{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:13:00Z","timestamp":1762978380329},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2004,5,6]],"date-time":"2004-05-06T00:00:00Z","timestamp":1083801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,5,6]],"date-time":"2004-05-06T00:00:00Z","timestamp":1083801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Hum Hypertens"],"published-print":{"date-parts":[[2004,10,1]]},"DOI":"10.1038\/sj.jhh.1001735","type":"journal-article","created":{"date-parts":[[2004,5,6]],"date-time":"2004-05-06T14:38:21Z","timestamp":1083854301000},"page":"693-699","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Losartan, an angiotensin II (AT1) receptor antagonist, preserves cerebral blood flow in hypertensive patients with a history of stroke"],"prefix":"10.1038","volume":"18","author":[{"given":"H","family":"Moriwaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Uno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Nagakane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Naritomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,5,6]]},"reference":[{"key":"BF1001735_CR1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1136\/bmj.1.5852.507","volume":"1","author":"S Strandgaard","year":"1973","unstructured":"Strandgaard S, Olesen J, Skinhoj E, Lassen NA . Autoregulation of brain circulation in severe arterial hypertension. BMJ 1973; 1: 507\u2013510.","journal-title":"BMJ"},{"key":"BF1001735_CR2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3995\/jstroke.9.463","volume":"9","author":"Y Kuriyama","year":"1987","unstructured":"Kuriyama Y et al. Report of six cases of hemodynamic TIA and its casual relations among hemodynamic parameters. Jpn J Stroke 1987; 9: 463\u2013468.","journal-title":"Jpn J Stroke"},{"key":"BF1001735_CR3","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/978-4-431-68340-7_5","volume-title":"How Should Elderly Hypertensive Patients be Treated?","author":"Y Kuriyama","year":"1989","unstructured":"Kuriyama Y, Sawada T, Omae T . Antihypertensive drugs and cerebral circulation. In: Omae T, Zanchetti A (ed). How Should Elderly Hypertensive Patients be Treated? Springer: Tokyo, 1989, pp 69\u201381."},{"key":"BF1001735_CR4","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1097\/00004872-198412000-00003","volume":"2","author":"DI Barry","year":"1984","unstructured":"Barry DI et al. Cerebrovascular aspects of converting-enzyme inhibition I: effects of intravenous captopril in spontaneously hypertensive and normotensive rats. J Hypertens 1984; 2: 589\u2013597.","journal-title":"J Hypertens"},{"key":"BF1001735_CR5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/00004872-198412000-00004","volume":"2","author":"JO Jarden","year":"1984","unstructured":"Jarden JO et al. Cerebrovascular aspects of converting-enzyme inhibition II: blood\u2013brain barrier permeability and effect of intracerebroventricular administration of captopril. J Hypertens 1984; 2: 599\u2013604.","journal-title":"J Hypertens"},{"issue":"5B","key":"BF1001735_CR6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/0002-9343(84)90891-X","volume":"76","author":"B Rajagopalan","year":"1984","unstructured":"Rajagopalan B, Raine AEG, Cooper R, Ledingham JGG . Changes in cerebral blood flow in patients with severe congestive cardiac failure before and after captopril treatment. Am J Med 1984; 76 (5B): 86\u201390.","journal-title":"Am J Med"},{"key":"BF1001735_CR7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/j.1365-2362.1986.tb01319.x","volume":"16","author":"OB Paulson","year":"1986","unstructured":"Paulson OB et al. Effect of captopril on the cerebral circulation in chronic heart failure. Eur J Clinical Invest 1986; 16: 124\u2013132.","journal-title":"Eur J Clinical Invest"},{"key":"BF1001735_CR8","first-page":"239","volume":"1","author":"Y Kuriyama","year":"1992","unstructured":"Kuriyama Y, Nakamura M, Sawada T, Omae T . Normalization of cerebral blood flow autoregulation after administration of a converting enzyme inhibitor (enalapril) in old stroke patients with hypertension. High Blood Pressure 1992; 1: 