{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:19:09Z","timestamp":1792149549368,"version":"4.4.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"published-print":{"date-parts":[[2002,3,1]]},"DOI":"10.1038\/sj.jhh.1001320","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:41:25Z","timestamp":1031251285000},"page":"153-158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Is aldosterone the missing link in refractory hypertension?: aldosterone-to-renin ratio as a marker of inappropriate aldosterone activity"],"prefix":"10.1038","volume":"16","author":[{"given":"P O","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R T","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T M","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"BF1001320_CR1","first-page":"222","volume":"90","author":"JW Conn","year":"1964","unstructured":"Conn JW . Plasma renin activity in primary aldosteronism JAMA 1964 90: 222\u2013225","journal-title":"JAMA"},{"key":"BF1001320_CR2","first-page":"322","volume":"102","author":"DL Longo","year":"1978","unstructured":"Longo DL, Esterly JA, Grim CE, Keitzer WF . Pathology of the adrenal gland in refractory low-renin hypertension Arch Pathol Lab Med 1978 102: 322\u2013327","journal-title":"Arch Pathol Lab Med"},{"key":"BF1001320_CR3","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S0140-6736(94)93003-1","volume":"344","author":"RD Gordon","year":"1994","unstructured":"Gordon RD . Mineralocorticoid hypertension Lancet 1994 344: 240\u2013243","journal-title":"Lancet"},{"key":"BF1001320_CR4","doi-asserted-by":"publisher","first-page":"596","DOI":"10.7326\/0003-4819-87-5-596","volume":"87","author":"JR Mitchell","year":"1977","unstructured":"Mitchell JR et al. Renin-aldosterone profiling in hypertension Ann Intern Med 1977 87: 596\u2013612","journal-title":"Ann Intern Med"},{"key":"BF1001320_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1445-5994.1976.tb03306.x","volume":"6","author":"PJ Dunn","year":"1976","unstructured":"Dunn PJ, Espiner EA . Outpatient screening tests for primary aldosteronism Aust NZJ Med 1976 6: 131\u2013135","journal-title":"Aust NZJ Med"},{"key":"BF1001320_CR6","first-page":"383","volume":"86","author":"C Hambling","year":"1993","unstructured":"Hambling C et al. Primary hyperaldosteronism\u2014evaluation of procedures for diagnosis and localization QJ Med 1993 86: 383\u2013392","journal-title":"QJ Med"},{"key":"BF1001320_CR7","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0025-6196(12)62114-4","volume":"65","author":"WF Young Jr","year":"1990","unstructured":"Young WF Jr et al. Primary aldosteronism: diagnosis and treatment Mayo Clin Proc 1990 65: 96\u2013110","journal-title":"Mayo Clin Proc"},{"key":"BF1001320_CR8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/0002-9343(83)91022-7","volume":"74","author":"EL Bravo","year":"1983","unstructured":"Bravo EL et al. The changing clinical spectrum of primary aldosteronism Am J Med 1983 74: 641\u2013651","journal-title":"Am J Med"},{"key":"BF1001320_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1001\/archinte.1969.00300120029004","volume":"123","author":"A Jose","year":"1969","unstructured":"Jose A, Kaplan NM . Plasma renin activity in the diagnosis of primary aldosteronism: failure to distinguish primary aldosteronism from essential hypertension Arch Intern Med 1969 123: 141\u2013146","journal-title":"Arch Intern Med"},{"key":"BF1001320_CR10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0002-9343(79)90786-1","volume":"67","author":"DH Streeten","year":"1979","unstructured":"Streeten DH, Tomycz N, Anderson GH . Reliability of screening methods for the diagnosis of primary aldosteronism Am J Med 1979 67: 403\u2013413","journal-title":"Am J Med"},{"key":"BF1001320_CR11","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1210\/jcem-58-5-783","volume":"58","author":"WA Banks","year":"1984","unstructured":"Banks WA, Kastin AJ, Biglieri EG, Ruiz AE . Primary adrenal hyperplasia: a new subset of