{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:42:17Z","timestamp":1770478937138,"version":"3.49.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2740,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1038\/sj.jid.5701192","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T09:45:10Z","timestamp":1197625510000},"page":"1588-1591","source":"Crossref","is-referenced-by-count":14,"title":["Polymorphism Patterns in the Promoter Region of the MC1R Gene Are Associated with Development of Freckles and Solar Lentigines"],"prefix":"10.1016","volume":"128","author":[{"given":"Tomonori","family":"Motokawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5701192_bb0010","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/hmg\/10.16.1701","article-title":"The melanocortin-1-receptor gene is the major freckle gene","volume":"10","author":"Bastiaens","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1038\/sj.jid.5701192_bb0015","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/hmg\/ddi219","article-title":"Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk","volume":"14","author":"Beaumont","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1038\/sj.jid.5701192_bb0020","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1523-1747.2001.01224.x","article-title":"Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma","volume":"116","author":"Box","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701192_bb0025","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1093\/hmg\/9.17.2531","article-title":"Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation","volume":"9","author":"Flanagan","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1038\/sj.jid.5701192_bb0030","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1006\/bbrc.1998.8459","article-title":"Human pigmentation phenotype: a point mutation generates nonfunctional MSH receptor","volume":"245","author":"Frandberg","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/sj.jid.5701192_bb0035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1600-0749.2005.00278.x","article-title":"Melanocortin-1 receptor structure and functional regulation","volume":"18","author":"Garcia-Borron","year":"2005","journal-title":"Pigment Cell Res"},{"key":"10.1038\/sj.jid.5701192_bb0040","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/archderm.1963.01590140059010","article-title":"Senile lentigo","volume":"87","author":"Hodgson","year":"1963","journal-title":"Arch Dermatol"},{"key":"10.1038\/sj.jid.5701192_bb0045","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1006\/bbrc.1999.1228","article-title":"Characterization of the promoter region of the human melanocortin-1 receptor (MC1R) gene","volume":"262","author":"Moro","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/sj.jid.5701192_bb0050","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-0749.2007.00364.x","article-title":"Effect of Val92Met and Arg163Gln variants of the MC1R gene on freckles and solar lentigines in Japanese","volume":"20","author":"Motokawa","year":"2007","journal-title":"Pigment Cell Res"},{"key":"10.1038\/sj.jid.5701192_bb0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jdermsci.2005.10.006","article-title":"Characteristic MC1R polymorphism in the Japanese population","volume":"41","author":"Motokawa","year":"2006","journal-title":"J Dermatol Sci"},{"key":"10.1038\/sj.jid.5701192_bb0060","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.0022-202X.2004.23444.x","article-title":"Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair","volume":"123","author":"Ringholm","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701192_bb0065","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1006\/bbrc.1999.0935","article-title":"Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair","volume":"260","author":"Schioth","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/sj.jid.5701192_bb0070","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1242\/jcs.115.11.2349","article-title":"Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation","volume":"115","author":"Scott","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1038\/sj.jid.5701192_bb0075","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/ng1296-384","article-title":"Val92Met variant of the melanocyte stimulating hormone receptor gene","volume":"14","author":"Xu","year":"1996","journal-title":"Nat Genet"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15339075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15339075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:15:05Z","timestamp":1708427705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15339075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0022202X15339075"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5701192","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}