{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:08:21Z","timestamp":1777622901556,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2832,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["KO1 AR052109"],"award-info":[{"award-number":["KO1 AR052109"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R01-AR30281"],"award-info":[{"award-number":["R01-AR30281"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["RO1-AR32599"],"award-info":[{"award-number":["RO1-AR32599"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["RO3 AR053313"],"award-info":[{"award-number":["RO3 AR053313"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["T32 AR07369"],"award-info":[{"award-number":["T32 AR07369"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1038\/sj.jid.5701121","type":"journal-article","created":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T04:41:24Z","timestamp":1193287284000},"page":"667-675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["The IgM Anti-Desmoglein 1 Response Distinguishes Brazilian Pemphigus Foliaceus (Fogo Selvagem) from Other Forms of Pemphigus"],"prefix":"10.1016","volume":"128","author":[{"given":"Luis A.","family":"Diaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip S.","family":"Prisayanh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Dasher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flor","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunter","family":"Hans-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandir dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahjat F.","family":"Qaqish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evandro A.","family":"Rivitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5701121_bb0010","series-title":"Cellular and molecular immunology","first-page":"190","article-title":"B cell activation and antibody production","author":"Abbas","year":"2005"},{"key":"10.1038\/sj.jid.5701121_bb0015","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/1523-1747.ep12317587","article-title":"Conformational epitopes of pemphigus antigens (Dsg1 and Dsg3) are calcium dependent and glycosylation independent","volume":"105","author":"Amagai","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0020","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(91)90360-B","article-title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion","volume":"67","author":"Amagai","year":"1991","journal-title":"Cell"},{"key":"10.1038\/sj.jid.5701121_bb0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0190-9622(99)70183-0","article-title":"The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile","volume":"40","author":"Amagai","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1087-0024.2004.00833.x","article-title":"Environmental risk factors in endemic pemphigus foliaceus (fogo selvagem)","volume":"9","author":"Aoki","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0035","first-page":"121","article-title":"Diagnosis of Lyme borreliosis using enzyme immunoanalysis","volume":"11","author":"Cermakova","year":"2005","journal-title":"Med Sci Monit"},{"key":"10.1038\/sj.jid.5701121_bb0040","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1440-1746.2006.04337.x","article-title":"Immunoglobulin class M anti-hepatitis B core antigen for serodiagnois of acute hepatitis: pitfalls and recommendations","volume":"21","author":"Chu","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1038\/sj.jid.5701121_bb0045","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.0022-202X.2004.23438.x","article-title":"Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and Chagas disease suggest a possible etiological link to fogo selvagem","volume":"123","author":"Diaz","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0050","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0190-9622(89)70079-7","article-title":"Endemic pemphigus foliaceus (fogo selvagem): I. Clinical features and immunopathology","volume":"20","author":"Diaz","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/1523-1747.ep13070394","article-title":"Endemic pemphigus foliaceus (fogo selvagem): II. Current and historic epidemiologic studies","volume":"92","author":"Diaz","year":"1989","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0060","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/1523-1747.ep12337524","article-title":"Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles","volume":"109","author":"Ding","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0065","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1046\/j.1523-1747.1999.00585.x","article-title":"The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic","volume":"112","author":"Ding","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0070","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2133.2006.07302.x","article-title":"Clinical and serological follow-up studies of endemic pemphigus foliaceus (fogo selvagem) in Western Parana, Brazil (1988\u20132003)","volume":"155","author":"Empinotti","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0075","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaut.2005.05.004","article-title":"Heritable factors shape natural human IgM reactivity to Ro60\/SS-A and may predispose for SLE-associated IgG anti-Ro and anti-La autoantibody production","volume":"25","author":"Ferreira","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1038\/sj.jid.5701121_bb0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1191\/0961203304lu485oa","article-title":"Clinical significance of anti-dsDNA antibody isotypes: IgG\/IgM ratio of anti-dsDNA antibodies as a prognostic marker for lupus nephritis","volume":"13","author":"Forger","year":"2004","journal-title":"Lupus"},{"key":"10.1038\/sj.jid.5701121_bb0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jviromet.2005.06.003","article-title":"Assessment of IgM enzyme immunoassay and IgG avidity assay for distinguishing between primary and secondary immune response to rubella vaccine","volume":"130","author":"Hamkar","year":"2005","journal-title":"J Virol Methods"},{"key":"10.1038\/sj.jid.5701121_bb0090","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/1523-1747.ep12298213","article-title":"An active focus of high prevalence of fogo selvagem on an Amerindian reservation in Brazil","volume":"107","author":"Hans-Filho","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0095","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1038\/sj.jid.5700388","article-title":"Prevalence of anti-desmoglein-3 antibodies in Endemic regions of fogo selvagem in Brazil","volume":"126","author":"Hilario-Vargas","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0100","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1084\/jem.20022031","article-title":"The