{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:58:53Z","timestamp":1787003933316,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":3288,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1038\/sj.jid.5700612","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T21:04:04Z","timestamp":1163624644000},"page":"2576-2582","source":"Crossref","is-referenced-by-count":49,"title":["Computer Simulation of Native Epidermal Enzyme Structures in the Presence and Absence of Hydrogen Peroxide (H2O2): Potential and Pitfalls"],"prefix":"10.1016","volume":"126","author":[{"given":"Nicholas C.J.","family":"Gibbons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Rokos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin U.","family":"Schallreuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5700612_bb0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.150.3692.72","article-title":"Catalase: kinetics of photooxidation","volume":"150","author":"Aronoff","year":"1965","journal-title":"Science"},{"key":"10.1038\/sj.jid.5700612_bb0015","doi-asserted-by":"crossref","first-page":"15018","DOI":"10.1073\/pnas.0504218102","article-title":"Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism","volume":"102","author":"Biterova","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700612_bb0020","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1152\/physrev.1970.50.3.319","article-title":"Catalase: Physical and chemical properties, mechanism of catalysis, and physiological role","volume":"50","author":"Deisseroth","year":"1970","journal-title":"Physiol Rev"},{"key":"10.1038\/sj.jid.5700612_bb0025","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.82.6.1604","article-title":"The NADPH binding site on beef liver catalase","volume":"82","author":"Fita","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700612_bb0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1107\/S0108768186097835","article-title":"The refined structure of beef liver catalase at 2.5\u00c5 resolution","volume":"42","author":"Fita","year":"1986","journal-title":"Acta Cryst B"},{"key":"10.1038\/sj.jid.5700612_bb0035","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1038\/sj.jid.5700151","article-title":"Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance","volume":"126","author":"Grando","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700612_bb0040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.0022-202X.2004.22230.x","article-title":"Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress","volume":"122","author":"Hasse","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700612_bb0045","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.0906-6705.2005.00265.x","article-title":"In vivo and in vitro evidence for autocrine DCoH\/HNF-1alpha transcription of albumin in the human epidermis","volume":"14","author":"Hasse","year":"2005","journal-title":"Exp Dermatol"},{"issue":"Part 2","key":"10.1038\/sj.jid.5700612_bb0050","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/bj3000531","article-title":"NADPH binding and control of catalase compound II formation: comparison of bovine, yeast, and Escherichia coli enzymes","volume":"300","author":"Hillar","year":"1994","journal-title":"Biochem J"},{"key":"10.1038\/sj.jid.5700612_bb0055","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1091\/mbc.E03-08-0629","article-title":"Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases","volume":"15","author":"Kim","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1038\/sj.jid.5700612_bb0060","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1073\/pnas.81.14.4343","article-title":"Catalase: a tetrameric enzyme with four tightly bound molecules of NADPH","volume":"81","author":"Kirkman","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700612_bb0065","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0021-9258(19)75835-9","article-title":"The function of catalase-bound NADPH","volume":"262","author":"Kirkman","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700612_bb0070","doi-asserted-by":"crossref","first-page":"13908","DOI":"10.1074\/jbc.274.20.13908","article-title":"Mechanisms of protection of catalase by NADPH. Kinetics and stoichiometry","volume":"274","author":"Kirkman","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700612_bb0075","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/10715769509147544","article-title":"Reactions of bovine liver catalase with superoxide radicals and hydrogen peroxide","volume":"22","author":"Lardinois","year":"1995","journal-title":"Free Radic Res"},{"key":"10.1038\/sj.jid.5700612_bb0080","series-title":"The Handbook of Infrared and Raman Characteristic Frequencies of Organic Molecules","first-page":"503","author":"Lin-Vien","year":"1991"},{"key":"10.1038\/sj.jid.5700612_bb0085","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/sj.jid.5700021","article-title":"UVA-induced modification of catalase charge properties in the epidermis is correlated with the skin phototype","volume":"126","author":"Maresca","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700612_bb0090","doi-asserted-by":"crossref","first-page":"42462","DOI":"10.1074\/jbc.M407464200","article-title":"Evidence for a new sub-class of methionine sulfoxide reductases B with an alternative thioredoxin recognition signature","volume":"279","author":"Neiers","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700612_bb0095","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0891-5849(01)00724-9","article-title":"Reactive oxygen species, antioxidants, and