P (2001). Mapping phenotypes: canalization, plasticity and developmental stability. TREE 16: 555\u2013561.","journal-title":"TREE"},{"key":"BF6800915_CR10","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0960-9822(01)00202-0","volume":"11","author":"M Delattre","year":"2001","unstructured":"Delattre M, F\u00e9lix M-A (2001). Polymorphism and evolution of vulval precursor cell lineages within two nematode genera, Caenorhabditis and Oscheius. Curr Biol 11: 631\u2013643.","journal-title":"Curr Biol"},{"key":"BF6800915_CR11","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nature02697","volume":"430","author":"DR Denver","year":"2004","unstructured":"Denver DR, Morris K, Lynch M, Thomas WK (2004). High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome. Nature 430: 679\u2013682.","journal-title":"Nature"},{"key":"BF6800915_CR12","first-page":"131","volume-title":"Variation \u2013 A Central Concept in Biology","author":"I Dworkin","year":"2005","unstructured":"Dworkin I (2005a). Canalization, cryptic variation, and developmental buffering: a critical examination and analytical perspective. In: Hallgrimsson B, Hall BK (eds). Variation \u2013 A Central Concept in Biology. Elsevier Inc.: Amsterdam. pp 131\u2013158."},{"key":"BF6800915_CR13","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/j.0014-3820.2005.tb01799.x","volume":"59","author":"I Dworkin","year":"2005","unstructured":"Dworkin I (2005b). A study of canalization and developmental stability in the sternopleural bristle system of Drosophila melanogaster. Evolution 59: 1500\u20131509.","journal-title":"Evolution"},{"key":"BF6800915_CR14","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cub.2003.10.001","volume":"13","author":"I Dworkin","year":"2003","unstructured":"Dworkin I, Palsson A, Birdsall K, Gibson G (2003). Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster. Curr Biol 13: 1888\u20131893.","journal-title":"Curr Biol"},{"key":"BF6800915_CR15","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1242\/dev.125.18.3667","volume":"125","author":"DM Eisenmann","year":"1998","unstructured":"Eisenmann DM, Maloof JN, Simske JS, Kenyon C, Kim SK (1998). The \u03b2-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development 125: 3667\u20133680.","journal-title":"Development"},{"key":"BF6800915_CR16","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nature01061","volume":"419","author":"A Eldar","year":"2002","unstructured":"Eldar A, Dorfman R, Weiss D, Ashe H, Shilo BZ, Barkai N (2002). Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature 419: 304\u2013308.","journal-title":"Nature"},{"key":"BF6800915_CR17","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S1534-5807(03)00292-2","volume":"5","author":"A Eldar","year":"2003","unstructured":"Eldar A, Rosin D, Shilo B-Z, Barkai N (2003). Self-enhanced ligand degradation underlies robustness of morphogen gradients. Dev Cell 5: 635\u2013646.","journal-title":"Dev Cell"},{"key":"BF6800915_CR18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/(SICI)1097-010X(19990415)285:1<3::AID-JEZ2>3.0.CO;2-J","volume":"28","author":"M-A F\u00e9lix","year":"1999","unstructured":"F\u00e9lix M-A (1999). Evolution of developmental mechanisms in nematodes. J Exp Zool (Mol Dev Evol) 28: 3\u201318.","journal-title":"J Exp Zool (Mol Dev Evol)"},{"key":"BF6800915_CR19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1242\/dev.124.1.253","volume":"124","author":"M-A F\u00e9lix","year":"1997","unstructured":"F\u00e9lix M-A, Sternberg PW (1997). Two nested gonadal inductions of the vulva in nematodes. Development 124: 253\u2013259.","journal-title":"Development"},{"key":"BF6800915_CR20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/genetics\/110.1.17","volume":"110","author":"E Ferguson","year":"1985","unstructured":"Ferguson E, Horvitz HR (1985). Identification and characterization of 22 genes that affect the vulval cell lineages of Caenorhabditis elegans. Genetics 