{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:37:18Z","timestamp":1791261438600,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>In the adult rodent, stroke induces an increase in endogenous neural progenitor cell (NPC) proliferation in the subventricular zone (SVZ) and neuroblasts migrate towards the ischemic boundary. We investigated the role of stromal cell-derived factor 1\u03b1 (SDF-1\u03b1) in mediating NPC migration after stroke. We found that cultured NPCs harvested from the normal adult SVZ, when they were overlaid onto stroke brain slices, exhibited significantly ( P &gt; 0.01) increased migration (67.2 \u00b1 25.2 \u03bcm) compared with the migration on normal brain slices (29.5729.5 \u03bcm). Immunohistochemistry showed that CXCR 4, a receptor of SDF-1\u03b1, is expressed in the NPCs and migrating neuroblasts in stroke brain. Blocking SDF-1\u03b1 by a neutralizing antibody against CXCR 4 significantly attenuated stroke-enhanced NPC migration. ELISA analysis revealed that SDF-1\u03b1 levels significantly increased ( P &gt; 0.01) in the stroke hemisphere (43.6 \u00b1 6.5 pg\/mg) when compared with the normal brain (25.2\u00b1 1.9 pg\/mg). Blind-well chamber assays showed that SDF-1\u03b1 enhanced NPC migration in a dose-dependent manner with maximum migration at a dose of 500ng\/mL. In addition, SDF-1\u03b1 induced directionally selective migration. These findings show that SDF-1\u03b1 generated in the stroke hemisphere may guide NPC migration towards the ischemic boundary via binding to its receptor CXCR 4 in the NPC. Thus, our data indicate that SDF-1\u03b1\/CXCR 4 is important for mediating specific migration of NPCs to the site of ischemic damaged neurons.<\/jats:p>","DOI":"10.1038\/sj.jcbfm.9600172","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T10:25:09Z","timestamp":1118831109000},"page":"125-134","source":"Crossref","is-referenced-by-count":261,"title":["Stromal Cell-Derived Factor 1\u03b1 Mediates Neural Progenitor Cell Motility after Focal Cerebral Ischemia"],"prefix":"10.1177","volume":"26","author":[{"given":"Adam M","family":"Robin","sequence":"first","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng G","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui L","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Katakowski","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"},{"name":"Oakland University, Physics Department, Rochester, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chopp","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Neurology Department, Detroit, Michigan, USA"},{"name":"Oakland University, Physics Department, Rochester, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,1,1]]},"reference":[{"key":"bibr1-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00191-X"},{"key":"bibr2-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"bibr3-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.18.4249"},{"key":"bibr4-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.7000"},{"key":"bibr5-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(02)00416-7"},{"key":"bibr6-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-13-05046.1997"},{"key":"bibr7-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199808)36:2<234::AID-NEU10>3.0.CO;2-E"},{"key":"bibr8-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.1.84"},{"key":"bibr9-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408258102"},{"key":"bibr10-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10775"},{"key":"bibr11-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092013799"},{"key":"bibr12-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9448"},{"key":"bibr13-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90046-9"},{"key":"bibr14-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00425-X"},{"key":"bibr15-sj.jcbfm.9600172","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10393"},{"key":"bibr16-sj.jcbfm.9600172","unstructured":"Paxinos G, Watson C, (eds) (1986) The rat brain in stereotaxic coordinates. 2nd ed. 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