{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:57:17Z","timestamp":1790254637873,"version":"4.1.0"},"reference-count":170,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2002,3,1]]},"DOI":"10.1038\/sj.ijo.0801948","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:35:19Z","timestamp":1031250919000},"page":"281-298","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Appetite suppression based on selective inhibition of NPY receptors"],"prefix":"10.1038","volume":"26","author":[{"given":"S","family":"Chamorro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Della-Zuana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L","family":"Fauch\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"F\u00e9l\u00e9tou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-P","family":"Galizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Levens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,3,11]]},"reference":[{"key":"BF0801948_CR1","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/0196-9781(84)90165-7","volume":"5","author":"AS Levine","year":"1984","unstructured":"Levine AS, Morley JE . Neuropeptide Y: a potent inducer of consummatory behavior in rats Peptides 1984 5: 1025\u20131029.","journal-title":"Peptides"},{"key":"BF0801948_CR2","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1016\/0024-3205(84)90032-8","volume":"24","author":"BG Stanley","year":"1984","unstructured":"Stanley BG, Leibowitz SF . Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus Life Sci 1984 24: 2635\u20132642.","journal-title":"Life Sci"},{"key":"BF0801948_CR3","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/0024-3205(85)90428-X","volume":"37","author":"LG Allen","year":"1985","unstructured":"Allen LG, Kalra PS, Crowley WR, Kalra SP . Comparison of the effects of neuropeptide Y and adrenergic transmitters on LH release and food intake in male rats Life Sci 1985 37: 617\u2013623.","journal-title":"Life Sci"},{"key":"BF0801948_CR4","first-page":"295","volume":"16","author":"B Beck","year":"1992","unstructured":"Beck B, Stricker-Krongrad A, Nicolas JP, Burlet C . Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long\u2013Evans rats mimics the feeding behaviour of obese Zucker rats Int J Obes Relat Metab Disord 1992 16: 295\u2013302.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801948_CR5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2337\/diab.46.2.209","volume":"46","author":"A Sainsbury","year":"1997","unstructured":"Sainsbury A, Cusin I, Rohner-Jeanrenaud F, Jeanrenaud B . Adrenalectomy prevents the obesity syndrome produced by chronic central neuropeptide Y infusion in normal rats Diabetes 1997 46: 209\u2013214.","journal-title":"Diabetes"},{"key":"BF0801948_CR6","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1016\/0024-3205(91)90608-E","volume":"48","author":"PE McKibbin","year":"1991","unstructured":"McKibbin PE, Rogers P, Williams G . Increased neuropeptide Y concentrations in the lateral hypothalamic area of the rat after the onset of darkness: possible relevance to the circadian periodicity of feeding behavior Life Sci 1991 48: 2527\u20132533.","journal-title":"Life Sci"},{"key":"BF0801948_CR7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0006-8993(90)90045-D","volume":"536","author":"M Jhanwar-Uniyal","year":"1990","unstructured":"Jhanwar-Uniyal M, Beck B, Burlet C, Leibowitz SF . Diurnal rhythm of neuropeptide Y-like immunoreactivity in the suprachiasmatic, arcuate and paraventricular nuclei and other hypothalamic sites Brain Res 1990 536: 331\u2013334.","journal-title":"Brain Res"},{"key":"BF0801948_CR8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0006-8993(97)00192-3","volume":"755","author":"A Sahu","year":"1997","unstructured":"Sahu A, Sninsky CA, Kalra SP . Evidence that hypothalamic neuropeptide Y gene expression and NPY levels in the paraventricular nucleus increase before the onset of hyperphagia in experimental diabetes Brain Res 1997 755: 339\u2013342.","journal-title":"Brain Res"},{"key":"BF0801948_CR9","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1093\/ps\/78.8.1203","volume":"78","author":"T Boswell","year":"1999","unstructured":"Boswell T, Dunn IC, Corr SA . Hypothalamic neuropeptide Y mRNA is increased after feed restriction in growing broilers Poultry Sci 1999 78: 1203\u20131207.","journal-title":"Poultry Sci"},{"key":"BF0801948_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1464-5491.1992.tb01719.x","volume":"9","author":"PM Jones","year":"1992","unstructured":"Jones PM, Pierson AM, Williams G, Ghatei MA, Bloom SR . Increased hypothalamic neuropeptide Y messenger RNA levels in two rat models of diabetes Diabetic Med 1992 9: 76\u201380.","journal-title":"Diabetic Med"},{"key":"BF0801948_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0006-8993(94)91374-9","volume":"656","author":"PD Lambert","year":"1994","unstructured":"Lambert PD, Wilding JP, Turton MD, Ghatei MA, Bloom SR . Effect of food deprivation and streptozotocin-induced diabetes on hypothalamic neuropeptide Y release as measured by a radioimmunoassay-linked microdialysis procedure Brain Res 1994 656: 135\u2013140.","journal-title":"Brain Res"},{"key":"BF0801948_CR12","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1093\/jn\/128.12.2520","volume":"128","author":"M Jang","year":"1998","unstructured":"Jang M, Romsos DR . Neuropeptide Y and corticotropin-releasing hormone concentrations within specific hypothalamic regions of lean but not ob\/ob mice respond to food-deprivation and refeeding: 1 J Nutr 1998 128: 2520\u20132525.","journal-title":"J Nutr"},{"key":"BF0801948_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0006-8993(95)00628-4","volume":"690","author":"S Dryden","year":"1995","unstructured":"Dryden S, Pickavance L, Frankish HM, Williams G . Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa\/fa) Zucker rats Brain Res 1995 690: 185\u2013188.","journal-title":"Brain Res"},{"key":"BF0801948_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1210\/endo.133.1.8100519","volume":"133","author":"PD Lambert","year":"1993","unstructured":"Lambert PD, Wilding JP, al-Dokhayel AA, Bohuon C, Comoy E, Gilbey SG, Bloom SR . A role for neuropeptide Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation Endocrinology 1993 133: 29\u201332.","journal-title":"Endocrinology"},{"key":"BF0801948_CR15","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0306-4522(94)00573-N","volume":"66","author":"A Burlet","year":"1995","unstructured":"Burlet A, Grouzmann E, Musse N, Fernette B, Nicolas JP, Burlet C . The immunological impairment of arcuate neuropeptide Y neurons by ricin A chain produces persistent decrease of food intake and body weight Neuroscience 1995 66: 151\u2013159.","journal-title":"Neuroscience"},{"key":"BF0801948_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0167-0115(95)00110-W","volume":"59","author":"MG Hulsey","year":"1995","unstructured":"Hulsey MG, Pless CM, White BD, Martin RJ . ICV administration of anti-NPY antisense oligonucleotide: effects on feeding behavior, body weight, peptide content and peptide release Regul Pept 1995 59: 207\u2013214.","journal-title":"Regul Pept"},{"key":"BF0801948_CR17","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1054\/npep.2000.0807","volume":"34","author":"WT Chance","year":"2000","unstructured":"Chance WT, Sheriff S, Peng F, Balasubramaniam A . Antagonism of NPY-induced feeding by pretreatment with cyclic AMP response element binding protein antisense oligonucleotide Neuropeptides 2000 34: 167\u2013172.","journal-title":"Neuropeptides"},{"key":"BF0801948_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0006-8993(98)00574-5","volume":"803","author":"WT Chance","year":"1998","unstructured":"Chance WT, Tao Z, Sheriff S, Balasubramaniam A . WRYamide, a NPY-based tripeptide that antagonizes feeding in rats Brain Res 1998 803: 39\u201343.","journal-title":"Brain Res"},{"key":"BF0801948_CR19","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/S0196-9781(01)00358-8","volume":"22","author":"AJ Danielsa","year":"2001","unstructured":"Danielsa AJ, Chance WT, Grizzle MK, Heyer D, Matthews JE . Food intake inhibition and reduction in body weight gain in rats treated with GI264879A, a non-selective NPY-Y1 receptor antagonist Peptides 2001 22: 483\u2013491.","journal-title":"Peptides"},{"key":"BF0801948_CR20","first-page":"R1500","volume":"274","author":"A Ishihara","year":"1998","unstructured":"Ishihara A, Tanaka T, Kanatani A, Fukami T, Ihara M, Fukuroda T . A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats Am J Physiol 1998 274: R1500\u20131504.","journal-title":"Am J Physiol"},{"key":"BF0801948_CR21","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0167-0115(98)00085-8","volume":"75\u201376","author":"CL Marin-Bivens","year":"1998","unstructured":"Marin-Bivens CL, Kalra SP, Olster DH . Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats Regul Pept 1998 75\u201376: 327\u2013334.","journal-title":"Regul Pept"},{"key":"BF0801948_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3181\/00379727-218-44263","volume":"218","author":"DR Gehlert","year":"1998","unstructured":"Gehlert DR . Multiple receptors for the pancreatic polypeptide (PP-fold) family: physiological implications Proc Soc Exp Biol Med 1998 218: 7\u201322.","journal-title":"Proc Soc Exp Biol Med"},{"key":"BF0801948_CR23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0195-6663(85)80006-4","volume":"6","author":"HP Weingarten","year":"1985","unstructured":"Weingarten HP . Stimulus control of eating: implications for a two-factor theory of hunger Appetite 1985 6: 387\u2013401.","journal-title":"Appetite"},{"key":"BF0801948_CR24","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1096\/fasebj.4.15.2253845","volume":"4","author":"RB Harris","year":"1990","unstructured":"Harris RB . Role of set-point theory in regulation of body weight FASEB J 1990 4: 3310\u20133318.","journal-title":"FASEB J"},{"key":"BF0801948_CR25","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1017\/S0029665100000422","volume":"59","author":"GA Bray","year":"2000","unstructured":"Bray GA . Afferent signals regulating food intake Proc Nutr Soc 2000 59: 373\u2013384.","journal-title":"Proc Nutr Soc"},{"key":"BF0801948_CR26","first-page":"525","volume-title":"Progress in obesity research","author":"BC Hansen","year":"1999","unstructured":"Hansen BC, Ortmeyer HK . Obesity, diabetes, and aging: lessons from life-time studies in monkeys. In: Guy-Grand B, Aihaud G (eds). Progress in obesity research Libbey: London 1999 525\u2013544."},{"key":"BF0801948_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0149-7634(95)00033-B","volume":"20","author":"KC Berridge","year":"1996","unstructured":"Berridge KC . Food reward: brain substrates of wanting and liking Neurosci Biobehav Rev 1996 20: 1\u201325.","journal-title":"Neurosci Biobehav Rev"},{"key":"BF0801948_CR28","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/0031-9384(90)90225-S","volume":"48","author":"G Collier","year":"1990","unstructured":"Collier G, Johnson DF . The time window of feeding Physiol Behav 1990 48: 771\u2013777.","journal-title":"Physiol Behav"},{"issue":"Suppl 1","key":"BF0801948_CR29","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1079\/BJN19970102","volume":"77","author":"J Waterhouse","year":"1997","unstructured":"Waterhouse J, Minors D, Atkinson G, Benton D . Chronobiology and meal times: internal and external factors Br J Nutr 1997 77(Suppl 1): S29\u201338.","journal-title":"Br J Nutr"},{"key":"BF0801948_CR30","first-page":"313","volume-title":"Handbook of Obesity","author":"SF Leibowitz","year":"1997","unstructured":"Leibowitz SF, Hoebel BG . Behavioral neuroscience of obesity. In: Bray GA, Bouchard C, James WPT (eds). Handbook of Obesity Marcel Dekker: New York 1997 313\u2013358."},{"key":"BF0801948_CR31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/j.1550-8528.1998.tb00354.x","volume":"6","author":"JP Flatt","year":"1998","unstructured":"Flatt JP . What do we most need to learn about food intake regulation Obes Res 1998 6: 307\u2013310.","journal-title":"Obes Res"},{"key":"BF0801948_CR32","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/S0196-9781(98)00117-X","volume":"19","author":"CM Brown","year":"1998","unstructured":"Brown CM, Fletcher PJ, Coscina DV . Neuropeptide Y-induced operant responding for sucrose is not mediated by dopamine Peptides 1998 19: 1667\u20131673.","journal-title":"Peptides"},{"key":"BF0801948_CR33","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/S0196-9781(00)00270-9","volume":"21","author":"CM Brown","year":"2000","unstructured":"Brown CM, Coscina DV, Fletcher PJ . The rewarding properties of neuropeptide Y in perifornical hypothalamus vs. nucleus accumbens Peptides 2000 21: 1279\u20131287.","journal-title":"Peptides"},{"key":"BF0801948_CR34","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0167-0115(92)90514-U","volume":"41","author":"M Heilig","year":"1992","unstructured":"Heilig M, McLeod S, Koob GK, Britton KT . Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test Regul Pept 1992 41: 61\u201369.","journal-title":"Regul Pept"},{"key":"BF0801948_CR35","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/0196-9781(91)90215-B","volume":"12","author":"JF Flood","year":"1991","unstructured":"Flood JF, Morley JE . Increased food intake by neuropeptide Y is due to an increased motivation to eat Peptides 1991 12: 1329\u20131332.","journal-title":"Peptides"},{"key":"BF0801948_CR36","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/0031-9384(95)02074-8","volume":"58","author":"RJ Seeley","year":"1995","unstructured":"Seeley RJ, Benoit SC, Davidson TL . Discriminative cues produced by NPY do not generalize to the interoceptive cues produced by food deprivation Physiol Behav 1995 58: 1237\u20131241.","journal-title":"Physiol Behav"},{"key":"BF0801948_CR37","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0006-8993(91)90763-L","volume":"561","author":"DC Jewett","year":"1991","unstructured":"Jewett DC, Schaal DW, Cleary J, Thompson T, Levine AS . The discriminative stimulus effects of neuropeptide Y Brain Res 1991 561: 165\u2013168.","journal-title":"Brain Res"},{"key":"BF0801948_CR38","doi-asserted-by":"publisher","first-page":"R1627","DOI":"10.1152\/ajpregu.2000.278.6.R1627","volume":"278","author":"AA Ammar","year":"2000","unstructured":"Ammar AA, Sederholm F, Saito TR, Scheurink AJ, Johnson AE, Sodersten P . NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior Am J Physiol Regul Integr Comp Physiol 2000 278: R1627\u20131633.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BF0801948_CR39","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0031-9384(98)00221-2","volume":"65","author":"AM Altizer","year":"1999","unstructured":"Altizer AM, Davidson TL . The effects of NPY and 5-TG on responding to cues for fats and carbohydrates Physiol Behav 1999 65: 685\u2013690.","journal-title":"Physiol Behav"},{"key":"BF0801948_CR40","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0167-0115(98)00095-0","volume":"75\u201376","author":"SC Woods","year":"1998","unstructured":"Woods SC, Figlewicz DP, Madden L, Porte D Jr, Sipols AJ, Seeley RJ . NPY and food intake: discrepancies in the model Regul Pept 1998 75\u201376: 403\u2013408.","journal-title":"Regul Pept"},{"key":"BF0801948_CR41","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0031-9384(98)00050-X","volume":"64","author":"DeVacaS Cabeza","year":"1998","unstructured":"Cabeza De Vaca S, Holiman S, Carr KD . A search for the metabolic signal that sensitizes lateral hypothalmic self-stimulation in food restricted rats Physiol Behav 1998 64: 251\u2013260.","journal-title":"Physiol Behav"},{"key":"BF0801948_CR42","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/0031-9384(95)00100-W","volume":"58","author":"MM Hagan","year":"1995","unstructured":"Hagan MM, Moss DE . Effect of peptide YY (PYY) on food associated conflict Physiol Behav 1995 58: 731\u2013735.","journal-title":"Physiol