{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:10:39Z","timestamp":1772136639519,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":2740,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1038\/sj.jid.5701197","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T04:45:10Z","timestamp":1197607510000},"page":"1476-1486","source":"Crossref","is-referenced-by-count":24,"title":["Protein Therapeutics for Junctional Epidermolysis Bullosa: Incorporation of Recombinant \u03b23 Chain into Laminin 332 in \u03b23-\/- Keratinocytes In Vitro"],"prefix":"10.1016","volume":"128","author":[{"given":"Olga","family":"Igoucheva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aislinn","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouni","family":"Uitto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitali","family":"Alexeev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/sj.jid.5701197_bb0010","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S1471-4914(01)02095-0","article-title":"Disease model: heritable skin blistering","volume":"7","author":"Arin","year":"2001","journal-title":"Trends Mol Med"},{"key":"10.1038\/sj.jid.5701197_bb0015","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.matbio.2005.05.006","article-title":"A simplified laminin nomenclature","volume":"24","author":"Aumailley","year":"2005","journal-title":"Matrix Biol"},{"issue":"Part 10","key":"10.1038\/sj.jid.5701197_bb0020","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1242\/jcs.109.10.2509","article-title":"Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly","volume":"109","author":"Baker","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1038\/sj.jid.5701197_bb0025","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/bc050283q","article-title":"Evaluation of cell-penetrating peptides (CPPs) as vehicles for intracellular delivery of antisense peptide nucleic acid (PNA)","volume":"17","author":"Bendifallah","year":"2006","journal-title":"Bioconjug Chem"},{"key":"10.1038\/sj.jid.5701197_bb0030","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbrc.2006.03.034","article-title":"High-affinity binding of the NC1 domain of collagen VII to laminin 5 and collagen IV","volume":"343","author":"Brittingham","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/sj.jid.5701197_bb0035","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1083\/jcb.111.6.3141","article-title":"Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4\/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes","volume":"111","author":"Carter","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1038\/sj.jid.5701197_bb0040","doi-asserted-by":"crossref","first-page":"14516","DOI":"10.1074\/jbc.272.23.14516","article-title":"Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal\u2013dermal adherence in human skin","volume":"272","author":"Chen","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5701197_bb0045","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jgm.1057","article-title":"Optimization of short-term transgene expression by sodium butyrate and ubiquitous chromatin opening elements (UCOEs)","volume":"9","author":"de Poorter","year":"2007","journal-title":"J Gene Med"},{"key":"10.1038\/sj.jid.5701197_bb0050","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1089\/hum.1998.9.9-1359","article-title":"Corrective transduction of human epidermal stem cells in laminin-5-dependent junctional epidermolysis bullosa","volume":"9","author":"Dellambra","year":"1998","journal-title":"Hum Gene Ther"},{"key":"10.1038\/sj.jid.5701197_bb0055","doi-asserted-by":"crossref","first-page":"10643","DOI":"10.1021\/bi00159a001","article-title":"Laminins and other strange proteins","volume":"31","author":"Engel","year":"1992","journal-title":"Biochemistry"},{"key":"10.1038\/sj.jid.5701197_bb0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.molmed.2007.03.006","article-title":"Ex vivo gene therapy cures a blistering skin disease","volume":"13","author":"Featherstone","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1038\/sj.jid.5701197_bb0065","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1067\/mjd.2000.106369","article-title":"Revised classification system for inherited epidermolysis bullosa: report of the Second International Consensus Meeting on diagnosis and classification of epidermolysis bullosa","volume":"42","author":"Fine","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/sj.jid.5701197_bb0070","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jconrel.2006.05.011","article-title":"Enhanced transfection of primary cortical cultures using arginine-grafted PAMAM dendrimer, PAMAM-Arg","volume":"114","author":"Kim","year":"2006","journal-title":"J Control Release"},{"key":"10.1038\/sj.jid.5701197_bb0075","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrd2039","article-title":"Protein therapeutics: new applications for pharmacogenetics","volume":"5","author":"Krejsa","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1038\/sj.jid.5701197_bb0080","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s003359900535","article-title":"IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa","volume":"8","author":"Kuster","year":"1997","journal-title":"Mamm