{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:05:57Z","timestamp":1791011157369,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T00:00:00Z","timestamp":1079481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T00:00:00Z","timestamp":1079481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Expo Sci Environ Epidemiol"],"published-print":{"date-parts":[[2004,11,1]]},"DOI":"10.1038\/sj.jea.7500345","type":"journal-article","created":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T10:21:11Z","timestamp":1079518871000},"page":"466-472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Exposure assessment in epidemiologic studies of adverse pregnancy outcomes and disinfection byproducts"],"prefix":"10.1038","volume":"14","author":[{"given":"Will D","family":"King","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Dodds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Anthony","family":"Armson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deshayne B","family":"Fell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Nimrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,3,17]]},"reference":[{"issue":"Suppl 1","key":"BF7500345_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1289\/ehp.02110s153","volume":"110","author":"TE Arbuckle","year":"2002","unstructured":"Arbuckle T.E., Hrudey S.E., Krasner S.W., Nuckols J.R., Richardson S.D., Singer P., Mendola P., Dodds L., Weisel C., Ashley D.L., Froese K.L., Pegram R.A., Schultz I.R., Reif J., Bachand A.M., Benoit F.M., Lynberg M., Poole C., and Waller K. Assessing exposure in epidemiologic studies to disinfection byproducts in drinking water: report from an international workshop. Environ Health Perspect 2002: 110(Suppl 1): 53\u201360.","journal-title":"Environ Health Perspect"},{"key":"BF7500345_CR2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/00039896.1993.9938403","volume":"48","author":"A Aschengrau","year":"1993","unstructured":"Aschengrau A., Zierler S., and Cohen A. Quality of community drinking water and the occurrence of late adverse pregnancy outcomes. Archi Environ Health 1993: 48: 105\u2013113.","journal-title":"Archi Environ Health"},{"key":"BF7500345_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/sj.jea.7500098","volume":"10","author":"LC Backer","year":"2000","unstructured":"Backer L.C., Ashley D.A., Bonin M.A., Cardinali F.L., Kieszak S.M., and Wooten J.V. Household exposures to drinking water disinfection byproducts: whole blood trihalomethane levels. J Expos Anal Environ Epidemiol 2000: 10: 321\u2013326.","journal-title":"J Expos Anal Environ Epidemiol"},{"issue":"9","key":"BF7500345_CR4","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1093\/oxfordjournals.aje.a117521","volume":"141","author":"FJ Bove","year":"1995","unstructured":"Bove F.J., Fulcomer M.C., Klotz J.B., Esmart J., Dufficy E.M., and Savrin J.E. Public drinking water contamination and birth outcomes. Am J Epidemiol 1995: 141(9): 850\u2013862.","journal-title":"Am J Epidemiol"},{"issue":"Suppl 1","key":"BF7500345_CR5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1289\/ehp.02110s161","volume":"110","author":"FJ Bove","year":"2002","unstructured":"Bove F.J., Shim Y., and Zeitz P. Drinking water contaminants and adverse pregnancy outcomes: a review. Environ Health Perspect 2002: 110(Suppl 1): 61\u201374.","journal-title":"Environ Health Perspect"},{"key":"BF7500345_CR6","unstructured":"Consumer Reports. Fit to drink?, January 1990 pp 27\u201343."},{"key":"BF7500345_CR7","doi-asserted-by":"crossref","unstructured":"Dodds L., King W.D., Allen A.C., Armson B.A., Fell D., and Nimrod C. Trihalomethanes in public water supplies and risk of stillbirth. Epidemiology 2004 (in press).","DOI":"10.1097\/01.ede.0000112209.47765.d9"},{"key":"BF7500345_CR8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/00001648-199905000-00007","volume":"10","author":"L Dodds","year":"1999","unstructured":"Dodds L., King W., Woolcott C., and Pole J. Trihalomethanes in public water supplies and adverse birth outcomes. Epidemiology 1999: 10(3): 233\u2013237.","journal-title":"Epidemiology"},{"key":"BF7500345_CR9","unstructured":"Environmental Protection Agency (EPA). EPA panel report and recommendations for conducting epidemiological research on possible reproductive and developmental effects of exposure to disinfected drinking water, Research Triangle Park, NC, 1998."},{"key":"BF7500345_CR10","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1097\/00001648-199809000-00003","volume":"9","author":"MD Gallagher","year":"1998","unstructured":"Gallagher M.D., Nuckols J.R., Stallones L., and Savitz D.A. Exposure to trihalomethanes and adverse pregnancy outcomes. Epidemiology 1998: 9: 484\u2013489.","journal-title":"Epidemiology"},{"key":"BF7500345_CR11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1136\/oem.58.7.437","volume":"58","author":"JJK Jaakkola","year":"2001","unstructured":"Jaakkola J.J.K., Magnus P., Skrondal A., Hwang B.