Behav"},{"key":"BF0801948_CR43","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0278-5846(95)00306-1","volume":"20","author":"MC Mauri","year":"1996","unstructured":"Mauri MC, Rudelli R, Somaschini E, Roncoroni L, Papa R, Mantero M, Longhini M . Penati Neurobiological and psychopharmacological basis in the therapy of bulimia and anorexia Prog Neuropsychopharmac Biol Psychiat 1996 20: 207\u2013240.","journal-title":"Prog Neuropsychopharmac Biol Psychiat"},{"key":"BF0801948_CR44","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/0300-9629(93)90406-T","volume":"106","author":"N Pages","year":"1993","unstructured":"Pages N, Orosco M, Rouch C, Yao O, Jacquot C, Bohuon C . Refeeding after 72 hour fasting alters neuropeptide Y and monoamines in various cerebral areas in the rat Comp Biochem Physiol Comp Physiol 1993 106: 845\u2013849.","journal-title":"Comp Biochem Physiol Comp Physiol"},{"key":"BF0801948_CR45","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0091-3057(93)90282-X","volume":"44","author":"N Pages","year":"1993","unstructured":"Pages N, Orosco M, Rouch C, Yao O, Jacquot C, Bohuon C . Fasting affects more markedly neuropeptide Y than monoamines in the rat brain Pharmac Biochem Behav 1993 44: 71\u201375.","journal-title":"Pharmac Biochem Behav"},{"key":"BF0801948_CR46","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0006-8993(90)91664-3","volume":"528","author":"B Beck","year":"1990","unstructured":"Beck B, Jhanwar-Uniyal M, Burlet A, Chapleur-Chateau M, Leibowitz SF, Burlet C . Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status Brain Res 1990 528: 245\u2013249.","journal-title":"Brain Res"},{"key":"BF0801948_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0006-8993(97)81680-0","volume":"774","author":"PS Widdowson","year":"1997","unstructured":"Widdowson PS, Upton R, Henderson L, Buckingham R, Wilson S, Williams G . Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat Brain Res 1997 774: 1\u201310.","journal-title":"Brain Res"},{"key":"BF0801948_CR48","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0006-8993(97)00160-1","volume":"758","author":"PS Widdowson","year":"1997","unstructured":"Widdowson PS . Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 \u2018feeding\u2019 receptor Brain Res 1997 758: 17\u201325.","journal-title":"Brain Res"},{"key":"BF0801948_CR49","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1097\/00001756-199803090-00032","volume":"9","author":"XG Xin","year":"1998","unstructured":"Xin XG, Huang XF . Down-regulated NPY receptor subtype-5 mRNA expression in genetically obese mouse brain Neuroreport 1998 9: 737\u2013741.","journal-title":"Neuroreport"},{"key":"BF0801948_CR50","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1523\/JNEUROSCI.20-09-03442.2000","volume":"20","author":"SC Benoit","year":"2000","unstructured":"Benoit SC, Schwartz MW, Lachey JL, Hagan MM, Rushing PA, Blake KA, Yagaloff KA, Kurylko G, Franco L, Danhoo W, Seeley RJ . A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences J Neurosci 2000 20: 3442\u20133448.","journal-title":"J Neurosci"},{"key":"BF0801948_CR51","doi-asserted-by":"publisher","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","volume":"18","author":"C Peyron","year":"1998","unstructured":"Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS . Neurons containing hypocretin (orexin) project to multiple neuronal systems J Neurosci 1998 18: 9996\u201310015.","journal-title":"J Neurosci"},{"key":"BF0801948_CR52","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0006-8993(98)01349-3","volume":"818","author":"N Vrang","year":"1999","unstructured":"Vrang N, Tang-Christensen M, Larsen PJ, Kristensen P . Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour Brain Res 1999 818: 499\u2013509.","journal-title":"Brain Res"},{"key":"BF0801948_CR53","first-page":"R1096","volume":"271","author":"DijkG Van","year":"1996","unstructured":"Van Dijk G, Thiele TE, Donahey JC, Campfield LA, Smith FJ, Burn P, Bernstein IL, Woods SC, Seeley RJ . Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain Am J Physiol 1996 271: R1096\u20131100.","journal-title":"Am J Physiol"},{"key":"BF0801948_CR54","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/0361-9230(85)90100-5","volume":"14","author":"BG Stanley","year":"1985","unstructured":"Stanley BG, Chin AS, Leibowitz SF . Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action Brain Res Bull 1985 14: 521\u2013524.","journal-title":"Brain Res Bull"},{"key":"BF0801948_CR55","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/0361-9230(90)90090-M","volume":"24","author":"IS McGregor","year":"1990","unstructured":"McGregor IS, Menendez JA, Atrens DM . Metabolic effects of neuropeptide Y injected into the sulcal prefrontal cortex Brain Res Bull 1990 24: 363\u2013367.","journal-title":"Brain Res Bull"},{"key":"BF0801948_CR56","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0006-8993(98)00652-0","volume":"805","author":"MM Hagan","year":"1998","unstructured":"Hagan MM, Castaneda E, Sumaya IC, Fleming SM, Galloway J, Moss DE . The effect of hypothalamic peptide YY on hippocampal acetylcholine release in vivo: implications for limbic function in binge-eating behavior Brain Res 1998 805: 20\u201328.","journal-title":"Brain Res"},{"key":"BF0801948_CR57","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0091-3057(94)90001-9","volume":"47","author":"JL Steinman","year":"1994","unstructured":"Steinman JL, Gunion MW, Morley JE . Forebrain and hindbrain involvement of neuropeptide Y in ingestive behaviors of rats Pharmac Biochem Behav 1994 47: 207\u2013214.","journal-title":"Pharmac Biochem Behav"},{"key":"BF0801948_CR58","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0196-9781(97)00468-3","volume":"19","author":"SL Cummings","year":"1998","unstructured":"Cummings SL, Truong BG, Gietzen DW . Neuropeptide Y and somatostatin in the anterior piriform cortex alter intake of amino acid-deficient diets Peptides 1998 19: 527\u2013535.","journal-title":"Peptides"},{"key":"BF0801948_CR59","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0006-8993(94)91348-X","volume":"665","author":"BH Li","year":"1994","unstructured":"Li BH, Xu B, Rowland NE, Kalra SP . c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption Brain Res 1994 665: 277\u2013284.","journal-title":"Brain Res"},{"key":"BF0801948_CR60","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0006-8993(94)01224-6","volume":"670","author":"PD Lambert","year":"1995","unstructured":"Lambert PD, Phillips PJ, Wilding JP, Bloom SR, Herbert J . c-fos expression in the paraventricular nucleus of the hypothalamus following intracerebroventricular infusions of neuropeptide Y Brain Res 1995 670: 59\u201365.","journal-title":"Brain Res"},{"key":"BF0801948_CR61","first-page":"163","volume":"53","author":"RD Palmiter","year":"1998","unstructured":"Palmiter RD, Erickson JC, Hollopeter G, Baraban SC, Schwartz MW . Life without neuropeptide Y Rec Prog Horm Res 1998 53: 163\u2013199.","journal-title":"Rec Prog Horm Res"},{"key":"BF0801948_CR62","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0167-0115(97)01007-0","volume":"70","author":"JC Erickson","year":"1997","unstructured":"Erickson JC, Ahima RS, Hollopeter G, Flier JS, Palmiter RD . Endocrine function of neuropeptide Y knockout mice Regul Pept 1997 70: 199\u2013202.","journal-title":"Regul Pept"},{"key":"BF0801948_CR63","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0167-0115(98)00092-5","volume":"75\u201376","author":"G Hollopeter","year":"1998","unstructured":"Hollopeter G, Erickson JC, Seeley RJ, Marsh DJ, Palmiter RD . Response of neuropeptide Y-deficient mice to feeding effectors Regul Pept 1998 75\u201376: 383\u2013389.","journal-title":"Regul Pept"},{"key":"BF0801948_CR64","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0006-8993(00)02285-X","volume":"868","author":"AW Bannon","year":"2000","unstructured":"Bannon AW, Seda J, Carmouche M, Francis JM, Norman MH, Karbon B, McCaleb ML . Behavioral characterization of neuropeptide Y knockout mice Brain Res 2000 868: 79\u201387.","journal-title":"Brain Res"},{"key":"BF0801948_CR65","doi-asserted-by":"publisher","first-page":"8927","DOI":"10.1523\/JNEUROSCI.17-23-08927.1997","volume":"89","author":"SC Baraban","year":"1997","unstructured":"Baraban SC, Hollopeter G, Erickson JC, Schwartzkroin PA, Palmiter RD . Knock-out mice reveal a critical antiepileptic role for neuropeptide Y J Neurosci 1997 89: 8927\u20138936.","journal-title":"J Neurosci"},{"key":"BF0801948_CR66","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S0006-8993(99)01962-9","volume":"848","author":"DJ Marsh","year":"1999","unstructured":"Marsh DJ, Miura GI, Yagaloff KA, Schwartz MW, Barsh GS, Palmiter RD . Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues Brain Res 1999 848: 66\u201377.","journal-title":"Brain Res"},{"key":"BF0801948_CR67","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/0196-9781(92)90093-I","volume":"13","author":"BG Stanley","year":"1992","unstructured":"Stanley BG, Magdalin W, Seirafi A, Nguyen MM, Leibowitz SF . Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect Peptides 1992 13: 581\u2013587.","journal-title":"Peptides"},{"key":"BF0801948_CR68","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0006-8993(93)91727-A","volume":"601","author":"T Shibasaki","year":"1993","unstructured":"Shibasaki T, Oda T, Imaki T, Ling N, Demura H . Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats Brain Res 1993 601: 313\u2013316.","journal-title":"Brain Res"},{"key":"BF0801948_CR69","first-page":"301","volume":"78","author":"EV Borisova","year":"1991","unstructured":"Borisova EV, Kadar T, Telegdy G . Bimodal effect of neuropeptide Y on feeding, and its antagonism by receptor blocking agents in rats Acta Physiol Hung 1991 78: 301\u2013308.","journal-title":"Acta Physiol Hung"},{"key":"BF0801948_CR70","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0006-8993(95)00644-6","volume":"690","author":"MG Dube","year":"1995","unstructured":"Dube MG, Kalra PS, Crowley WR, Kalra SP . Evidence of a physiological role for neuropeptide Y in ventromedial hypothalamic lesion-induced hyperphagia Brain Res 1995 690: 275\u2013278.","journal-title":"Brain Res"},{"key":"BF0801948_CR71","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0006-8993(94)90103-1","volume":"646","author":"MG Dube","year":"1994","unstructured":"Dube MG, Xu B, Crowley WR, Kalra PS, Kalra SP . Evidence that neuropeptide Y is a physiological signal for normal food intake Brain Res 1994 646: 341\u2013344.","journal-title":"Brain Res"},{"key":"BF0801948_CR72","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S0006-8993(97)01310-3","volume":"781","author":"B He","year":"1998","unstructured":"He B, White BD, Edwards GL, Martin RJ . Neuropeptide Y antibody attenuates 2-deoxy-D-glucose induced feeding in rats Brain Res 1998 781: 348\u2013350.","journal-title":"Brain Res"},{"key":"BF0801948_CR73","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/0196-9781(94)90083-3","volume":"15","author":"MJ Walter","year":"1994","unstructured":"Walter MJ, Scherrer JF, Flood JF, Morley JE . Effects of localized injections of neuropeptide Y antibody on motor activity and other behaviors Peptides 1994 15: 607\u2013613.","journal-title":"Peptides"},{"key":"BF0801948_CR74","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0169-328X(94)90377-8","volume":"21","author":"A Akabayashi","year":"1994","unstructured":"Akabayashi A, Wahlestedt C, Alexander JT, Leibowitz SF . Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion Brain Res Mol Brain Res 1994 21: 55\u201361.","journal-title":"Brain Res Mol Brain Res"},{"key":"BF0801948_CR75","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1006\/meth.2000.1076","volume":"22","author":"PS Kalra","year":"2000","unstructured":"Kalra PS, Kalra SP . Use of antisense oligodeoxynucleotides to study the physiological functions of neuropeptide Y Methods 2000 22: 249\u2013254.","journal-title":"Methods"},{"key":"BF0801948_CR76","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1089\/oli.1.1997.7.575","volume":"7","author":"S Agrawal","year":"1997","unstructured":"Agrawal S, Zhao Q, Jiang Z, Oliver C, Giles H, Heath J, Serota D . Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats Antisense Nucleic Acid Drug Dev 1997 7: 575\u2013584.","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"BF0801948_CR77","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1677\/joe.0.1570169","volume":"157","author":"S Dryden","year":"1998","unstructured":"Dryden S, Pickavance L, Tidd D, Williams G . The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus J Endocrinol 1998 157: 169\u2013175.","journal-title":"J Endocrinol"},{"key":"BF0801948_CR78","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0167-0115(98)00096-2","volume":"75\u201376","author":"A Kanatani","year":"1998","unstructured":"Kanatani A, Ito J, Ishihara A, Iwaasa H, Fukuroda T, Fukami T, MacNeil DJ, Van der Ploeg LH, Ihara M . NPY-induced feeding involves the action of a Y1-like receptor in rodents Regul Pept 1998 75\u201376: 409\u2013415.","journal-title":"Regul Pept"},{"key":"BF0801948_CR79","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0196-9781(99)00044-3","volume":"20","author":"PS Widdowson","year":"1999","unstructured":"Widdowson PS, Henderson L, Pickavance L, Buckingham R, Tadayyon M, Arch JR, Williams G . Hypothalamic NPY status during positive energy balance and the effects of the NPY antagonist, BW 1229U91, on the consumption of highly palatable energy-rich diet Peptides 1999 20: 367\u2013372.","journal-title":"Peptides"},{"key":"BF0801948_CR80","first-page":"275","volume":"293","author":"DA Schober","year":"2000","unstructured":"Schober DA, Gackenheimer SL, Heiman ML, Gehlert DR . Pharmacological characterization of (125)I-1229U91 binding to Y1 and Y4 neuropeptide Y\/Peptide YY receptors J Pharmac Exp Ther 2000 293: 275\u2013280.","journal-title":"J Pharmac Exp Ther"},{"key":"BF0801948_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.bjp.0704049","volume":"133","author":"C Mollereau","year":"2001","unstructured":"Mollereau C, Gouarderes C, Dumont Y, Kotani M, Detheux M, Doods H, Parmentier M, Quirion R, Zajac JM . Agonists and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226 Br J Pharmac 2001 133: 1\u20134.","journal-title":"Br J Pharmac"},{"key":"BF0801948_CR82","first-page":"294","volume":"20","author":"AG Blomqvist","year":"1997","unstructured":"Blomqvist AG, Herzog H . Y-receptor subtypes-how many more? TINS 1997 20: 294\u2013298.","journal-title":"TINS"},{"key":"BF0801948_CR83","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S0196-9781(96)00347-6","volume":"18","author":"A Balasubramaniam","year":"1997","unstructured":"Balasubramaniam A . Neuropeptide Y family of hormones: receptor subtypes and antagonists Peptides 1997 18: 445\u2013457.","journal-title":"Peptides"},{"key":"BF0801948_CR84","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/B978-012304990-2\/50006-8","volume-title":"Neuropeptide Y and Drug Development","author":"Dan Larhammar","year":"1997","unstructured":"Larhammar D . Extraordinary structural diversity of NPYfamily receptors Academic Press: London 1997 88\u2013105."},{"key":"BF0801948_CR85","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/sj.bjp.0700883","volume":"120","author":"SR Glaum","year":"1997","unstructured":"Glaum SR, Miller RJ, Rhim H, Maclean D, Georgic LM, MacKenzie RG, Grundemar L . Characterisation of Y3 receptor-mediated synaptic inhibition by chimeric neuropeptide Y-peptide YY peptides in the rat brainstem Br J Pharmac 1997 120: 481\u2013487.","journal-title":"Br J Pharmac"},{"key":"BF0801948_CR86","doi-asserted-by":"publisher","first-page":"27217","DOI":"10.1074\/jbc.271.44.27217","volume":"271","author":"M Matsumoto","year":"1996","unstructured":"Matsumoto M, Nomura T, Momose K, Ideka Y, Kondou Y, Akiho H, Togami J, Kimura Y, Okada M, Yamaguchi T . Inactivation of a novel neuropeptide Y\/Peptide YY receptor gene in primate species J Biol Chem 1996 271: 27217\u201327220.","journal-title":"J Biol Chem"},{"key":"BF0801948_CR87","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1074\/jbc.272.6.3622","volume":"272","author":"PM Rose","year":"1997","unstructured":"Rose PM, Lynch JS, Frazier ST, Fisher SM, Chung W, Battaglino P, Fathi Z, Leibel R, Fernandes P . Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine Y5 receptor maybe a pseudogene J Biol Chem 1997 272: 3622\u20133627.","journal-title":"J Biol Chem"},{"key":"BF0801948_CR88","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0169-328X(97)00302-1","volume":"53","author":"AM Burkhoff","year":"1998","unstructured":"Burkhoff AM, Linemeyer DL, Salon JA . Distribution of a novel hypothalamic neuropeptide Y receptor gene and its absence in rat Mol Brain Res 1998 53: 311\u2013316.","journal-title":"Mol Brain Res"},{"key":"BF0801948_CR89","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0014-2999(00)00255-7","volume":"395","author":"DE Mullins","year":"2000","unstructured":"Mullins DE, Guzzi M, Xia L, Parker EM . Pharmacological characterisation of the cloned neuropeptide Y y6 receptor Eur J Pharmac 2000 395: 87\u201393.","journal-title":"Eur J Pharmac"},{"key":"BF0801948_CR90","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/S0169-328X(99)00152-7","volume":"70","author":"P Starb\u00e4ck","year":"1999","unstructured":"Starb\u00e4ck P, Lundell I, Fredriksson R, Berglund MM, Yan YL, Wraith A, S\u00f6derberg C, Postlethwait JH, Larhammar D . Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor Mol Brain Res 1999 70: 242\u2013252.","journal-title":"Mol Brain Res"},{"key":"BF0801948_CR91","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1006\/bbrc.1997.7886","volume":"241","author":"M Ringvall","year":"1997","unstructured":"Ringvall M, Berglund MM, Larhammar D . Multiplicity of neuropeptide Y receptors: cloning of a third distinct subtype in the zebrafish Biochem Biophys Res Commun 1997 241: 749\u2013755.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF0801948_CR92","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0167-0115(98)00051-2","volume":"75\u201376","author":"AK Arvidsson","year":"1998","unstructured":"Arvidsson AK, Wraith A, J\u00f6nsson-Rylander AC, Larhammar D . Cloning of neuropeptide Y\/peptide YY receptor from the atlantic cod: the Yb receptor Regul Peptides 1998 75\u201376: 39\u201343.","journal-title":"Regul Peptides"},{"key":"BF0801948_CR93","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1046\/j.1460-9568.1998.00350.x","volume":"10","author":"CP Tensen","year":"1998","unstructured":"Tensen CP, Cox KJA, Burke JF, Leurs R, van der Schors RC, Geraerts WPM, Vreugdenhil E, van Heerikhuizen H . Molecular cloning and characterization of an invertebrate homologue of a neuropeptide Y receptor Euro J Neurosci 1998 10: 3409\u20133416.","journal-title":"Euro J Neurosci"},{"key":"BF0801948_CR94","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0021-9258(18)48446-3","volume":"267","author":"XJ Li","year":"1992","unstructured":"Li XJ, Wu YN, North RA, Fortes M . Cloning, functional expres-sion, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster J Biol Chem 1992 267: 9\u201312.","journal-title":"J Biol Chem"},{"key":"BF0801948_CR95","volume-title":"NPY-Y7 receptor gene","author":"H Herzog","year":"2000","unstructured":"Herzog H . NPY-Y7 receptor gene International application published under the patent cooperation treaty (PCT). International publication number: WO 00\/00606 2000."},{"key":"BF0801948_CR96","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0169-328X(00)00052-8","volume":"77","author":"RMC Parker","year":"2000","unstructured":"Parker RMC, Copeland NG, Eyre HJ, Liu M, Gilbert DJ, Crawford J, Couzens M, Sutherland GR, Jenkins NA, Herzog H . Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family Mol Brain Res 2000 77: 199\u2013208.","journal-title":"Mol Brain Res"},{"key":"BF0801948_CR97","doi-asserted-by":"publisher","first-page":"6703","DOI":"10.1016\/S0021-9258(18)53306-8","volume":"268","author":"H Herzog","year":"1993","unstructured":"Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J . Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor J Biol Chem 1993 268: 6703\u20136707.","journal-title":"J Biol Chem"},{"key":"BF0801948_CR98","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1006\/geno.1997.4684","volume":"41","author":"H Herzog","year":"1997","unstructured":"Herzog H, Darby K, Ball H, Hort Y, Beck-Sickinger A, Shine J . Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation Genomics 1997 41: 315\u2013319.","journal-title":"Genomics"},{"key":"BF0801948_CR99","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1006\/geno.1997.4698","volume":"41","author":"CM Lutz","year":"1997","unstructured":"Lutz CM, Frankel WN, Richards JE, Thompson DA . Neuropeptide Y receptor genes on human chromosome 4q31-q32 Map to conserved linkage groups on mouse chromosomes 3 and 8 Genomics 1997 41: 498\u2013500.","journal-title":"Genomics"},{"key":"BF0801948_CR100","doi-asserted-by":"publisher","first-page":"27272","DOI":"10.1074\/jbc.270.45.27272","volume":"270","author":"HJ Ball","year":"1995","unstructured":"Ball HJ, Shine J, Herzog H . Multiple promoters regulate tissue-specific expression of the human NPY-Y1 receptor gene T J Biol Chem 1995 270: 27272\u201327276.","journal-title":"T J Biol Chem"},{"key":"BF0801948_CR101","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1006\/bbrc.1993.2334","volume":"196","author":"H Herzog","year":"1993","unstructured":"Herzog H, Selbie LA, Zee RYL, Morris B, Shine J . Neuropeptide-Y Y1 receptor gene polymorphism: cross-sectional analyses in essential hypertension and obesity Biochem Biophys Res Commun 1993 196: 902\u2013906.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF0801948_CR102","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1046\/j.1471-4159.1999.0730913.x","volume":"73","author":"EM Parker","year":"1999","unstructured":"Parker EM, Xia L . Extensive alternative splicing in the 5'-untranslated region of the rat and human neuropeptide Y Y5 receptor genes regulates receptor expression J Neurochem 1999 73: 913\u2013920.","journal-title":"J Neurochem"},{"key":"BF0801948_CR103","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s001250050732","volume":"40","author":"C Roche","year":"1997","unstructured":"Roche C, Boutin P, Dina C, Gyapay G, Basdevant A, Hager J, Guy-Grand B, Clement K, Froguel P . Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity Diabetologia 1997 40: 671\u2013675.","journal-title":"Diabetologia"},{"key":"BF0801948_CR104","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/sj.ijo.0800550","volume":"22","author":"K Rosenkranz","year":"1998","unstructured":"Rosenkranz K, Hinney A, Ziegler A, von Prittwitz S, Barth N, Roth H, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt M, Sch\u00e4fer H, Remschmidt H, Hebebrand J . Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes Int J Obes Relat Metab Disord 1998 22: 157\u2013163.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801948_CR105","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/sj.ijo.0801200","volume":"24","author":"CP Jenkinson","year":"2000","unstructured":"Jenkinson CP, Cray K, Walder K, Herzog H, Hanson R, Ravussin E . Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians Int J Obes Relat Metab Disord 2000 24: 580\u2013584.