{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:23:14Z","timestamp":1777792994506,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>\n                    The hippocampus is injured in both hypoxia\u2014ischemia (HI) and perinatal iron deficiency that are co-morbidities in infants of diabetic mothers and intrauterine growth restricted infants. We hypothesized that preexisting perinatal iron deficiency predisposes the hippocampus to greater injury when exposed to a relatively mild HI injury. Iron-sufficient and iron-deficient rats (hematocrit 40% lower and brain iron concentration 55% lower) were subjected to unilateral HI injury of 15, 30, or 45 mins ( n = 12 to 13\/HI duration) on postnatal day 14. Sixteen metabolite concentrations were measured from an 11 \/\/L volume on the ipsilateral (HI) and contralateral (control) hippocampi 1 week later using in vivo\n                    <jats:sup>1<\/jats:sup>\n                    H NMR spectroscopy. The concentrations of creatine, glutamate, myo-inositol, and N-acetylaspartate were lower on the control side in the iron-deficient group ( P &lt; 0.02, each). Magnetic resonance imaging showed hippocampal injury in the majority of the iron-deficient rats (58% versus 11%, P &lt; 0.0001) with worsening severity with increasing durations of HI ( P = 0.0001). Glucose, glutamate, N-acetylaspartate, and taurine concentrations were decreased and glutamine, lactate and myo-inositol concentrations, and glutamate\/glutamine ratio were increased on the HI side in the iron-deficient group ( P &lt; 0.01, each), mainly in the 30 and 45 mins HI subgroups ( P &lt; 0.02, each). These neurochemical changes likely reflect the histochemically detected neuronal injury and reactive astrocytosis in the iron-deficient group and suggest that perinatal iron deficiency predisposes the hippocampus to greater injury from exposure to a relatively mild HI insult.\n                  <\/jats:p>","DOI":"10.1038\/sj.jcbfm.9600376","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T04:23:06Z","timestamp":1153887786000},"page":"729-740","source":"Crossref","is-referenced-by-count":30,"title":["Perinatal Iron Deficiency Predisposes the Developing Rat Hippocampus to Greater Injury from Mild to Moderate Hypoxia\u2014Ischemia"],"prefix":"10.1177","volume":"27","author":[{"given":"Raghavendra","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA"},{"name":"Center 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