-F., Becher G., and Dybing E. Foetal growth and duration of gestation relative to water chlorination. Occup Environ Med 2001: 58: 437\u2013442.","journal-title":"Occup Environ Med"},{"key":"BF7500345_CR12","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0890-6238(00)00086-1","volume":"14","author":"BAJ Kallen","year":"2000","unstructured":"Kallen B.A.J., and Robert E. Drinking water chlorination and delivery outcome\u2014a registry-based study in Sweden. Reprod Toxicol 2000: 14: 303\u2013309.","journal-title":"Reprod Toxicol"},{"key":"BF7500345_CR13","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1289\/ehp.96104516","volume":"104","author":"S Kanitz","year":"1996","unstructured":"Kanitz S., Franco Y., Patrone V., Caltabellotta M., Raffo E., Riggi C., Timitilli D., and Ravera G. Association between drinking water disinfection and somatic parameters at birth. Environ Health Perspect 1996: 104(5): 516\u2013520.","journal-title":"Environ Health Perspect"},{"key":"BF7500345_CR14","volume-title":"Methods in Observational Epidemiology","author":"JL Kelsey","year":"1996","unstructured":"Kelsey J.L., Whittemore A.S., Evans A.S., and Thompson W.D. Methods in Observational Epidemiology. Oxford University Press, New York, 1996."},{"key":"BF7500345_CR15","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/0272-4332.205058","volume":"20","author":"BD Kerger","year":"2000","unstructured":"Kerger B.D., Schmidt C.E., and Paustenbach D.J. Assessment of airborne exposure to trihalomethanes from tap water in residential showers and baths. Risk Anal 2000: 20: 637\u2013651.","journal-title":"Risk Anal"},{"key":"BF7500345_CR16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/00001648-199907000-00008","volume":"10","author":"JB Klotz","year":"1999","unstructured":"Klotz J.B., and Pyrch L.A. Neural tube defects and drinking water disinfection byproducts. Epidemiology 1999: 10: 383\u2013390.","journal-title":"Epidemiology"},{"key":"BF7500345_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/00001648-199209000-00005","volume":"3","author":"MD Kramer","year":"1992","unstructured":"Kramer M.D., Lynch C.F., Isacson P., and Hanson J.W. The association of waterborne chloroform with intrauterine growth retardation. Epidemiology 1992: 3: 407\u2013413.","journal-title":"Epidemiology"},{"key":"BF7500345_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/j.1551-8833.1989.tb03258.x","volume":"81","author":"SW Krasner","year":"1989","unstructured":"Krasner S.W., McGuire M.J., Jacaugelo J.G., Patania N.L., Reagen K.M., and Aieta E.M. The occurrence of disinfection byproducts in US drinking water. J Am Water Works Assoc 1989: 81: 41\u201353.","journal-title":"J Am Water Works Assoc"},{"key":"BF7500345_CR19","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0048-9697(97)00274-X","volume":"208","author":"HW Kuo","year":"1997","unstructured":"Kuo H.W., Chiang T.F., Lo I.I., Lai J.S., Chan C.C., and Wand J.D. VOC concentration in Taiwan's household drinking water. Science of the Total Environ 1997: 208: 41\u201347.","journal-title":"Science of the Total Environ"},{"key":"BF7500345_CR20","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1289\/ehp.01109597","volume":"109","author":"M Lynberg","year":"2001","unstructured":"Lynberg M., Nuckols J.R., Langlois P., Ashley D., Singer P., Mendola P., Wilkes C., Krapfl H., Miles E., Speight V., Lin B., Small L., Miles A., Bonin M., Zeitz P., Tadkod A., Henry J., and Forrester M.B. Assessing exposure to disinfection byproducts in women of reproductive age living in Corpus Christi, Texas, and Cobb county, Georgia: descriptive results and methods. Environ Health Perspect 2001: 109(6): 597\u2013604.","journal-title":"Environ Health Perspect"},{"key":"BF7500345_CR21","first-page":"91","volume":"19","author":"CJ Mills","year":"1998","unstructured":"Mills C.J., Bull R.J., Cantor K., Reif J., Hrudey S., and an expert working group. Health risk of drinking water chlorination byproduct: report of an expert working group. Chronic Diseases Canada 1998: 19(3): 91\u2013102.","journal-title":"Chronic Diseases Canada"},{"key":"BF7500345_CR22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/oem.57.2.73","volume":"57","author":"MJ Nieuwenhuijsen","year":"2000","unstructured":"Nieuwenhuijsen M.J., Toledano M.B., Eaton N.E., Fawell J., and Elliott P. Chlorine disinfection byproducts in water and their association with adverse reproductive outcomes: a review. J Occup Environ Med 2000: 57: 73\u201385.","journal-title":"J Occup Environ Med"},{"key":"BF7500345_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/j.1551-8833.1979.tb04321.x","volume":"7","author":"BG