primary hyperaldosteronism J Clin Endocrinol Metab 1984 58: 783\u2013785","journal-title":"J Clin Endocrinol Metab"},{"key":"BF1001320_CR12","doi-asserted-by":"publisher","first-page":"877","DOI":"10.7326\/0003-4819-121-11-199412010-00010","volume":"121","author":"JD Blumenfeld","year":"1994","unstructured":"Blumenfeld JD et al. Diagnosis and treatment of primary hyperaldosteronism Ann Intern Med 1994 121: 877\u2013885","journal-title":"Ann Intern Med"},{"key":"BF1001320_CR13","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1440-1681.1991.tb01446.x","volume":"18","author":"RD Gordon","year":"1991","unstructured":"Gordon RD et al. Clinical and pathological diversity of primary aldosteronism, including a new familial variety Clin Exp Pharmacol Physiol 1991 18: 283\u2013286","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BF1001320_CR14","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/sj.jhh.1000444","volume":"11","author":"H Ignatowska-Switalska","year":"1997","unstructured":"Ignatowska-Switalska H et al. Evaluation of plasma aldosterone to plasma renin activity ratio inpatients with primary aldosteronism J Hum Hypertens 1997 11: 373\u2013378","journal-title":"J Hum Hypertens"},{"key":"BF1001320_CR15","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1530\/acta.0.1130564","volume":"113","author":"PE Lins","year":"1986","unstructured":"Lins PE, Adamson U . Plasma aldosterone-plasma renin activity ratio. A simple test to identifypatients with primary aldosteronism Acta Endocrinol (Copenh) 1986 113: 564\u2013569","journal-title":"Acta Endocrinol (Copenh)"},{"key":"BF1001320_CR16","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1001\/archinte.1993.00410180075008","volume":"153","author":"MH Weinberger","year":"1993","unstructured":"Weinberger MH, Fineberg NS . The diagnosis of primary aldosteronism and separation of two major subtypes Arch Intern Med 1993 153: 2125\u20132129","journal-title":"Arch Intern Med"},{"key":"BF1001320_CR17","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/sj.jhh.1001013","volume":"14","author":"PO Lim","year":"2000","unstructured":"Lim PO et al. High prevalence of primary aldosteronism in the Tayside hypertensive clinic population J Hum Hypertens 2000 14: 311\u2013315","journal-title":"J Hum Hypertens"},{"key":"BF1001320_CR18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1440-1681.1994.tb02519.x","volume":"21","author":"RD Gordon","year":"1994","unstructured":"Gordon RD et al. High incidence of primary aldosteronism in 199patients referred with hypertension Clin Exp Pharmacol Physiol 1994 21: 315\u2013318","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BF1001320_CR19","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/BF01476798","volume":"58","author":"A Helber","year":"1980","unstructured":"Helber A et al. Evidence for a subgroup of essential hypertensives with non-suppressible excretion of aldosterone during sodium loading Klin Wochenschr 1980 58: 439\u2013447","journal-title":"Klin Wochenschr"},{"key":"BF1001320_CR20","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1172\/JCI106359","volume":"49","author":"RD Collins","year":"1970","unstructured":"Collins RD et al. Abnormally sustained aldosterone secretion during salt loading inpatients with various forms of benign hypertension; relation to plasma renin activity J Clin Invest 1970 49: 1415\u20131426","journal-title":"J Clin Invest"},{"key":"BF1001320_CR21","first-page":"816","volume":"78","author":"CE Grim","year":"1971","unstructured":"Grim CE, Peters TJ, Maher JF . Low renin hypertension: a state of inappropriate secretion of aldosterone J Lab Clin Med 1971 78: 816\u2013817","journal-title":"J Lab Clin Med"},{"key":"BF1001320_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j.1440-1681.1987.tb00371.x","volume":"14","author":"RD Gordon","year":"1987","unstructured":"Gordon RD, Hamlet SM, Tunny TJ, Klemm SA . Aldosterone-producing adenomas responsive to angiotensin pose problems in diagnosis Clin Exp