{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:30:59Z","timestamp":1782930659297,"version":"3.54.5"},"reference-count":21,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cereb Blood Flow Metab"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p> Alterations of blood flow contribute to major clinical complications in invasive infections such as sepsis and bacterial meningitis. As a unique feature streptococci \u2013 in particular, Streptococcus pneumoniae, the most frequent pathogen in bacterial meningitis \u2013 release hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) because of the absence of functional catalase. In a 6 h rat model of experimental meningitis, we studied the impact of bacterial H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> production on regional cerebral blood flow (rCBF) and intracranial pressure (ICP). Compared to wild-type D39 pneumococci, the increase of rCBF was diminished in meningitis induced by the H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> defective SpxB<jats:sup>\u2212<\/jats:sup> mutant (maximum increase, 135% \u00b1 17% versus 217% \u00b1 23% of the individual baseline; P &lt; 0.01) or after treatment of D39-induced meningitis with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-degrading catalase or with tetraethylammonium (TEA), a blocker of calcium-sensitive potassium channels, which mediate H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced vasodilation. Catalase did not significantly reduce the remaining rCBF increase caused by SpxB<jats:sup>\u2212<\/jats:sup>, supporting the predominant role of bacterial H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. We conclude that in addition to host-sided mediators, bacterial-derived H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> acts as a potent vasodilator, which accounts for a certain proportion of the early cerebral hyperperfusion in pneumococcal meningitis. <\/jats:p>","DOI":"10.1038\/sj.jcbfm.9600474","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T11:37:35Z","timestamp":1172057855000},"page":"1792-1797","source":"Crossref","is-referenced-by-count":17,"title":["Bacterial Hydrogen Peroxide Contributes to Cerebral Hyperemia during Early Stages of Experimental Pneumococcal Meningitis"],"prefix":"10.1177","volume":"27","author":[{"given":"Olaf M","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Department of Experimental Neurology, Center for Anatomy, Charit\u00e9-Universitaetsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurology, Center for Anatomy, Charit\u00e9-Universitaetsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg R","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Experimental Neurology, Center for Anatomy, Charit\u00e9-Universitaetsmedizin Berlin, Berlin, Germany"},{"name":"Department of Cell Biology and Neurobiology, Center for Anatomy, Charit\u00e9-Universitaetsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,11,1]]},"reference":[{"key":"bibr1-sj.jcbfm.9600474","first-page":"220","volume":"87","author":"Acheson GH","year":"1946","journal-title":"J Pharmacol Exp Therap"},{"key":"bibr2-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"bibr3-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00032-3"},{"key":"bibr4-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23223"},{"key":"bibr5-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12035"},{"key":"bibr6-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021334"},{"key":"bibr7-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200208000-00010"},{"key":"bibr8-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01932-05"},{"key":"bibr9-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021333"},{"key":"bibr10-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00375-5"},{"key":"bibr11-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199709000-00008"},{"key":"bibr12-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.3990-3997.2000"},{"key":"bibr13-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.6.1442"},{"key":"bibr14-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199506090-00018"},{"key":"bibr15-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109850"},{"key":"bibr16-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.7.1584"},{"key":"bibr17-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.11.2290"},{"key":"bibr18-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1996.425954.x"},{"key":"bibr19-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.3.959"},{"key":"bibr20-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(95)00131-X"},{"key":"bibr21-sj.jcbfm.9600474","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(03)00078-5"}],"container-title":["Journal of Cerebral Blood Flow &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/sj.jcbfm.9600474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1038\/sj.jcbfm.9600474","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1038\/sj.jcbfm.9600474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T23:45:14Z","timestamp":1741650314000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1038\/sj.jcbfm.9600474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1038\/sj.jcbfm.9600474"],"URL":"https:\/\/doi.org\/10.1038\/sj.jcbfm.9600474","relation":{},"ISSN":["0271-678X","1559-7016"],"issn-type":[{"value":"0271-678X","type":"print"},{"value":"1559-7016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}