role of intramolecular epitope spreading in the pathogenesis of endemic pemphigus foliaceus (fogo selvagem)","volume":"197","author":"Li","year":"2003","journal-title":"J Exp Med"},{"key":"10.1038\/sj.jid.5701121_bb0105","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1172\/JCI23587","article-title":"Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays","volume":"115","author":"Li","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.jid.5701121_bb0110","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1346-8138.2001.tb00055.x","article-title":"Bullous pemphigoid: end of the century overview","volume":"28","author":"Liu","year":"2001","journal-title":"J Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0115","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00281-004-0187-x","article-title":"Natural serum IgM maintains immunological homeostasis and prevents autoimmunity","volume":"26","author":"Manson","year":"2005","journal-title":"Springer Semin Immunopathol"},{"issue":"Suppl 1","key":"10.1038\/sj.jid.5701121_bb0120","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1086\/338827","article-title":"Laboratory diagnosis of toxoplasma gondii infection and toxoplasmosis","volume":"185","author":"Montoya","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1038\/sj.jid.5701121_bb0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1399-0039.1997.tb02707.x","article-title":"An epitope in the third hypervariable region of the DRB1 gene is involved in the susceptibility to endemic pemphigus foliaceus (fogo selvagem) in three different Brazilian populations","volume":"49","author":"Moraes","year":"1997","journal-title":"Tissue Antigens"},{"key":"10.1038\/sj.jid.5701121_bb0130","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1365-3083.1996.d01-306.x","article-title":"The self-reactive antibody repertoire of normal human serum IgM is acquired in early childhood and remains conserved throughout life","volume":"44","author":"Mouthon","year":"1996","journal-title":"Scand J Immunol"},{"key":"10.1038\/sj.jid.5701121_bb0135","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1699-0463.1996.tb00737.x","article-title":"Serological and clinical findings in patients with serological evidence of reactivated Epstein\u2013Barr virus infection","volume":"104","author":"Obel","year":"1996","journal-title":"APMIS"},{"key":"10.1038\/sj.jid.5701121_bb0140","first-page":"189","article-title":"The epitopes on bovine pemphigus foliaceus antigen are calcium dependent and located on the peptide backbone of this glycoprotein","volume":"2","author":"Olague-Alcala","year":"1993","journal-title":"Chron Dermat"},{"key":"10.1038\/sj.jid.5701121_bb0145","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1590\/S0036-46652006000200007","article-title":"Toxoplasma-IgM and IgG-avidity in single samples from areas with a high infection rate can determine the risk of mother-to-child transmission","volume":"48","author":"Reis","year":"2006","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"10.1038\/sj.jid.5701121_bb0150","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/1523-1747.ep12611868","article-title":"Pregnant women with endemic pemphigus foliaceus (fogo selvagem) give birth to disease-free babies","volume":"99","author":"Rocha-Alvarez","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0155","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1001\/archderm.143.7.895","article-title":"Endemic pemphigus vulgaris","volume":"143","author":"Rocha-Alvarez","year":"2007","journal-title":"Arch Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0160","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1056\/NEJM198906013202206","article-title":"The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem)","volume":"320","author":"Rock","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.jid.5701121_bb0165","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/1523-1747.ep12464490","article-title":"Serological abnormalities in patients with endemic pemphigus foliaceus (fogo selvagem), their relatives and normal donors from endemic and non-endemic areas of Brazil","volume":"91","author":"Squiquera","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0170","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1600-0609.2005.00516.x","article-title":"Evidence that human autoimmune thrombocytopenia mediated by both immunoglobulin isotypes IgM and IgG is an independent disease entity","volume":"75","author":"Stahl","year":"2005","journal-title":"Eur J Haematol"},{"key":"10.1038\/sj.jid.5701121_bb0175","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jaut.2005.08.003","article-title":"Warm autoimmune hemolytic anemia is an IgM\u2013IgG immune complex disease","volume":"25","author":"Stahl","year":"2005","journal-title":"J Autoimmunity"},{"key":"10.1038\/sj.jid.5701121_bb0180","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/1523-1747.ep12695334","article-title":"Antigenic specificity of fogo selvagem autoantibodies is similar to North American pemphigus foliaceus and distinct from pemphigus vulgaris","volume":"87","author":"Stanley","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0185","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1523-1747.2003.12017.x","article-title":"The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus","volume":"120","author":"Warren","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701121_bb0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM200007063430104","article-title":"The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil","volume":"343","author":"Warren","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.jid.5701121_bb0195","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1002\/art.21379","article-title":"Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB \u00d7 NZW)F1 mouse","volume":"52","author":"Werwitzke","year":"2005","journal-title":"Arthritis Rheum"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15337623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15337623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:18:11Z","timestamp":1742429891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15337623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0022202X15337623"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5701121","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1092882.547821","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1092882.549932","asserted-by":"object"}]},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The IgM Anti-Desmoglein 1 Response Distinguishes Brazilian Pemphigus Foliaceus (Fogo Selvagem) from Other Forms of Pemphigus","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/sj.jid.5701121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}