{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:06:33Z","timestamp":1791439593848,"version":"4.3.3"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,8,26]],"date-time":"2004-08-26T00:00:00Z","timestamp":1093478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,8,26]],"date-time":"2004-08-26T00:00:00Z","timestamp":1093478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2005,2,1]]},"DOI":"10.1038\/sj.jp.7211193","type":"journal-article","created":{"date-parts":[[2004,8,26]],"date-time":"2004-08-26T09:38:14Z","timestamp":1093513094000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["A Randomized-Controlled Trial of Prophylactic Hydrocortisone Supplementation for the Prevention of Hypotension in Extremely Low Birth Weight Infants"],"prefix":"10.1038","volume":"25","author":[{"given":"Meica M","family":"Efird","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann T","family":"Heerens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip V","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl L","family":"Bose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,8,26]]},"reference":[{"key":"BF7211193_CR1","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1136\/adc.69.3_Spec_No.284","volume":"69","author":"AB Gill","year":"1993","unstructured":"Gill AB, Weindling AM . Randomized controlled trial of plasma protein fraction versus dopamine in hypotensive very low birthweight infants. Arch Dis Child 1993;69:284\u2013287.","journal-title":"Arch Dis Child"},{"key":"BF7211193_CR2","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/sj.jp.7210563","volume":"21","author":"I Al-Aveel","year":"2001","unstructured":"Al-Aveel I, Pursley DM, Rubin LP, Shah B, Weisberger S, Richardson DK . Variations in prevalence of hypotension, hypertension, and vasopressor use in NICUs. J Perinatol 2001;21:272\u2013278.","journal-title":"J Perinatol"},{"key":"BF7211193_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0378-3782(89)90120-5","volume":"19","author":"AMC Watkins","year":"1989","unstructured":"Watkins AMC, West CR, Cooke RWI . Blood pressure and cerebral haemorrhage and ischaemia in very low birth weight infants. Early Hum Dev 1989;19:103\u2013110.","journal-title":"Early Hum Dev"},{"key":"BF7211193_CR4","first-page":"238","volume":"95","author":"RF Goldstein","year":"1995","unstructured":"Goldstein RF, Thompson RJ, Oehler JM, Brazy JE . Influence of acidosis, hypoxemia, and hypotension on neurodevelopmental outcomes in very low birth weight infants. Pediatrics 1995;95:238\u2013243.","journal-title":"Pediatrics"},{"key":"BF7211193_CR5","doi-asserted-by":"publisher","first-page":"F99","DOI":"10.1136\/fn.81.2.F99","volume":"81","author":"J Zhang","year":"1999","unstructured":"Zhang J, Penny DJ, Kim NS, Yu VY, Smolick JJ . Mechanisms of blood pressure increases induced by dopamine in hypotensive preterm neonates. Arch Dis Child Fetal Neonatal Ed 1999;81:F99\u2013F104.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BF7211193_CR6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1542\/peds.92.5.715","volume":"92","author":"HJ Helbock","year":"1993","unstructured":"Helbock HJ, Insoft RM, Conte FA . Glucocorticoid-responsive hypotension in extremely low birth weight newborns. Pediatrics 1993;92:715\u2013717.","journal-title":"Pediatrics"},{"key":"BF7211193_CR7","first-page":"11A","volume":"39","author":"RM Ward","year":"1991","unstructured":"Ward RM, Kimura RE, Rich-Denson C . Addisonian crisis in extremely premature neonates. Clin Res 1991;39:11A.","journal-title":"Clin Res"},{"key":"BF7211193_CR8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1542\/peds.95.1.120","volume":"95","author":"KL Watterberg","year":"1995","unstructured":"Watterberg KL, Scott SM . Evidence of early adrenal insufficiency in babies who develop bronchopulmonary dysplasia. Pediatrics 1995;95:120\u2013125.","journal-title":"Pediatrics"},{"key":"BF7211193_CR9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1055\/s-2007-994127","volume":"14","author":"CE Hanna","year":"1997","unstructured":"Hanna CE, Jett PL, Laird MR, Mandel SH, LaFranchi SH, Reynolds JW . Corticosteroid binding globulin, total serum cortisol, and stress in extremely low-birth-weight infants. Am J Perinatol 1997;14:201\u2013204.","journal-title":"Am J Perinatol"},{"key":"BF7211193_CR10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/BF01956753","volume":"152","author":"A