110: 17\u201372.","journal-title":"Genetics"},{"key":"BF6800915_CR21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/genetics\/123.1.109","volume":"123","author":"EL Ferguson","year":"1989","unstructured":"Ferguson EL, Horvitz HR (1989). The Multivulva phenotype of certain C. elegans mutants results from defects in two functionally-redundant pathways. Genetics 123: 109\u2013121.","journal-title":"Genetics"},{"key":"BF6800915_CR22","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1086\/432265","volume":"80","author":"T Flatt","year":"2005","unstructured":"Flatt T (2005). The evolutionary genetics of canalization. Q Rev Biol 80: 287\u2013316.","journal-title":"Q Rev Biol"},{"key":"BF6800915_CR23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1515\/9780691187051","volume-title":"Fitness Landscapes and the Origin of Species","author":"S Gavrilets","year":"2004","unstructured":"Gavrilets S (2004). Fitness Landscapes and the Origin of Species. University Presses of California: Columbia and Princeton. p 432."},{"key":"BF6800915_CR24","first-page":"641","volume-title":"Cells, Embryos and Evolution","author":"J Gerhart","year":"1997","unstructured":"Gerhart J, Kirschner M (1997). Cells, Embryos and Evolution. Blackwell Science, Inc.: Oxford. p 641."},{"key":"BF6800915_CR25","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nrg1426","volume":"5","author":"G Gibson","year":"2004","unstructured":"Gibson G, Dworkin I (2004). Uncovering cryptic genetic variation. Nat Rev Genet 5: 681\u2013690.","journal-title":"Nat Rev Genet"},{"key":"BF6800915_CR26","first-page":"200","volume":"271","author":"G Gibson","year":"1996","unstructured":"Gibson G, Hogness DS (1996). Effect of polymorphism in the Drosophila regulatory gene Ultrabithorax on homeotic stability. Nature 271: 200\u2013203.","journal-title":"Nature"},{"key":"BF6800915_CR27","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/(SICI)1521-1878(200004)22:4<372::AID-BIES7>3.0.CO;2-J","volume":"22","author":"G Gibson","year":"2000","unstructured":"Gibson G, Wagner G (2000). Canalization in evolutionary genetics: a stabilizing theory? Bioessays 22: 372\u2013380.","journal-title":"Bioessays"},{"key":"BF6800915_CR28","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1073\/pnas.0506476103","volume":"103","author":"CA Giurumescu","year":"2006","unstructured":"Giurumescu CA, Sternberg PW, Asthagiri AR (2006). Intercellular coupling amplifies fate segregation during Caenorhabditis elegans vulval development. Proc Natl Acad Sci USA 103: 1331\u20131336.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6800915_CR29","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1101\/gad.11.20.2715","volume":"11","author":"A Hajnal","year":"1997","unstructured":"Hajnal A, Whitfield CW, Kim SK (1997). Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase. Genes Dev 11: 2715\u20132728.","journal-title":"Genes Dev"},{"key":"BF6800915_CR30","first-page":"542","volume-title":"Principles of Population Genetics","author":"DL Hartl","year":"1997","unstructured":"Hartl DL, Clark AG (1997). Principles of Population Genetics. Sinauer Associates, Inc.: Sunderland, MA. p 542."},{"key":"BF6800915_CR31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/genetics\/111.3.655","volume":"111","author":"DL Hartl","year":"1985","unstructured":"Hartl DL, Dykhuizen DE, Dean AM (1985). Limits of adaptation: the evolution of selective neutrality. Genetics 111: 655\u2013674.","journal-title":"Genetics"},{"key":"BF6800915_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S1097-2765(05)00001-8","volume":"6","author":"NA Hopper","year":"2000","unstructured":"Hopper NA, Lee J, Sternberg PW (2000). ARK-1 inhibits EGFR signaling in C. elegans. Mol Cell 6: 65\u201375.","journal-title":"Mol Cell"},{"key":"BF6800915_CR33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/genetics\/130.1.195","volume":"130","author":"D Houle","year":"1992","unstructured":"Houle D (1992). Comparing evolvability and variability of quantitative traits. Genetics 130: 195\u2013204.","journal-title":"Genetics"},{"key":"BF6800915_CR34","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1023\/A:1017034925212","volume":"102\u2013103","author":"D Houle","year":"1998","unstructured":"Houle D (1998). How should we explain variation in the genetic variance of traits? Genetica 102\u2013103: 241\u2013253.","journal-title":"Genetica"},{"key":"BF6800915_CR35","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/genetics\/97.3-4.639","volume":"97","author":"H Kacser","year":"1981","unstructured":"Kacser H, Burns JA (1981). The molecular basis of dominance. Genetics 97: 639\u2013666.","journal-title":"Genetics"},{"key":"BF6800915_CR36","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature01278","volume":"421","author":"RS Kamath","year":"2003","unstructured":"Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M et al. (2003). Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231\u2013237.","journal-title":"Nature"},{"key":"BF6800915_CR37","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1242\/dev.00987","volume":"131","author":"G Kao","year":"2004","unstructured":"Kao G, Tuck S, Baillie D, Sundaram MV (2004). C. elegans SUR-6\/PR55 cooperates with LET-92\/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites. Development 131: 755\u2013765.","journal-title":"Development"},{"key":"BF6800915_CR38","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0092-8674(95)90317-8","volume":"82","author":"WS Katz","year":"1995","unstructured":"Katz WS, Hill RJ, Clandinin TR, Sternberg PW (1995). Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates. Cell 82: 297\u2013307.","journal-title":"Cell"},{"key":"BF6800915_CR39","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0092-8674(95)90302-X","volume":"82","author":"C Kenyon","year":"1995","unstructured":"Kenyon C (1995). A perfect vulva every time: gradients and signalling cascades in C. elegans. Cell 82: 171\u2013174.","journal-title":"Cell"},{"key":"BF6800915_CR40","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1242\/dev.121.8.2655","volume":"121","author":"M Koga","year":"1995","unstructured":"Koga M, Ohshima Y (1995). Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans. Development 121: 2655\u20132666.","journal-title":"Development"},{"key":"BF6800915_CR41","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1006\/scdb.1999.0337","volume":"10","author":"DC Krakauer","year":"1999","unstructured":"Krakauer DC, Nowak MA (1999). Evolutionary preservation of redundant duplicated genes. Sem Cell Dev Biol 10: 555\u2013559.","journal-title":"Sem Cell Dev Biol"},{"key":"BF6800915_CR42","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1073\/pnas.032668599","volume":"99","author":"DC Krakauer","year":"2002","unstructured":"Krakauer DC, Plotkin JB (2002). Redundancy, antiredundancy, and the robustness of genomes. Proc Natl Acad Sci USA 99: 1405\u20131409.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6800915_CR43","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/j.1558-5646.1999.tb05361.x","volume":"53","author":"M Lynch","year":"1999","unstructured":"Lynch M, Blanchard JL, Houle D, Kibota T, Schultz S, Vassileva L et al. (1999). Spontaneous deleterious mutation. Evolution 53: 645\u2013663.","journal-title":"Evolution"},{"key":"BF6800915_CR44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0168-9525(98)01659-X","volume":"15","author":"HH McAdams","year":"1999","unstructured":"McAdams HH, Arkin A (1999). It's a noisy business! Genetic regulation at the nanomolar scale. Trends Genet 15: 65\u201369.","journal-title":"Trends Genet"},{"key":"BF6800915_CR45","first-page":"468","volume":"17","author":"CD Meiklejohn","year":"2002","unstructured":"Meiklejohn CD, Hartl DL (2002). A single mode of canalization. TREE 17: 468\u2013473.","journal-title":"TREE"},{"key":"BF6800915_CR46","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/S0960-9822(02)00839-4","volume":"12","author":"E