{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:58:53Z","timestamp":1787003933203,"version":"build-2736575974"},"reference-count":91,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2953,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1038\/sj.jid.5700889","type":"journal-article","created":{"date-parts":[[2007,6,7]],"date-time":"2007-06-07T06:44:53Z","timestamp":1181198693000},"page":"2563-2576","source":"Crossref","is-referenced-by-count":20,"title":["Single Base Instability Is Promoted in Vulvar Lichen Sclerosus"],"prefix":"10.1016","volume":"127","author":[{"given":"Ronald A.","family":"Tapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wesley Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Andrew Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent L.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5700889_bb0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/10408448509037459","article-title":"Regeneration and the mechanism of epidermal tumor promotion","volume":"14","author":"Argyris","year":"1985","journal-title":"Crit Rev Toxicol"},{"key":"10.1038\/sj.jid.5700889_bb0015","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.0022-202x.2001.01385.x","article-title":"Mosaic pattern of maternal and paternal keratinocyte clones in normal human epidermis revealed by analysis of X-chromosome inactivation","volume":"117","author":"Asplund","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mrfmmm.2004.10.011","article-title":"Genetic tumor archeology: microdissection and genetic heterogeneity in squamous and basal cell carcinoma","volume":"571","author":"Backvall","year":"2005","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0025","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.0906-6705.2004.00211.x","article-title":"Mutation spectra of epidermal p53 clones adjacent to basal cell carcinoma and squamous cell carcinoma","volume":"13","author":"Backvall","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2133.2004.05683.x","article-title":"The density of epidermal p53 clones is higher adjacent to squamous cell carcinoma in comparison with basal cell carcinoma","volume":"150","author":"Backvall","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrc1799","article-title":"Epigenetic gene silencing in cancer \u2013 a mechanism for early oncogenic pathway addiction?","volume":"6","author":"Baylin","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/sj.jid.5700889_bb0040","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1073\/pnas.93.1.274","article-title":"Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells","volume":"93","author":"Berg","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700889_bb0045","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/em.20111","article-title":"Mutator phenotype in cancer: timing and perspectives","volume":"45","author":"Bielas","year":"2005","journal-title":"Environ Mol Mutagen"},{"key":"10.1038\/sj.jid.5700889_bb0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/hmg\/4.3.383","article-title":"Spectrum of germline mutations in the RB1 gene: a study of 232 patients with hereditary and non hereditary retinoblastoma","volume":"4","author":"Blanquet","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1038\/sj.jid.5700889_bb0055","first-page":"5248","article-title":"A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"Boland","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700889_bb0060","first-page":"1727","article-title":"A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications","volume":"63","author":"Braakhuis","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700889_bb0065","doi-asserted-by":"crossref","first-page":"25421","DOI":"10.1074\/jbc.M101032200","article-title":"DNA repair excision nuclease attacks undamaged DNA. A potential source of spontaneous mutations","volume":"276","author":"Branum","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700889_bb0070","first-page":"69","article-title":"Skin Precancer","volume":"32","author":"Brash","year":"1998","journal-title":"Cancer Surv"},{"key":"10.1038\/sj.jid.5700889_bb0075","doi-asserted-by":"crossref","first-page":"10124","DOI":"10.1073\/pnas.88.22.10124","article-title":"A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma","volume":"88","author":"Brash","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700889_bb0080","doi-asserted-by":"crossref","first-page":"10567","DOI":"10.1073\/pnas.162369899","article-title":"Somatic stem cells and the kinetics of mutagenesis and carcinogenesis","volume":"99","author":"Cairns","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700889_bb0085","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00008469-199512000-00008","article-title":"Squamous cell carcinoma arising in vulval lichen sclerosus: a longitudinal cohort study","volume":"4","author":"Carli","year":"1995","journal-title":"Eur J Cancer Prev"},{"key":"10.1038\/sj.jid.5700889_bb0090","first-page":"313","article-title":"Vulvar carcinoma associated with lichen sclerosus. Experience at the Florence, Italy, Vulvar