{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:24:43Z","timestamp":1786389883919,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2001,12,1]]},"DOI":"10.1038\/sj.jp.7210631","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T17:08:10Z","timestamp":1206724090000},"page":"S40-S42","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Bilirubin\u2013Albumin Binding and Free Bilirubin"],"prefix":"10.1038","volume":"21","author":[{"given":"Charles E","family":"Ahlfors","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,1,21]]},"reference":[{"key":"BF7210631_CR1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1542\/peds.81.3.399","volume":"81","author":"M Perlman","year":"1988","unstructured":"Perlman M, Frank JW Bilirubin: beyond the blood\u2013brain barrier Pediatrics 1988 81 304","journal-title":"Pediatrics"},{"key":"BF7210631_CR2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1542\/peds.62.4.460","volume":"62","author":"MA Pearlman","year":"1978","unstructured":"Pearlman MA, Gartner LM, Lee K, et al Absence of kernicterus in low-birth-weight infants from 1971 through 1976: comparison with findings in 1966 and 1967 Pediatrics 1978 62 460","journal-title":"Pediatrics"},{"key":"BF7210631_CR3","unstructured":"Brown AK, Johnson LL Loss of concern about jaundice and the re-emergence of kernicterus in full-term infants in the era of managed care In: Fanaroff AA, Klaus MH, editors. The Yearbook of Neonatal and Perinatal Medicine St. Louis: Mosby 1996 p. XVII\u2013XXVIII"},{"key":"BF7210631_CR4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1542\/peds.79.4.553","volume":"79","author":"PJ Robinson","year":"1987","unstructured":"Robinson PJ, Rapoport SI Binding effect of albumin on uptake of bilirubin by brain Pediatrics 1987 79 553","journal-title":"Pediatrics"},{"key":"BF7210631_CR5","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1136\/adc.30.154.501","volume":"30","author":"BM Crosse","year":"1955","unstructured":"Crosse BM, Meyer TC, Gerrrard JW Kernicterus and prematurity Arch Dis Child 1955 30 501","journal-title":"Arch Dis Child"},{"key":"BF7210631_CR6","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/j.1651-2227.1961.tb08191.x","volume":"50","author":"D Trolle","year":"1961","unstructured":"Trolle D Discussion on the advisability of performing exchange transfusion in neonatal jaundice of unknown aetiology Acta Paediatr Scand 1961 50 392","journal-title":"Acta Paediatr Scand"},{"key":"BF7210631_CR7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1542\/peds.21.6.875","volume":"21","author":"RC Harris","year":"1958","unstructured":"Harris RC, Lucey JF, MacLean JR Kernicterus in premature infants associated with low concentrations of bilirubin in the plasma Pediatrics 1958 21 875","journal-title":"Pediatrics"},{"key":"BF7210631_CR8","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/S0021-9258(17)30230-2","volume":"254","author":"R Brodersen","year":"1979","unstructured":"Brodersen R Bilirubin solubility and interaction with albumin and phospholipid J Biol Chem 1979 254 2364","journal-title":"J Biol Chem"},{"key":"BF7210631_CR9","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1172\/JCI103864","volume":"38","author":"GB Odell","year":"1959","unstructured":"Odell GB Studies in kernicterus: I. The protein binding of bilirubin J Clin Invest 1959 38 823","journal-title":"J Clin Invest"},{"key":"BF7210631_CR10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1067\/mpd.2000.108566","volume":"137","author":"CE Ahlfors","year":"2000","unstructured":"Ahlfors CE Unbound bilirubin associated with kernicterus: a historical approach J Pediatr 2000 137 540","journal-title":"J Pediatr"},{"key":"BF7210631_CR11","first-page":"591","volume":"97","author":"L Johnson","year":"1959","unstructured":"Johnson L, Sarmiento F, Blanc WA, Day RI Kernicterus in rats with an inherited deficiency of glucuronyl transferase Am J Dis Child 1959 97 591","journal-title":"Am J Dis Child"},{"key":"BF7210631_CR12","first-page":"91","volume":"28","author":"R Shimabuku","year":"1982","unstructured":"Shimabuku R, Nakamura H Total and unbound bilirubin determination using an automated