Fauser","year":"1993","unstructured":"Fauser A, Pohlandt F, Bartmann P, Gortner L . Rapid increase of blood pressure in extremely low birth weight infants after a single dose of dexamethasone. Eur J Pediatr 1993;152:354\u2013356.","journal-title":"Eur J Pediatr"},{"key":"BF7211193_CR11","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/S0022-3476(99)70284-2","volume":"134","author":"RE Gaissmaier","year":"1999","unstructured":"Gaissmaier RE, Poblandt F . Single-dose dexamethasone treatment of hypotension in preterm infants. J Pediatr 1999;134:701\u2013705.","journal-title":"J Pediatr"},{"key":"BF7211193_CR12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/sj.jp.7200202","volume":"19","author":"P Tantivit","year":"1999","unstructured":"Tantivit P, Subramanian N, Garg M, Ramanathan R, deLemos RA . Low serum cortisol in term newborns with refractory hypotension. J Perinatol 1999;19:352\u2013357.","journal-title":"J Perinatol"},{"key":"BF7211193_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1542\/peds.104.1.15","volume":"104","author":"TM O\u2019Shea","year":"1999","unstructured":"O\u2019Shea TM, Kothadia JM, Klinepeter KL, et al. Randomized placebo-control trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilatory dependency in very low birth weight infants: outcome of study participants at 1-year adjusted age. Pediatrics 1999;104:15\u201321.","journal-title":"Pediatrics"},{"key":"BF7211193_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.jp.7200520","volume":"21","author":"PV Gordon","year":"2001","unstructured":"Gordon PV, Young ML, Marshall DD . Focal small bowel perforation: an adverse effect of early postnatal dexamethasone therapy in extremely low birth weight infants. J Perinatol 2001;21:1\u20135.","journal-title":"J Perinatol"},{"key":"BF7211193_CR15","doi-asserted-by":"publisher","first-page":"pe63.","DOI":"10.1542\/peds.104.5.e63","volume":"104","author":"BJ Stoll","year":"1999","unstructured":"Stoll BJ, Temprosa M, Tyson JE, et al. Dexamethasone therapy increases infection in very low birth weight infants. Pediatrics 1999;104:pe63. http:\/\/www.pediatrics.org\/cgi\/content\/full\/104\/5\/e63.","journal-title":"Pediatrics"},{"key":"BF7211193_CR16","first-page":"180A","volume":"37","author":"CB Hanna","year":"1989","unstructured":"Hanna CB, Gilhooly JT, Reynolds JW . Hydrocortisone replacement in extremely premature infants with cortisol insufficiency. Clin Res 1989;37:180A.","journal-title":"Clin Res"},{"key":"BF7211193_CR17","doi-asserted-by":"publisher","first-page":"F122","DOI":"10.1136\/fn.84.2.F122","volume":"84","author":"PC Ng","year":"2001","unstructured":"Ng PC, Lam CWK, Fok TF, et al. Refractory hypotension in preterm infants with adrenocortical insufficiency. Arch Dis Child Fetal Neonatal Ed 2001;84:F122\u2013F124.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BF7211193_CR18","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1542\/peds.107.5.1070","volume":"107","author":"I Seri","year":"2001","unstructured":"Seri I, Tan R, Evans J . Cardiovascular effects of hydrocortisone in preterm infants with pressor-resistant hypotension. Pediatrics 2001;107:1070\u20131074.","journal-title":"Pediatrics"},{"key":"BF7211193_CR19","first-page":"182","volume-title":"Neofax: A Manual of Drugs Used in Neonatal Care","author":"TE Young","year":"1999","unstructured":"Young TE, Mangum OB, editors. Neofax: A Manual of Drugs Used in Neonatal Care. Raleigh, NC: Acorn Publishing; 1999. pp. 182\u2013183."},{"key":"BF7211193_CR20","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1542\/peds.44.6.959","volume":"44","author":"JA Kitterman","year":"1969","unstructured":"Kitterman JA, Phibbs RH, Tooley WH . Aortic blood pressure in normal newborn infants during the first 12 hours of life. Pediatrics 1969;44:959\u2013968.","journal-title":"Pediatrics"},{"key":"BF7211193_CR21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1542\/peds.67.5.607","volume":"67","author":"HT Versmold","year":"1981","unstructured":"Versmold HT, Kitterman JA, Phibbs RH, Gregory GA, Tooley WH . Aortic blood pressure during the first 12 hours of life in infants with birth weight 610 to 4,220 grams. Pediatrics 1981;67:607\u2013613.","journal-title":"Pediatrics"},{"key":"BF7211193_CR22","doi-asserted-by":"crossref","unstructured":"The International Neonatal Network. The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. Lancet 1993;342:193\u2013198.","DOI":"10.1016\/0140-6736(93)92296-6"},{"key":"BF7211193_CR23","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","author":"L Papile","year":"1978","unstructured":"Papile L, Burstein J, Burstein R, Koffler H . Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1500 grams. J Pediatr 1978;92:529\u2013534.","journal-title":"J Pediatr"},{"key":"BF7211193_CR24","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1651-2227.1986.tb10235.x","volume":"75","author":"SA Calvert","year":"1986","unstructured":"Calvert SA, Hoskins EM, Fong KW, Forsyth SC . Periventricular leukomalacia; ultrasonic diagnosis and neurologic outcome. Acta Paediatr Scand 1986;75:489\u2013496.","journal-title":"Acta Paediatr Scand"},{"key":"BF7211193_CR25","first-page":"2447","volume-title":"Fetal and Neonatal Physiology","author":"JSD Winter","year":"1998","unstructured":"Winter JSD . Fetal and neonatal adrenocortical physiology. In: Poplin RA, Fox WW, editors. Fetal and Neonatal Physiology. Philadelphia, PA: WB Saunders; 1998. pp. 2447\u20132459."},{"key":"BF7211193_CR26","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1055\/s-2007-994127","volume":"14","author":"CE Hanna","year":"1997","unstructured":"Hanna CE, Jett PL, Laird MR, Mandel SH, LaFranchi SH, Reynolds TW . Corticosteroid binding globulin, total serum cortisol, and stress in extremely low birth weight infants. Am J Perinatol 1997;14:201\u2013204.","journal-title":"Am J Perinatol"},{"key":"BF7211193_CR27","first-page":"2921","volume":"82","author":"PL Jett","year":"1997","unstructured":"Jett PL, Samuels MH, McDaniel PA, et al. Variability of plasma cortisol levels in extremely low birth weight infants. J Clin Endocrinol Metab 1997;82:2921\u20132925.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF7211193_CR28","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0378-3782(01)00124-4","volume":"62","author":"WD Engle","year":"2001","unstructured":"Engle WD . Blood pressure in the very low birth weight neonate. Early Hum Dev 2001;62:97\u2013130.","journal-title":"Early Hum Dev"},{"key":"BF7211193_CR29","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/00008480-200104000-00005","volume":"13","author":"I Seri","year":"2001","unstructured":"Seri I, Evans J . Controversies in the diagnosis and management of hypotension in the newborn infant. Curr Opin Pediatr 2001;13:116\u2013123.","journal-title":"Curr Opin Pediatr"},{"key":"BF7211193_CR30","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/S0095-5108(18)30030-7","volume":"26","author":"P Nuntnarumit","year":"1999","unstructured":"Nuntnarumit P, Yang W, Bada-Ellzey HS . Blood pressure measurements in the newborn. Clin Perinatol 1999;26:981\u2013996.","journal-title":"Clin Perinatol"},{"key":"BF7211193_CR31","doi-asserted-by":"publisher","first-page":"F168","DOI":"10.1136\/fn.81.3.F168","volume":"81","author":"J Lee","year":"1999","unstructured":"Lee J, Rajadurai VS, Tan KW . Blood pressure standards for very low birth-weight infants during the first day of life. Arch Dis Child Fetal Neonatal Ed 1999;81:F168\u2013F170.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BF7211193_CR32","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1203\/00006450-199501000-00021","volume":"37","author":"SM Scott","year":"1995","unstructured":"Scott SM, Watterberg KL . Effect of gestational age, postnatal age, and illness on plasma cortisol concentrations in premature infants. Pediatr Res 1995;37:112\u2013116.","journal-title":"Pediatr Res"},{"key":"BF7211193_CR33","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0022-3476(96)70404-3","volume":"128","author":"C Korte","year":"1996","unstructured":"Korte C, Styne D, Merritt TA, Mayes D, Wertz A, Helbock HJ . Adrenocortical function in the very low birth weight infant: improved testing sensitivity and association with neonatal outcome. J Pediatr 1996;128:257\u2013263.","journal-title":"J Pediatr"},{"key":"BF7211193_CR34","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1111\/j.1651-2227.2000.tb03358.x","volume":"89","author":"M Heckmann","year":"2000","unstructured":"Heckmann M, Wudy SA, Haack D, Pohlandt F . Serum cortisol concentrations in ill preterm infants less than 30 weeks gestational age. Acta Paediatr 2000;89:1098\u20131103.","journal-title":"Acta