Pharmacol Physiol 1987 14: 175\u2013179","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BF1001320_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1210\/jcem-49-1-87","volume":"49","author":"EG Biglieri","year":"1979","unstructured":"Biglieri EG, Schambelan M . The significance of elevated levels of plasma 18-hydroxycorticosterone inpatients with primary aldosteronism J Clin Endocrinol Metab 1979 49: 87\u201391","journal-title":"J Clin Endocrinol Metab"},{"key":"BF1001320_CR24","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0140-6736(92)93225-C","volume":"340","author":"RD Gordon","year":"1992","unstructured":"Gordon RD, Klemm SA, Tunny TJ, Stowasser M . Primary aldosteronism\u2014hypertension with a genetic-basis Lancet 1992 340: 159\u2013161","journal-title":"Lancet"},{"key":"BF1001320_CR25","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/355262a0","volume":"355","author":"RP Lifton","year":"1992","unstructured":"Lifton RP et al. A chimaeric 11 beta-hydroxy-lase\/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension Nature 1992 355: 262\u2013265","journal-title":"Nature"},{"key":"BF1001320_CR26","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1445-5994.1996.tb00600.x","volume":"26","author":"MA Brown","year":"1996","unstructured":"Brown MA, Cramp HA, Zammit VC, Whitworth JA . Primary hyperaldosteronism: a missed diagnosis in \u2018essential hypertensives\u2019? Aust NZJ Med 1996 26: 533\u2013538","journal-title":"Aust NZJ Med"},{"key":"BF1001320_CR27","first-page":"762","volume":"26","author":"PH Eng","year":"1997","unstructured":"Eng PH et al. Aldosterone to renin ratios in the evaluation of primary aldosteronism Ann Acad Med Singapore 1997 26: 762\u2013766","journal-title":"Ann Acad Med Singapore"},{"key":"BF1001320_CR28","first-page":"17","volume":"45","author":"A Kreze Jr","year":"1999","unstructured":"Kreze A Jr et al. Occurrence of primary aldosteronism in a group of ambulatory hypertensivepatients Vnitr Lek 1999 45: 17\u201321","journal-title":"Vnitr Lek"},{"key":"BF1001320_CR29","first-page":"S177[P3.77]","volume":"17 (Suppl\u20093)","author":"BL Rayner","year":"1999","unstructured":"Rayner BL, Opie LH, Davidson JS . Primary hyperaldosteronism: How common is it inpatients with severe hypertension? J Hypertens 1999 17 (Suppl\u20093): S177[P3.77]","journal-title":"J Hypertens"},{"key":"BF1001320_CR30","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1001\/archinte.1981.00340130033011","volume":"141","author":"K Hiramatsu","year":"1981","unstructured":"Hiramatsu K et al. A screening test to identify aldosterone-producing adenoma by measuring plasma renin activity. Results in hypertensivepatients Arch Intern Med 1981 141: 1589\u20131593","journal-title":"Arch Intern Med"},{"key":"BF1001320_CR31","first-page":"S310","volume":"11 (Suppl\u20095)","author":"RD Gordon","year":"1993","unstructured":"Gordon RD et al. How common is primary aldosteronism? Is it the most frequent cause of curable hypertension? J Hypertens Suppl 1993 11 (Suppl\u20095): S310\u2013S311","journal-title":"J Hypertens Suppl"},{"key":"BF1001320_CR32","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/S0140-6736(05)70723-6","volume":"353","author":"PO Lim","year":"1999","unstructured":"Lim PO . Primary aldosteronism in general practice Lancet 1999 353: 1013\u20131014","journal-title":"Lancet"},{"key":"BF1001320_CR33","first-page":"79P","volume":"81","author":"DL Davies","year":"1979","unstructured":"Davies DL et al. Aldosterone and its stimuli in normal and hypertensive man: are essential hypertension and primary hyperaldosteronism without tumour the same condition? J Endocrinol 1979 81: 79P\u201391P","journal-title":"J Endocrinol"},{"key":"BF1001320_CR34","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1177\/000456327901600196","volume":"16","author":"JJ Brown","year":"1979","unstructured":"Brown JJ et al. Are idiopathic hyperaldosteronism and low-renin hypertension variants of essential hypertension? Ann Clin Biochem 