{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:35:21Z","timestamp":1771356921501,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2001,8]]},"DOI":"10.1038\/sj.ijo.0801677","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T16:35:08Z","timestamp":1032453308000},"page":"1144-1153","source":"Crossref","is-referenced-by-count":31,"title":["Obesity treatment with a progressive clinical tri-therapy combining sibutramine and a supervised diet\u2013exercise intervention"],"prefix":"10.1038","volume":"25","author":[{"given":"S","family":"B\u00e9rub\u00e9-Parent","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Prud'homme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"St-Pierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Doucet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,8,2]]},"reference":[{"key":"BF0801677_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0002-9343(98)00411-2","volume":"106","author":"M Apfelbaum","year":"1999","unstructured":"Apfelbaum M, Vague P, Ziegler O, Hanotin C, Thomas F, Leutenegger E . Long-term maintenance of weight loss after a very-low-calorie diet: efficacy and tolerability of sibutramine vs placebo Am J Med 1999 106: 179\u2013184.","journal-title":"Am J Med"},{"key":"BF0801677_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/sj.ijo.0800540","volume":"22","author":"C Hanotin","year":"1998","unstructured":"Hanotin C, Thomas F, Jones SP, Leutenegger E, Drouin P . Efficacy and tolerability of sibutramine in obese patients: a dose-ranging study Int J Obes Relat Metab Disord 1998 22: 32\u201338.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801677_CR3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/j.1550-8528.1999.tb00701.x","volume":"7","author":"GA Bray","year":"1999","unstructured":"Bray GA, Blackburn GL, Ferguson JM, Greenway FL, Jain AK, Mendel CM, Mendels J, Ryan DH, Schwartz SL, Scheinbaum ML, Seaton TB . Sibutramine produces dose-related weight loss Obes Res 1999 7: 189\u2013198.","journal-title":"Obes Res"},{"key":"BF0801677_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/j.1550-8528.1998.tb00324.x","volume":"6","author":"HM Seagle","year":"1998","unstructured":"Seagle HM, Bessen DH, Hill JO . Effects of sibutramine on resting metabolic rate and weight loss in overweight women Obes Res 1998 6: 115\u2013121.","journal-title":"Obes Res"},{"key":"BF0801677_CR5","first-page":"61 (0235)","volume":"18","author":"F Kelly","year":"1994","unstructured":"Kelly F, Wade AG, Jones SP, Johnson SG . Sibutramine hydrochloride vs dexenfluramine: weight loss in obese subjects Int J Obes Relat Metab Disord 1994 18: 61 (0235).","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801677_CR6","first-page":"388","volume":"114","author":"IP Connoley","year":"1995","unstructured":"Connoley IP, Heal DJ, Stock MJ . A study in rats on the effects of sibutramine on food intake and thermogenesis Br J Pharmac 1995 114: 388.","journal-title":"Br J Pharmac"},{"key":"BF0801677_CR7","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1476-5381.1996.tb15170.x","volume":"117","author":"IP Connoley","year":"1996","unstructured":"Connoley IP, Frost I, Heal DJ, Stock MJ . Role of b-adrenoreceptors in mediating thermogenic effects of sibutramine Br J Pharmac 1996 117: 170.","journal-title":"Br J Pharmac"},{"key":"BF0801677_CR8","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/sj.ijo.0801045","volume":"23","author":"KM Walsh","year":"1999","unstructured":"Walsh KM, Leen E, Lean MEJ . The effect of sibutramine on resting energy expenditure and adrenaline-induced thermogenesis in obese females Int J Obes Relat Metab Disord 1999 23: 1009\u20131015.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801677_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/j.1550-8528.1998.tb00308.x","volume":"6","author":"BJ Rolls","year":"1998","unstructured":"Rolls BJ, Shide DJ, Thorwart ML, Ulbrecht JS . Sibutramine reduces food intake in non-dieting women with obesity Obes Res 1998 6: 1\u201311.","journal-title":"Obes Res"},{"key":"BF0801677_CR10","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/sj.ijo.0801059","volume":"23","author":"DL Hansen","year":"1999","unstructured":"Hansen DL, Toubro S, Stock MJ, Macdonald IA, Astrup A . The effect of sibutramine on energy expenditure and appetite during chronic treatment without dietary restriction Int J Obes Relat Metab Disord 1999 23: 1016\u20131024.