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801948_CR106","first-page":"2608","volume":"9","author":"DR Lynch","year":"1989","unstructured":"Lynch DR, Walker MW, Miller RJ, Snyder SH . Neuropeptide Y receptor binding sites in rat brain: differential autoradiographic localizations with 125I-peptide YY and 125I-neuropeptide Y imply receptor heterogeneity J Neuroscienc 1989 9: 2608\u20132612.","journal-title":"J Neuroscienc"},{"key":"BF0801948_CR107","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1097\/00007611-199808000-00002","volume":"91","author":"WSJr Poston","year":"1998","unstructured":"Poston WS Jr, Foreyt JP, Borrell L, Haddock CK . Challenges in obesity management South Med J 1998 91: 710\u2013720.","journal-title":"South Med J"},{"key":"BF0801948_CR108","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1006\/exnr.2000.7446","volume":"165","author":"MM Durkin","year":"2000","unstructured":"Durkin MM, Walker MW, Smith KE, Gustafson EL, Gerld C, Branchek TA . Expression of a novel neuropeptide Y receptor subtype involved in food intake: an in situ hybridization study of Y5 mRNA distribution in rat brains Exp Neurol 2000 165: 90\u2013100.","journal-title":"Exp Neurol"},{"key":"BF0801948_CR109","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1046\/j.1460-9568.1999.00553.x","volume":"11","author":"RM Parker","year":"1999","unstructured":"Parker RM, Herzog H . Regional distribution of Y-receptor subtype mRNAs in rat brain Eur J Neurosci 1999 11: 1431\u20131448.","journal-title":"Eur J Neurosci"},{"key":"BF0801948_CR110","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/B978-012304990-2\/50005-6","volume-title":"Neuropeptide Y and drug development","author":"Y Dumont","year":"1997","unstructured":"Dumont Y, Jacques D, St-Pierre J-A, Quirion R . Neuropeptide Y receptor subtypes in the mammalian brain: species differences and status in the human central nervous system. In: Grundemar L & Bloom SR (eds). Neuropeptide Y and drug development Academic Press: London 1997 57\u201386."},{"key":"BF0801948_CR111","first-page":"375","volume-title":"Handbook of chemical neuroanatomy","author":"Y Dumont","year":"2000","unstructured":"Dumont Y, Jacques D, St-Pierre J-A, Tong Y, Parker R, Herzog H, Quirion R . Neuropeptide Y, peptide YY and pancreatic polypeptide receptor proteins and mRNAs in mammalian brain. In: Quirion R, Bj\u00f6rklund A, H\u00f6kfelt T (eds). Handbook of chemical neuroanatomy 16: Elsevier: Amsterdam 2000 375\u2013475."},{"key":"BF0801948_CR112","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1097\/00001756-199603220-00013","volume":"7","author":"Y Dumont","year":"1996","unstructured":"Dumont Y, St-Pierre J-A, Quirion R . Comparative autoradiographic distribution of neuropeptide Y Y1 receptors visualized with the Y1 receptor agonist [125I][Leu31, Pro34] PYY and the non peptide antagonist [3H]BIBP3226 Neuroreport 1996 7: 901\u2013904.","journal-title":"Neuroreport"},{"key":"BF0801948_CR113","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0169-328X(97)00107-1","volume":"48","author":"Y Tong","year":"1997","unstructured":"Tong Y, Dumont Y, Shen SH, Quirion R . Comparative developmental profile of the neuropeptide Y Y1 receptor gene and protein in the rat brain Brain Res Mol Brain Res 1997 48: 323\u2013332.","journal-title":"Brain Res Mol Brain Res"},{"key":"BF0801948_CR114","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/S0306-4522(98)00089-X","volume":"86","author":"L Caberlotto","year":"1998","unstructured":"Caberlotto L, Tinner B, Brunneman B, Aagnati L, Fuxe K . On the relationship of neuropeptide Y Y1 receptor-immunoreactive neuronal structure to the neuropetide Y-immunoreactive nerve terminal networks. A double immunolabelling analysis in the rat brain Neuroscience 1998 86: 827\u2013845.","journal-title":"Neuroscience"},{"key":"BF0801948_CR115","doi-asserted-by":"publisher","first-page":"5565","DOI":"10.1523\/JNEUROSCI.18-15-05565.1998","volume":"18","author":"Y Dumont","year":"1998","unstructured":"Dumont Y, Fournier A, Quirion R . Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain J Neurosci 1998 18: 5565\u20135574.","journal-title":"J Neurosci"},{"key":"BF0801948_CR116","doi-asserted-by":"publisher","first-page":"13518","DOI":"10.1073\/pnas.96.23.13518","volume":"96","author":"DJ Marsh","year":"1999","unstructured":"Marsh DJ, Baraban SC, Hollopeter G, Palmiter RD . Role of the Y5 neuropeptide Y receptor in limbic seizures Proc Natl Acad Sci USA 1999 96: 13518\u201313523.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF0801948_CR117","doi-asserted-by":"publisher","first-page":"12852","DOI":"10.1073\/pnas.220232997","volume":"97","author":"A Thorsell","year":"2000","unstructured":"Thorsell A, Michalkiewicz M, Dumont Y, Quirion R, Caberlotto L, Rimondini R, Mathe AA, Heilig M . Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression Proc Natl Acad Sci USA 2000 97: 12852\u201312857.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF0801948_CR118","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S0167-0115(98)00089-5","volume":"75\u201376","author":"P Wyss","year":"1998","unstructured":"Wyss P, Stricker-Krongrad A, Brunner L, Miller J, Crossthwaite A, Whitebread S, Criscione L . The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes Regul Pept 1998 75\u201376: 363\u2013371.","journal-title":"Regul Pept"},{"key":"BF0801948_CR119","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/S0196-9781(00)00156-X","volume":"21","author":"EM Parker","year":"2000","unstructured":"Parker EM, Balasubramaniam A, Guzzi M, Mullins DE, Salisbury BG, Sheriff S, Witten MB, Hwa JJ . [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake Peptides 2000 21: 393\u2013399.","journal-title":"Peptides"},{"key":"BF0801948_CR120","doi-asserted-by":"publisher","first-page":"36043","DOI":"10.1074\/jbc.M000626200","volume":"275","author":"C Cabrele","year":"2000","unstructured":"Cabrele C, Langer M, Bader R, Wieland HA, Doods HN, Zerbe O, Beck-Sickinger AG . The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats J Biol Chem 2000 275: 36043\u201336048.","journal-title":"J Biol Chem"},{"key":"BF0801948_CR121","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0167-0115(99)00108-1","volume":"87","author":"K McCrea","year":"2000","unstructured":"McCrea K, Wisialowski T, Cabrele C, Church B, Beck-Sickinger A, Kraegen E, Herzog H . 2-36[K4,RYYSA(19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake Regul Pept 2000 87: 47\u201358.","journal-title":"Regul Pept"},{"key":"BF0801948_CR122","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nm0698-718","volume":"4","author":"DJ Marsh","year":"1998","unstructured":"Marsh DJ, Hollopeter G, Kafer KE, Palmiter RD . Role of the Y5 receptor in feeding and obesity Nature Med 1998 4: 718\u2013721.","journal-title":"Nature Med"},{"key":"BF0801948_CR123","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1152\/jn.2000.83.2.723","volume":"83","author":"MW Ho","year":"2000","unstructured":"Ho MW, Beck-Sickinger AG, Colmers WF . Neuropeptide Y(5) receptors reduce synaptic excitation in proximal subiculum, but not epileptiform activity in rat hippocampal slices J Neurophysiol 2000 83: 723\u2013734.","journal-title":"J Neurophysiol"},{"key":"BF0801948_CR124","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.2337\/diab.46.11.1792","volume":"46","author":"AO Schaffhauser","year":"1997","unstructured":"Schaffhauser AO, Stricker-Krongrad A, Brunner L, Cumin F, Gerald C, Whitebread S, Criscione L, Hofbauer KG . Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides Diabetes 1997 46: 1792\u20131798.","journal-title":"Diabetes"},{"key":"BF0801948_CR125","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1677\/joe.0.1590307","volume":"159","author":"M Tang-Christensen","year":"1998","unstructured":"Tang-Christensen M, Kristensen P, Stidsen CE, Brand CL, Larsen PJ . Central administration of Y5 receptor antisense decreases spontaneous food intake and attenuates feeding in response to exogenous neuropeptide Y J Endocrinol 1998 159: 307\u2013312.","journal-title":"J Endocrinol"},{"key":"BF0801948_CR126","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0031-9384(99)00031-1","volume":"66","author":"MC Flynn","year":"1999","unstructured":"Flynn MC, Turrin NP, Plata-Salaman CR, Ffrench-Mullen JM . Feeding response to neuropeptide Y-related compounds in rats treated with Y5 receptor antisense or sense phosphothiooligodeoxynucleotide Physiol Behav 1999 66: 881\u2013884.","journal-title":"Physiol Behav"},{"key":"BF0801948_CR127","unstructured":"Patent WO 9962892 to Novartis Pharmaceuticals"},{"key":"BF0801948_CR128","unstructured":"Patent WO 9827063 to Banyu Pharmaceuticals"},{"key":"BF0801948_CR129","unstructured":"Patent WO 0020376 to Ortho-McNeil Pharmaceuticals"},{"key":"BF0801948_CR130","unstructured":"Patent WO 9964394 to Schering Corporation"},{"key":"BF0801948_CR131","unstructured":"Patent WO 9835957 to Bayer Corporation"},{"key":"BF0801948_CR132","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.1021\/jm000269t","volume":"43","author":"MH Norman","year":"2000","unstructured":"Norman MH, Chen N, Chen Z, Fotsch C, Hale C, Han N, Hurt R, Jenkins T, Kincaid J, Liu L, Lu Y, Moreno O, Santora VJ, Sonnenberg JD, Karbon W . Structure\u2013activity relationships of a series of Pyrrolo[3, 2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists J Med Chem 2000 43: 4288\u20134312.","journal-title":"J Med Chem"},{"key":"BF0801948_CR133","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S0960-894X(00)00311-5","volume":"10","author":"JJ McNally","year":"2000","unstructured":"McNally JJ, Youngman MA, Lovenberg TW, Nepomuceno D, Wilson S, Dax SL . N-acylated alpha-(3-pyridylmethyl)-beta-aminotetralin antagoinists of the human neuropeptide Y Y5 receptor Bioorg Med Chem Lett 2000 10: 1641\u20131643.","journal-title":"Bioorg Med Chem Lett"},{"key":"BF0801948_CR134","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1172\/JCI4188","volume":"102","author":"L Criscione","year":"1998","unstructured":"Criscione L, Rigollier P, Batzl-Hartmann C, Rueger H, Stricker-Krongrad A, Wyss P, Brunner L, Whitebread S, Yamaguchi Y, Gerald C, Heurich RO, Walker MW, Chiesi M, Schilling W, Hofbauer KG, Levens N . Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor J Clin Invest 1998 102: 2136\u20132145.","journal-title":"J Clin Invest"},{"key":"BF0801948_CR135","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.ijo.0801190","volume":"24","author":"ZuanaO Della","year":"2000","unstructured":"Della Zuana O, Sadlo M, Germain M, F\u00e9l\u00e9tou M, Chamorro S, Tisserand F, de Montrion C, Boivin JF, Duhault J, Boutin JA, Levens N . Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade Int J Obes Relat Metab Disord 2000 24: 1\u201311.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0801948_CR136","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/S0899-9007(00)00449-4","volume":"16","author":"MM Meguid","year":"2000","unstructured":"Meguid MM, Fetissov SO, Varma M, Sato T, Zhang L, Laviano A, Rossi-Fanelli F . Hypothalamic dopamine and serotonin in the regulation of food intake Nutrition 2000 16: 843\u2013857.","journal-title":"Nutrition"},{"key":"BF0801948_CR137","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0014-2999(96)00935-1","volume":"321","author":"MR Zarrindast","year":"1997","unstructured":"Zarrindast MR, Oveisi MR . Effects of monoamine receptor antagonists on nicotine-induced hypophagia in the rat Eur J Pharmac 1997 321: 157\u2013162.","journal-title":"Eur J Pharmac"},{"key":"BF0801948_CR138","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/S0899-9007(00)00415-9","volume":"16","author":"PJ Wellman","year":"2000","unstructured":"Wellman PJ . Norepinephrine and the control of food intake Nutrition 2000 16: 837\u2013842.","journal-title":"Nutrition"},{"key":"BF0801948_CR139","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0014-2999(01)00768-3","volume":"414","author":"A Kask","year":"2001","unstructured":"Kask A, Vasar E, Heidmets LT, Allikmets L, Wikberg JE . Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat Eur J Pharmac 2001 414: 215\u2013224.","journal-title":"Eur J Pharmac"},{"key":"BF0801948_CR140","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1046\/j.1365-2826.2000.00526.x","volume":"12","author":"S Pu","year":"2000","unstructured":"Pu S, Dhillon H, Moldawer LL, Kalra PS, Kalra SP . Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor J Neuroendocrinol 2000 12: 827\u2013832.","journal-title":"J Neuroendocrinol"},{"key":"BF0801948_CR141","unstructured":"Patent Fast-Alert December 24, 1999."},{"key":"BF0801948_CR142","unstructured":"Patent Fast-Alert October 9, 1998."},{"key":"BF0801948_CR143","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1006\/bbrc.2000.2696","volume":"272","author":"A Kanatani","year":"2000","unstructured":"Kanatani A, Ishihara A, Iwaasa H, Nakamura K, Okamoto O, Hidaka M, Ito J, Fukuroda T, MacNeil DJ, Van der Ploeg LH, Ishii Y, Okabe T, Fukami T, Ihara M . L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist Biochem Biophys Res Commun 2000 272: 169\u2013173.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF0801948_CR144","volume-title":"Abstract presented at the 6th International NPY Conference","author":"A Kanatani","year":"2001","unstructured":"Kanatani A, Fukami T, Ishihara A, Ishii Y, MacNeil DJ, Van der Ploeg LHT, Ihara K . Anorexigenic effects of orally-active NPY antagonists: participation of Y1 and Y5 receptors in feeding behavior Abstract presented at the 6th International NPY Conference Sydney, Australia April 2001."},{"key":"BF0801948_CR145","volume-title":"Abstract presented at the 6th International NPY Conference","author":"RL Elliott","year":"2001","unstructured":"Elliott RL, Oliver RM, Hammond M, Patterson TA, She L, Hargrove DM, Martin KA, Maurer TS, Kalvass JC, Morgan BM, DaSilva-Jardine P, Stevenson RW, Mack C, Cassella J . The in vitro and in vivo characterization of 3-{2-[6-(2-tert-butoxyethoxy)-pyridin-3-yl]-1H-imidazol-4-yl}-benzonitrile (I), a potent and selective NPY Y5 antagonist Abstract presented at the 6th International NPY Conference Sydney, Australia April 2001."},{"key":"BF0801948_CR146","volume-title":"Abstract presented at the 6th International NPY Conference","author":"OrtizAA Antal-Zimanyi,","year":"2001","unstructured":"Antal-Zimanyi, Ortiz AA, Rassnick S, Hogan JB, Huang Y, Bruce MA, Gillman KW, Poindexter GS . Evidence supporting the role of the Y1, but not the Y5 receptor in food intake in rats Abstract presented at the 6th International NPY Conference Sydney, Australia April 2001."},{"key":"BF0801948_CR147","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S0167-0115(98)00088-3","volume":"75\u201376","author":"AC Haynes","year":"1998","unstructured":"Haynes AC, Arch JR, Wilson S, McClue S, Buckingham RE . Characterization of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor? Regul Pept 1998 75\u201376: 355\u2013361.","journal-title":"Regul Pept"},{"key":"BF0801948_CR148","doi-asserted-by":"publisher","first-page":"2828","DOI":"10.1046\/j.1432-1327.2001.02161.x","volume":"268","author":"RM Soll","year":"2001","unstructured":"Soll RM, Dinger MC, Lundell I, Larhammer D, Beck-Sickinger AG . Novel analogues of neuropeptide Y with a preference for the Y1-receptor Eur J Biochem 2001 268: 2828\u20132837.","journal-title":"Eur J Biochem"},{"key":"BF0801948_CR149","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/13514","volume":"5","author":"P Naveilhan","year":"1999","unstructured":"Naveilhan P, Hassani H, Canals JM, Ekstrand AJ, Larefalk A, Chhajlani V, Arenas E, Gedda K, Svensson L, Thoren P, Ernfors P . Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor Nature Med 1999 5: 1188\u20131193.","journal-title":"Nature Med"},{"key":"BF0801948_CR150","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1159\/000127265","volume":"66","author":"C Broberger","year":"1997","unstructured":"Broberger C, Landry M, Wong H, Walsh JN, Hokfelt T . Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus Neuroendocrinology 1997 66: 393\u2013408.","journal-title":"Neuroendocrinology"},{"key":"BF0801948_CR151","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/sj.bjp.0703162","volume":"129","author":"Y Dumont","year":"2000","unstructured":"Dumont Y, Cadieux A, Doods H, Pheng LH, Abounader R, Hamel E, Jacques D, Regoli D, Quirion R . BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist Br J Pharmac 2000 129: 1075\u20131088.","journal-title":"Br J Pharmac"},{"key":"BF0801948_CR152","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/382168a0","volume":"382","author":"C Gerald","year":"1996","unstructured":"Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank R . A receptor subtype involved in neuropeptide-Y-induced food intake Nature 1996 382: 168\u2013171.","journal-title":"Nature"},{"key":"BF0801948_CR153","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1034\/j.1399-3011.2000.00788.x","volume":"56","author":"Y Takebayashi","year":"2000","unstructured":"Takebayashi Y, Koga H, Togami J, Inui A, Kurihara H, Koshiya K, Furuya T, Tanaka A, Murase K . Design of the Y1-receptor-selective cyclic peptide based on the C-terminal sequence of neuropeptide Y J Pept Res 2000 56: 409\u2013415.","journal-title":"J Pept Res"},{"key":"BF0801948_CR154","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1210\/endo.141.3.7387","volume":"141","author":"A Kanatani","year":"2000","unstructured":"Kanatani A, Mashiko S, Murai N, Sugimoto N, Ito J, Fukuroda T, Fukami T, Morin N, MacNeil DJ, Vand der Ploeg LH, Saga Y, Nishimura S, Ihara M . Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice Endocrinology 2000 141: 1011\u20131016.","journal-title":"Endocrinology"},{"key":"BF0801948_CR155","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nm0698-722","volume":"4","author":"T Pedrazzini","year":"1998","unstructured":"Pedrazzini T, Seydoux J, Kunstner P, Aubert JF, Grouzmann E, Beermann T, Brunner HR . Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor Nature Med 1998 4: 722\u2013726.","journal-title":"Nature Med"},{"key":"BF0801948_CR156","doi-asserted-by":"publisher","first-page":"15659","DOI":"10.1073\/pnas.95.26.15659","volume":"95","author":"A Kushi","year":"1998","unstructured":"Kushi A, Sasai H, Koizumi H, Takeda N, Yokoyama M, Nakamura M . Obesity and mild hyperinsulinemia found in neuropeptide-Y1 receptor-deficient mice Proc Natl Acad Sci USA 1998 95: 15659\u201315664.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF0801948_CR157","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S0006-8993(99)01974-5","volume":"848","author":"DG Baskin","year":"1999","unstructured":"Baskin DG, Figlewicz Lattermann D, Seeley RJ, Woods SC, Porte D Jr, Schwartz MW . Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight Brain Res 1999 848: 114\u2013123.","journal-title":"Brain Res"},{"key":"BF0801948_CR158","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0167-0115(95)00103-I","volume":"59","author":"M Heilig","year":"1995","unstructured":"Heilig M . Antisense inhibition of neuropeptide Y (NPY)-Y1 receptor expression blocks the anxiolytic-like action of NPY in amigdala and paradoxically increases feeding Regul Pept 1995 59: 201\u2013205.","journal-title":"Regul Pept"},{"key":"BF0801948_CR159","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0167-0115(98)00097-4","volume":"75\u201376","author":"AO Schaffhauser","year":"1998","unstructured":"Schaffhauser AO, Whitebread S, Haener R, Hofbauer KG, Stricker-Krongrad A . Neuropeptide Y Y1 receptor antisense oligodeoxynucleotides enhance food intake in energy-deprived rats Regul Pept 1998 75\u201376: 417\u2013423.","journal-title":"Regul Pept"},{"key":"BF0801948_CR160","first-page":"343","volume":"7","author":"FJ Lopez-Valpuesta","year":"1996","unstructured":"Lopez-Valpuesta FJ, Nyce JW, Myers RD . NPY-Y1 receptor antisense injected centrally in rats caused hyperthermia and feeding Neuropharmac Neurotoxicol 1996 7: 343\u2013368.","journal-title":"Neuropharmac Neurotoxicol"},{"key":"BF0801948_CR161","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1098\/rspb.1996.0130","volume":"263","author":"FJ Lopez-Valpuesta","year":"1996","unstructured":"Lopez-Valpuesta FJ, Nyce JW, Griffin-Biggs TA, Ice JC, Myers RD . Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats Proc R Soc Lond B Biol Sci 1996 263: 881\u2013886.","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"BF0801948_CR162","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0167-0115(96)00074-2","volume":"65","author":"HN Doods","year":"1996","unstructured":"Doods HN, Wieland HA, Engel W, Eberlein W, Willim K-D, Enteroth M, Wienen W, Rudolf K . BIBP 3226, the first selective neuropeptide Y1 receptor antagonist: a review of its pharmacological properties Regul Pept 1996 65: 71\u201377.","journal-title":"Regul Pept"},{"key":"BF0801948_CR163","doi-asserted-by":"publisher","first-page":"R11","DOI":"10.1016\/0014-2999(94)90822-2","volume":"271","author":"K Rudolf","year":"1994","unstructured":"Rudolf K, Eberlein W, Engel W, Wieland HA, Willim K, Entzeroth M, Wienen W, Beck-Sickinger AG, Doods HN . The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP 3226 Eur J Pharmac 1994 271: R11\u201313.","journal-title":"Eur J Pharmac"},{"key":"BF0801948_CR164","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1038\/sj.bjp.0701969","volume":"124","author":"A Kask","year":"1998","unstructured":"Kask A, Rago L, Harro J . Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226 Br J Pharmac 1998 124: 1507\u20131515.","journal-title":"Br J Pharmac"},{"key":"BF0801948_CR165","doi-asserted-by":"publisher","first-page":"R3","DOI":"10.1016\/S0014-2999(96)00838-2","volume":"317","author":"A Kask","year":"1996","unstructured":"Kask A, R\u00e4go L, Harro J . Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP 3226: antagonism with diazepam Eur J Pharmac 1996 317: R3\u20134.","journal-title":"Eur J Pharmac"},{"key":"BF0801948_CR166","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/sj.bjp.0702084","volume":"125","author":"HA Wieland","year":"1998","unstructured":"Wieland HA, Engel W, Eberlein W, Rudolf K, Doods HN . Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents Br J Pharmac 1998 125: 549\u2013555.","journal-title":"Br J Pharmac"},{"key":"BF0801948_CR167","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1006\/bbrc.1999.1750","volume":"266","author":"A Kanatani","year":"1999","unstructured":"Kanatani A, Kanno T, Ishihara M, Sakuraba A, Tanaka T, Tsuchiya Y, Mase T, Fukuroda T, Fukami T, Ihara M . The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability Biochem Biophys Res Commun 1999 266: 88\u201391.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF0801948_CR168","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1124\/mol.59.3.501","volume":"59","author":"A Kanatani","year":"2001","unstructured":"Kanatani A, Hata M, Mashiko S, Ishihara A, Okamoto O, Haga Y, Ohe T, Kanno T, Murai N, Ishii Y, Fukuroda T, Fukami T, Ihara M . A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814 Mol Pharmac 2001 59: 501\u2013505.","journal-title":"Mol Pharmac"},{"key":"BF0801948_CR169","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1139\/y99-131","volume":"78","author":"J Duhault","year":"2000","unstructured":"Duhault J, Boulanger M, Chamorro S, Boutin JA, Della Zuana Odile, Douillet E, Fauchere J-L, Feletou M, Germain M, Husson B, Vega Monge A, Renard P, Tisserand F . Food intake regulation in rodents: Y5 or Y1 NPY receptors or both? Can J Physiol Pharmacol 2000 78: 173\u2013185.","journal-title":"Can J Physiol Pharmacol"},{"key":"BF0801948_CR170","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1139\/y99-119","volume":"78","author":"Y Dumont","year":"2000","unstructured":"Dumont Y, Cadieux A, Doods H, Fournier A, Quiron R . Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIBO3304 (Y1) and CGP71683A (Y5) Can J Physiol Pharmac 2000 78: 116\u2013125.","journal-title":"Can J Physiol Pharmac"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/0801948.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/0801948","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/0801948.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:03:36Z","timestamp":1650326616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/0801948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":170,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3,1]]}},"alternative-id":["BF0801948"],"URL":"https:\/\/doi.org\/10.1038\/sj.ijo.0801948","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,1]]},"assertion":[{"value":"1 January 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2002","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}