{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:10:39Z","timestamp":1787242239269,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1038\/sj.ijo.0802919","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T04:30:27Z","timestamp":1115872227000},"page":"571-578","source":"Crossref","is-referenced-by-count":61,"title":["Insulin resistance and impaired glucose tolerance in obese children and adolescents referred to a tertiary-care center in Israel"],"prefix":"10.1038","volume":"29","author":[{"given":"S","family":"Shalitin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Abrahami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lilos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Phillip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,3,1]]},"reference":[{"issue":"Suppl 4","key":"BF0802919_CR1","doi-asserted-by":"publisher","first-page":"239s","DOI":"10.1038\/oby.2001.125","volume":"9","author":"RJ Deckelbaum","year":"2001","unstructured":"Deckelbaum RJ, Williams CL . Childhood obesity: the health issue. Obes Rev 2001; 9 (Suppl 4): 239s\u2013243s.","journal-title":"Obes Rev"},{"key":"BF0802919_CR2","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1001\/jama.288.14.1728","volume":"288","author":"CL Ogden","year":"2002","unstructured":"Ogden CL, Flegal KM, Carroll MD, Johnson CL . Prevalence and trends in overweight among US children and adolescents, 1999\u20132000. JAMA 2002; 288: 1728\u20131732.","journal-title":"JAMA"},{"key":"BF0802919_CR3","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/35007508","volume":"404","author":"PG Kopelman","year":"2000","unstructured":"Kopelman PG . Obesity as a medical problem. Nature 2000; 404: 635\u2013643.","journal-title":"Nature"},{"key":"BF0802919_CR4","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/S0022-3476(96)80124-7","volume":"128","author":"O Pinhas-Hamiel","year":"1996","unstructured":"Pinhas-Hamiel O, Dolan LM, Daniels SR . Increased incidence of non-insulin dependent diabetes mellitus among adolescents. J Pediatr 1996; 128: 608\u2013615.","journal-title":"J Pediatr"},{"issue":"suppl 6","key":"BF0802919_CR5","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1515\/jpem-2000-s612","volume":"13","author":"SA Arslanian","year":"2000","unstructured":"Arslanian SA . Type 2 diabetes mellitus in children: pathophysiology and risk factors. J Pediatr Endocrinol Metab 2000; 13 (suppl 6): 1385\u20131394.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"BF0802919_CR6","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care 2000; 23: 381\u2013389.","DOI":"10.2337\/diacare.23.3.381"},{"key":"BF0802919_CR7","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1007\/s001250050603","volume":"12","author":"S Caprio","year":"1996","unstructured":"Caprio S, Bronson M, Sherwin RS, Rife F, Tamborlane WV . Co-existence of severe insulin resistance and hyperinsulinemia in pre- adolescent obese children. Diabetologia 1996; 12: 1489\u20131497.","journal-title":"Diabetologia"},{"key":"BF0802919_CR8","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.2337\/diabetes.48.10.2039","volume":"48","author":"A Moran","year":"1999","unstructured":"Moran A, Jacobs DR, Steinberger J, Hong CP, Prineas R, Luepker RV, Sinaiko AR . Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 1999; 48: 2039\u20132044.","journal-title":"Diabetes"},{"key":"BF0802919_CR9","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1056\/NEJM199603213341207","volume":"334","author":"KS Polonsky","year":"1996","unstructured":"Polonsky KS, Sturis J, Bell GI . Non-insulin dependent diabetes mellitus\u2014a genetically programmed failure of the beta cell to complete for insulin resistence. N Engl J Med 1996; 334: 777\u2013783.","journal-title":"N Engl J Med"},{"key":"BF0802919_CR10","doi-asserted-by":"publisher","first-page":"701","DOI":"10.2337\/diab.46.4.701","volume":"46","author":"SL Edelstein","year":"1997","unstructured":"Edelstein SL, Knowler WC, Bain RP, Andres R, Barrett-Connor EL, Dowse GK, Haffner SM, Pettitt DJ, Sorkin JD, Muller DC, Collins VR, Hamman RF . Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes 1997; 46: 701\u2013710.","journal-title":"Diabetes"},{"key":"BF0802919_CR11","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1001\/jama.1990.03440210043030","volume":"263","author":"SM Haffner","year":"1990","unstructured":"Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK . Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 1990; 263: 2893\u20132899.","journal-title":"JAMA"},{"key":"BF0802919_CR12","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1056\/NEJMoa012578","volume":"346","author":"R Sinha","year":"2002","unstructured":"Sinha R, Fisch G, Teague B, Tabborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S . Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002; 346: 802\u2013810.","journal-title":"N Engl J Med"},{"key":"BF0802919_CR13","doi-asserted-by":"publisher","first-page":"118","DOI":"10.2337\/diacare.26.1.118","volume":"26","author":"C Invitti","year":"2003","unstructured":"Invitti C, Guzzaloni G, Gilardini L, Morabito F, Viberti G . Prevalence and concomitants of glucose intolerance in European obese children and adolescents. Diabetes Care 2003; 26: 118\u2013124.","journal-title":"Diabetes Care"},{"key":"BF0802919_CR14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1136\/adc.44.235.291","volume":"44","author":"WA Marshall","year":"1969","unstructured":"Marshall WA, Tanner JM . Variations in the pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291\u2013303.","journal-title":"Arch Dis Child"},{"key":"BF0802919_CR15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1136\/adc.45.239.13","volume":"45","author":"WA Marshall","year":"1970","unstructured":"Marshall WA, Tanner JM . Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 12\u201323.","journal-title":"Arch Dis Child"},{"key":"BF0802919_CR16","doi-asserted-by":"publisher","first-page":"E29","DOI":"10.1542\/peds.102.3.e29","volume":"102","author":"SE Barlow","year":"1998","unstructured":"Barlow SE, Dietz WH . Obesity evaluation and treatment: Expert Committee recommendations. The Maternal and Child Health Bureau, Health Resources and Services Administration and the Department of Health and Human Services. Pediatrics 1998; 102: E29.","journal-title":"Pediatrics"},{"key":"BF0802919_CR17","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. Screening for type 2 diabetes. Diabetes Care 2004; 27 (Suppl 1): S11\u2013S14.","DOI":"10.2337\/diacare.27.2007.S11"},{"key":"BF0802919_CR18","first-page":"E214","volume":"237","author":"RA De Fronzo","year":"1979","unstructured":"De Fronzo RA, Tobin JD, Andres R . Glucose clamp technique: a method for quantifying insulin secretion and resistence. Am J Physiol 1979; 237: E214\u2013E223.","journal-title":"Am J Physiol"},{"key":"BF0802919_CR19","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.2337\/diacare.25.11.2081","volume":"25","author":"GI Uwaifo","year":"2002","unstructured":"Uwaifo GI, Fallon EM, Chin J, Elberg J, Parikh SJ, Yanovski JA . Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care 2002; 25: 2081\u20132087.","journal-title":"Diabetes Care"},{"key":"BF0802919_CR20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2337\/diacare.23.1.57","volume":"23","author":"E Bonora","year":"2000","unstructured":"Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M . Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000; 23: 57\u201363.","journal-title":"Diabetes Care"},{"key":"BF0802919_CR21","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412\u2013419.","journal-title":"Diabetologia"},{"key":"BF0802919_CR22","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","volume":"85","author":"A Katz","year":"2000","unstructured":"Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ . Quantitative Insulin Sensitivity Check Index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402\u20132410.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF0802919_CR23","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1210\/jcem.87.1.8292","volume":"87","author":"J Hrebicek","year":"2002","unstructured":"Hrebicek J, Janout V, Malincikova J, Horakova D, Cizek L . Detection of insulin resistance by simple Quantitative Insulin Sensitivity Check Index (QUICKI) for epidemiological assessment and prevention. J Clin Endocrinol Metab 2002; 87: 144\u2013147.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF0802919_CR24","volume-title":"BMDP. Statistical Software","author":"WJ Dixon","year":"1993","unstructured":"Dixon WJ . BMDP. Statistical Software. University of California Press: Berkeley, CA; 1993."},{"key":"BF0802919_CR25","doi-asserted-by":"crossref","unstructured":"Update on the 1987. Task Force Report on High Blood Pressure in Children and Adolescents. A working group report from the National High Blood Pressure Education Program. Pediatrics 1996; 98: 649\u2013658.","DOI":"10.1542\/peds.98.4.649"},{"key":"BF0802919_CR26","unstructured":"NGHS Coordinating Center. NHLBI Growth and Health Study (NGHS) data monitoring report. Baltimore: Maryland Medical Research; 1998."},{"key":"BF0802919_CR27","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1007\/s001250051215","volume":"42","author":"MP Hermans","year":"1999","unstructured":"Hermans MP, Levy JC, Morris RJ, Turner RC . Comparison of insulin sensitivity tests across a range of glucose tolerance from normal to diabetes. Diabetologia 1999; 42: 678\u2013687.","journal-title":"Diabetologia"},{"key":"BF0802919_CR28","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1053\/meta.2002.34029","volume":"51","author":"G Guzzaloni","year":"2002","unstructured":"Guzzaloni G, Grugni G, Mazzilli G, Moro D, Morabito F . Comparison between \u03b2-cell function and insulin resistance indexes in prepubertal and pubertal obese children. Metabolism 2002; 51: 1011\u20131016.","journal-title":"Metabolism"},{"key":"BF0802919_CR29","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1210\/jc.2002-021442","volume":"88","author":"MI Goran","year":"2003","unstructured":"Goran MI, Ball GDC, Cruz ML . Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. J Clin Endocrinol Metab 2003; 88: 1417\u20131427.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF0802919_CR30","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/0026-0495(86)90135-6","volume":"35","author":"GL Burke","year":"1986","unstructured":"Burke GL, Webber LS, Srinivasan SR, Radhakrishnamurthy B, Freedman DS, Berenson GS . Fasting plasma glucose and insulin levels and their relashionship to cardiovascular risk factors in children: Bogalusa Heart Study. Metabolism 1986; 35: 441\u2013446.","journal-title":"Metabolism"},{"key":"BF0802919_CR31","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.2337\/diacare.25.12.2184","volume":"25","author":"MI Goran","year":"2002","unstructured":"Goran MI, Bergman RN, Cruz ML, Watanabe RM . Insulin resistance and associated compensatory responses in African-American and Hispanic children. Diabetes Care 2002; 25: 2184\u20132190.","journal-title":"Diabetes Care"},{"key":"BF0802919_CR32","doi-asserted-by":"publisher","first-page":"909","DOI":"10.7326\/0003-4819-113-12-909","volume":"113","author":"JH Warram","year":"1990","unstructured":"Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR . Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 1990; 113: 909\u2013915.","journal-title":"Ann Intern Med"},{"key":"BF0802919_CR33","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1053\/meta.2003.50065","volume":"52","author":"SR Srinivasan","year":"2003","unstructured":"Srinivasan SR, Frontini MG, Berenson GS . Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes: The Bogalusa Heart Study. Metabolism 2003; 52: 443\u2013450.","journal-title":"Metabolism"},{"key":"BF0802919_CR34","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1210\/jc.2002-020917","volume":"88","author":"MI Goran","year":"2003","unstructured":"Goran MI, Coronges K, Bergman RN, Cruz ML, Gower B . Influence of family history of type 2 diabetes on insulin sensitivity in prepubertal children. J Clin Endocrinol Metab 2003; 88: 192\u2013195.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF0802919_CR35","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/S0022-3476(89)80438-X","volume":"114","author":"S Caprio","year":"1989","unstructured":"Caprio S, Plewe G, Diamond MP, Simonson DC, Boulward SD, Sherwin RS, Tamborlane V . Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity. J Pediatr 1989; 114: 963\u2013967.","journal-title":"J Pediatr"},{"key":"BF0802919_CR36","doi-asserted-by":"publisher","first-page":"908","DOI":"10.2337\/diab.43.7.908","volume":"43","author":"SA Arslanian","year":"1995","unstructured":"Arslanian SA, Kalhan SC . Correlations between fatty acid and glucose metabolism: potential explanation of insulin resistance of puberty. Diabetes 1995; 43: 908\u2013914.","journal-title":"Diabetes"},{"key":"BF0802919_CR37","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1067\/mpd.2001.118535","volume":"139","author":"AR Sinaiko","year":"2001","unstructured":"Sinaiko AR, Jacobs Jr DR, Steinberger J, Moran A, Luepker R, Rocchini AP, Prineas RJ . Insulin resistance syndrome in childhood: associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors. J Pediatr 2001; 139: 700\u2013707.","journal-title":"J Pediatr"},{"key":"BF0802919_CR38","first-page":"523","volume":"89","author":"CA Stuart","year":"1997","unstructured":"Stuart CA, Gilkison CR, Keenan BS, Nagamani M . Hyperinsulinemia and acanthosis nigricans in African Americans. J Natl Med Assoc 1997; 89: 523\u2013527.","journal-title":"J Natl Med Assoc"},{"key":"BF0802919_CR39","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1067\/mpd.2001.112657","volume":"138","author":"TT Nguyen","year":"2001","unstructured":"Nguyen TT, Keil MF, Russell DL, Pathomvanich A, Uwaifo GI, Sebring NG, Reynolds JC, Yanovski JA . Relation of acanthosis nigricans to hyperinsulinemia and insulin sensitivity in overweight African American and white children. J Pediatr 2001; 138: 474\u2013480.","journal-title":"J Pediatr"},{"key":"BF0802919_CR40","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/0026-0495(90)90002-T","volume":"39","author":"RC Bonadonna","year":"1990","unstructured":"Bonadonna RC, Groop L, Kraemer N, Ferrannini E, Del Prato S, DeFronzo RA . Obesity and insulin resistance in humans: a dose response study. Metabolism 1990; 39: 