{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:11:44Z","timestamp":1791418304905,"version":"4.3.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2002,9,27]],"date-time":"2002-09-27T00:00:00Z","timestamp":1033084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1038\/sj.ijo.0802079","type":"journal-article","created":{"date-parts":[[2002,10,15]],"date-time":"2002-10-15T10:59:52Z","timestamp":1034679592000},"page":"1289-1295","source":"Crossref","is-referenced-by-count":173,"title":["Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague\u2013Dawley rats"],"prefix":"10.1038","volume":"26","author":[{"given":"O","family":"Della-Zuana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Presse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ortola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Duhault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JL","family":"Nahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Levens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,9,27]]},"reference":[{"key":"BF0802079_CR1","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1210\/endo-125-3-1660","volume":"125","author":"JM Vaughan","year":"1989","unstructured":"Vaughan JM, Fischer WH, Hoeger C, Rivier J, Vale W . Characterization of melanin-concentrating hormone from rat hypothalamus Endocrinology 1989 125: 1660\u20131665.","journal-title":"Endocrinology"},{"key":"BF0802079_CR2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/cne.903190204","volume":"319","author":"JC Bittencourt","year":"1992","unstructured":"Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, Vale W, Sawchenko PE . The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization J Comp Neurol 1992 319: 218\u2013245.","journal-title":"J Comp Neurol"},{"key":"BF0802079_CR3","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1054\/npep.1999.0055","volume":"33","author":"NA Tritos","year":"1999","unstructured":"Tritos NA, Maratos-Flier E . Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone Neuropeptides 1999 33: 339\u2013349.","journal-title":"Neuropeptides"},{"key":"BF0802079_CR4","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/25341","volume":"396","author":"M Shimada","year":"1998","unstructured":"Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E . Mice lacking melanin concentrating hormone are hypophagic and lean Nature 1998 396: 670\u2013674.","journal-title":"Nature"},{"key":"BF0802079_CR5","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.0.CO;2-R","volume":"402","author":"CF Elias","year":"1998","unstructured":"Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK . Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area Comp Neurol 1998 402: 442\u2013459.","journal-title":"Comp Neurol"},{"key":"BF0802079_CR6","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1210\/endo.138.1.4887","volume":"138","author":"M Rossi","year":"1997","unstructured":"Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR . Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight Endocrinology 1997 138: 351\u2013356.","journal-title":"Endocrinology"},{"key":"BF0802079_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/380243a0","volume":"380","author":"D Qu","year":"1996","unstructured":"Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R, Maratos-Flier E . A role for melanin-concentrating hormone in the central regulation of feeding behaviour Nature 1996 380: 243\u2013247.","journal-title":"Nature"},{"key":"BF0802079_CR8","doi-asserted-by":"publisher","first-page":"4739","DOI":"10.1210\/endo.139.11.6432","volume":"139","author":"A Sahu","year":"1998","unstructured":"Sahu A . Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat Endocrinology 1998 139: 4739\u20134742.","journal-title":"Endocrinology"},{"key":"BF0802079_CR9","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S0006-8993(99)02005-3","volume":"846","author":"M Rossi","year":"1999","unstructured":"Rossi M, Beak SA, Choi SJ, Small CJ, Morgan DG, Ghatei MA, Smith DM, Bloom SR . Investigation of the feeding effects of melanin concentrating hormone on food intake\u2014action independent of galanin and the melanocortin receptors Brain Res 1999 846: 164\u2013170.","journal-title":"Brain Res"},{"key":"BF0802079_CR10","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/0306-4522(95)00481-5","volume":"71","author":"F Presse","year":"1996","unstructured":"Presse F, Sorokovsky I, Max JP, Nicolaidis S, Nahon JL . Melanin-concentrating hormone is a potent anorectic peptide regulated by food-deprivation and glucopenia in the rat Neuroscience 1996 71: 735\u2013745.","journal-title":"Neuroscience"},{"key":"BF0802079_CR11","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1172\/JCI10660","volume":"107","author":"DS Ludwig","year":"2001","unstructured":"Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E . Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance J Clin Invest 2001 107: 379\u2013386.","journal-title":"J Clin Invest"},{"key":"BF0802079_CR12","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/00075197-199811000-00015","volume":"1","author":"L Brunner","year":"1998","unstructured":"Brunner L, Levens N . The regulatory role of leptin in food intake Curr Opin Clin Nutr Metab Care 1998 1: 565\u2013571.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"BF0802079_CR13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0006-8993(99)01977-0","volume":"848","author":"C Broberger","year":"1999","unstructured":"Broberger C . Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin\/hypocretin and neuropeptide Y Brain Res 1999 848: 101\u2013113.","journal-title":"Brain Res"},{"key":"BF0802079_CR14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0896-6273(00)81084-3","volume":"22","author":"JK Elmquist","year":"1999","unstructured":"Elmquist JK, Elias CF, Saper CB . From lesions to leptin: hypothalamic control of food-intake and body weight Neuron 1999 22: 221\u2013232.","journal-title":"Neuron"},{"key":"BF0802079_CR15","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/00001756-200001170-00023","volume":"11","author":"V Sergeyev","year":"2000","unstructured":"Sergeyev V, Broberger C, Gorbatyuk O, Hokfelt T . Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin\/orexin in the rat hypothalamus Neuroreport 2000 11: 117\u2013121.","journal-title":"Neuroreport"},{"key":"BF0802079_CR16","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.2337\/diabetes.47.11.1687","volume":"47","author":"NA Tritos","year":"1998","unstructured":"Tritos NA, Vicent D, Gillette J, Ludwig DS, Flier ES, Maratos-Flier E . Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus Diabetes 1998 47: 1687\u20131692.","journal-title":"Diabetes"},{"key":"BF0802079_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/35065604","volume":"410","author":"M Yamada","year":"2000","unstructured":"Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R, Ogawa M, Chou CJ, Xia B, Crawley JN, Felder CC, Deng C-X, Wess J . Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean Nature 2000 410: 207\u2013212.","journal-title":"Nature"},{"key":"BF0802079_CR18","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/j.1471-4159.1966.tb09873.x","volume":"13","author":"J Glowinski","year":"1966","unstructured":"Glowinski J, Iversen LL . Regional studies of catecholamines in the rat brain. I. The disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain J. Neurochem 1966 13: 655\u2013669.","journal-title":"J. Neurochem"},{"key":"BF0802079_CR19","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1210\/endo.131.3.1505462","volume":"131","author":"F Presse","year":"1992","unstructured":"Presse F, Hervieu G, Imaki T, Sawchenko PE, Vale W, Nahon JL . Rat melanin-concentrating hormone messenger ribonucleic acid expression: marked changes during development and after stress and glucocorticoid stimuli Endocrinology 1992 131: 1241\u20131250.","journal-title":"Endocrinology"},{"key":"BF0802079_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cne.1191","volume":"435","author":"Y Saito","year":"2001","unstructured":"Saito Y, Cheng M, Leslie FM, Civelli O . Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain J Comp Neurol 2001 435: 1\u20135.","journal-title":"J Comp Neurol"},{"key":"BF0802079_CR21","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1055\/s-2007-1018767","volume":"15","author":"ER Kuhn","year":"1983","unstructured":"Kuhn ER, Bellon K, Huybrechts L, Heyns W . Endocrine differences between the Wistar and Sprague\u2013Dawley laboratory rat: influence of cold adaptation Horm Metab Res 1983 15: 491\u2013498.","journal-title":"Horm Metab Res"},{"key":"BF0802079_CR22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/sj.ijo.0801948","volume":"26","author":"S Chamorro","year":"2002","unstructured":"Chamorro S, Della-Zuana O, Fauch\u00e8re J-L, F\u00e9l\u00e9tou M, Galizzi J-P, Levens N . Appetite suppression based on selective inhibition of NPY receptors Int J Obes Relat Metab Disord 2002 26: 281\u2013298.","journal-title":"Int J Obes Relat Metab Disord"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/0802079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0802079","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0802079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:24:27Z","timestamp":1684221867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/0802079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,27]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["BF0802079"],"URL":"https:\/\/doi.org\/10.1038\/sj.ijo.0802079","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,27]]}}}