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801677_CR11","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/0278-5846(88)90003-6","volume":"12","author":"WR Buckett","year":"1988","unstructured":"Buckett WR, Thomas PC, Luscombe GP . The pharmacology of sibutramine hydrochloride (BTS 54524), a new anti-depressant which induces rapid noradrenergic down-regulation Prog Neuropsychopharm Biol Psychol 1988 12: 575\u2013584.","journal-title":"Prog Neuropsychopharm Biol Psychol"},{"key":"BF0801677_CR12","first-page":"581","volume":"288","author":"C Gundlah","year":"1997","unstructured":"Gundlah C, Martin KF, Heal DJ, Auerbach SB . In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor J Pharm Ther 1997 288: 581\u2013591.","journal-title":"J Pharm Ther"},{"key":"BF0801677_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/j.1550-8528.1996.tb00544.x","volume":"4","author":"GA Bray","year":"1996","unstructured":"Bray GA, Ryan DH, Gordon D, Heidingsfelder S, Cerise F, Wilson K . A double-blind randomized placebo-controlled trial of sibutramine Obes Res 1996 4: 263\u2013270.","journal-title":"Obes Res"},{"key":"BF0801677_CR14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1079\/NRR19930010","volume":"6","author":"JP Despres","year":"1993","unstructured":"Despres JP, Lamarche B . Effects of diet and physical activity on adiposity and body fat distribution: implication for the prevention of cardiovascular disease Nutr Res Rev 1993 6: 137\u2013159.","journal-title":"Nutr Res Rev"},{"key":"BF0801677_CR15","first-page":"397","volume":"16","author":"DJ Goldstein","year":"1992","unstructured":"Goldstein DJ . Beneficial health effects of modest weight loss Int J Obes Relat Metab Disord 1992 16: 397\u2013415.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801677_CR16","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1093\/ajcn\/56.4.662","volume":"56","author":"B Buemann","year":"1992","unstructured":"Buemann B, Astrup A, Madsen J, Christensen NJ . A 24-h energy expenditure study on reduced-obese and nonobese women: effect of B-blockade Am J Clin Nutr 1992 56: 662\u2013670.","journal-title":"Am J Clin Nutr"},{"key":"BF0801677_CR17","first-page":"1","volume":"8","author":"E Doucet","year":"2000","unstructured":"Doucet E, St-Pierre S, Alm\u00e9ras N, Mauri\u00e8ge P, Richard D, Tremblay A . Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? J Clin Endocrinol Metab 2000 8: 1\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF0801677_CR18","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1093\/ajcn\/62.4.735","volume":"62","author":"DE Larson","year":"1995","unstructured":"Larson DE, Ferrano RT, Robertson DS, Ravussin E . Energy metabolism in weight-stable post obese individuals Am J Clin Nutr 1995 62: 735\u2013739.","journal-title":"Am J Clin Nutr"},{"key":"BF0801677_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/ajcn\/54.1.123","volume":"54","author":"CJGR Field","year":"1991","unstructured":"Field CJGR, Marliss EB . Changes in circulating leucocytes and mitogen responses during very-low-energy all-protein reducing diets Am J Clin Nutr 1991 54: 123\u2013129.","journal-title":"Am J Clin Nutr"},{"key":"BF0801677_CR20","first-page":"353","volume":"20","author":"DC Nieman","year":"1996","unstructured":"Nieman DC, Nehlsen-Cannarella SL, Henson DA, Butterworth DE, Fagoaga OR, Warren BJ, Rainwater MK . Immune response to obesity and moderate weight loss Int J Obes Relat Metab Disord 1996 20: 353\u2013360.