Clinic","volume":"48","author":"Carli","year":"2003","journal-title":"J Reprod Med"},{"key":"10.1038\/sj.jid.5700889_bb0095","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0046-8177(98)90198-8","article-title":"Vulvar lichen sclerosus and squamous cell carcinoma: a cohort, case\u2013control, and investigational study with historical perspective; implications for chronic inflammation and sclerosis in the development of neoplasia","volume":"29","author":"Carlson","year":"1998","journal-title":"Hum Pathol"},{"key":"10.1038\/sj.jid.5700889_bb0100","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00129039-200106000-00008","article-title":"Concordant p53 and mdm-2 protein expression in vulvar squamous cell carcinoma and adjacent lichen sclerosus","volume":"9","author":"Carlson","year":"2001","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1038\/sj.jid.5700889_bb0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00000372-200002000-00002","article-title":"Comparative immunophenotypic study of lichen sclerosus: epidermotropic CD57+ lymphocytes are numerous \u2013 implications for pathogenesis","volume":"22","author":"Carlson","year":"2000","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/sj.jid.5700889_bb0110","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/00000372-200110000-00020","article-title":"Incidental histopathologic patterns: possible evidence of \u2018field cancerization\u2019 surrounding skin tumors","volume":"23","author":"Carlson","year":"2001","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/sj.jid.5700889_bb0115","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1073\/pnas.91.9.3749","article-title":"N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations","volume":"91","author":"Cha","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700889_bb0120","first-page":"1268","article-title":"Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins","volume":"58","author":"Coller","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700889_bb0125","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.274.5286.430","article-title":"Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53","volume":"274","author":"Denissenko","year":"1996","journal-title":"Science"},{"key":"10.1038\/sj.jid.5700889_bb0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1383-5718(00)00058-9","article-title":"Hydrogen peroxide induced mutations at the HPRT locus in primary human T-lymphocytes","volume":"469","author":"Diaz-Llera","year":"2000","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0135","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0898-6568(00)00084-X","article-title":"The importance of being K-Ras","volume":"12","author":"Ellis","year":"2000","journal-title":"Cell Signal"},{"key":"10.1038\/sj.jid.5700889_bb0140","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0027-5107(94)90157-0","article-title":"Determination of hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age","volume":"308","author":"Finette","year":"1994","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(00)00482-2","article-title":"Redox-modulated pathways in inflammatory skin diseases","volume":"30","author":"Fuchs","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1038\/sj.jid.5700889_bb0150","first-page":"951","article-title":"Squamous cell carcinoma in chronic lymphedema: case report and review of the literature","volume":"28","author":"Furukawa","year":"2002","journal-title":"Dermatol Surg"},{"key":"10.1038\/sj.jid.5700889_bb0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/em.20024","article-title":"Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease","volume":"44","author":"Goodman","year":"2004","journal-title":"Environ Mol Mutagen"},{"key":"10.1038\/sj.jid.5700889_bb0160","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.genom.3.022502.103043","article-title":"Genetic and epigenetic alterations in colon cancer","volume":"3","author":"Grady","year":"2002","journal-title":"Annu Rev Genomic Hum Genet"},{"key":"10.1038\/sj.jid.5700889_bb0165","first-page":"4855","article-title":"Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis","volume":"54","author":"Greenblatt","year":"1994","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700889_bb0170","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0027-5107(92)90186-6","article-title":"In vivo human somatic mutation: frequency and spectrum with