Paediatr"},{"key":"BF7211193_CR35","doi-asserted-by":"publisher","first-page":"F174","DOI":"10.1136\/fn.76.3.F174","volume":"76","author":"D Bourchier","year":"1997","unstructured":"Bourchier D, Weston PJ . Randomized trial of dopamine compared with hydrocortisone for the treatment of hypotensive very low birthweight infants. Arch Dis Child 1997;76:F174\u2013F178.","journal-title":"Arch Dis Child"},{"key":"BF7211193_CR36","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1651-2227.1998.tb01444.x","volume":"87","author":"U Merz","year":"1998","unstructured":"Merz U, Pfaffle R, Peschgens Th, Hornchen H . The hypothalamic\u2013pituitary\u2013adrenal axis in preterm infants weighing &lt;1250 g: association with perinatal data and chronic lung disease. Acta Paediatr 1998;87:313\u2013317.","journal-title":"Acta Paediatr"},{"key":"BF7211193_CR37","doi-asserted-by":"publisher","first-page":"F171","DOI":"10.1136\/fn.81.3.F171","volume":"81","author":"M Heckmann","year":"1999","unstructured":"Heckmann M, Wudy SA, Haack D, Pohlandt F . Reference range for serum cortisol in well preterm infants. Arch Dis Child Fetal Neonatal Ed 1999;81:F171\u2013F174.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BF7211193_CR38","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1161\/01.HYP.12.4.393","volume":"12","author":"A Jazayeri","year":"1988","unstructured":"Jazayeri A, Meyer III WJ . Glucocorticoid modulation of \u03b2-adrenergic receptors of cultured rat arterial smooth muscle cells. Hypertension 1988;12:393\u2013398.","journal-title":"Hypertension"},{"key":"BF7211193_CR39","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1542\/peds.95.6.883","volume":"95","author":"CM Botas","year":"1995","unstructured":"Botas CM, Kurlat I, Young SM, Sola A . Disseminated candidal infections and intravenous hydrocortisone in preterm infants. Pediatrics 1995;95:883\u2013887.","journal-title":"Pediatrics"},{"key":"BF7211193_CR40","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1006\/mgme.2000.3127","volume":"72","author":"PV Gordon","year":"2001","unstructured":"Gordon PV, Marshall DD, Stiles AD, Price WA . The clinical, morphologic, and molecular changes in the ileum associated with early postnatal dexamethasone administration: from the baby's bowel to the researcher's bench. Mol Genet Metab 2001;72:92\u2013103.","journal-title":"Mol Genet Metab"},{"key":"BF7211193_CR41","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1542\/peds.104.1.91","volume":"104","author":"JS Garland","year":"1999","unstructured":"Garland JS, Alex CP, Pauly TH, et al. A three-day course of dexamethasone therapy to prevent chronic lung disease in ventilated neonates: a randomized trial. Pediatrics 1999;104:91\u201399.","journal-title":"Pediatrics"},{"key":"BF7211193_CR42","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1056\/NEJM200101113440203","volume":"344","author":"AR Stark","year":"2001","unstructured":"Stark AR, Carlo WA, Tyson JE, et al. Adverse effects of early dexamethasone in extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med 2001;344:95\u2013101.","journal-title":"N Engl J Med"},{"key":"BF7211193_CR43","first-page":"170","volume":"53","author":"R Karlsson","year":"2000","unstructured":"Karlsson R, Kallio J, Toppari J, Scheinin M, Kero P . Antenatal and early postnatal dexamethasone treatment decreases cortisol secretion in preterm infants. Horm Res 2000;53:170\u2013176.","journal-title":"Horm Res"},{"key":"BF7211193_CR44","doi-asserted-by":"publisher","first-page":"3548","DOI":"10.1210\/jcem.82.11.4392","volume":"82","author":"PC Ng","year":"1997","unstructured":"Ng PC, Wong GWK, Lam CWK, et al. Pituitary\u2013adrenal response in preterm very low birth weight infants after treatment with antenatal corticosteroids. J Clin Endocrinol Metab 1997;82:3548\u20133552.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7211193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211193","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T15:37:00Z","timestamp":1647617820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7211193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,26]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2,1]]}},"alternative-id":["BF7211193"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7211193","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,26]]},"assertion":[{"value":"26 August 2004","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}