{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:13:18Z","timestamp":1784650398658,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2923,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1038\/sj.jid.5700927","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T10:34:16Z","timestamp":1183026856000},"page":"2740-2748","source":"Crossref","is-referenced-by-count":27,"title":["A Citrus Polymethoxy Flavonoid, Nobiletin Inhibits Sebum Production and Sebocyte Proliferation, and Augments Sebum Excretion in Hamsters"],"prefix":"10.1016","volume":"127","author":[{"given":"Takashi","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Akimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5700927_bb0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1046\/j.1365-4362.2003.01540.x","article-title":"Increased hydrogen peroxide generation by neutrophils from patients with acne inflammation","volume":"42","author":"Akamatsu","year":"2003","journal-title":"Int J Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0015","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.0022-202X.2005.23718.x","article-title":"Expression of perilipin A on the surface of lipid droplets increases along with the differentiation of hamster sebocytes in vivo and in vitro","volume":"124","author":"Akimoto","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0923-1811(03)00003-3","article-title":"Effects of UV irradiation on the sebaceous gland and sebum secretion in hamsters","volume":"31","author":"Akitomo","year":"2003","journal-title":"J Dermatol Sci"},{"key":"10.1038\/sj.jid.5700927_bb0025","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1006\/excr.1994.1093","article-title":"Induction of a common pathway of apoptosis by staurosporine","volume":"211","author":"Bertrand","year":"1994","journal-title":"Exp Cell Res"},{"key":"10.1038\/sj.jid.5700927_bb0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1388-1981(99)00110-9","article-title":"Lipid translocation across the plasma membrane of mammalian cells","volume":"1439","author":"Bevers","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/sj.jid.5700927_bb0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.clindermatol.2004.03.005","article-title":"Acne and Propionibacterium acnes","volume":"22","author":"Bojar","year":"2004","journal-title":"Clin Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0040","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11745-002-0945-8","article-title":"Intestinal apolipoprotein B secretion is inhibited by the flavonoid quercetin: potential role of microsomal triglyceride transfer protein and diacylglycerol acyltransferase","volume":"37","author":"Casaschi","year":"2002","journal-title":"Lipids"},{"key":"10.1038\/sj.jid.5700927_bb0045","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1023\/A:1011884200848","article-title":"Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats","volume":"56","author":"Cha","year":"2001","journal-title":"Plant Foods Hum Nutr"},{"key":"10.1038\/sj.jid.5700927_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2165\/00128071-200506010-00002","article-title":"Retinoid therapy for acne","volume":"6","author":"Chivot","year":"2005","journal-title":"Am J Clin Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0055","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2133.1994.tb08519.x","article-title":"Effects of benzoyl peroxide and erythromycin alone and in combination against antibiotic-sensitive and -resistant skin bacteria from acne patients","volume":"131","author":"Eady","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0060","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/ncb1279","article-title":"Membrane phosphatidylserine distribution as a non-apoptotic signaling mechanism in lymphocytes","volume":"7","author":"Elliott","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1038\/sj.jid.5700927_bb0065","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1095\/biolreprod67.1.340","article-title":"Capacitation induces cyclic adenosine 3\u2032, 5\u2032-monophosphate-dependent, but apoptosis-unrelated, exposure of aminophospholipids at the apical head plasma membrane of boar sperm cells","volume":"67","author":"Gadella","year":"2002","journal-title":"Biol Reprod"},{"key":"10.1038\/sj.jid.5700927_bb0070","doi-asserted-by":"crossref","first-page":"C807","DOI":"10.1152\/ajpcell.2001.280.4.C807","article-title":"Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis","volume":"280","author":"Harmon","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1038\/sj.jid.5700927_bb0075","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.0022-202X.2005.23866.x","article-title":"Augmentation of lipogenesis by 15-deoxy-\u039412, 14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-\u039412, 14-prostaglandin J2 production","volume":"125","author":"Iwata","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0080","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1271\/bbb.63.896","article-title":"Antiproliferative activity of flavonoids on several cancer cell lines","volume":"63","author":"Kawaii","year":"1999","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1038\/sj.jid.5700927_bb0085","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1523-1747.2000.00868.x","article-title":"The role of specific retinoid receptors in sebocyte growth and differentiation in culture","volume":"114","author":"Kim","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0090","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1182\/blood.V84.5.1415.bloodjournal8451415","article-title":"Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis","volume":"84","author":"Koopman","year":"1994","journal-title":"Blood"},{"key":"10.1038\/sj.jid.5700927_bb0095","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.clindermatol.2004.03.009","article-title":"Acne: topical treatment","volume":"22","author":"Krautheim","year":"2004","journal-title":"Clin Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0100","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0006-2952(94)90184-8","article-title":"Potentiation of \u03b2-adrenoceptor agonist-mediated lipolysis by quercetin and fisetin in isolated rat