Oliver","year":"1979","unstructured":"Oliver B.G., and Lawence J. Haloforms in drinking water: a study of precursors and precursor removal. J Am Water Works Assoc 1979: 7: 161\u2013163.","journal-title":"J Am Water Works Assoc"},{"key":"BF7500345_CR24","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/0043-1354(95)00026-H","volume":"29","author":"H Pourmogahaddas","year":"1995","unstructured":"Pourmogahaddas H., and Stevens A.A. Relationship between trihalomethanes and haloacetic acids with total organic halogen during chlorination. Water Res 1995: 29: 2059\u20132062.","journal-title":"Water Res"},{"key":"BF7500345_CR25","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1289\/ehp.961041056","volume":"104","author":"JS Reif","year":"1996","unstructured":"Reif J.S., Hatch M.C., Bracken M., Holmes L., Schwetz B., and Singer P.C. Reproductive and developmental effects of disinfection byproducts in drinking water. Environ Health Perspect 1996: 104: 1056\u20131061.","journal-title":"Environ Health Perspect"},{"key":"BF7500345_CR26","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1289\/ehp.95103592","volume":"103","author":"DA Savitz","year":"1995","unstructured":"Savitz D.A., Andrews K.W., and Pasore L.M. Drinking water and pregnancy outcome in Central North Carolina: source, amount, and trihalomethane levels. Environ Health Perspect 1995: 103: 592\u2013596.","journal-title":"Environ Health Perspect"},{"key":"BF7500345_CR27","first-page":"459","volume":"2","author":"GM Shaw","year":"1991","unstructured":"Shaw G.M., Malcoe L.H., Milea A., and Swan S.H. Chlorinated water exposures and congenital cardiac anomalies (letter to the editor). Epidemiology 1991: 2: 459\u2013460.","journal-title":"Epidemiology"},{"key":"BF7500345_CR28","first-page":"201","volume-title":"Safety of Water Disinfection: Balancing Microbial Risks","author":"PC Singer","year":"1993","unstructured":"Singer P.C. Formation and characterization of disinfection byproducts, In: Cruan G.F. (ed.) Safety of Water Disinfection: Balancing Microbial Risks. International Life Sciences Inst. Press, Washington DC, 1993 pp 201\u2013219."},{"key":"BF7500345_CR29","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/00001648-199803000-00006","volume":"9","author":"K Waller","year":"1998","unstructured":"Waller K., Swan S.H., DeLorenze G., and Hopkins B. Trihalomethanes in drinking water and spontaneous abortion. Epidemiology 1998: 9: 134\u2013140.","journal-title":"Epidemiology"},{"key":"BF7500345_CR30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1289\/ehp.9610448","volume":"104","author":"CP Weisel","year":"1996","unstructured":"Weisel C.P., and Jo W.K. Ingestion, inhalation and dermal exposures to chloroform and trichloroethene from tap water. Environ Health Perspect 1996: 104(1): 48\u201351.","journal-title":"Environ Health Perspect"},{"key":"BF7500345_CR31","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0045-6535(96)00378-5","volume":"34","author":"DT Williams","year":"1997","unstructured":"Williams D.T., LeBel G.L., and Benoit F.M. Disinfection byproducts in Canadian drinking water. Chemosphere 1997: 34(2): 299\u2013316.","journal-title":"Chemosphere"},{"key":"BF7500345_CR32","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1016\/S0043-1354(01)00080-X","volume":"35","author":"WW Wu","year":"2001","unstructured":"Wu W.W., Benjamin M.M., and Korshin G.V. Effects of thermal treatment on halogenated disinfection byproducts in drinking water. Water Res 2001: 35(15): 3545\u20133550.","journal-title":"Water Res"},{"key":"BF7500345_CR33","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1289\/ehp.00108765","volume":"108","author":"CY Yang","year":"2000","unstructured":"Yang C.Y., Cheng B.H., Tsai S.S., Wu T.N., Lin M.C., and Lin K.C. Association between chlorination of drinking water and adverse pregnancy outcome in Taiwan. Environ Health Perspect 2000: 108: 765\u2013768.","journal-title":"Environ Health Perspect"}],"container-title":["Journal of Exposure Science & Environmental Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7500345.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7500345","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7500345.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T15:55:42Z","timestamp":1647446142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7500345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,17]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,11,1]]}},"alternative-id":["BF7500345"],"URL":"https:\/\/doi.org\/10.1038\/sj.jea.7500345","relation":{},"ISSN":["1559-0631","1559-064X"],"issn-type":[{"value":"1559-0631","type":"print"},{"value":"1559-064X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,17]]},"assertion":[{"value":"17 March 2004","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}