{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:24:37Z","timestamp":1789032277739,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2003,4,1]]},"DOI":"10.1038\/sj.jp.7210913","type":"journal-article","created":{"date-parts":[[2003,5,7]],"date-time":"2003-05-07T10:12:21Z","timestamp":1052302341000},"page":"181-185","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Proton Magnetic Resonance Spectroscopy Improves Outcome Prediction in Perinatal CNS Insults"],"prefix":"10.1038","volume":"23","author":[{"given":"Munaf","family":"Kadri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanford","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Holshouser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Deming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Peverini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Ashwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,5,6]]},"reference":[{"key":"BF7210913_CR1","first-page":"314","volume-title":"Neurology of the Newborn","author":"JJ Volpe","year":"1995","unstructured":"Volpe JJ . Hypoxic\u2013ischemic encephalopathy: clinical aspects. In: Volpe JJ, editor. Neurology of the Newborn. 3 ed. Philadelphia: WB Saunders, Co; 1995. p. 314\u2013369."},{"key":"BF7210913_CR2","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/S0022-3476(89)80132-5","volume":"114","author":"CM Robertson","year":"1989","unstructured":"Robertson CM, Finer NN, Grace MG . School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr 1989;114:753\u2013760.","journal-title":"J Pediatr"},{"key":"BF7210913_CR3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1542\/peds.68.1.36","volume":"68","author":"KB Nelson","year":"1981","unstructured":"Nelson KB, Ellenberg JH . Apgar scores as predictors of chronic neurologic disability. Pediatrics 1981;68:36\u201344.","journal-title":"Pediatrics"},{"key":"BF7210913_CR4","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","volume":"33","author":"HB Sarnat","year":"1976","unstructured":"Sarnat HB, Sarnat MS . Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 1976;33:696\u20136705.","journal-title":"Arch Neurol"},{"key":"BF7210913_CR5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0887-8994(96)00049-5","volume":"14","author":"A Majnemer","year":"1996","unstructured":"Majnemer A, Rosenblatt B . Evoked potentials as predictors of outcome in neonatal intensive care unit survivors: review of the literature. Pediatr Neurol 1996;14:189\u2013195.","journal-title":"Pediatr Neurol"},{"key":"BF7210913_CR6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/0013-4694(82)90106-7","volume":"53","author":"G Holmes","year":"1982","unstructured":"Holmes G, Rowe J, Hafford J, Schmidt R, Testa M, Zimmerman A . Prognostic value of the electroencephalogram in neonatal asphyxia. Electroencephalogr Clin Neurophysiol 1982;53:60\u201372.","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"BF7210913_CR7","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/0887-8994(91)90029-K","volume":"7","author":"TS Rosenkrantz","year":"1991","unstructured":"Rosenkrantz TS, Zalneraitis EL . Prediction of survival in severely asphyxiated infants. Pediatr Neurol 1991;7:446\u2013451.","journal-title":"Pediatr Neurol"},{"key":"BF7210913_CR8","first-page":"427","volume":"16","author":"AJ Barkovich","year":"1995","unstructured":"Barkovich AJ, Westmark K, Partridge C, Sola A, Ferriero DM . Perinatal asphyxia: MR findings in the first 10 days. Am J Neuroradiol 1995;16:427\u2013438.","journal-title":"Am J Neuroradiol"},{"key":"BF7210913_CR9","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0095-5108(18)30396-8","volume":"20","author":"KB Nelson","year":"1993","unstructured":"Nelson KB, Emery III ES . Birth asphyxia and the neonatal brain: what do we know and when do we know it? Clin Perinatol 1993;20:327\u2013344.","journal-title":"Clin Perinatol"},{"key":"BF7210913_CR10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S1071-9091(99)80033-3","volume":"6","author":"MI Shevell","year":"1999","unstructured":"Shevell MI, Ashwal S, Novotny E . Proton magnetic resonance spectroscopy: clinical applications in children with nervous system diseases. Semin Pediatr Neurol 1999;6:68\u201377.","journal-title":"Semin Pediatr Neurol"},{"key":"BF7210913_CR11","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0887-8994(97)00140-9","volume":"17","author":"SK Shu","year":"1997","unstructured":"Shu SK, Ashwal S, Holshouser BA, Nystrom G, Hinshaw Jr DB . Prognostic value of 1H-MRS in perinatal CNS insults. Pediatr Neurol 1997;17:309\u2013318.","journal-title":"Pediatr Neurol"},{"key":"BF7210913_CR12","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1148\/radiology.202.2.9015079","volume":"202","author":"BA Holshouser","year":"1997","unstructured":"Holshouser BA, Ashwal S, Luh GY, et al. Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children. Radiology 1997;202:487\u2013496.","journal-title":"Radiology"},{"key":"BF7210913_CR13","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1002\/ana.410410410","volume":"41","author":"S Ashwal","year":"1997","unstructured":"Ashwal S, Holshouser BA, Tomasi LG, et al. 1H- magnetic resonance spectroscopy-determined cerebral lactate and poor neurological outcomes in children with central nervous system disease. Ann Neurol 1997;41:470\u2013481.","journal-title":"Ann Neurol"},{"key":"BF7210913_CR14","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1203\/00006450-199402000-00004","volume":"35","author":"F Groenendaal","year":"1994","unstructured":"Groenendaal F, Veenhoven RH, van der Grond J, Jansen GH, Witkamp TD, de Vries LS . Cerebral lactate and N-acetyl-aspartate\/choline ratios in asphyxiated full-term neonates demonstrated in vivo using proton magnetic resonance spectroscopy. Pediatr Res 1994;35:148\u2013151.","journal-title":"Pediatr Res"},{"key":"BF7210913_CR15","first-page":"1399","volume":"20","author":"AJ Barkovich","year":"1999","unstructured":"Barkovich AJ, Baranski K, Vigneron D, et al. Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. Am J Neuroradiol 1999;20:1399\u20131405.","journal-title":"Am J Neuroradiol"},{"key":"BF7210913_CR16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1542\/peds.69.5.529","volume":"69","author":"KB Nelson","year":"1982","unstructured":"Nelson KB, Ellenberg JH . Children who \u201coutgrew\u2019 cerebral palsy. Pediatrics 1982;69:529\u2013536.","journal-title":"Pediatrics"},{"key":"BF7210913_CR17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1469-8749.1988.tb04723.x","volume":"30","author":"MC Piper","year":"1988","unstructured":"Piper MC, Mazer B, Silver KM, Ramsay M . Resolution of neurological symptoms in high-risk infants during the first two years of life. Dev Med Child Neurol 1988;30:26\u201335.","journal-title":"Dev Med Child Neurol"},{"key":"BF7210913_CR18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S0022-3476(05)82544-2","volume":"121","author":"DH Fiser","year":"1992","unstructured":"Fiser DH . Assessing the outcome of pediatric intensive care. J Pediatr 1992;121:68\u201374.","journal-title":"J Pediatr"},{"key":"BF7210913_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/(SICI)1522-2586(200001)11:1<9::AID-JMRI2>3.0.CO;2-6","volume":"11","author":"BA Holshouser","year":"2000","unstructured":"Holshouser BA, Ashwal S, Shu S, Hinshaw Jr DB . Proton MR spectroscopy in children with acute brain injury: comparison of short and long echo time acquisitions. J Magn Reson Imaging 2000;11:9\u201319.","journal-title":"J Magn Reson Imaging"},{"key":"BF7210913_CR20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/mrm.1910140104","volume":"14","author":"U Klose","year":"1990","unstructured":"Klose U . In vivo proton spectroscopy in presence of eddy currents. Magn Reson Med 1990;14:26\u201330.","journal-title":"Magn Reson Med"},{"key":"BF7210913_CR21","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-5223(96)70268-4","volume":"112","author":"S Ashwal","year":"1996","unstructured":"Ashwal S, Holshouser BA, Hinshaw Jr DB, Schell RM, Bailey L . Proton magnetic resonance spectroscopy in the evaluation of children with congenital heart disease and acute central nervous system injury. J Thorac Cardiovasc Surg 1996;112:403\u2013414.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BF7210913_CR22","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/mrm.1910300405","volume":"30","author":"R Kreis","year":"1993","unstructured":"Kreis R, Ernst T, Ross BD . Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Reson Med 1993;30:424\u2013437.","journal-title":"Magn Reson Med"},{"key":"BF7210913_CR23","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1523\/JNEUROSCI.13-03-00981.1993","volume":"13","author":"J Urenjak","year":"1993","unstructured":"Urenjak J, Williams SR, Gadian DG, Noble M . Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 1993;13:981\u2013989.","journal-title":"J Neurosci"},{"key":"BF7210913_CR24","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1046\/j.1471-4159.2000.0740254.x","volume":"74","author":"KK Bhakoo","year":"2000","unstructured":"Bhakoo KK, Pearce D . In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo. J Neurochem 2000;74:254\u2013262.","journal-title":"J Neurochem"},{"key":"BF7210913_CR25","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/j.1469-8749.1993.tb11680.x","volume":"35","author":"CJ Peden","year":"1993","unstructured":"Peden CJ, Rutherford MA, Sargentoni J, Cox IJ, Bryant DJ, Dubowitz LM . Proton spectroscopy of the neonatal brain following hypoxic\u2013ischaemic injury. Dev Med Child Neurol 1993;35:502\u2013510.","journal-title":"Dev Med Child Neurol"},{"key":"BF7210913_CR26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1203\/00006450-199909000-00007","volume":"46","author":"NJ Robertson","year":"1999","unstructured":"Robertson NJ, Cox IJ, Cowan FM, Counsell SJ, Azzopardi D, Edwards AD . Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res 1999;46:287\u2013296.","journal-title":"Pediatr Res"},{"key":"BF7210913_CR27","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1203\/00006450-200103000-00009","volume":"49","author":"AM Roelants-Van Rijn","year":"2001","unstructured":"Roelants-Van Rijn AM, van der Grond J, de Vries LS, Groenendaal F . Value of 1H-MRS using different echo times in neonates with cerebral hypoxia\u2013ischemia. Pediatr Res 2001;49:356\u2013362.","journal-title":"Pediatr Res"},{"key":"BF7210913_CR28","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S0887-8994(01)00368-X","volume":"26","author":"FB Foz","year":"2002","unstructured":"Foz FB, Lucchini FL, Palimieri S, et al. Language plasticity revealed by electroencephalogram mapping. Pediatr Neurol 2002;26:106\u2013115.","journal-title":"Pediatr Neurol"},{"key":"BF7210913_CR29","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/brain\/awf020","volume":"125","author":"L Hertz-Pannier","year":"2002","unstructured":"Hertz-Pannier L, Chiron C, Jambaque I, et al. Late plasticity for language in a child's non-dominant hemisphere: A pre- and post-surgery fMRI study. Brain 2002;125:361\u2013372.","journal-title":"Brain"},{"key":"BF7210913_CR30","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1203\/00006450-199706000-00001","volume":"41","author":"J Penrice","year":"1997","unstructured":"Penrice J, Lorek A, Cady EB, et al. Proton magnetic resonance spectroscopy of the brain during acute hypoxia\u2013ischemia and delayed cerebral energy failure in the newborn piglet. Pediatr Res 1997;41:795\u20137802.","journal-title":"Pediatr Res"},{"key":"BF7210913_CR31","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1203\/00006450-199412000-00003","volume":"36","author":"A Lorek","year":"1994","unstructured":"Lorek A, Takei Y, Cady EB, et al. Delayed (\u201csecondary\u201d) cerebral energy failure after acute hypoxia\u2013ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res 1994;36:699\u20136706.","journal-title":"Pediatr Res"},{"key":"BF7210913_CR32","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1046\/j.1471-4159.1994.62062356.x","volume":"62","author":"MJ During","year":"1994","unstructured":"During MJ, Fried I, Leone P, Katz A, Spencer DD . Direct measurement of extracellular lactate in the human hippocampus during spontaneous seizures. J Neurochem 1994;62:2356\u20132361.","journal-title":"J Neurochem"},{"key":"BF7210913_CR33","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1148\/radiology.196.1.7784568","volume":"196","author":"H Lanfermann","year":"1995","unstructured":"Lanfermann H, Kugel H, Heindel W, Herholz K, Heiss WD, Lackner K . Metabolic changes in acute and subacute cerebral infarctions: Findings at proton MR spectroscopic imaging. Radiology 1995;196:203\u2013210.","journal-title":"Radiology"},{"key":"BF7210913_CR34","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1212\/WNL.42.7.1349","volume":"42","author":"OA Petroff","year":"1992","unstructured":"Petroff OA, Graham GD, Blamire AM, et al. Spectroscopic imaging of stroke in humans: histopathology correlates of spectral changes. Neurology 1992;42:1349\u20131354.","journal-title":"Neurology"},{"key":"BF7210913_CR35","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/ana.410380309","volume":"38","author":"H Hetherington","year":"1995","unstructured":"Hetherington H, Kuzniecky R, Pan J, et al. Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T. Ann Neurol 1995;38:396\u20133404.","journal-title":"Ann Neurol"},{"key":"BF7210913_CR36","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1002\/jmri.1880070626","volume":"7","author":"DE Saunders","year":"1997","unstructured":"Saunders DE, Howe FA, van den Boogaart A, Griffiths JR, Brown MM . Discrimination of metabolite from lipid and macromolecule resonances in cerebral infarction in humans using short echo proton spectroscopy. J Magn Reson Imaging 1997;7:1116\u20131121.","journal-title":"J Magn Reson Imaging"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7210913.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7210913","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7210913.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T15:41:44Z","timestamp":1647618104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7210913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,1]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,4,1]]}},"alternative-id":["BF7210913"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7210913","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,1]]},"assertion":[{"value":"6 May 2003","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}