Meir","year":"2002","unstructured":"Meir E, von Dassow G, Munro E, Odell GM (2002). Robustness, flexibility, and the role of lateral inhibition in the neurogenic network. Curr Biol 12: 778\u2013786.","journal-title":"Curr Biol"},{"key":"BF6800915_CR47","doi-asserted-by":"publisher","first-page":"13396","DOI":"10.1073\/pnas.1835613100","volume":"100","author":"CC Milton","year":"2003","unstructured":"Milton CC, Huynh B, Batterham P, Rutherford SL, Hoffmann AA (2003). Quantitative trait symmetry independent of Hsp90 buffering: distinct modes of genetic canalization and developmental stability. Proc Natl Acad Sci USA 100: 13396\u201313401.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6800915_CR48","doi-asserted-by":"publisher","first-page":"4553","DOI":"10.1242\/dev.00670","volume":"130","author":"N Moghal","year":"2003","unstructured":"Moghal N, Garcia LR, Khan LA, Iwasaki K, Sternberg PW (2003). Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein G\u03b1q and excitable cells in C. elegans. Development 130: 4553\u20134566.","journal-title":"Development"},{"key":"BF6800915_CR49","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1046\/j.1525-142X.2003.03035.x","volume":"5","author":"HF Nijhout","year":"2003","unstructured":"Nijhout HF, Berg AM (2003). A mechanistic study of evolvability using the mitogen-activated protein kinase cascade. Evol Dev 5: 281\u2013294.","journal-title":"Evol Dev"},{"key":"BF6800915_CR50","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0960-9822(02)00690-5","volume":"12","author":"M Ohmachi","year":"2002","unstructured":"Ohmachi M, Rocheleau C, Church D, Lambie E, Schedl T, Sundaram M (2002). C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation. Curr Biol 12: 427\u2013433.","journal-title":"Curr Biol"},{"key":"BF6800915_CR51","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.tree.2005.06.001","volume":"20","author":"M Pigliucci","year":"2005","unstructured":"Pigliucci M (2005). Evolution of phenotypic plasticity: where are we going now? Trends Ecol Evol 20: 481\u2013486.","journal-title":"Trends Ecol Evol"},{"key":"BF6800915_CR52","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1007\/s004270050137","volume":"207","author":"PJ Polaczyk","year":"1998","unstructured":"Polaczyk PJ, Gasperini R, Gibson G (1998). Naturally occurring genetic variation affects Drosophila photoreceptor determination. Dev Genes Evol 207: 462\u2013470.","journal-title":"Dev Genes Evol"},{"key":"BF6800915_CR53","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1086\/426873","volume":"165","author":"SR Proulx","year":"2005","unstructured":"Proulx SR, Phillips PC (2005). The opportunity for canalization and the evolution of genetic networks. Am Naturalist 165: 147\u2013162.","journal-title":"Am Naturalist"},{"key":"BF6800915_CR54","first-page":"739","volume-title":"C. elegans II","author":"DL Riddle","year":"1997","unstructured":"Riddle DL, Albert PS (1997). Genetic and environmental regulation of dauer larva development. In: Riddle DL, Blumenthal T, Meyer BJ, Priess JR (eds). C. elegans II. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY. pp 739\u2013768."},{"key":"BF6800915_CR55","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1002\/1521-1878(200012)22:12<1095::AID-BIES7>3.0.CO;2-A","volume":"22","author":"SL Rutherford","year":"2000","unstructured":"Rutherford SL (2000). From genotype to phenotype: buffering mechanisms and the storage of genetic information. Bioessays 22: 1095\u20131105.","journal-title":"Bioessays"},{"key":"BF6800915_CR56","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nature01234","volume":"420","author":"DD Shaye","year":"2002","unstructured":"Shaye DD, Greenwald I (2002). Endocytosis-mediated downregulation of LIN-12\/Notch upon Ras activation in Caenorhabditis elegans. Nature 420: 686\u2013690.","journal-title":"Nature"},{"key":"BF6800915_CR57","doi-asserted-by":"publisher","first-page":"10528","DOI":"10.1073\/pnas.102303999","volume":"99","author":"ML Siegal","year":"2002","unstructured":"Siegal ML, Bergman A (2002). Waddington's canalization revisited: developmental stability and evolution. Proc Natl Acad Sci USA 99: 10528\u201310532.