239\u2013244.","journal-title":"High Blood Pressure"},{"key":"BF1001735_CR9","first-page":"2019","volume":"35","author":"H Iida","year":"1994","unstructured":"Iida H et al. Quantitative mapping of regional cerebral blood flow using iodine-123-IMP and SPECT. J Nucl Med 1994; 35: 2019\u20132030.","journal-title":"J Nucl Med"},{"key":"BF1001735_CR10","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1097\/00004647-199609000-00003","volume":"16","author":"H Iida","year":"1996","unstructured":"Iida H et al. A multicenter validation of regional cerebral blood flow quantitation using [123I]iodoamphetamine and single photon emission computed tomography. J Cereb Blood Flow Metab 1996; 16: 781\u2013793.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BF1001735_CR11","first-page":"1348","volume":"39","author":"H Moriwaki","year":"1998","unstructured":"Moriwaki H et al. Iodine-123-iomazenil and iodine-123-iodoamphetamine SPECT in major cerebral artery occlusive disease. J Nucl Med 1998; 39: 1348\u20131353.","journal-title":"J Nucl Med"},{"key":"BF1001735_CR12","first-page":"70","volume-title":"Neuroanatomy and Cranial Computed Tomography","author":"HJ Kretschmann","year":"1986","unstructured":"Kretschmann HJ, Weinrich W . Neuroanatomy and Cranial Computed Tomography. Thieme: New York, 1986, pp 70\u201374."},{"key":"BF1001735_CR13","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1161\/01.STR.31.10.2478","volume":"31","author":"Y Nishimura","year":"2000","unstructured":"Nishimura Y, Ito T, Saavedra JM . Angiotensin II AT1 blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats. Stroke 2000; 31: 2478\u20132486.","journal-title":"Stroke"},{"key":"BF1001735_CR14","doi-asserted-by":"publisher","first-page":"150S","DOI":"10.1016\/S0895-7061(99)00218-6","volume":"12","author":"O Chung","year":"1999","unstructured":"Chung O, Unger T . Angiotensin II receptor blockade and end-organ protection. Am J Hypertens 1999; 12: 150S\u2013156S.","journal-title":"Am J Hypertens"},{"key":"BF1001735_CR15","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1161\/01.HYP.33.2.613","volume":"33","author":"M Horiuchi","year":"1999","unstructured":"Horiuchi M, Akishita M, Dzau VJ . Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension 1999; 33: 613\u2013621.","journal-title":"Hypertension"},{"key":"BF1001735_CR16","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1097\/00004872-199311000-00001","volume":"11","author":"A Husain","year":"1993","unstructured":"Husain A . The chymase\u2013angiotensin system in humans. J Hypertens 1993; 11: 1155\u20131159.","journal-title":"J Hypertens"},{"key":"BF1001735_CR17","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1161\/01.CIR.100.6.654","volume":"100","author":"S Takai","year":"1999","unstructured":"Takai S, Jin D, Sakaguchi M, Miyazaki M . Chymase-dependent angiotensin II formation in human vascular tissue. Circulation 1999; 100: 654\u2013658.","journal-title":"Circulation"},{"key":"BF1001735_CR18","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","volume":"359","author":"B Dahl\u00f6f","year":"2002","unstructured":"Dahl\u00f6f B et al, for the LIFE Study Group. Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. Lancet 2002; 359: 995\u20131003.","journal-title":"Lancet"}],"container-title":["Journal of Human Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1001735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1001735","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1001735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T20:34:49Z","timestamp":1647549289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1001735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,6]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10,1]]}},"alternative-id":["BF1001735"],"URL":"https:\/\/doi.org\/10.1038\/sj.jhh.1001735","relation":{},"ISSN":["0950-9240","1476-5527"],"issn-type":[{"value":"0950-9240","type":"print"},{"value":"1476-5527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,6]]},"assertion":[{"value":"26 May 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2004","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}