{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:24:56Z","timestamp":1777793096356,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>Nuclear factor-\u03baB (NF-\u03baB) plays a key role in inflammation, which is involved in the development of cerebral vasospasm after subarachnoid hemorrhage (SAH). In the present study, we assessed the potential role of NF-\u03baB in regulation of cerebral vasospasm. Nuclear factor-\u03baB DNA-binding activity was measured in cultured vascular smooth muscle cells (VSMCs) treated with hemolysate and pyrrolidine dithiocarbamate (PDTC, 80 \u03bcmol\/L), an inhibitor of NF-\u03baB. Forty-two rabbits were divided into three groups: control, SAH, and PDTC groups ( n = 14 for each group). The caliber of the basilar artery was evaluated. Nuclear factor-\u03baB DNA-binding activity and the gene expression levels of cytokines and adhesion molecules in the basilar artery were measured. Immunohistochemical study was performed to assess the expression and localization of tumor necrosis factor (TNF)-\u03b1, intercellular adhesion molecule (ICAM)-1, and myeloperoxidase (MPO). It was observed that NF-\u03baB DNA-binding activity was significantly increased by treatment with hemolysate in cultured VSCMs, but this increase was suppressed by pretreatment with PDTC. Severe vasospasm was observed in the SAH group, which was attenuated in the PDTC group. Subarachnoid hemorrhage could induce increases of NF-\u03baB DNA-binding activity and the gene expression levels of TNF-\u03b1, interleukin (IL)-1\u03b2, ICAM-1, and vascular cell adhesion molecule (VCAM)-1, which were reduced in the PDTC group. Immunohistochemical study demonstrated that the expression levels of TNF-\u03b1, ICAM-1, and MPO were all increased in the SAH group, but these increases were attenuated in the PDTC group. Our results suggest that NF-\u03baB is activated in the arterial wall after SAH, which potentially leads to vasospasm development through induction of inflammatory response.<\/jats:p>","DOI":"10.1038\/sj.jcbfm.9600456","type":"journal-article","created":{"date-parts":[[2007,2,10]],"date-time":"2007-02-10T04:46:50Z","timestamp":1171082810000},"page":"1583-1592","source":"Crossref","is-referenced-by-count":77,"title":["Potential Contribution of Nuclear Factor-\u03baB to Cerebral Vasospasm after Experimental Subarachnoid Hemorrhage in Rabbits"],"prefix":"10.1177","volume":"27","author":[{"given":"Meng-Liang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Xin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hua","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ping","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jinling Hospital, 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