{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:05:21Z","timestamp":1790521521314,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2953,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1038\/sj.jid.5700953","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T07:49:21Z","timestamp":1184831361000},"page":"2558-2562","source":"Crossref","is-referenced-by-count":122,"title":["Genetic Variations in NALP1 Are Associated with Generalized Vitiligo in a Romanian Population"],"prefix":"10.1016","volume":"127","author":[{"given":"Ying","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanca A.","family":"Birlea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela R.","family":"Fain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Spritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5700953_bb0010","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1034\/j.1600-0749.2003.00032.x","article-title":"Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their relatives","volume":"16","author":"Alkhateeb","year":"2003","journal-title":"Pigment Cell Res"},{"key":"10.1038\/sj.jid.5700953_bb0015","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/hmg\/11.6.661","article-title":"Mapping of an autoimmunity susceptibility locus (AIS1) to chromosome 1p31.3\u2013p32.2","volume":"11","author":"Alkhateeb","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1038\/sj.jid.5700953_bb0020","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrg1916","article-title":"A tutorial on statistical methods for population association studies","volume":"7","author":"Balding","year":"2006","journal-title":"Nat Rev Genet"},{"key":"10.1038\/sj.jid.5700953_bb0025","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1038\/sj.jid.5700953_bb0030","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1086\/430279","article-title":"A novel linkage to generalized vitiligo on 4q13\u2013q21 identified in a genomewide linkage analysis of Chinese families","volume":"76","author":"Chen","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1038\/sj.jid.5700953_bb0035","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1086\/375451","article-title":"A genomewide screen for generalized vitiligo: confirmation of AIS1 on chromosome 1p31 and evidence for additional susceptibility loci","volume":"72","author":"Fain","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1038\/sj.jid.5700953_bb0040","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.molcel.2007.01.032","article-title":"Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation","volume":"25","author":"Faustin","year":"2007","journal-title":"Mol Cell"},{"key":"10.1038\/sj.jid.5700953_bb0045","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1056\/NEJMe078017","article-title":"Modern genetics, ancient defenses, and potential therapies","volume":"356","author":"Gregersen","year":"2007","journal-title":"New Engl J Med"},{"key":"10.1038\/sj.jid.5700953_bb0050","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archderm.1977.01640010049006","article-title":"Prevalence of vitiligo: epidemiological survey of the Isle of Bornholm, Denmark","volume":"113","author":"Howitz","year":"1977","journal-title":"Arch Dermatol"},{"key":"10.1038\/sj.jid.5700953_bb0055","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa061592","article-title":"NALP1 in vitiligo-associated multiple autoimmune disease","volume":"356","author":"Jin","year":"2007","journal-title":"New Engl J Med"},{"key":"10.1038\/sj.jid.5700953_bb0060","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","article-title":"Inflammasome components NALP1 and 3 show distinct but separate expression profiles in human tissues, suggesting a site-specific role in the inflammatory response","volume":"55","author":"Kummer","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/sj.jid.5700953_bb0065","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-0749.2005.00242.x","article-title":"Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo","volume":"18","author":"Laberge","year":"2005","journal-title":"Pigment Cell Res"},{"key":"10.1038\/sj.jid.5700953_bb0070","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1001\/archderm.1993.01680290066010","article-title":"Pattern of familial aggregation of vitiligo","volume":"129","author":"Majumder","year":"1993","journal-title":"Arch Dermatol"},{"key":"10.1038\/sj.jid.5700953_bb0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/1536867X0100100104","article-title":"Haplotype analysis in population-based association studies","volume":"1","author":"Mander","year":"2001","journal-title":"Stata J"},{"key":"10.1038\/sj.jid.5700953_bb0080","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1086\/324470","article-title":"Evidence for a susceptibility gene, SLEV1, on chromosome 17p13 in families with vitiligo-related systemic lupus erythematosus","volume":"69","author":"Nath","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1038\/sj.jid.5700953_bb0085","first-page":"981","article-title":"Genetic epidemiology of vitiligo: multilocus recessivity cross-validated","volume":"55","author":"Nath","year":"1994","journal-title":"Am J Hum Genet"},{"key":"10.1038\/sj.jid.5700953_bb0090","series-title":"The Pigmentary System","first-page":"551","article-title":"Vitiligo vulgaris","author":"Nordlund","year":"2006"},{"key":"10.1038\/sj.jid.5700953_bb0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-0749.2007.00384.x","article-title":"The genetics of generalized vitiligo and associated autoimmune diseases","volume":"20","author":"Spritz","year":"2007","journal-title":"Pigment Cell Res"},{"key":"10.1038\/sj.jid.5700953_bb0100","article-title":"The genetics of generalized vitiligo","author":"Spritz","year":"2007","journal-title":"Curr Dir Autoimmunity"},{"key":"10.1038\/sj.jid.5700953_bb0105","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1086\/381134","article-title":"Novel vitiligo susceptibility loci on chromosomes 7 (AIS2) and 8 (AIS3), confirmation of SLEV1 on chromosome 17, and their roles in an autoimmune diathesis","volume":"74","author":"Spritz","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1038\/sj.jid.5700953_bb0110","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1365-4632.2006.02907.x","article-title":"Genetic epidemiology of vitiligo: a study of 815 probands and their families from south China","volume":"45","author":"Sun","year":"2006","journal-title":"Int J Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15331869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15331869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T05:23:13Z","timestamp":1556688193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15331869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0022202X15331869"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5700953","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}