{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:29:21Z","timestamp":1791289761835,"version":"4.3.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>\n                    Brain function requires oxygen and maintenance of brain capillary oxygenation is important. We evaluated how faithfully frontal lobe near-infrared spectroscopy (NIRS) follows haemoglobin saturation ( S\n                    <jats:sub>Cap<\/jats:sub>\n                    ) and how calculated mitochondrial oxygen tension ( P\n                    <jats:sub>Mito<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) influences motor performance. Twelve healthy subjects (20 to 29 years), supine and seated, inhaled O\n                    <jats:sub>2<\/jats:sub>\n                    air-mixtures (10% to 100%) with and without added 5% carbon dioxide and during hyperventilation. Two measures of frontal lobe oxygenation by NIRS (NIRO-200 and INVOS) were compared with capillary oxygen saturation ( S\n                    <jats:sub>Cap<\/jats:sub>\n                    ) as calculated from the O\n                    <jats:sub>2<\/jats:sub>\n                    content of brachial arterial and right internal jugular venous blood. At control S\n                    <jats:sub>Cap<\/jats:sub>\n                    (78% \u00b1 4%; mean \u00b1 s.d.) was halfway between the arterial (98% \u00b1 1%) and jugular venous oxygenation ( S\n                    <jats:sub>V<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ; 61% \u00b1 6%). Both NIRS devices monitored S\n                    <jats:sub>Cap<\/jats:sub>\n                    ( P &lt; 0.001) within ~5% as S\n                    <jats:sub>v<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    increased from 39% \u00b1 5% to 79% \u00b1 7% with an increase in the transcranial ultrasound Doppler determined middle cerebral artery flow velocity from 29 \u00b1 8 to 65 \u00b1 15 cm\/sec. When S\n                    <jats:sub>Cap<\/jats:sub>\n                    fell below ~70% with reduced flow and inspired oxygen tension, P\n                    <jats:sub>Mito<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decreased ( P &lt; 0.001) and brain lactate release increased concomitantly ( P &lt; 0.001). Handgrip strength correlated with the measured (NIRS) and calculated capillary oxygenation values as well as with P\n                    <jats:sub>Mito<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ( r &gt; 0.74; P &lt; 0.05). These results show that NIRS is an adequate cerebral capillaryoxygenation-level-dependent (COLD) measure during manipulation of cerebral blood flow or inspired oxygen tension, or both, and suggest that motor performance correlates with the frontal lobe COLD signal.\n                  <\/jats:p>","DOI":"10.1038\/sj.jcbfm.9600416","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T09:58:41Z","timestamp":1162288721000},"page":"1082-1093","source":"Crossref","is-referenced-by-count":183,"title":["Capillary-Oxygenation-Level-Dependent Near-Infrared Spectrometry in Frontal Lobe of Humans"],"prefix":"10.1177","volume":"27","author":[{"given":"Peter","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Copenhagen Muscle Research Centre, Department of Anaesthesia, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen A","family":"Dawson","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Centre, Department of Anaesthesia, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Nybo","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes J","family":"van Lieshout","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Academic Medical Centre, Cardiovascular Research Institute Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels H","family":"Secher","sequence":"additional","affiliation":[{"name":"Copenhagen Muscle Research Centre, Department of Anaesthesia, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Gjedde","sequence":"additional","affiliation":[{"name":"Centre of Functionally Integrative Neuroscience, Aarhus University Hospitals, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"bibr1-sj.jcbfm.9600416","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20427"},{"key":"bibr2-sj.jcbfm.9600416","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"bibr3-sj.jcbfm.9600416","doi-asserted-by":"publisher","DOI":"10.1007\/BF01958769"},{"key":"bibr4-sj.jcbfm.9600416","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.030262"},{"key":"bibr5-sj.jcbfm.9600416","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327574"},{"key":"bibr6-sj.jcbfm.9600416","first-page":"R911","volume":"287","author":"Dawson EA","year":"2004","journal-title":"Am J 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