{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T23:57:06Z","timestamp":1769644626542,"version":"3.49.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2001,12,1]]},"DOI":"10.1038\/sj.jp.7210630","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T17:08:10Z","timestamp":1206724090000},"page":"S30-S34","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genetic Interactions in the Pathogenesis of Neonatal Hyperbilirubinemia: Gilbert's Syndrome and Glucose-6-Phosphate Dehydrogenase Deficiency"],"prefix":"10.1038","volume":"21","author":[{"given":"Michael","family":"Kaplan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,1,21]]},"reference":[{"key":"BF7210630_CR1","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1046\/j.1440-1746.1999.01984.x","volume":"14","author":"B Burchell","year":"1999","unstructured":"Burchell B, Hume R Molecular genetic basis of Gilbert's Syndrome J Gastroenterol Hepatol 1999 14 960\u20136","journal-title":"J Gastroenterol Hepatol"},{"key":"BF7210630_CR2","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/0016-5085(87)90123-5","volume":"92","author":"M Muraca","year":"1987","unstructured":"Muraca M, Fevery J, Blanckaert N Relationships between serum bilirubins and production and conjugation of bilirubin. Studies in Gilbert's Syndrome, Crigler\u2013Najjar disease, hemolytic disorders and rat models Gastroenterology 1987 92 309\u201317","journal-title":"Gastroenterology"},{"key":"BF7210630_CR3","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","volume":"333","author":"PJ Bosma","year":"1995","unstructured":"Bosma PJ, Chowdhury JR, Bakker C, et al The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's Syndrome N Engl J Med 1995 333 1171\u20135","journal-title":"N Engl J Med"},{"key":"BF7210630_CR4","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/S0140-6736(96)91273-8","volume":"347","author":"G Monaghan","year":"1996","unstructured":"Monaghan G, Ryan M, Seddon R, Hume R, Burchell B Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome Lancet 1996 347 578\u201381","journal-title":"Lancet"},{"key":"BF7210630_CR5","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S0168-8278(00)80268-8","volume":"33","author":"MTM Raijmakers","year":"2000","unstructured":"Raijmakers MTM, Jansen PLM, Steegers EAP, Peters WHM Association of human liver bilirubin UDP-glucuronosyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene J Hepatol 2000 33 348\u201351","journal-title":"J Hepatol"},{"key":"BF7210630_CR6","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1542\/peds.103.6.1224","volume":"103","author":"Y Maruo","year":"1999","unstructured":"Maruo Y, Nishizawa K, Sato H, Doida Y, Shimada M Association of neonatal hyperbilirubinemia with bilirubin UDP-glucuronosyltransferase polymorphism Pediatrics 1999 103 1224\u20137","journal-title":"Pediatrics"},{"key":"BF7210630_CR7","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","volume":"84","author":"E Beutler","year":"1994","unstructured":"Beutler E G6PD deficiency Blood 1994 84 3613\u201336","journal-title":"Blood"},{"key":"BF7210630_CR8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0095-5108(18)30098-8","volume":"25","author":"M Kaplan","year":"1998","unstructured":"Kaplan M, Hammerman C Severe neonatal hyperbilirubinemia. A potential complication of glucose-6-phosphate dehydrogenase deficiency Clin Perinatol 1998 25 575\u201390","journal-title":"Clin Perinatol"},{"key":"BF7210630_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1651-2227.1994.tb13216.x","volume":"394","author":"T Valaes","year":"1994","unstructured":"Valaes T Severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency: pathogenesis and global epidemiology Acta Paediatr Suppl 1994 394 58\u201376","journal-title":"Acta Paediatr Suppl"},{"key":"BF7210630_CR10","doi-asserted-by":"crossref","first-page":"736A","DOI":"10.1542\/peds.104.S6.1208","volume":"104","author":"L Johnson","year":"1999","unstructured":"Johnson L, Brown AK A pilot registry for acute and chronic kernicterus in term and near term infants Pediatrics 1999 104 (suppl) 736A","journal-title":"Pediatrics"},{"key":"BF7210630_CR11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1067\/mpd.2001.115312","volume":"139","author":"M Kaplan","year":"2001","unstructured":"Kaplan M, Hammerman C, Vreman HJ, Stevenson DK, Beutler E Acute hemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase\u2013deficient heterozygotes J Pediatr 2001 139 137\u201340","journal-title":"J Pediatr"},{"key":"BF7210630_CR12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1542\/peds.90.3.401","volume":"90","author":"M Kaplan","year":"1992","unstructured":"Kaplan M, Abramov A Neonatal hyperbilirubinemia associated with glucose-6-phosphate dehydrogenase deficiency in Sephardic\u2013Jewish infants: incidence, severity and the effect of phototherapy Pediatrics 1992 90 401\u201395","journal-title":"Pediatrics"},{"key":"BF7210630_CR13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/S0022-3476(95)70510-4","volume":"126","author":"TM Slusher","year":"1995","unstructured":"Slusher TM, Vreman HJ, McLaren DW, Lewison LJ, Brown AK, Stevenson DK Glucose-6-phosphate dehydrogenase deficiency and carboxyhemoglobin concentrations associated with bilirubin-related morbidity and death in Nigerian infants