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6800915_CR58","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/375142a0","volume":"375","author":"JS Simske","year":"1995","unstructured":"Simske JS, Kim SK (1995). Sequential signalling during Caenorhabditis elegans vulval induction. Nature 375: 142\u2013146.","journal-title":"Nature"},{"key":"BF6800915_CR59","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0959-437X(00)00110-6","volume":"10","author":"RJ Sommer","year":"2000","unstructured":"Sommer RJ (2000). Evolution of nematode development. Curr Opin Gen Dev 10: 443\u2013448.","journal-title":"Curr Opin Gen Dev"},{"key":"BF6800915_CR60","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1126\/science.8016644","volume":"265","author":"RJ Sommer","year":"1994","unstructured":"Sommer RJ, Sternberg PW (1994). Changes of induction and competence during the evolution of vulva development in nematodes. Science 265: 114\u2013118.","journal-title":"Science"},{"key":"BF6800915_CR61","doi-asserted-by":"crossref","unstructured":"Sternberg PW (2005). Vulval development. In: WormBook (ed). The C. elegans Research Community, WormBook, doi\/10.1895\/wormbook.1.6.1, http:\/\/www.wormbook.org .","DOI":"10.1895\/wormbook.1.6.1"},{"key":"BF6800915_CR62","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/genetics\/140.3.857","volume":"140","author":"SM Stigler","year":"1995","unstructured":"Stigler SM (1995). Galton and identification by fingerprints. Genetics 140: 857\u2013860.","journal-title":"Genetics"},{"key":"BF6800915_CR63","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","volume":"56","author":"J Sulston","year":"1977","unstructured":"Sulston J, Horvitz HR (1977). Postembryonic cell lineages of the nematode Caenorhabditis elegans. Dev Biol 56: 110\u2013156.","journal-title":"Dev Biol"},{"key":"BF6800915_CR64","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/0012-1606(80)90353-X","volume":"78","author":"JE Sulston","year":"1980","unstructured":"Sulston JE, White JG (1980). Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans. Dev Biol 78: 577\u2013597.","journal-title":"Dev Biol"},{"key":"BF6800915_CR65","doi-asserted-by":"crossref","unstructured":"Sundaram M (2006). RTK\/Ras\/MAP signaling. In: WormBook (ed). The C. elegans Research Community WormBook, doi\/10.1895\/wormbook.1.80.1, http:\/\/www.wormbook.org .","DOI":"10.1895\/wormbook.1.80.1"},{"key":"BF6800915_CR66","doi-asserted-by":"publisher","first-page":"9716","DOI":"10.1073\/pnas.96.17.9716","volume":"96","author":"E van Nimwegen","year":"1999","unstructured":"van Nimwegen E, Crutchfield JP, Huynen M (1999). Neutral evolution of mutational robustness. Proc Natl Acad Sci USA 96: 9716\u20139720.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6800915_CR67","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1111\/j.0014-3820.2000.tb00557.x","volume":"54","author":"LL Vassilieva","year":"2000","unstructured":"Vassilieva LL, Hook AM, Lynch M (2000). The fitness effects of spontaneous mutations in Caenorhabditis elegans. Evolution 54: 1234\u20131246.","journal-title":"Evolution"},{"key":"BF6800915_CR68","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/35018085","volume":"406","author":"G von Dassow","year":"2000","unstructured":"von Dassow G, Meir E, Munro EM, Odell GM (2000). The segment polarity network is a robust developmental module. Nature 406: 188\u2013192.","journal-title":"Nature"},{"key":"BF6800915_CR69","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/150563a0","volume":"150","author":"CH Waddington","year":"1942","unstructured":"Waddington CH (1942). Canalization of development and