{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:18:05Z","timestamp":1791155885644,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1038\/sj.ijo.0803271","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T12:23:31Z","timestamp":1143635011000},"page":"S7-S12","source":"Crossref","is-referenced-by-count":116,"title":["Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake"],"prefix":"10.1038","volume":"30","author":[{"name":"Endocannabinoid Research Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Matias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Di Marzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"BF0803271_CR1","first-page":"605","volume":"34","author":"WA Devane","year":"1988","unstructured":"Devane WA, Dysarz FA, Johnson MR, Melvin LS, Howlett AC . Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 1988; 34: 605\u2013613.","journal-title":"Mol Pharmacol"},{"key":"BF0803271_CR2","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1021\/ja01062a046","volume":"86","author":"Y Gaoni","year":"1964","unstructured":"Gaoni Y, Mechoulam R . Isolation, structure, and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964; 86: 1646\u20131647.","journal-title":"J Am Chem Soc"},{"key":"BF0803271_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/365061a0","volume":"365","author":"S Munro","year":"1993","unstructured":"Munro S, Thomas KL, Abu-Shaar M . Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993; 365: 61\u201365.","journal-title":"Nature"},{"key":"BF0803271_CR4","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.brainresrev.2003.11.005","volume":"45","author":"JM McPartland","year":"2004","unstructured":"McPartland JM . Phylogenomic and chemotaxonomic analysis of the endocannabinoid system. Brain Res Rev 2004; 45: 18\u201329.","journal-title":"Brain Res Rev"},{"key":"BF0803271_CR5","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1126\/science.1470919","volume":"258","author":"WA Devane","year":"1992","unstructured":"Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992; 258: 1946\u20131949.","journal-title":"Science"},{"key":"BF0803271_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","volume":"50","author":"R Mechoulam","year":"1995","unstructured":"Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 1995; 50: 83\u201390.","journal-title":"Biochem Pharmacol"},{"key":"BF0803271_CR7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1006\/bbrc.1995.2437","volume":"215","author":"T Sugiura","year":"1995","unstructured":"Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 1995; 215: 89\u201397.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF0803271_CR8","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0165-6147(00)01805-8","volume":"22","author":"E Schlicker","year":"2001","unstructured":"Schlicker E, Kathmann M . Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol Sci 2001; 22: 565\u2013572.","journal-title":"Trends Pharmacol Sci"},{"key":"BF0803271_CR9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1172\/JCI17725","volume":"112","author":"D Cota","year":"2003","unstructured":"Cota D, Marsicano G, Tschop M, Grubler Y, Flachskamm C, Schubert M et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 2003; 112: 423\u2013431.","journal-title":"J Clin Invest"},{"key":"BF0803271_CR10","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1126\/science.1063545","volume":"296","author":"RI Wilson","year":"2002","unstructured":"Wilson RI, Nicoll RA . Endocannabinoid signaling in the brain. Science 2002; 296: 678\u2013682.","journal-title":"Science"},{"key":"BF0803271_CR11","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrd1495","volume":"3","author":"V Di Marzo","year":"2004","unstructured":"Di Marzo V, Bifulco M, De Petrocellis L . The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 2004; 3: 771\u2013784.","journal-title":"Nat Rev Drug Discov"},{"key":"BF0803271_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/384083a0","volume":"384","author":"BF Cravatt","year":"1996","unstructured":"Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB . Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 1996; 384: 83\u201387.","journal-title":"Nature"},{"key":"BF0803271_CR13","doi-asserted-by":"publisher","first-page":"10819","DOI":"10.1073\/pnas.152334899","volume":"99","author":"TP Dinh","year":"2002","unstructured":"Dinh TP, Carpenter D, Leslie FM, Freund TF, Katona I, Sensi SL et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci USA 2002; 99: 10819\u201310824.