1979 16: 380\u2013388","journal-title":"Ann Clin Biochem"},{"key":"BF1001320_CR35","first-page":"203","volume":"27","author":"L Baer","year":"1970","unstructured":"Baer L et al. Pseudo-primary aldosteronism. An entity distinct from true primary aldosteronism Circ Res 1970 27: 203\u2013220","journal-title":"Circ Res"},{"key":"BF1001320_CR36","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0300-595X(81)80005-9","volume":"10","author":"MA Schalekamp","year":"1981","unstructured":"Schalekamp MA, Wenting GJ, Man in \u2018t Veld AJ . Pathogenesis of mineralocorticoid hypertension Clin Endocrinol Metab 1981 10: 397\u2013418","journal-title":"Clin Endocrinol Metab"},{"key":"BF1001320_CR37","first-page":"1727","volume":"4","author":"GJ Wenting","year":"1982","unstructured":"Wenting GJ, Man in \u2018t Veld AJ, Derkx FH, Schalekamp MA . Recurrence of hypertension in primary aldosteronism after discontinuation of spironolactone. Time course of changes in cardiac output and body fluid volumes Clin Exp Hypertens [A] 1982 4: 1727\u20131748","journal-title":"Clin Exp Hypertens [A]"},{"key":"BF1001320_CR38","volume-title":"Aldosterone and other adrenal steroids. In: Zanchetti A, Tarazi RC (eds). Handbook of Hypertension","author":"EL Bravo","year":"1986","unstructured":"Bravo EL . Aldosterone and other adrenal steroids. In: Zanchetti A, Tarazi RC (eds). Handbook of Hypertension Elsevier Science Publishers: Amsterdam 1986; pp\u2009603\u2013625"},{"key":"BF1001320_CR39","first-page":"743","volume":"45","author":"A Distler","year":"1973","unstructured":"Distler A, Just HJ, Philipp T . Studies on the mechanism of aldosterone-induced hypertension in man Clin Sci Mol Med 1973 45: 743\u2013750","journal-title":"Clin Sci Mol Med"},{"key":"BF1001320_CR40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00004872-199002000-00001","volume":"8","author":"JD Firth","year":"1990","unstructured":"Firth JD, Raine AE, Ledingham JG . The mechanism of pressure natriuresis J Hypertens 1990 8: 97\u2013103","journal-title":"J Hypertens"},{"key":"BF1001320_CR41","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1161\/01.HYP.12.4.450","volume":"12","author":"CA Gaillard","year":"1988","unstructured":"Gaillard CA et al. Enhanced natriuretic effect of atrial natriuretic factor during mineralocorticoid escape in humans Hypertension 1988 12: 450\u2013456","journal-title":"Hypertension"},{"key":"BF1001320_CR42","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1210\/jcem-63-4-815","volume":"63","author":"T Yamaji","year":"1986","unstructured":"Yamaji T et al. Plasma levels of atrial natriuretic peptide in primary aldosteronism and essential hypertension J Clin Endocrinol Metab 1986 63: 815\u2013818","journal-title":"J Clin Endocrinol Metab"},{"key":"BF1001320_CR43","first-page":"I163","volume":"40","author":"GJ Wenting","year":"1977","unstructured":"Wenting GJ, Man in \u2018t Veld AJ, Verhoeven RP, Derkx FHM, Schalekamp MADH . Volume-pressure relationships during development of mineralocorticoid hypertension in man Circ Res 1977 40: I163\u2013I170","journal-title":"Circ Res"},{"key":"BF1001320_CR44","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1172\/JCI105573","volume":"46","author":"NM Kaplan","year":"1967","unstructured":"Kaplan NM . The steroid content of adrenal adenomas and measurements of aldosterone production inpatients with essential hypertension and primary aldosteronism J Clin Invest 1967 46: 728\u2013734","journal-title":"J Clin Invest"},{"issue":"3","key":"BF1001320_CR45","doi-asserted-by":"publisher","first-page":"411","DOI":"10.7326\/0003-4819-79-3-411","volume":"79","author":"MOHINDER P. SAMBHI","year":"1973","unstructured":"Clinical conference: essential hypertension: new concepts about mechanisms Ann Intern Med 1973 79: 411\u2013424","journal-title":"Annals of Internal Medicine"},{"key":"BF1001320_CR46","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1042\/cs0630257","volume":"63","author":"C Beretta-Piccoli","year":"1982","unstructured":"Beretta-Piccoli