452\u2013459.","journal-title":"Metabolism"},{"key":"BF0802919_CR41","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1097\/00001573-199609000-00007","volume":"11","author":"KM Rexrode","year":"1996","unstructured":"Rexrode KM, Manson JE, Hennekens CH . Obesity and cardiovascular disease. Curr Opin Cardiol 1996; 11: 490\u2013495.","journal-title":"Curr Opin Cardiol"},{"key":"BF0802919_CR42","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/0140-6736(92)92814-V","volume":"340","author":"BC Martin","year":"1992","unstructured":"Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR . Role of glucose and insulin resistance in development of type 2 diabetes: results of a 25-year follow-up study. Lancet 1992; 340: 925\u2013929.","journal-title":"Lancet"},{"key":"BF0802919_CR43","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1056\/NEJM199312303292703","volume":"329","author":"S Lillioja","year":"1993","unstructured":"Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennett PH, Bogardus C . Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians. N Engl J Med 1993; 329: 1988\u20131992.","journal-title":"N Engl J Med"},{"key":"BF0802919_CR44","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1001\/archinte.1995.00430020078010","volume":"155","author":"X Jiang","year":"1995","unstructured":"Jiang X, Srinivasan SR, Webber LS, Wattigney WA, Berenson GS . Association of fasting insulin level with serum lipid and lipoprotein levels in children, adolescents, and young adults: the Bogalusa Heart Study. Arch Intern Med 1995; 155: 190\u2013196.","journal-title":"Arch Intern Med"},{"key":"BF0802919_CR45","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1210\/jcem.83.8.5005","volume":"83","author":"J Yip","year":"1998","unstructured":"Yip J, Facchini F, Reaven GM . Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab 1998; 83: 2773\u20132776.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF0802919_CR46","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1136\/bmj.317.7154.319","volume":"317","author":"M Vanhala","year":"1998","unstructured":"Vanhala M, Vanhala P, Kumpusalo E . Relation between obesity from childhood to adulthood and the metabolic syndrome: population based study. BMJ 1998; 317: 319.","journal-title":"BMJ"},{"key":"BF0802919_CR47","doi-asserted-by":"publisher","first-page":"390","DOI":"10.2337\/diacare.19.4.390","volume":"19","author":"GF Lewis","year":"1996","unstructured":"Lewis GF, Steiner G . Acute effects of insulin in the control of VLDL production in humans. Implications for the insulin-resistant state. Diabetes Care 1996; 19: 390\u2013393.","journal-title":"Diabetes Care"},{"key":"BF0802919_CR48","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3109\/07853899709002451","volume":"27","author":"P Arner","year":"1995","unstructured":"Arner P . Differences in lipolysis between human subcutaneous and omental adipose tissues. Ann Med 1995; 27: 435\u2013438.","journal-title":"Ann Med"},{"key":"BF0802919_CR49","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0022-2275(20)36957-1","volume":"34","author":"AR Tall","year":"1993","unstructured":"Tall AR . Plasma cholesteryl ester transfer protein. J Lipid Res 1993; 34: 1255\u20131274.","journal-title":"J Lipid Res"},{"key":"BF0802919_CR50","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1093\/ajcn\/55.6.1033","volume":"155","author":"D Spigelman","year":"1992","unstructured":"Spigelman D, Israel RG, Rouchard C, Willet WC . Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? Am J Clin Nutr 1992; 155: 1033\u20131044.","journal-title":"Am J Clin Nutr"},{"key":"BF0802919_CR51","first-page":"189","volume":"12","author":"Z Josefsberg","year":"1976","unstructured":"Josefsberg Z, Vilunski E, Hanukuglu A, Bialik O, Brown M, Karp M, Laron Z . Glucose and insulin responses to an oral glucose load in normal children and adolescents in Israel. Isr J Med Sci 1976; 12: 189\u2013194.","journal-title":"Isr J Med Sci"},{"key":"BF0802919_CR52","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1172\/JCI119628","volume":"100","author":"E Ferrannini","year":"1997","unstructured":"Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G . Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest 1997; 100: 1166\u20131173.","journal-title":"J Clin Invest"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/0802919.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0802919","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0802919.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T03:33:30Z","timestamp":1684208010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/0802919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,1]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["BF0802919"],"URL":"https:\/\/doi.org\/10.1038\/sj.ijo.0802919","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,1]]}}}