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801677_CR21","first-page":"37","volume":"52","author":"DD Stallone","year":"1994","unstructured":"Stallone DD . The influence of obesity and its treatment on the immune system Nutr Rev 1994 52: 37\u201350.","journal-title":"Nutr Rev"},{"key":"BF0801677_CR22","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0002-8223(21)03768-8","volume":"85","author":"BT Burton","year":"1985","unstructured":"Burton BT, Foster WR . Health implications of obesity: an NIH consensus development conference J Am Diet Assoc 1985 85: 1117\u20131121.","journal-title":"J Am Diet Assoc"},{"key":"BF0801677_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1046\/j.1467-789x.2000.00006.x","volume":"1","author":"A Tremblay","year":"2000","unstructured":"Tremblay A, Doucet E . Obesity: a disease or a biological adaptation? Obes Rev 2000 1: 27\u201335.","journal-title":"Obes Rev"},{"key":"BF0801677_CR24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/sj.ijo.0800378","volume":"21","author":"MD White","year":"1997","unstructured":"White MD, Bouchard G, Bueman B, Alm\u00e9ras N, Despr\u00e9s JP, Bouchard C, Tremblay A . Energy and macronutrient balances for humans in a whole body metabolic chamber without control of preceeding diet and activity level Int J Obes Relat Metab Disord 1997 21: 135\u2013140.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801677_CR25","unstructured":"The Canadian Nutrient File . Health and Welfare Canada 1991."},{"key":"BF0801677_CR26","first-page":"53","volume-title":"Anthropometric standardization reference manual","author":"TG Lohman","year":"1988","unstructured":"Lohman TG, Roche AF, Martorerell R . Skinfold thicknesses and measurement technique. In: Lohham TGRA, Martello R (eds). Anthropometric standardization reference manual Human Kinetics Champaign, IL 1988 53\u201380."},{"key":"BF0801677_CR27","first-page":"20","volume-title":"Evaluation and regulation of body build and composition","author":"AR Behnke","year":"1974","unstructured":"Behnke AR, Wilmore JH . Evaluation and regulation of body build and composition Prentice-Hall: Englewood Cliffs, NJ 1974 20\u201337."},{"key":"BF0801677_CR28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1172\/JCI102041","volume":"28","author":"EA Meneely","year":"1949","unstructured":"Meneely EA, Kaltreider NL . Volume of the lung determined by helium dilution J Clin Invest 1949 28: 129\u2013139.","journal-title":"J Clin Invest"},{"key":"BF0801677_CR29","first-page":"238","volume":"4","author":"WE Siri","year":"1956","unstructured":"Siri WE . The gross composition of the body Adv Biol Med Physiol 1956 4: 238\u2013280.","journal-title":"Adv Biol Med Physiol"},{"key":"BF0801677_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1113\/jphysiol.1949.sp004363","volume":"109","author":"JB Weir","year":"1949","unstructured":"Weir JB . New method for calculating metabolic rate with special references to protein metabolism J Physiol (Lond) 1949 109: 1\u20139.","journal-title":"J Physiol (Lond)"},{"key":"BF0801677_CR31","unstructured":"Laboratories R . Body-composition assessments in youth and adults In: Roche E Jr (ed.) Report of the Sixth ROSS Conference on medical Research Ross Laboratories: Colombus, OH 1985 11."},{"key":"BF0801677_CR32","first-page":"615","volume":"101","author":"R Richterich","year":"1971","unstructured":"Richterich R, Dauwwalder H . Zur bestimmung der plasma-glukose-konzentration mit der hexokinase-glucose-6-phosphat-deshydrogenase-methode Schweiz Med WochenschrSchweiz Med Wochenschr 1971 101: 615\u2013618.","journal-title":"Schweiz Med WochenschrSchweiz Med Wochenschr"},{"key":"BF0801677_CR33","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0026-0495(86)90146-0","volume":"35","author":"S Moorjani","year":"1986","unstructured":"Moorjani S, Gagn\u00e9 C, Lupien PJ, Brun D . Plasma triglycerides related decrease in high density lipoprotein cholesterol and its association with myocardial infarction in heterozygous familial hypercholesterolemia Metabolism 1986 35: 311\u2013316.","journal-title":"Metabolism"},{"key":"BF0801677_CR34","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/j.1550-8528.1998.tb00351.x","volume":"6","author":"C Hanotin","year":"1998","unstructured":"Hanotin C, Thomas F, Jones SP, Leutenegger E, Drouin P . A comparison of sibutramine and dexfenfluramine in the treatment of obesity Obes Res 1998 6: 285\u2013291.","journal-title":"Obes Res"},{"key":"BF0801677_CR35","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/j.1550-8528.1999.tb00415.x","volume":"7","author":"E Doucet","year":"1999","unstructured":"Doucet E, Imbeault P, Alm\u00e9ras N, Tremblay A . Physical activity and low-fat diet: is it enough to maintain weight stability in the reduced-obese individual following weight loss by drug therapy and energy