{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:42Z","timestamp":1740126342982,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T00:00:00Z","timestamp":1194912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001771","name":"University of Newcastle, Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001771","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Animal Health Board, New Zealand"},{"name":"Otago Innovation Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>Oral vaccination of mice with live <jats:italic>Mycobacterium bovis<\/jats:italic> BCG in lipid\u2010formulation induces a \u03b3\u2010interferon response that can be measured systemically, and confers protection against aerosolized mycobacterial challenge. Here, we have investigated cytokine responses following the vaccination, drawing comparisons between mice that received single or multiple oral immunizations and between mice receiving formulations containing live BCG or non\u2010replicating mycobacterial antigens. Single oral immunization with lipid\u2010formulated live BCG invoked secreted and cellular IFN\u2010\u03b3 responses in mice 8 weeks post\u2010vaccination, the magnitudes of which were significantly elevated in mice receiving multiple immunizations over the 8\u2010week period. Single oral immunization with live BCG also invoked an interleukin\u20102 response (but not TNF\u2010\u03b1 or IL\u20104), although the magnitude was not elevated by multiple immunizations. Multiple immunizations with lipid\u2010formulated soluble or particulate non\u2010replicating mycobacterial antigens failed to invoke cytokine responses, except for a low\u2010level IFN\u2010\u03b3 response in mice multiple immunized with lipid\u2010formulated heat\u2010killed BCG. These results are discussed in contrast to the known patterns of cytokine induction following parenteral\u2010route immunization with live or non\u2010replicating mycobacterial antigens and with practical reference to the development of oral\u2010delivery vaccines against tuberculosis.<\/jats:p>","DOI":"10.1038\/sj.icb.7100126","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T10:59:13Z","timestamp":1194951553000},"page":"214-217","source":"Crossref","is-referenced-by-count":5,"title":["Murine cytokine responses following multiple oral immunizations using lipid\u2010formulated mycobacterial antigens"],"prefix":"10.1111","volume":"86","author":[{"given":"Martin L","family":"Cross","sequence":"first","affiliation":[{"name":"Centre for Innovation, University of Otago Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R","family":"Lambeth","sequence":"additional","affiliation":[{"name":"Centre for Innovation, University of Otago Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank E","family":"Aldwell","sequence":"additional","affiliation":[{"name":"Centre for Innovation, University of Otago Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,13]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70552-7"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00288.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1994.14.281"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762005000500002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.1.101-108.2003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1903-1905.2005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.11.017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00539-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2006.36701"},{"key":"e_1_2_7_10_1","series-title":"Advancing Global Health: Facing Disease Issues at the Wildlife, Human and Livestock Interface","first-page":"64","author":"Lesellier S","year":"2006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.1996.tb00014.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0605321"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1711.2005.01369.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2005.01.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09629350020027564"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsymp.5650027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.150"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken1952.32.1"},{"key":"e_1_2_7_19_1","first-page":"738","article-title":"Comparative study of adjuvant\u2010induced arthritis in susceptible and resistant strains of rats. 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