age","volume":"266","author":"Grist","year":"1992","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0175","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/carcin\/16.5.993","article-title":"Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expression","volume":"16","author":"Guinee","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1038\/sj.jid.5700889_bb0180","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrfmmm.2004.09.013","article-title":"Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis","volume":"571","author":"Halliday","year":"2005","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0185","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1038\/sj.jid.5700889_bb0190","doi-asserted-by":"crossref","first-page":"10012","DOI":"10.1021\/bi034631s","article-title":"Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms","volume":"42","author":"Hu","year":"2003","journal-title":"Biochemistry"},{"key":"10.1038\/sj.jid.5700889_bb0195","first-page":"3333","article-title":"Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease","volume":"60","author":"Hussain","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700889_bb0200","first-page":"4023","article-title":"Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes","volume":"58","author":"Hussain","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700889_bb0205","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrc1046","article-title":"Radical causes of cancer","volume":"3","author":"Hussain","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/sj.jid.5700889_bb0210","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1242\/dev.126.11.2409","article-title":"The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis","volume":"126","author":"Jensen","year":"1999","journal-title":"Development (Cambridge, England)"},{"key":"10.1038\/sj.jid.5700889_bb0215","doi-asserted-by":"crossref","first-page":"14025","DOI":"10.1073\/pnas.93.24.14025","article-title":"Frequent clones of p53-mutated keratinocytes in normal human skin","volume":"93","author":"Jonason","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700889_bb0220","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/nar\/gkg137","article-title":"Mutagenic potentials of damaged nucleic acids produced by reactive oxygen\/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary","volume":"31","author":"Kamiya","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/sj.jid.5700889_bb0225","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mrfmmm.2004.10.010","article-title":"UVR-induced G-C to C-G transversions from oxidative DNA damage","volume":"571","author":"Kino","year":"2005","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0230","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1074\/jbc.M511690200","article-title":"Oncogenic RAS induces accelerated transition through G2\/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints","volume":"281","author":"Knauf","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700889_bb0235","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/humu.1380050107","article-title":"Somatic spectrum of cancer-associated single basepair substitutions in the TP53 gene is determined mainly by endogenous mechanisms of mutation and by selection","volume":"5","author":"Krawczak","year":"1995","journal-title":"Hum Mutat"},{"key":"10.1038\/sj.jid.5700889_bb0240","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/25292","article-title":"Genetic instabilities in human cancers","volume":"396","author":"Lengauer","year":"1998","journal-title":"Nature"},{"key":"10.1038\/sj.jid.5700889_bb0245","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0002-9440(10)62511-4","article-title":"Persistent p53 mutations in single cells from normal human skin","volume":"159","author":"Ling","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.jid.5700889_bb0250","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/MCB.14.6.4225","article-title":"Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer","volume":"14","author":"Magewu","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1038\/sj.jid.5700889_bb0255","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/hmg\/5.2.215","article-title":"Somatic mutations are frequent and increase with age in human kidney epithelial cells","volume":"5","author":"Martin","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1038\/sj.jid.5700889_bb0260","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1383-5742(99)00026-5","article-title":"The contribution of exogenous and endogenous mutagens to in vivo mutations","volume":"428","author":"Morley","year":"1999","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0265","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1073\/pnas.91.1.360","article-title":"UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement","volume":"91","author":"Nakazawa","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700889_bb0270","doi-asserted-by":"crossref","first-page":"43568","DOI":"10.1074\/jbc.M407117200","article-title":"In vivo bypass efficiencies and mutational signatures of the guanine oxidation products 2-aminoimidazolone and 5-guanidino-4-nitroimidazole","volume":"279","author":"Neeley","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700889_bb0275","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/152308604773934314","article-title":"Role of reactive oxygen species in skin carcinogenesis","volume":"6","author":"Nishigori","year":"2004","journal-title":"Antioxid Redox Signal"},{"key":"10.1038\/sj.jid.5700889_bb0280","first-page":"433","article-title":"Quantitative detection of ultraviolet-specific p53 mutations in normal skin from Japanese