{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:48:29Z","timestamp":1791118109714,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":3076,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1038\/sj.jid.5700742","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T14:37:13Z","timestamp":1173969433000},"page":"1713-1719","source":"Crossref","is-referenced-by-count":33,"title":["Topical Application of Neuronal Nitric Oxide Synthase Inhibitor Accelerates Cutaneous Barrier Recovery and Prevents Epidermal Hyperplasia Induced by Barrier Disruption"],"prefix":"10.1016","volume":"127","author":[{"given":"Kazuyuki","family":"Ikeyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyoshi","family":"Fuziwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Denda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5700742_bb0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0923-1811(94)00359-M","article-title":"Involvement of protein kinase C in bradykinin-induced intracellular calcium increase in primary cultured human keratinocytes","volume":"9","author":"Aoyama","year":"1995","journal-title":"J Dermatol Sci"},{"key":"10.1038\/sj.jid.5700742_bb0015","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1523-1747.2001.01238.x","article-title":"Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment","volume":"116","author":"Ashida","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0020","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s004030050303","article-title":"Distinct subpopulations in HaCaT cells as revealed by the characteristics of intracellular calcium release induced by phosphoinositide-coupled agonists","volume":"290","author":"Biro","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/sj.jid.5700742_bb0025","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.0022-202X.2004.22731.x","article-title":"The neuronal nitric oxide synthase is upregulated in mouse skin repair and in response to epidermal growth factor in human HaCaT keratinocytes","volume":"123","author":"Boissel","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0030","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1073\/pnas.86.22.9030","article-title":"Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum","volume":"86","author":"Bredt","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700742_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1523-1747.1998.00084.x","article-title":"Nitric oxide in human skin: current status and future prospects","volume":"110","author":"Bruch-Gerharz","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.niox.2004.04.005","article-title":"Nitric oxide function in the skin","volume":"10","author":"Cals-Grierson","year":"2004","journal-title":"Nitric Oxide"},{"key":"10.1038\/sj.jid.5700742_bb0045","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0006-2952(97)00375-4","article-title":"Role of nitric oxide and its intracellular signalling pathways in the control of Ca2+ homeostasis","volume":"55","author":"Clementi","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/sj.jid.5700742_bb0050","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1046\/j.1365-2133.2000.03466.x","article-title":"Barrier recovery rate varies time-dependently in human skin","volume":"142","author":"Denda","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0055","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1046\/j.1523-1747.1998.00364.x","article-title":"Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: implication for seasonal exacerbations of inflammatory dermatoses","volume":"111","author":"Denda","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0060","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/1523-1747.ep12276640","article-title":"Trans-4-(aminomethyl)cyclohexane carboxylic acid (T-AMCHA), an anti-fibrinolytic agent, accelerates barrier recovery and prevents the epidermal hyperplasia induced by epidermal injury in hairless mice and humans","volume":"109","author":"Denda","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0065","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1046\/j.1523-1747.2003.12367.x","article-title":"Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis","volume":"121","author":"Denda","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0070","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000056387","article-title":"Coordinate regulation of epidermal differentiation and barrier homeostasis","volume":"14","author":"Elias","year":"2001","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.1038\/sj.jid.5700742_bb0075","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.0022-202X.2005.23668.x","article-title":"Stratum corneum defensive functions: an integrated view","volume":"125","author":"Elias","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0080","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1078\/0171-9335-00425","article-title":"Nitric oxide regulates synthesis of gene products involved in keratinocyte differentiation and ceramide metabolism","volume":"83","author":"Gallala","year":"2004","journal-title":"Eur J Cell Biol"},{"key":"10.1038\/sj.jid.5700742_bb0085","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0002-9440(10)64416-1","article-title":"Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo","volume":"161","author":"Giustizieri","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.jid.5700742_bb0090","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"269","author":"Grynkiewicz","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700742_bb0095","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1152\/jn.2000.83.1.198","article-title":"Calcium channel activation facilitated by nitric oxide in retinal ganglion cells","volume":"83","author":"Hirooka","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1038\/sj.jid.5700742_bb0100","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1096\/fj.02-0126com","article-title":"Nitric oxide promotes intracellular calcium release from mitochondria in striatal neurons","volume":"16","author":"Horn","year":"2002","journal-title":"FASEB J"},{"key":"10.1038\/sj.jid.5700742_bb0105","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1006\/cbir.2001.0751","article-title":"cGMP-regulated store-operated calcium entry in human hepatoma cells","volume":"25","author":"Jiang","year":"2001","journal-title":"Cell Biol Int"},{"issue":"Part 2","key":"10.1038\/sj.jid.5700742_bb0110","first-page":"H1613","article-title":"NO decreases phosphorylation of focal adhesion proteins via reduction of Ca in rat aortic smooth muscle cells","volume":"274","author":"Kaur","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1038\/sj.jid.5700742_bb0115","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/bbrc.1998.8269","article-title":"Inhibition by imipramine of ATP-evoked responses in rat pheochromocytoma cells","volume":"244","author":"Koizumi","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/sj.jid.5700742_bb0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physiolgenomics.2000.2.1.21","article-title":"nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle","volume":"2","author":"Lau","year":"2000","journal-title":"Physiol Genomics"},{"key":"10.1038\/sj.jid.5700742_bb0125","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI115617","article-title":"Calcium and potassium are important regulators of barrier homeostasis in murine epidermis","volume":"89","author":"Lee","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.jid.5700742_bb0130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s004030050268","article-title":"Detection of nitric oxide and nitric oxide synthases in psoriasis","volume":"290","author":"Ormerod","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/sj.jid.5700742_bb0135","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1172\/JCI115183","article-title":"Barrier function regulates epidermal DNA synthesis","volume":"87","author":"Proksch","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.jid.5700742_bb0140","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1172\/JCI119206","article-title":"Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis","volume":"99","author":"Romero-Graillet","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.jid.5700742_bb0145","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00372131","article-title":"Inositol phosphate formation and release of intracellular free calcium by bradykinin in HaCaT keratinocytes","volume":"285","author":"Rosenbach","year":"1993","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/sj.jid.5700742_bb0150","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1046\/j.1523-1747.2000.00116.x","article-title":"Nitric oxide inhibits cornified envelope formation in human keratinocytes by inactivating transglutaminases and activating protein 1","volume":"115","author":"Rossi","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0155","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2133.2005.06718.x","article-title":"Differential expression of nitric oxide synthases in human scalp epidermal and hair follicle pigmentary units: implications for regulation of melanogenesis","volume":"153","author":"Sowden","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0160","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1034\/j.1398-9995.2001.00131.x","article-title":"Increased serum nitrate levels in infants with atopic dermatitis","volume":"56","author":"Taniuchi","year":"2001","journal-title":"Allergy"},{"key":"10.1038\/sj.jid.5700742_bb0165","doi-asserted-by":"crossref","first-page":"9651","DOI":"10.1074\/jbc.273.16.9651","article-title":"Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation","volume":"273","author":"Watanabe","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700742_bb0170","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2230.2003.01365.x","article-title":"Nitric oxide: a key mediator in cutaneous physiology","volume":"28","author":"Weller","year":"2003","journal-title":"Clin Exp Dermatol"},{"key":"10.1038\/sj.jid.5700742_bb0175","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.1988.tb18806.x","article-title":"Signal transduction for proliferation and differentiation in keratinocytes","volume":"548","author":"Yuspa","year":"1988","journal-title":"Ann N Y Acad Sci"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15334436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15334436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T07:04:04Z","timestamp":1628665444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15334436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0022202X15334436"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5700742","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}