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF0803271_CR14","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1083\/jcb.200305129","volume":"163","author":"T Bisogno","year":"2003","unstructured":"Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A et al. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol 2003; 163: 463\u2013478.","journal-title":"J Cell Biol"},{"key":"BF0803271_CR15","doi-asserted-by":"publisher","first-page":"5298","DOI":"10.1074\/jbc.M306642200","volume":"279","author":"Y Okamoto","year":"2004","unstructured":"Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N . Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem 2004; 279: 5298\u20135305.","journal-title":"J Biol Chem"},{"key":"BF0803271_CR16","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S0896-6273(03)00235-6","volume":"38","author":"V Chevaleyre","year":"2003","unstructured":"Chevaleyre V, Castillo PE . Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability. Neuron 2003; 38: 461\u2013472.","journal-title":"Neuron"},{"key":"BF0803271_CR17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.pharmthera.2004.07.008","volume":"104","author":"MJ McFarland","year":"2004","unstructured":"McFarland MJ, Barker EL . Anandamide transport. Pharmacol Ther 2004; 104: 117\u2013135.","journal-title":"Pharmacol Ther"},{"key":"BF0803271_CR18","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0024-3205(99)00282-9","volume":"65","author":"RG Pertwee","year":"1999","unstructured":"Pertwee RG . Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors. Life Sci 1999; 65: 597\u2013605.","journal-title":"Life Sci"},{"key":"BF0803271_CR19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0306-4522(98)00749-0","volume":"92","author":"L De Petrocellis","year":"1999","unstructured":"De Petrocellis L, Melck D, Bisogno T, Milone A, Di Marzo V . Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response. Neuroscience 1999; 92: 377\u2013387.","journal-title":"Neuroscience"},{"key":"BF0803271_CR20","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1111\/j.1471-4159.2005.03103.x","volume":"93","author":"I Matias","year":"2005","unstructured":"Matias I, McPartland JM, Di Marzo V . Occurrence and Possible Biological Role of the Endocannabinoid System in the Sea Squirt Ciona intestinalis. J Neurochem 2005; 93: 1141\u20131156.","journal-title":"J Neurochem"},{"key":"BF0803271_CR21","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1111\/j.1471-4159.2005.03406.x","volume":"95","author":"M Valenti","year":"2005","unstructured":"Valenti M, Cottone E, Martinez R, De Pedro N, Rubio M, Viveros MP et al. The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake. J Neurochem 2005; 95: 662\u2013672.","journal-title":"J Neurochem"},{"key":"BF0803271_CR22","doi-asserted-by":"publisher","first-page":"10013","DOI":"10.1523\/JNEUROSCI.3298-04.2004","volume":"24","author":"K Soderstrom","year":"2004","unstructured":"Soderstrom K, Tian Q, Valenti M, Di Marzo V . Endocannabinoids link feeding state and auditory perception-related gene expression. J Neurosci 2004; 24: 10013\u201310021.","journal-title":"J Neurosci"},{"key":"BF0803271_CR23","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/35071088","volume":"410","author":"V Di Marzo","year":"2001","unstructured":"Di Marzo V, Goparaju SK, Wang L, Liu J, Batkai S, Jarai Z et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 2001; 410: 822\u2013825.","journal-title":"Nature"},{"key":"BF0803271_CR24","doi-asserted-by":"publisher","first-page":"32726","DOI":"10.1074\/jbc.M302123200","volume":"278","author":"M Maccarrone","year":"2003","unstructured":"Maccarrone M, Bari M, Di Rienzo M, Finazzi-Agro A, Rossi A . Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. J Biol Chem 2003; 278: 32726\u201332732.","journal-title":"J Biol Chem"},{"key":"BF0803271_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/molehr\/gah130","volume":"11","author":"M Maccarrone","year":"2004","unstructured":"Maccarrone M, Fride E, Bisogno T, Bari M, Cascio MG, Battista N et al. Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob\/ob) mice and implications for fertility. Mol Hum Reprod 2004; 11: 21\u201328.","journal-title":"Mol Hum Reprod"},{"key":"BF0803271_CR26","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/sj.ijo.0802583","volume":"28","author":"C Ravinet Trillou","year":"2004","unstructured":"Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrie P . CB1 cannabinoid receptor knockout in mice leads to leanness, resistence to diet-induced obesity and enhanced leptin sensitivity. Int J Obes Relat Metab Disord 2004; 28: 640\u2013648.