{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:24:09Z","timestamp":1789899849155,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1038\/sj.ijo.0801863","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:34:59Z","timestamp":1031250899000},"page":"143-149","source":"Crossref","is-referenced-by-count":68,"title":["Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats"],"prefix":"10.1038","volume":"26","author":[{"given":"F","family":"Rohner-Jeanrenaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LS","family":"Craft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bridwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TM","family":"Suter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FC","family":"Tinsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DL","family":"Smiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DR","family":"Burkhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Statnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ML","family":"Heiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ravussin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JF","family":"Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,2,15]]},"reference":[{"key":"BF0801863_CR1","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1523\/JNEUROSCI.15-03-02471.1995","volume":"15","author":"J Douglass","year":"1995","unstructured":"Douglass J, McKinzie AA, Couceyro P . PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine J Neurosci 1995 15: 2471\u20132481.","journal-title":"J Neurosci"},{"key":"BF0801863_CR2","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1073\/pnas.96.6.2722","volume":"96","author":"L Thim","year":"1999","unstructured":"Thim L, Kristensen P, Nielsen PF, Wulff BS, Clausen JT . Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat Proc Natl Acad Sci USA 1999 96: 2722\u20132727.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF0801863_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0014-5793(98)00543-2","volume":"428","author":"L Thim","year":"1998","unstructured":"Thim L, Nielsen PF, Judge ME, Andersen AS, Diers I, Egel-Mitani M, Hastrup S . Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast FEBS Lett 1998 428: 263\u2013268.","journal-title":"FEBS Lett"},{"key":"BF0801863_CR4","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1021\/bi00510a038","volume":"20","author":"J Spiess","year":"1981","unstructured":"Spiess J, Villarreal J, Vale W . Isolation and sequence analysis of a somatostatin-like polypeptide from ovine hypothalamus Biochemistry 1981 20: 1982\u20131988.","journal-title":"Biochemistry"},{"key":"BF0801863_CR5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/(SICI)1098-2396(19990901)33:3<163::AID-SYN1>3.0.CO;2-T","volume":"33","author":"MJ Kuhar","year":"1999","unstructured":"Kuhar MJ, Yoho LL . CART peptide analysis by Western blotting Synapse 1999 33: 163\u2013171.","journal-title":"Synapse"},{"key":"BF0801863_CR6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0891-0618(97)00212-3","volume":"12","author":"PR Couceyro","year":"1997","unstructured":"Couceyro PR, Koylu EO, Kuhar MJ . Further studies on the anatomical distribution of CART by in situ hybridization J Chem Neuroanat 1997 12: 229\u2013241.","journal-title":"J Chem Neuroanat"},{"key":"BF0801863_CR7","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0006-8993(99)01977-0","volume":"848","author":"C Broberger","year":"1999","unstructured":"Broberger C . Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin\/hypocretin and neuropeptide Y Brain Res 1999 848: 101\u2013113.","journal-title":"Brain Res"},{"key":"BF0801863_CR8","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/S0896-6273(00)80656-X","volume":"21","author":"CF Elias","year":"1998","unstructured":"Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK . Leptin activates hypothalamic CART neurons projecting to the spinal cord Neuron 1998 21: 1375\u20131385.","journal-title":"Neuron"},{"key":"BF0801863_CR9","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/29993","volume":"393","author":"P Kristensen","year":"1998","unstructured":"Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD et al. Hypothalamic CART is a new anorectic peptide regulated by leptin Nature 1998 393: 72\u201376.","journal-title":"Nature"},{"key":"BF0801863_CR10","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/35007534","volume":"404","author":"MW Schwartz","year":"2000","unstructured":"Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG . Central nervous system control of food intake Nature 2000 404: 661\u2013671.","journal-title":"Nature"},{"key":"BF0801863_CR11","doi-asserted-by":"publisher","first-page":"RC5","DOI":"10.1523\/JNEUROSCI.19-10-j0006.1999","volume":"19","author":"N Vrang","year":"1999","unstructured":"Vrang N, Larsen PJ, Clausen JT, Kristensen P . Neurochemical characterization of hypothalamic cocaine\u2013amphetamineregulated transcript neurons J Neurosci 1999 19: RC5.","journal-title":"J Neurosci"},{"key":"BF0801863_CR12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0006-8993(98)01349-3","volume":"818","author":"N Vrang","year":"1999","unstructured":"Vrang N, Tang-Christensen M, Larsen PJ, Kristensen P . Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour Brain Res 1999 818: 499\u2013509.","journal-title":"Brain Res"},{"key":"BF0801863_CR13","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1210\/endo.141.2.7295","volume":"141","author":"N Vrang","year":"2000","unstructured":"Vrang N, Larsen PJ, Kristensen P, Tang-Christensen M . Central administration of cocaine\u2013amphetamine-regulated transcript activates hypothalamic neuroendocrine neurons in the rat Endocrinology 2000 141: 794\u2013801.","journal-title":"Endocrinology"},{"key":"BF0801863_CR14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/(SICI)1098-2396(199808)29:4<293::AID-SYN1>3.0.CO;2-0","volume":"29","author":"PD Lambert","year":"1998","unstructured":"Lambert PD, Couceyro PR, McGirr KM, Dall Vechia SE, Smith Y, Kuhar MJ . CART peptides in the central control of feeding and interactions with neuropeptide Y Synapse 1998 29: 293\u2013298.","journal-title":"Synapse"},{"key":"BF0801863_CR15","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1097\/00001756-200009280-00040","volume":"11","author":"C Wang","year":"2000","unstructured":"Wang C, Billington CJ, Levine AS, Kotz CM . Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression Neuroreport 2000 11: 3251\u20133255.","journal-title":"Neuroreport"},{"key":"BF0801863_CR16","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/oby.2000.76","volume":"8","author":"PJ Larsen","year":"2000","unstructured":"Larsen PJ, Vrang N, Petersen PC, Kristensen P . Chronic intracerebroventricular administration of recombinant CART (42\u201389) peptide inhibits and causes weight loss in lean and obese Zucker (fa\/fa) rats Obes Res 2000 8: 590\u2013596.","journal-title":"Obes Res"},{"key":"BF0801863_CR17","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1079\/PNS19910069","volume":"50","author":"PR Flatt","year":"1991","unstructured":"Flatt PR, Barnett CR, Shibier O, Swanston-Flatt SK . Direct and indirect actions of nutrients in the regulation of insulin secretion from the pancreatic beta cells Proc Nutr Soc 1991 50: 559\u2013566.","journal-title":"Proc Nutr Soc"},{"key":"BF0801863_CR18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1159\/000421672","volume":"70","author":"M Elia","year":"1992","unstructured":"Elia M, Livesey G . Energy expenditure and fuel selection in biological systems: the theory and practice of calculations based on indirect calorimetry and tracer methods World Rev Nutr Diet 1992 70: 68\u2013131.","journal-title":"World Rev Nutr Diet"},{"key":"BF0801863_CR19","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1210\/endo.141.8.7588","volume":"141","author":"T Okumura","year":"2000","unstructured":"Okumura T, Yamada H, Motomura W, Kohgo Y . Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system Endocrinology 2000 141: 2854\u20132860.","journal-title":"Endocrinology"},{"key":"BF0801863_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0149-7634(05)80037-5","volume":"14","author":"NJ Rothwell","year":"1990","unstructured":"Rothwell NJ . Central effects of CRF on metabolism and energy balance Neurosci Biobehav Rev 1990 14: 263\u2013271.","journal-title":"Neurosci Biobehav Rev"},{"key":"BF0801863_CR21","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1210\/endo.141.8.7700","volume":"141","author":"RD Cone","year":"2000","unstructured":"Cone RD . The corticotropin-releasing hormone system and feeding behavior- a complex web begins to unravel Endocrinology 2000 141: 2713\u20132714.","journal-title":"Endocrinology"},{"issue":"Suppl 2","key":"BF0801863_CR22","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1038\/sj.ijo.0801275","volume":"24","author":"D Richard","year":"2000","unstructured":"Richard D, Huang Q, Timofeeva E . The corticotropin-releasing hormone system in the regulation of energy balance in obesity Int J Obes Relat Metab Disord 2000 24(Suppl 2): S36\u201339.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801863_CR23","doi-asserted-by":"publisher","first-page":"10373","DOI":"10.1073\/pnas.96.18.10373","volume":"96","author":"ZW Wang","year":"1999","unstructured":"Wang ZW, Zhou YT, Kakuma T, Lee Y, Higa M, Kalra SP, Dube MG, Kalra PS, Unger RH . Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia Proc Natl Acad Sci USA 1999 96: 10373\u201310378.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/0801863.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0801863","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0801863.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:21:29Z","timestamp":1684221689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/0801863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["BF0801863"],"URL":"https:\/\/doi.org\/10.1038\/sj.ijo.0801863","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}