C et al. Relation of arterial pressure with body sodium, body potassium and plasma potassium in essential hypertension Clin Sci 1982 63: 257\u2013270","journal-title":"Clin Sci"},{"key":"BF1001320_CR47","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/00004872-199715010-00006","volume":"15","author":"I Komiya","year":"1997","unstructured":"Komiya I et al. An abnormal sodium metabolism in Japanesepatients with essential hypertension, judged by serum sodium distribution, renal function and the renin-aldosterone system J Hypertens 1997 15: 65\u201372","journal-title":"J Hypertens"},{"key":"BF1001320_CR48","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3109\/10641968009037132","volume":"2","author":"FC Reubi","year":"1980","unstructured":"Reubi FC, Weidmann P . Relationships between sodium clearance, plasma renin activity, plasma aldosterone, renal hemodynamics and blood pressure in essential hypertension Clin Exp Hypertens 1980 2: 593\u2013612","journal-title":"Clin Exp Hypertens"},{"key":"BF1001320_CR49","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/S0002-8703(99)70004-9","volume":"138","author":"MP Schlaich","year":"1999","unstructured":"Schlaich MP et al. Relation between the renin-angiotensin-aldosterone system and left ventricular structure and function in young normotensive and mildly hypertensive subjects Am Heart J 1999 138: 810\u2013817","journal-title":"Am Heart J"},{"key":"BF1001320_CR50","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1161\/01.HYP.12.2.192","volume":"12","author":"R Pedrinelli","year":"1988","unstructured":"Pedrinelli R . Dietary sodium change in primary aldosteronism. Atrial natriuretic factor, hormonal, and vascular responses Hypertension 1988 12: 192\u2013198","journal-title":"Hypertension"},{"key":"BF1001320_CR51","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1291\/hypres.22.17","volume":"22","author":"A Sato","year":"1999","unstructured":"Sato A, Suzuki Y, Saruta T . Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy inpatients with essential hypertension Hypertens Res 1999 22: 17\u201322","journal-title":"Hypertens Res"},{"key":"BF1001320_CR52","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/sj.jhh.1001138","volume":"15","author":"PO Lim","year":"2001","unstructured":"Lim PO, Donnan PT, MacDonald TM . Aldosterone to renin ratio as a determinant of exercise blood pressure response in hypertensivepatients J Hum Hypertens 2001 15: 119\u2013123","journal-title":"J Hum Hypertens"},{"key":"BF1001320_CR53","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1001\/archinte.1972.03650060041007","volume":"130","author":"RM Carey","year":"1972","unstructured":"Carey RM, Douglas JG, Schweikert JR, Liddle GW . The syndrome of essential hypertension and suppressed plasma renin activity. Normalization of blood pressure with spironolactone Arch Intern Med 1972 130: 849\u2013854","journal-title":"Arch Intern Med"},{"key":"BF1001320_CR54","doi-asserted-by":"publisher","first-page":"831","DOI":"10.7326\/0003-4819-75-6-831","volume":"75","author":"RF Spark","year":"1971","unstructured":"Spark RF, Melby JC . Hypertension and low plasma renin activity: presumptive evidence for mineralocorticoid excess Ann Intern Med 1971 75: 831\u2013836","journal-title":"Ann Intern Med"},{"key":"BF1001320_CR55","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1136\/bmj.1.6004.251","volume":"1","author":"BE Karlberg","year":"1976","unstructured":"Karlberg BE, Kagedal B, Tegler L, Tolagen K . Renin concentrations and effects of propranolol and spironolactone inpatients with hypertension Br Med J 1976 1: 251\u2013254","journal-title":"Br Med J"},{"key":"BF1001320_CR56","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1365-2362.1977.tb01624.x","volume":"7","author":"JA Sundsfjord","year":"1977","unstructured":"Sundsfjord JA, Odegaard AE . Renin levels and spironolactone treatment in general practice: similar blood pressure lowering effect of spironolactone in low