patients","volume":"6","author":"Ouhtit","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1038\/sj.jid.5700889_bb0285","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/1043-4682(92)90014-M","article-title":"Epidermal keratinocyte stem cells: their maintenance and regulation","volume":"3","author":"Parkinson","year":"1992","journal-title":"Semin Cell Biol"},{"key":"10.1038\/sj.jid.5700889_bb0290","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/1523-1747.ep12321071","article-title":"Ultraviolet light induces expression of p53 and p21 in human skin: effect of sunscreen and constitutive p21 expression in skin appendages","volume":"105","author":"Ponten","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0295","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1046\/j.1523-1747.2002.00020.x","article-title":"Keratinocyte stem cells: a commentary","volume":"119","author":"Potten","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0300","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0002-9440(10)64924-3","article-title":"Monoclonal gamma-T-cell receptor rearrangement in vulvar lichen sclerosus and squamous cell carcinomas","volume":"160","author":"Regauer","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.jid.5700889_bb0305","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/(SICI)1098-2744(200004)27:4<298::AID-MC8>3.0.CO;2-4","article-title":"Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N'-nitro-N-nitrosoguanidine and promoted by mezerein","volume":"27","author":"Rehman","year":"2000","journal-title":"Mol Carcinogen"},{"key":"10.1038\/sj.jid.5700889_bb0310","first-page":"111","article-title":"Reconstruction of the two-dimensional distribution of p53 positive patches in sun-exposed skin morphologically normal skin","volume":"11","author":"Ren","year":"1997","journal-title":"Inter J Oncol"},{"key":"10.1038\/sj.jid.5700889_bb0315","first-page":"1791","article-title":"Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin","volume":"150","author":"Ren","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.jid.5700889_bb0320","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/(SICI)1097-0215(19960621)69:3<174::AID-IJC4>3.0.CO;2-X","article-title":"Two distinct p53 immunohistochemical patterns in human squamous-cell skin cancer, precursors and normal epidermis","volume":"69","author":"Ren","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1038\/sj.jid.5700889_bb0325","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/nar\/26.1.295","article-title":"SV40 large tumor antigen (T antigen): database of mutants","volume":"26","author":"Robinson","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/sj.jid.5700889_bb0330","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00000372-200206000-00008","article-title":"Vulvar malignant melanoma associated with human papillomavirus DNA: report of two cases and review of literature","volume":"24","author":"Rohwedder","year":"2002","journal-title":"Am J Dermatopathol"},{"key":"10.1038\/sj.jid.5700889_bb0335","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1038\/sj.bjc.6601444","article-title":"TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva","volume":"89","author":"Rolfe","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1038\/sj.jid.5700889_bb0340","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0027-5107(97)00287-X","article-title":"Spontaneous mutagenesis in mammalian cells is caused mainly by oxidative events and can be blocked by antioxidants and metallothionein","volume":"402","author":"Rossman","year":"1998","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0345","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1067\/mjd.2002.120909","article-title":"Lymphedema: an immunologically vulnerable site for development of neoplasms","volume":"47","author":"Ruocco","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0350","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1365-2133.2004.06142.x","article-title":"Oxidative stress is implicated in the pathogenesis of lichen sclerosus","volume":"151","author":"Sander","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0355","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/carcin\/24.3.353","article-title":"Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models","volume":"24","author":"Seril","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1038\/sj.jid.5700889_bb0360","first-page":"217","article-title":"Chronic inflammation and cancer","volume":"16","author":"Shacter","year":"2002","journal-title":"Oncology (Williston Park)"},{"key":"10.1038\/sj.jid.5700889_bb0365","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/nar\/22.6.972","article-title":"The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA","volume":"22","author":"Shen","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/sj.jid.5700889_bb0370","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.1133427","article-title":"The consensus coding sequences of human breast and colorectal