{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:07:31Z","timestamp":1791198451957,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T00:00:00Z","timestamp":1168905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI\u201050618"],"award-info":[{"award-number":["AI\u201050618"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    infection is an important cause of central nervous system and ocular disease, both in immunocompromised and in certain immunocompetent populations. Although parasite\u2010mediated host cell lysis is probably the principal cause of tissue destruction in immunodeficiency states, hypersensitivity and inflammatory responses may underlie severe disease in otherwise immuno\u2010sufficient individuals. In this review, we have critically evaluated the body of experimental evidence indicating a role of CD4 T cells in systemic and local immunopathology associated with\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection. We also discuss the pathogenic roles of cytokines produced by T helper (Th) 1 and Th17 cells and the protective and homeostatic roles of interleukin (IL)\u201010, transforming growth factor\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and IL\u201027 in modulating hypersensitivity responses induced by\n                    <jats:italic>T. gondii<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1038\/sj.icb.7100038","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T18:51:03Z","timestamp":1168973463000},"page":"155-159","source":"Crossref","is-referenced-by-count":104,"title":["Cytokine regulation of immunopathology in toxoplasmosis"],"prefix":"10.1111","volume":"85","author":[{"given":"Pamela J","family":"Gaddi","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Brown University  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,16]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4037-4044.2002"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/322800"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.5.2619"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.4.569"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.4049\/jimmunol.143.6.2045","article-title":"Importance of endogenous IFN\u2010gamma for prevention of toxoplasmic encephalitis in mice","volume":"143","author":"Suzuki Y","year":"1989","journal-title":"J 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