peroxidase micromethod Kobe J Med Sci 1982 28 91","journal-title":"Kobe J Med Sci"},{"key":"BF7210631_CR13","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/S0022-3476(78)81095-6","volume":"93","author":"W Cashore","year":"1978","unstructured":"Cashore W, Gartner L, Oh W, Stern L Clinical application of neonatal bilirubin-binding determinations: current status J Pediatr 1978 93 827","journal-title":"J Pediatr"},{"key":"BF7210631_CR14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1542\/peds.69.3.255","volume":"69","author":"RL Levine","year":"1982","unstructured":"Levine RL, Fredericks WR, Rapoport SI Entry of bilirubin into the brain due to opening of the blood\u2013brain barrier Pediatrics 1982 69 255","journal-title":"Pediatrics"},{"key":"BF7210631_CR15","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/S0140-6736(82)92377-7","volume":"1","author":"WJ Brown","year":"1982","unstructured":"Brown WJ, Buist NRM, Cory Gipson HTR, et al Fatal benzyl alcohol poisoning in a neonatal intensive care unit Lancet 1982 1 1250","journal-title":"Lancet"},{"key":"BF7210631_CR16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1542\/peds.69.3.260","volume":"69","author":"DA Ritter","year":"1982","unstructured":"Ritter DA, Kenny JD, Norton J, Rudolph AJ A prospective study of free bilirubin and other risk factors in the development of kernicterus in premature infants Pediatrics 1982 69 260","journal-title":"Pediatrics"},{"key":"BF7210631_CR17","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1067\/mpd.2001.116281","volume":"139","author":"CE Ahlfors","year":"2001","unstructured":"Ahlfors CE Benzyl alcohol, kernicterus, and unbound bilirubin J Pediatr 2001 139 317","journal-title":"J Pediatr"},{"key":"BF7210631_CR18","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/j.1442-200X.1992.tb01024.x","volume":"34","author":"H Nakamura","year":"1992","unstructured":"Nakamura H, Yonetani M, Uetani Y, et al Determination of serum unbound bilirubin for prediction of kernicterus in low birth weight infants Acta Paediatr Jpn 1992 34 642","journal-title":"Acta Paediatr Jpn"},{"key":"BF7210631_CR19","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1203\/00006450-198608000-00018","volume":"20","author":"RP Wennberg","year":"1986","unstructured":"Wennberg RP, Hance AJ Experimental bilirubin encephalopathy: importance of total bilirubin, protein binding, and blood\u2013brain barrier Pediatr Res 1986 20 789","journal-title":"Pediatr Res"},{"key":"BF7210631_CR20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1542\/peds.93.1.50","volume":"93","author":"M Funato","year":"1994","unstructured":"Funato M, Tamai H, Shimada S, Nakamura H Vigintiphobia, unbound bilirubin, and auditory brainstem responses Pediatrics 1994 93 50","journal-title":"Pediatrics"},{"key":"BF7210631_CR21","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1542\/peds.107.4.664","volume":"107","author":"SB Amin","year":"2001","unstructured":"Amin SB, Ahlfors C, Orlando MS, Dalzell LE, Merle KS, Guillet R Auditory brainstem response and bilirubin binding in premature infants Pediatrics 2001 107 664","journal-title":"Pediatrics"},{"key":"BF7210631_CR22","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1006\/abio.2000.4485","volume":"279","author":"CE Ahlfors","year":"2000","unstructured":"Ahlfors CE Measurement of plasma unbound unconjugated bilirubin Anal Biochem 2000 279 130","journal-title":"Anal Biochem"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7210631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7210631","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7210631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T13:19:29Z","timestamp":1647609569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7210631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,1]]},"references-count":22,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2001,12,1]]}},"alternative-id":["BF7210631"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7210631","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,1]]},"assertion":[{"value":"21 January 2002","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}