the mammalian thioredoxin system","volume":"31","author":"Nordberg","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1038\/sj.jid.5700612_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0111317","article-title":"Selenium biochemistry: chemical and physical studies","volume":"54","author":"Odom","year":"1983","journal-title":"Struct Bond"},{"key":"10.1038\/sj.jid.5700612_bb0105","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/sj.jid.5700116","article-title":"The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation","volume":"126","author":"Ogawa","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700612_bb0110","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/jmbi.1999.3458","article-title":"Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism","volume":"296","author":"Putnam","year":"2000","journal-title":"J Mol Biol"},{"key":"10.1038\/sj.jid.5700612_bb0115","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1073\/pnas.78.8.4767","article-title":"Structure and heme environment of beef liver catalase at 2.5\u00c5 resolution","volume":"78","author":"Reid","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700612_bb0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jrs.1114","article-title":"In vivo fluorescence excitation spectroscopy and in vivo FT-Raman spectroscopy in human skin: evidence of H2O2 oxidation of epidermal albumin in patients with vitiligo","volume":"35","author":"Rokos","year":"2004","journal-title":"J Raman Spectrosc"},{"key":"10.1038\/sj.jid.5700612_bb0125","doi-asserted-by":"crossref","first-page":"9533","DOI":"10.1073\/pnas.171178698","article-title":"Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme","volume":"98","author":"Sandalova","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700612_bb0130","first-page":"1190","article-title":"Pseudocatalase treatment in xeroderma pigmentosum: a case report","volume":"140","author":"Schallreuter","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700612_bb0135","series-title":"Autoimmune Diseases of the Skin. Pathogenesis, Diagnosis, Management","first-page":"367","article-title":"Vitiligo","author":"Schallreuter","year":"2005"},{"key":"10.1038\/sj.jid.5700612_bb0140","first-page":"505","article-title":"Oxidative stress in the human epidermis","volume":"140","author":"Schallreuter","year":"2005","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1038\/sj.jid.5700612_bb0145","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/sj.jid.5700086","article-title":"Functioning methionine sulfoxide reductase A and B are present in human skin","volume":"126","author":"Schallreuter","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700612_bb0150","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.bbrc.2004.01.082","article-title":"Activation\/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo","volume":"315","author":"Schallreuter","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/sj.jid.5700612_bb0155","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.jidsp.5640189","article-title":"In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase","volume":"4","author":"Schallreuter","year":"1999","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1038\/sj.jid.5700612_bb0160","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00371781","article-title":"Defects in antioxidant defense and calcium transport in the epidermis of xeroderma pigmentosum patients","volume":"283","author":"Schallreuter","year":"1991","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/sj.jid.5700612_bb0165","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbrc.2006.01.124","article-title":"Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus","volume":"342","author":"Schallreuter","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/sj.jid.5700612_bb0170","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000246690","article-title":"Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients","volume":"190","author":"Schallreuter","year":"1995","journal-title":"Dermatology"},{"key":"10.1038\/sj.jid.5700612_bb0175","series-title":"The Enzymes","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1874-6047(08)60245-0","article-title":"Catalase","author":"Schonbaum","year":"1976"},{"key":"10.1038\/sj.jid.5700612_bb0180","article-title":"Oxidative stress via hydrogen peroxide affects proopiomelanocortin-peptides directly in the epidermis of patients with vitiligo","author":"Spencer","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700612_bb0185","first-page":"845","article-title":"Xeroderma pigmentosum: development of photoformation of hydrogen peroxide and catalytic activity in skin cells; application to an early diagnosis and to a tentative treatment","volume":"296","author":"Vuillaume","year":"1983","journal-title":"C R Seances Acad Sci III"},{"key":"10.1038\/sj.jid.5700612_bb0190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.jid.5700051","article-title":"UVA-irradiated pheomelanin alters the structure of catalase and decreases its activity in human skin","volume":"126","author":"Wood","year":"2006","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15327147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15327147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T15:26:19Z","timestamp":1628090779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15327147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0022202X15327147"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5700612","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}