{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:41:26Z","timestamp":1779234086999,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":3349,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1038\/sj.jid.5700449","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T19:37:14Z","timestamp":1151005034000},"page":"2296-2301","source":"Crossref","is-referenced-by-count":41,"title":["Histamine Is Released following Aminolevulinic Acid-Photodynamic Therapy of Human Skin and Mediates an Aminolevulinic Acid Dose-Related Immediate Inflammatory Response"],"prefix":"10.1016","volume":"126","author":[{"given":"Rebecca C.C.","family":"Brooke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Animesh","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meneka K.","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.B.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin K.","family":"Church","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Friedmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine F.","family":"Clough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley E.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5700449_bb0010","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1751-1097.1997.tb01940.x","article-title":"Phthalocyanine photodynamic therapy: disparate effects of pharmacologic inhibitors on cutaneous photosensitivity and on tumor regression","volume":"65","author":"Anderson","year":"1997","journal-title":"Photochem Photobiol"},{"key":"10.1038\/sj.jid.5700449_bb0015","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0781.2005.00147.x","article-title":"Photodynamic therapy in dermatology \u2013 an update","volume":"21","author":"Babilas","year":"2005","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1038\/sj.jid.5700449_bb0020","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1124\/mol.60.5.1133","article-title":"Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q\/11)-subunits in constitutive and agonist-mediated signaling","volume":"60","author":"Bakker","year":"2001","journal-title":"Mol Pharmacol"},{"key":"10.1038\/sj.jid.5700449_bb0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/10739680490425958","article-title":"Recovery of nitric oxide from acetylcholine-mediated vasodilatation in human skin in vivo","volume":"11","author":"Boutsiouki","year":"2004","journal-title":"Microcirculation"},{"key":"10.1038\/sj.jid.5700449_bb0030","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0304-3835(02)00092-7","article-title":"Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors","volume":"183","author":"Cecic","year":"2002","journal-title":"Cancer Lett"},{"key":"10.1038\/sj.jid.5700449_bb0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-0781.2004.00085.x","article-title":"The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy","volume":"20","author":"Clark","year":"2004","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1038\/sj.jid.5700449_bb0040","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1046\/j.1365-2133.1998.02217.x","article-title":"Effects of H1 antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging","volume":"138","author":"Clough","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0045","first-page":"2908","article-title":"Evidence for an important role of neutrophils in the efficacy of photodynamic therapy in vivo","volume":"56","author":"de Vree","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700449_bb0050","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","article-title":"Photodynamic therapy","volume":"90","author":"Dougherty","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/sj.jid.5700449_bb0055","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2133.1990.tb06270.x","article-title":"Inhibition of photosensitivity in erythropoietic protoporphyria with terfenadine","volume":"122","author":"Farr","year":"1990","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0190-9622(81)70103-8","article-title":"The human sunburn reaction: histologic and biochemical studies","volume":"5","author":"Gilchrest","year":"1981","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0065","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jaci.2004.07.054","article-title":"H1 histamine receptor mediates inflammatory responses in human keratinocytes","volume":"114","author":"Giustizieri","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/sj.jid.5700449_bb0070","first-page":"1785","article-title":"Involvement of nitric oxide during phthalocyanine (Pc4) photodynamic therapy-mediated apoptosis","volume":"58","author":"Gupta","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700449_bb0075","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.4049\/jimmunol.145.12.4365","article-title":"Role of histamine in natural killer cell-mediated resistance against tumor cells","volume":"145","author":"Hellstrand","year":"1990","journal-title":"J Immunol"},{"key":"10.1038\/sj.jid.5700449_bb0080","first-page":"6896","article-title":"Release of prostaglandin E2 from cells by photodynamic treatment in vitro","volume":"49","author":"Henderson","year":"1989","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700449_bb0085","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0162-3109(95)00047-X","article-title":"Photofrin II induces cytokine secretion by mouse spleen cells and human peripheral mononuclear cells","volume":"31","author":"Herman","year":"1996","journal-title":"Immunopharmacology"},{"key":"10.1038\/sj.jid.5700449_bb0090","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000085108","article-title":"Histamine