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BF0803271_CR27","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/sj.bjp.0705968","volume":"143","author":"SA Tucci","year":"2004","unstructured":"Tucci SA, Rogers EK, Korbonits M, Kirkham TC . The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin. Br J Pharmacol 2004; 143: 520\u2013533.","journal-title":"Br J Pharmacol"},{"key":"BF0803271_CR28","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1079\/BJN20041256","volume":"92","author":"PD Cani","year":"2004","unstructured":"Cani PD, Montoya ML, Neyrinck AM, Delzenne NM, Lambert DM . Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide. Br J Nutr 2004; 92: 757\u2013761.","journal-title":"Br J Nutr"},{"key":"BF0803271_CR29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/sj.bjp.0704767","volume":"136","author":"TC Kirkham","year":"2002","unstructured":"Kirkham TC, Williams CM, Fezza F, Di Marzo V . Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 2002; 136: 550\u2013557.","journal-title":"Br J Pharmacol"},{"key":"BF0803271_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejphar.2003.10.012","volume":"483","author":"J De Vry","year":"2004","unstructured":"De Vry J, Schreiber R, Eckel G, Jentzsch KR . Behavioral mechanisms underlying inhibition of food-maintained responding by the cannabinoid receptor antagonist\/inverse agonist SR141716A. Eur J Pharmacol 2004; 483: 55\u201363.","journal-title":"Eur J Pharmacol"},{"key":"BF0803271_CR31","doi-asserted-by":"publisher","first-page":"6402","DOI":"10.1073\/pnas.101119098","volume":"98","author":"A Berger","year":"2001","unstructured":"Berger A, Crozier G, Bisogno T, Cavaliere P, Innis S, Di Marzo V . Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. Proc Natl Acad Sci USA 2001; 98: 6402\u20136406.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF0803271_CR32","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0952-3278(03)00056-5","volume":"69","author":"S Watanabe","year":"2003","unstructured":"Watanabe S, Doshi M, Hamazaki T . n-3 Polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in mice. Prostaglandins Leukot Essent Fatty Acids 2003; 69: 51\u201359.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"BF0803271_CR33","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S0006-8993(03)03046-4","volume":"983","author":"L Hanus","year":"2003","unstructured":"Hanus L, Avraham Y, Ben-Shushan D, Zolotarev O, Berry EM, Mechoulam R . Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain. Brain Res 2003; 983: 144\u2013151.","journal-title":"Brain Res"},{"key":"BF0803271_CR34","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/s000180300031","volume":"60","author":"I Matias","year":"2003","unstructured":"Matias I, Leonhardt M, Lesage J, De Petrocellis L, Dupouy JP, Vieau D et al. Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels. Cell Mol Life Sci 2003; 60: 382\u2013389.","journal-title":"Cell Mol Life Sci"},{"key":"BF0803271_CR35","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/sj.npp.1300695","volume":"30","author":"P Monteleone","year":"2005","unstructured":"Monteleone P, Matias I, Martiadis V, De Petrocellis L, Maj M, Di Marzo V . Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge eating disorder, but not in bulimia nervosa. Neuropsychopharmacology 2005; 30: 1216\u20131221.","journal-title":"Neuropsychopharmacology"},{"key":"BF0803271_CR36","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nn1457","volume":"8","author":"V Di Marzo","year":"2005","unstructured":"Di Marzo V, Matias I . Endocannabinoid control of food intake and energy balance. Nat Neurosci 2005; 8: 585\u2013589.","journal-title":"Nat Neurosci"},{"key":"BF0803271_CR37","doi-asserted-by":"crossref","unstructured":"Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R . The emerging role of the endocannabinoid system in endocrine regulation and energy balance, 2005; Nov 23; [E-pub ahead of print].","DOI":"10.1210\/er.2005-0009"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/0803271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0803271","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/0803271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:37:38Z","timestamp":1684222658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/0803271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,29]]},"references-count":37,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["BF0803271"],"URL":"https:\/\/doi.org\/10.1038\/sj.ijo.0803271","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,29]]}}}