the inheritance of acquired characters. Nature 150: 563\u2013565.","journal-title":"Nature"},{"key":"BF6800915_CR70","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1111\/j.1558-5646.1996.tb02342.x","volume":"50","author":"A Wagner","year":"1996","unstructured":"Wagner A (1996). Does evolutionary plasticity evolve? Evolution 50: 1008\u20131023.","journal-title":"Evolution"},{"key":"BF6800915_CR71","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/genetics\/154.3.1389","volume":"154","author":"A Wagner","year":"2000","unstructured":"Wagner A (2000). The role of population size, pleiotropy and fitness effects of mutations in the evolution of overlapping gene functions. Genetics 154: 1389\u20131401.","journal-title":"Genetics"},{"key":"BF6800915_CR72","first-page":"367","volume-title":"Robustness and Evolvability in Living Systems","author":"A Wagner","year":"2005","unstructured":"Wagner A (2005a). Robustness and Evolvability in Living Systems. Princeton University Press: Princeton and Oxford. p 367."},{"key":"BF6800915_CR73","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1016\/j.febslet.2005.01.063","volume":"579","author":"A Wagner","year":"2005","unstructured":"Wagner A (2005b). Robustness, evolvability, and neutrality. FEBS Lett 579: 1772\u20131778.","journal-title":"FEBS Lett"},{"key":"BF6800915_CR74","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/bies.20170","volume":"27","author":"A Wagner","year":"2005","unstructured":"Wagner A (2005c). Distributed robustness versus redundancy as causes of mutational robustness. Bioessays 27: 176\u2013188.","journal-title":"Bioessays"},{"key":"BF6800915_CR75","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/j.1558-5646.1997.tb02420.x","volume":"51","author":"GP Wagner","year":"1997","unstructured":"Wagner GP, Booth G, Bagheri-Chaichian H (1997a). A population genetic theory of canalization. Evolution 51: 329\u2013347.","journal-title":"Evolution"},{"key":"BF6800915_CR76","first-page":"569","volume":"103","author":"GP Wagner","year":"1997","unstructured":"Wagner GP, Laublicher MD, Bagheri-Chaichian H (1997b). Genetic measurement theory of epistatic effects. Genetica 103: 569\u2013580.","journal-title":"Genetica"},{"key":"BF6800915_CR77","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1006\/bulm.2001.0244","volume":"63","author":"CO Wilke","year":"2001","unstructured":"Wilke CO (2001). Adaptive evolution on neutral networks. Bull Math Biol 63: 715\u2013730.","journal-title":"Bull Math Biol"},{"key":"BF6800915_CR78","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1126\/science.1091639","volume":"303","author":"AS Yoo","year":"2004","unstructured":"Yoo AS, Bais C, Greenwald I (2004). Crosstalk between the EGFR and LIN-12\/Notch pathways in C. elegans vulval development. Science 303: 663\u2013666.","journal-title":"Science"},{"key":"BF6800915_CR79","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1126\/science.7652556","volume":"269","author":"CH Yoon","year":"1995","unstructured":"Yoon CH, Lee J, Jongeward GD, Sternberg PW (1995). Similarity of sli-1, a regulator of vulval development in Caenorhabditis elegans, to the mammalian proto-oncogene, c-cbl. Science 269: 1102\u20131105.","journal-title":"Science"}],"container-title":["Heredity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6800915.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6800915","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6800915.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T23:58:44Z","timestamp":1707436724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6800915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,13]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["BF6800915"],"URL":"https:\/\/doi.org\/10.1038\/sj.hdy.6800915","relation":{},"ISSN":["0018-067X","1365-2540"],"issn-type":[{"value":"0018-067X","type":"print"},{"value":"1365-2540","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,13]]}}}