cancers","volume":"314","author":"Sjoblom","year":"2006","journal-title":"Science"},{"key":"10.1038\/sj.jid.5700889_bb0375","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Slaughter","year":"1953","journal-title":"Cancer"},{"key":"10.1038\/sj.jid.5700889_bb0380","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1001\/archderm.1995.01690190048009","article-title":"Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas","volume":"131","author":"Spencer","year":"1995","journal-title":"Arch Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0385","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/humu.10212","article-title":"Human Gene Mutation Database (HGMD): 2003 update","volume":"21","author":"Stenson","year":"2003","journal-title":"Hum Mutat"},{"key":"10.1038\/sj.jid.5700889_bb0390","first-page":"597","article-title":"\u201cLow-risk\u201d and \u201chigh-risk\u201d HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases","volume":"197","author":"Stenzel","year":"2001","journal-title":"Pathol Res Pract"},{"key":"10.1038\/sj.jid.5700889_bb0395","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mrfmmm.2005.12.008","article-title":"Distributions of five common point mutants in the human tracheal-bronchial epithelium","volume":"596","author":"Sudo","year":"2006","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0400","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/sj.jid.5600549.x","article-title":"Low frequency of genetic change in p53 immunopositive clones in human epidermis","volume":"113","author":"Tabata","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0405","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/gyno.1994.1091","article-title":"Analysis of HPV-positive and -negative vulvar carcinomas for alterations in c-myc, Ha-, Ki-, and N-ras genes","volume":"53","author":"Tate","year":"1994","journal-title":"Gynecol Oncol"},{"key":"10.1038\/sj.jid.5700889_bb0410","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ng1205","article-title":"Have environmental mutagens caused oncomutations in people?","volume":"34","author":"Thilly","year":"2003","journal-title":"Nat Genet"},{"key":"10.1038\/sj.jid.5700889_bb0415","first-page":"5793","article-title":"The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells","volume":"63","author":"Tomita-Mitchell","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700889_bb0420","first-page":"1493","article-title":"Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers","volume":"10","author":"Tornaletti","year":"1995","journal-title":"Oncogene"},{"key":"10.1038\/sj.jid.5700889_bb0425","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1046\/j.1523-1747.2002.19513.x","article-title":"Overexpression of wild-type p53 in lichen sclerosus adjacent to human papillomavirus-negative vulvar cancer","volume":"119","author":"Vanin","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700889_bb0430","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2165\/00129785-200101040-00005","article-title":"Detecting rare mutations associated with cancer risk","volume":"1","author":"Wilson","year":"2001","journal-title":"Am J Pharmacogenomics"},{"key":"10.1038\/sj.jid.5700889_bb0435","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0167-7012(99)00098-6","article-title":"Species-specific detection of hydrocarbon-utilizing bacteria","volume":"39","author":"Wilson","year":"1999","journal-title":"J Microbiol Methods"},{"key":"10.1038\/sj.jid.5700889_bb0440","first-page":"79","article-title":"Needle-in-a-haystack detection and identification of base substitution mutations in human tissues","volume":"406","author":"Wilson","year":"1999","journal-title":"Mutat Res"},{"key":"10.1038\/sj.jid.5700889_bb0445","first-page":"1830","article-title":"Oncogenic base substitution mutations in circulating leukocytes of normal individuals","volume":"60","author":"Wilson","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700889_bb0450","doi-asserted-by":"crossref","first-page":"13948","DOI":"10.1073\/pnas.241353198","article-title":"Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations","volume":"98","author":"Zhang","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5700889_bb0455","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/2496","article-title":"Tumour amplified kinase STK15\/BTAK induces centrosome amplification, aneuploidy and transformation","volume":"20","author":"Zhou","year":"1998","journal-title":"Nat Genet"},{"key":"10.1038\/sj.jid.5700889_bb0460","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/372773a0","article-title":"Sunburn and p53 in the onset of skin cancer","volume":"372","author":"Ziegler","year":"1994","journal-title":"Nature"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1533195X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1533195X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T13:52:54Z","timestamp":1628949174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X1533195X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":91,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0022202X1533195X"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5700889","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}