{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:25:00Z","timestamp":1777793100342,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>Hemiparesis is the most common deficit after cerebral stroke. Constraint-induced movement therapy (CIMT) is a new neurorehabilitation method that emphasizes task-relevant repetitive training for the stroke hand. Twelve chronic stroke patients were studied with single-photon emission computerized tomography at rest before and after the two-week CIMT period. Increased perfusion was found in motor control related areas. The specific areas with an increase in perfusion in the affected hemisphere were in the precentral gyrus, premotor cortex (Brodmann's area 6 (BA6)), frontal cortex, and superior frontal gyrus (BA10). In the nonaffected hemisphere, perfusion was increased in the superior frontal gyrus (BA6) and cingulate gyrus (BA31). In the cerebellum increased perfusion was seen bilaterally. The brain areas with increased perfusion receive and integrate the information from different sensory systems and plan the movement execution. Regional cerebral perfusion decreased in the lingual gyrus (BA18) in the affected hemisphere. In the nonaffected frontal cortex, two areas with decreased perfusion were found in the middle frontal gyrus (BA8\/10). Also, the fusiform gyrus (BA20) and inferior temporal gyrus (BA37) in the non-affected hemisphere showed decreased perfusion. Intensive movement therapy appears to change local cerebral perfusion in areas known to participate in movement planning and execution. These changes might be a sign of active reorganization processes after CIMT in the chronic state of stroke.<\/jats:p>","DOI":"10.1038\/sj.jcbfm.9600158","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T10:26:42Z","timestamp":1117621602000},"page":"1668-1674","source":"Crossref","is-referenced-by-count":36,"title":["Increased Perfusion in Motor Areas after Constraint-Induced Movement Therapy in Chronic Stroke: A Single-Photon Emission Computerized Tomography Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Mervi","family":"K\u00f6n\u00f6nen","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland"},{"name":"Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyrki T","family":"Kuikka","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland"},{"name":"Niuvanniemi Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Husso-Saastamoinen","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esko","family":"Vanninen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritva","family":"Vanninen","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Soimakallio","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esa","family":"Mervaala","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhani","family":"Sivenius","sequence":"additional","affiliation":[{"name":"Brain Research and Rehabilitation Center Neuron, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kauko","family":"Pitk\u00e4nen","sequence":"additional","affiliation":[{"name":"Brain Research and Rehabilitation Center Neuron, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina M","family":"Tarkka","sequence":"additional","affiliation":[{"name":"Brain Research and Rehabilitation Center Neuron, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"bibr1-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290112"},{"key":"bibr2-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199807000-00003"},{"key":"bibr3-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227183"},{"key":"bibr4-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.4.1017"},{"key":"bibr5-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200301200-00025"},{"key":"bibr6-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf282"},{"key":"bibr7-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2004.45.2.241"},{"key":"bibr8-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199306000-00013"},{"key":"bibr9-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(99)90163-6"},{"key":"bibr10-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.6.1210"},{"key":"bibr11-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.3.586"},{"key":"bibr12-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0757"},{"key":"bibr13-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5269.1791"},{"key":"bibr14-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(99)00022-X"},{"key":"bibr15-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1999.3934"},{"key":"bibr16-sj.jcbfm.9600158","doi-asserted-by":"publisher","DOI":"10.1177\/154596830201600403"},{"key":"bibr17-sj.jcbfm.9600158","doi-asserted-by":"crossref","unstructured":"Tarkka IM, Pitk\u00e4nen K, Sivenius J (2005) Paretic stroke hand rehabilitation with constraint-induced movement therapy. 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