adipocytes","volume":"47","author":"Kuppusamy","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/sj.jid.5700927_bb0105","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF00373379","article-title":"Agents that cause enlargement of sebaceous glands in hairless mice. II. Ultraviolet radiation","volume":"284","author":"Lesnik","year":"1992","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/sj.jid.5700927_bb0110","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/S0006-2952(03)00203-X","article-title":"Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages","volume":"65","author":"Lin","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/sj.jid.5700927_bb0115","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1349-7006.2001.tb02156.x","article-title":"The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice","volume":"92","author":"Minagawa","year":"2001","journal-title":"Jpn J Cancer Res"},{"key":"10.1038\/sj.jid.5700927_bb0120","doi-asserted-by":"crossref","first-page":"13683","DOI":"10.1021\/bi050643x","article-title":"Mechanism of neurotrophic action of nobiletin in PC12D cells","volume":"44","author":"Nagase","year":"2005","journal-title":"Biochemistry"},{"key":"10.1038\/sj.jid.5700927_bb0125","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/sj.jid.5700289","article-title":"13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes","volume":"126","author":"Nelson","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0130","first-page":"4","article-title":"Physiopathology of acne vulgaris: recent data, new understanding of the treatments","volume":"14","author":"Pawin","year":"2004","journal-title":"Eur J Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0135","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/sj.jid.5700202","article-title":"Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo","volume":"126","author":"Rittie","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0140","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0006-2952(88)90169-4","article-title":"Flavonoids are scavengers of superoxide anions","volume":"37","author":"Robak","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/sj.jid.5700927_bb0145","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0150","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1046\/j.0022-202x.2001.01516.x","article-title":"Epidermal growth factor and 1\u03b1, 25-dihydroxyvitamin D3 suppress lipogenesis in hamster sebaceous gland cells in vitro","volume":"117","author":"Sato","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0155","first-page":"1025","volume":"62","author":"Sato","year":"2002","journal-title":"Cancer Res"},{"key":"10.1038\/sj.jid.5700927_bb0160","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2133.2005.06530.x","article-title":"Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III","volume":"153","author":"Schaller","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000211087","article-title":"Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese\u2013Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands","volume":"6","author":"Seki","year":"1993","journal-title":"Skin Pharmacol"},{"key":"10.1038\/sj.jid.5700927_bb0170","doi-asserted-by":"crossref","first-page":"17797","DOI":"10.1074\/jbc.M201594200","article-title":"Evaluation of the role of phosphatidylserine translocase activity in ABCA1-mediated lipid efflux","volume":"277","author":"Smith","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700927_bb0175","first-page":"139","article-title":"Changes of comedonal cytokines and sebum secretion after UV irradiation in acne patients","volume":"12","author":"Suh","year":"2002","journal-title":"Eur J Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0180","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0960-0760(00)00172-2","article-title":"Genistein affects lipogenesis and lipolysis in isolated rat adipocytes","volume":"75","author":"Szkudelska","year":"2000","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1038\/sj.jid.5700927_bb0185","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bcp.2004.04.006","article-title":"Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro","volume":"68","author":"Tanaka","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/sj.jid.5700927_bb0190","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000017846","article-title":"An overview of topical antibiotics for acne treatment","volume":"196","author":"Toyoda","year":"1998","journal-title":"Dermatology"},{"key":"10.1038\/sj.jid.5700927_bb0195","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/sj.jid.5700336","article-title":"Peroxisome proliferator-activated receptors increase human sebum production","volume":"126","author":"Trivedi","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0200","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1242\/jcs.114.20.3631","article-title":"Transient expression of phosphatidylserine at cell\u2013cell contact areas is required for myotube formation","volume":"114","author":"van den Eijnde","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1038\/sj.jid.5700927_bb0205","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1523-1747.2003.12029.x","article-title":"Differentiation and apoptosis in human immortalized sebocytes","volume":"120","author":"Wr\u00f3bel","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5700927_bb0210","doi-asserted-by":"crossref","first-page":"18240","DOI":"10.1074\/jbc.272.29.18240","article-title":"Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids","volume":"272","author":"Zhou","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5700927_bb0215","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/1523-1747.ep12471782","article-title":"Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro","volume":"96","author":"Zouboulis","year":"1991","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15332255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15332255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T05:38:38Z","timestamp":1629092318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15332255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0022202X15332255"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5700927","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}