Genome"},{"key":"10.1038\/sj.jid.5701197_bb0085","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/1523-1747.ep12324108","article-title":"Gamma 2 chain of laminin-5 is recognized by monoclonal antibody GB3","volume":"105","author":"Matsui","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701197_bb0090","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1084\/jem.187.8.1273","article-title":"Extent of laminin-5 assembly and secretion effect junctional epidermolysis bullosa phenotype","volume":"187","author":"Matsui","year":"1998","journal-title":"J Exp Med"},{"key":"10.1038\/sj.jid.5701197_bb0095","doi-asserted-by":"crossref","first-page":"23496","DOI":"10.1074\/jbc.270.40.23496","article-title":"The assembly of laminin-5 subunits","volume":"270","author":"Matsui","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.jid.5701197_bb0100","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/nm1504","article-title":"Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells","volume":"12","author":"Mavilio","year":"2006","journal-title":"Nat Med"},{"key":"10.1038\/sj.jid.5701197_bb0105","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1073\/pnas.78.8.4975","article-title":"Intercellular recognition: quantitation of initial binding events","volume":"78","author":"McClay","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5701197_bb0110","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1046\/j.1523-1747.2003.12515.x","article-title":"Targeted inactivation of murine laminin gamma2-chain gene recapitulates human junctional epidermolysis bullosa","volume":"121","author":"Meng","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1038\/sj.jid.5701197_bb0115","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.841339","article-title":"Characterization of a new human diploid cell strain, IMR-90","volume":"196","author":"Nichols","year":"1977","journal-title":"Science"},{"key":"10.1038\/sj.jid.5701197_bb0120","first-page":"543","article-title":"Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors","volume":"132","author":"Nickoloff","year":"1988","journal-title":"Am J Pathol"},{"issue":"Suppl 1","key":"10.1038\/sj.jid.5701197_bb0125","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/S0923-1811(00)00142-0","article-title":"The importance of laminin 5 in the dermal\u2013epidermal basement membrane","volume":"24","author":"Nishiyama","year":"2000","journal-title":"J Dermatol Sci"},{"key":"10.1038\/sj.jid.5701197_bb0130","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1073\/pnas.091484998","article-title":"In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa","volume":"98","author":"Robbins","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.jid.5701197_bb0135","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1089\/104303401750298599","article-title":"Impact of laminin 5 beta3 gene versus protein replacement on gene expression patterns in junctional epidermolysis bullosa","volume":"12","author":"Robbins","year":"2001","journal-title":"Hum Gene Ther"},{"key":"10.1038\/sj.jid.5701197_bb0140","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/sj.gt.3300730","article-title":"Corrective gene transfer of keratinocytes from patients with junctional epidermolysis bullosa restores assembly of hemidesmosomes in reconstructed epithelia","volume":"5","author":"Vailly","year":"1998","journal-title":"Gene Therapy"},{"key":"10.1038\/sj.jid.5701197_bb0145","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/jmg.2005.039685","article-title":"Epidermolysis bullosa. I. Molecular genetics of the junctional and hemidesmosomal variants","volume":"43","author":"Varki","year":"2006","journal-title":"J Med Genet"},{"key":"10.1038\/sj.jid.5701197_bb0150","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jmg.2006.045302","article-title":"Epidermolysis bullosa. II. Type VII collagen mutations and phenotype\u2013genotype correlations in the dystrophic subtypes","volume":"44","author":"Varki","year":"2007","journal-title":"J Med Genet"},{"key":"10.1038\/sj.jid.5701197_bb0155","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1472-6750-5-17","article-title":"CpG-island fragments from the HNRPA2B1\/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter\/enhancer in mammalian cells","volume":"5","author":"Williams","year":"2005","journal-title":"BMC Biotechnol"},{"key":"10.1038\/sj.jid.5701197_bb0160","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nm1063","article-title":"Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa","volume":"10","author":"Woodley","year":"2004","journal-title":"Nat Med"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15338823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15338823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T12:44:29Z","timestamp":1630327469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15338823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0022202X15338823"],"URL":"https:\/\/doi.org\/10.1038\/sj.jid.5701197","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1097512.553589","asserted-by":"object"}]},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}