restriction? Obes Res 1999 7: 323\u2013333.","journal-title":"Obes Res"},{"key":"BF0801677_CR36","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1056\/NEJM198802253180802","volume":"8","author":"E Ravussin","year":"1988","unstructured":"Ravussin E, Lillioja S, Knowler WC, Christin L, Freymond D, Abbott WGH, Boyce V, Howard BV, Bogardus C . Reduced rate of energy expenditure as a risk factor for body-weight gain New Engl J Med 1988 8: 467\u2013472.","journal-title":"New Engl J Med"},{"key":"BF0801677_CR37","first-page":"E650","volume":"259","author":"F Zurlo","year":"1990","unstructured":"Zurlo F, Lillioja S, Esposito Del Puente A, Raz I, Saad MF, Swinburn BA, Knowler WC, Bogardus C, Ravussin E . Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24h-RQ Am J Physiol 1990 259: E650\u2013E657.","journal-title":"Am J Physiol"},{"key":"BF0801677_CR38","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1056\/NEJM199503093321001","volume":"332","author":"RL Leibel","year":"1995","unstructured":"Leibel RL, Rosenbaum M, Hirsch J . Changes in energy expenditure resulting from altered body weight New Engl J Med 1995 332: 621\u2013628.","journal-title":"New Engl J Med"},{"key":"BF0801677_CR39","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.2337\/diacare.15.11.1701","volume":"15","author":"J Henriksson","year":"1992","unstructured":"Henriksson J . Effects of physical training on the metabolism of skeletal muscle Diabetes Care 1992 15: 1707\u20131711.","journal-title":"Diabetes Care"},{"key":"BF0801677_CR40","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1097\/00005768-199812000-00002","volume":"30","author":"CB Scanga","year":"1998","unstructured":"Scanga CB, Verde TJ, Paolone AM, Anderson RE, Wadden TA . Effects of weight loss and exercise training on natural killer cell activity in obese women Med Sci Sports Exerc 1998 30: 1666\u20131671.","journal-title":"Med Sci Sports Exerc"},{"key":"BF0801677_CR41","first-page":"9","volume":"48","author":"DS Kelley","year":"1994","unstructured":"Kelley DS, Daudu PA, Branch LB, Johson HL, Taylor PC, Mackey B . Energy restriction decreases number of circulating natural killer cells and serum levels of immunoglobulins in overweight women Eur J Clin Nutr 1994 48: 9\u201318.","journal-title":"Eur J Clin Nutr"},{"key":"BF0801677_CR42","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1128\/CDLI.1.2.202-205.1994","volume":"1","author":"DD Stallone","year":"1994","unstructured":"Stallone DD, Stunkard AJ, Zweiman B, Wadden TA, Foster GD . Decline in delayed-type hypersensitivity response in obese women following weight reduction Clin Diagn Lab Immunol 1994 1: 202\u2013205.","journal-title":"Clin Diagn Lab Immunol"},{"key":"BF0801677_CR43","first-page":"296","volume-title":"Exercise physiology","author":"WD Mc Ardle","year":"1996","unstructured":"Mc Ardle WD, Katch FI, Katch VL . Functional capacity of the cardiovascular system. In: Balado D (ed). Exercise physiology 4th edn, chap 17. William and Wilkins: Baltimore, MD 1996 296\u2013312."},{"key":"BF0801677_CR44","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1249\/00005768-198406000-00002","volume":"16","author":"DR Seals","year":"1984","unstructured":"Seals DR, Hagberg JM . The effect of exercise training on human hypertension Med Sci Sports Exerc 1984 16: 207\u2013215.","journal-title":"Med Sci Sports Exerc"},{"key":"BF0801677_CR45","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1152\/jappl.1991.70.4.1633","volume":"70","author":"C Plourde","year":"1991","unstructured":"Plourde C, Rousseau-Migeron S, Nadeau A . B-adrenoreceptor adenylate cyclase system adaptation to physical training in rat ventricular tissue J Appl Physiol 1991 70: 1633\u20131638.","journal-title":"J Appl Physiol"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/0801677.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0801677","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0801677.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:18:44Z","timestamp":1684221524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/0801677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["BF0801677"],"URL":"https:\/\/doi.org\/10.1038\/sj.ijo.0801677","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}