and normal reninpatients Eur J Clin Invest 1977 7: 389\u2013392","journal-title":"Eur J Clin Invest"},{"key":"BF1001320_CR57","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/0002-9149(75)90174-5","volume":"36","author":"JI Drayer","year":"1975","unstructured":"Drayer JI et al. Intrapatient comparison of treatment with chlorthalidone, spironolactone and propranolol in normoreninemic essential hypertension Am J Cardiol 1975 36: 716\u2013721","journal-title":"Am J Cardiol"},{"key":"BF1001320_CR58","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/cpt197721162","volume":"21","author":"RK Ferguson","year":"1977","unstructured":"Ferguson RK, Turek DM, Rovner DR . Spironolactone and hydrochlorothiazide in normal-renin and low-renin essential hypertension Clin Pharmacol Ther 1977 21: 62\u201369","journal-title":"Clin Pharmacol Ther"},{"key":"BF1001320_CR59","doi-asserted-by":"publisher","first-page":"36K","DOI":"10.1016\/0002-9149(90)91276-C","volume":"65","author":"M Henry","year":"1990","unstructured":"Henry M, Wehrlen M, Pelletier B, Capron MH . Spironolactone versus nifedipine in essential hypertension Am J Cardiol 1990 65: 36K\u201338K","journal-title":"Am J Cardiol"},{"key":"BF1001320_CR60","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.0954-6820.1975.tb04950.x","volume":"197","author":"SB Solheim","year":"1975","unstructured":"Solheim SB, Sundsfjord JA, Giezendanner L . The effect of spironolactone (Aldactone) and methyldopa in low and normal renin hypertension Acta Med Scand 1975 197: 451\u2013456","journal-title":"Acta Med Scand"},{"key":"BF1001320_CR61","first-page":"225","volume":"1","author":"PO Lim","year":"1999","unstructured":"Lim PO, Brennan GM, Jung RT, MacDonald TM . Diagnosing primary aldosteronism with frusemide stimulation test in hypertensivepatients with raised aldosterone to renin ratio Med Biochem 1999 1: 225\u2013231","journal-title":"Med Biochem"},{"key":"BF1001320_CR62","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1046\/j.1365-2125.1999.00070.x","volume":"48","author":"PO Lim","year":"1999","unstructured":"Lim PO, Jung RT, MacDonald TM . Raised aldosterone to renin ratio predicts anti-hypertensive efficacy of spironolactone. A prospective cohort follow-up study Br J Clin Pharmacol 1999 48: 756\u2013760","journal-title":"Br J Clin Pharmacol"},{"key":"BF1001320_CR63","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1136\/heart.86.1.113","volume":"86","author":"MJ Brown","year":"2001","unstructured":"Brown MJ . Matching the right drug to the rightpatient in essential hypertension Heart 2001 86: 113\u2013120","journal-title":"Heart"},{"key":"BF1001320_CR64","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1440-1681.1985.tb02641.x","volume":"12","author":"SM Hamlet","year":"1985","unstructured":"Hamlet SM, Tunny TJ, Woodland E, Gordon RD . Is aldosterone\/renin ratio useful to screen a hypertensive population for primary aldosteronism? Clin Exp Pharmacol Physiol 1985 12: 249\u2013252","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BF1001320_CR65","first-page":"2854","volume":"85","author":"KC Loh","year":"2000","unstructured":"Loh KC et al. Prevalence of primary aldosteronism among Asian hypertensive patients in Singapore J Clin Endocrinol Metab 2000 85: 2854\u20132859","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1001320.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1001320","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1001320.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T14:28:30Z","timestamp":1647527310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1001320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3,1]]}},"alternative-id":["BF1001320"],"URL":"https:\/\/doi.org\/10.1038\/sj.jhh.1001320","relation":{},"ISSN":["0950-9240","1476-5527"],"issn-type":[{"value":"0950-9240","type":"print"},{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,1]]},"assertion":[{"value":"20 August 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}