in allergic inflammation and immune modulation","volume":"137","author":"Jutel","year":"2005","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1038\/sj.jid.5700449_bb0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/1523-1747.ep12261010","article-title":"Participation of mast cells and complement in the immediate phase of haematoporphyrin-induced phototoxicity","volume":"82","author":"Kamide","year":"1984","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0923-1811(01)00147-5","article-title":"Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes","volume":"28","author":"Kohda","year":"2002","journal-title":"J Dermatol Sci"},{"key":"10.1038\/sj.jid.5700449_bb0105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3835(98)00349-8","article-title":"Contribution of myeloid and lymphoid host cells to the curative outcome of mouse sarcoma treatment by photodynamic therapy","volume":"137","author":"Korbelik","year":"1999","journal-title":"Cancer Lett"},{"key":"10.1038\/sj.jid.5700449_bb0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1117\/12.434715","article-title":"Relevance of PDT-induced inflammatory response for the outcome of photodynamic therapy","volume":"4257","author":"Korbelik","year":"2001","journal-title":"Proc SPIE"},{"key":"10.1038\/sj.jid.5700449_bb0115","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/bjc.1995.108","article-title":"Induction of immune cell infiltration into murine SCCVII tumour by photofrin-based photodynamic therapy","volume":"71","author":"Krosl","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1038\/sj.jid.5700449_bb0120","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.4049\/jimmunol.152.7.3570","article-title":"Histamine induces leukocyte rolling in post-capillary venules. A P-selectin-mediated event","volume":"152","author":"Kubes","year":"1994","journal-title":"J Immunol"},{"key":"10.1038\/sj.jid.5700449_bb0125","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/1523-1747.ep12275345","article-title":"Delayed phase of hematoporphyrin-induced phototoxicity: modulation by complement, leukocytes, and antihistamines","volume":"84","author":"Lim","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0130","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/1523-1747.ep12346356","article-title":"Histamine in human epidermal cells is induced by ultraviolet light injury","volume":"106","author":"Malaviya","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1365-2133.2003.04898.x","article-title":"Histological changes and involvement of apoptosis after photodynamic therapy for actinic keratoses","volume":"148","author":"Nakaseko","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0140","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1751-1097.1981.tb05429.x","article-title":"The effect of protoporphyrin on histamine secretion by rat peritoneal mast cells: a dual phototoxic reaction","volume":"33","author":"Ortner","year":"1981","journal-title":"Photochem Photobiol"},{"key":"10.1038\/sj.jid.5700449_bb0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/1523-1747.ep12285644","article-title":"Iontophoretic delivery of ALA provides a quantitative model for ALA pharmacokinetics and PpIX phototoxicity in human skin","volume":"108","author":"Rhodes","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0150","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000237357","article-title":"Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells","volume":"111","author":"Saito","year":"1996","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1038\/sj.jid.5700449_bb0155","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/S0091-6749(03)01878-5","article-title":"H1-receptors: localization and role in airway physiology and in immune functions","volume":"112","author":"Togias","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/sj.jid.5700449_bb0160","first-page":"868","article-title":"The skin inflammatory response to photodynamic therapy","volume":"148","author":"Walker","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700449_bb0165","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1078\/0171-2985-00221","article-title":"The immunological consequences of photodynamic treatment of cancer, a literature review","volume":"207","author":"van Duijnhoven","year":"2003","journal-title":"Immunobiology"},{"key":"10.1038\/sj.jid.5700449_bb0170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1562\/0031-8655(2003)078<0075:ESCLIM>2.0.CO;2","article-title":"Elevated serum cytokine levels in mesothelioma patients who have undergone pleurectomy or extrapleural pneumonectomy and adjuvant intraoperative photodynamic therapy","volume":"78","author":"Yom","year":"2003","journal-title":"Photochem Photobiol"},{"key":"10.1038\/sj.jid.5700449_bb0175","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.0022-202x.2001.01668.x","article-title":"Histamine is involved in ultraviolet B-induced pigmentation of guinea pig skin","volume":"118","author":"Yoshida","year":"2002","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15326646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15326646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T20:23:35Z","timestamp":1683491015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15326646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0022202X15326646"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5700449","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}