J Pediatr 1995 126 102\u20138","journal-title":"J Pediatr"},{"key":"BF7210630_CR14","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0378-3782(87)90026-0","volume":"15","author":"T Meloni","year":"1987","unstructured":"Meloni T, Cutillo S, Testa U, Luzatto L Neonatal jaundice and severity of glucose-6-phosphate dehydrogenase deficiency in Sardinian babies Early Hum Dev 1987 15 317\u201322","journal-title":"Early Hum Dev"},{"key":"BF7210630_CR15","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1046\/j.1365-2141.1996.d01-1745.x","volume":"93","author":"M Kaplan","year":"1996","unstructured":"Kaplan M, Vreman HJ, Hammerman C, Leiter C, Abramov A, Stevenson DK Contribution of haemolysis to jaundice in Sephardic Jewish glucose-6-phosphate dehydrogenase\u2013deficient neonates Br J Haematol 1996 93 822\u20137","journal-title":"Br J Haematol"},{"key":"BF7210630_CR16","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1203\/00006450-196909000-00008","volume":"3","author":"T Valaes","year":"1969","unstructured":"Valaes T, Karaklis A, Stravrakakis D, Bavela-Stravrakakis K, Perakis A, Doxiadis SA Incidence and mechanism of neonatal jaundice related to glucose-6-phosphate dehydrogenase deficiency Pediatr Res 1969 3 448\u201358","journal-title":"Pediatr Res"},{"key":"BF7210630_CR17","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1542\/peds.100.2.252","volume":"100","author":"DK Stevenson","year":"1997","unstructured":"Stevenson DK, Vreman HJ Carbon monoxide and bilirubin production in neonates Pediatrics 1997 100 252\u20134","journal-title":"Pediatrics"},{"key":"BF7210630_CR18","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1651-2227.1976.tb04898.x","volume":"65","author":"TF Necheles","year":"1976","unstructured":"Necheles TF, Rai US, Valaes T The role of hemolysis in neonatal hyperbilirubinemia as reflected in carboxyhemoglobin levels Acta Paediatr Scand 1976 65 361\u20137","journal-title":"Acta Paediatr Scand"},{"key":"BF7210630_CR19","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0022-3476(96)80138-7","volume":"128","author":"M Kaplan","year":"1996","unstructured":"Kaplan M, Rubaltelli FF, Hammerman C, et al Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency J Pediatr 1996 128 695\u20137","journal-title":"J Pediatr"},{"key":"BF7210630_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.102.3.538","volume":"102","author":"M Kaplan","year":"1998","unstructured":"Kaplan M, Muraca M, Hammerman C, et al Bilirubin conjugation, reflected by conjugated bilirubin fractions, in glucose-6-phosphate dehydrogenase\u2013deficient neonates: a determining factor in the pathogenesis of hyperbilirubinemia Pediatrics 1998 102 (3) 1\u20136 Available at http:\/\/www.pediatrics.org\/cgi\/content\/full\/102\/3\/e37","journal-title":"Pediatrics"},{"key":"BF7210630_CR21","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/S0022-3476(98)70356-7","volume":"132","author":"JD Bancroft","year":"1998","unstructured":"Bancroft JD, Kreamer B, Gourley GR Gilbert Syndrome accelerates the development of neonatal jaundice J Pediatr 1998 132 656\u201360","journal-title":"J Pediatr"},{"key":"BF7210630_CR22","doi-asserted-by":"publisher","first-page":"12128","DOI":"10.1073\/pnas.94.22.12128","volume":"94","author":"M Kaplan","year":"1997","unstructured":"Kaplan M, Renbaum P, Levi-Lahad E, Hammerman C, Lahad A, Beutler E Gilbert Syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia Proc Natl Acad Sci USA 1997 94 12128\u201332","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF7210630_CR23","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1182\/blood.V91.3.1093","volume":"91","author":"A Iolascon","year":"1998","unstructured":"Iolascon A, Faienza MF, Moretti A, Perotta S, Miraglia del Giudice E UGT1 promoter polymorphism accounts for increased neonatal appearance of hereditary spherocytosis Blood 1998 91 1093","journal-title":"Blood"},{"key":"BF7210630_CR24","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/S0140-6736(00)02610-6","volume":"356","author":"M Kaplan","year":"2000","unstructured":"Kaplan M, Hammerman C, Renbaum P, Klein G, Levy-Lahad E Gilbert's syndrome and hyperbilirubinemia in ABO-incompatible neonates Lancet 2000 356 652\u20133","journal-title":"Lancet"},{"key":"BF7210630_CR25","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0022-3476(99)70201-5","volume":"134","author":"G Monaghan","year":"1999","unstructured":"Monaghan G, McLellan A, McGeehan A, et al Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn J Pediatr 1999 134 441\u20136","journal-title":"J Pediatr"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7210630.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7210630","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7210630.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T16:28:47Z","timestamp":1647620927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7210630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,1]]},"references-count":25,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2001,12,1]]}},"alternative-id":["BF7210630"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7210630","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,1]]},"assertion":[{"value":"21 January 2002","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}