{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:39:30Z","timestamp":1778521170948,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T00:00:00Z","timestamp":1108598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T00:00:00Z","timestamp":1108598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2005,5,1]]},"DOI":"10.1038\/sj.jp.7211258","type":"journal-article","created":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T15:57:12Z","timestamp":1108655832000},"page":"325-330","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Randomized, Triple-Blind, Placebo-Controlled Trial of Prophylactic Oral Phenobarbital to Reduce the Need for Phototherapy in G6PD-Deficient Neonates"],"prefix":"10.1038","volume":"25","author":[{"given":"Srinivas","family":"Murki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourabh","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Narang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urmi","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurjeevan","family":"Garewal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,2,17]]},"reference":[{"key":"BF7211258_CR1","first-page":"196","volume":"58","author":"JG Jolly","year":"1972","unstructured":"Jolly JG, Sarup BM, Bhatnagar DP, Maini SC . Glucose 6 phosphate dehydrogenase deficiency in India. J Indian Med Assoc 1972;58:196.","journal-title":"J Indian Med Assoc"},{"key":"BF7211258_CR2","doi-asserted-by":"crossref","unstructured":"Valaes T, Drummond GS, Kappas A . Control of hyperbilirubinemia in glucose 6 phosphate dehydrogenase deficient newborns using an inhibitor of bilirubin production, Sn-Mesoporphyrin. Pediatrics 1998;101: http:\/\/www.pediatrics.org\/cgi\/content\/full\/105\/5\/el.","DOI":"10.1542\/peds.101.5.e1"},{"key":"BF7211258_CR3","doi-asserted-by":"crossref","unstructured":"Kaplan M, Muraca M, Hammerman C, et al. Bilirubin conjugation reflected by conjugated bilirubin fractions in glucose 6 phosphate dehydrogenase deficient neonates \u2014 a determining factor in the pathogenesis of hyperbilirubinemia. Pediatrics 1998;102: http:\/\/www.pediatrics.org\/egi\/content\/full\/102\/3\/e37.","DOI":"10.1542\/peds.102.3.e37"},{"key":"BF7211258_CR4","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1159\/000208087","volume":"54","author":"T Meloni","year":"1975","unstructured":"Meloni T, Costa S, Cuuntilo S . Haptoglobin, hemopexin, hemoglobin and haematocrit in newborns with erythrocytes glucose 6 phosphate dehydrogenase deficiency. Acta Hematol 1975;54:284\u2013288.","journal-title":"Acta Hematol"},{"key":"BF7211258_CR5","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1203\/00006450-196909000-00008","volume":"3","author":"T Valaes","year":"1969","unstructured":"Valaes T, Karaklis A, Stavrakakis D, Bavela-Stavrakakis K, Perakis A, Doxiadis SA . Incidence and mechanism of neonatal jaundice retated to G6PD deficiency. Pediatr Res 1969;3:448\u2013458.","journal-title":"Pediatr Res"},{"key":"BF7211258_CR6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1542\/peds.104.1.68","volume":"104","author":"M Kaplan","year":"1999","unstructured":"Kaplan M, Buetller E, Vreman HJ, et al. Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase deficient heterozygotes. Pediatr 1999;104:68\u201374.","journal-title":"Pediatr"},{"key":"BF7211258_CR7","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S0022-3476(73)80442-1","volume":"82","author":"T Meloni","year":"1973","unstructured":"Meloni T, Cagnazzo G, Dore A, Cuuntillo S . Phenobarbital for prevention of hyperbilirubinemia in glucose-6-phosphate dehydrogenase deficient newborn infants. J Pediatr 1973;82:1048.","journal-title":"J Pediatr"},{"key":"BF7211258_CR8","first-page":"197","volume":"274","author":"T Meloni","year":"1972","unstructured":"Meloni T, Dore A, Cuuntilo S . The effect of phenobarbitone in the hyperbilirubinemia of neonates with deficiency of glucose-6-phosphate dehydrogenase of the erythrocytes. Helv Pediatr Acta 1972;274:197 [German].","journal-title":"Helv Pediatr Acta"},{"key":"BF7211258_CR9","first-page":"359","volume":"17","author":"JC Gall","year":"1965","unstructured":"Gall JC, Brewer GJ, Dern RJ . Studies of glucose-6-phosphate dehydrogenase activity of individual erythrocytes: the methemoglobin elution test for identification of female heterozygotes for G6PD deficiency. Am J Hum Genet. 1965;17:359.","journal-title":"Am J Hum Genet."},{"key":"BF7211258_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0095-5108(18)30567-0","volume":"17","author":"TN Valaes","year":"1990","unstructured":"Valaes TN, Harvey-Wilkes K . Pharmacologic approaches to the prevention and treatment of neonatal hyperbilirubinemia. Clin Perinatol 1990;17:245\u2013273.","journal-title":"Clin Perinatol"},{"key":"BF7211258_CR11","unstructured":"National Neonatology Forum. The National Neonatal\u2013Perinatal Database, India. Report for the Year 2000; p. 39."},{"key":"BF7211258_CR12","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0022-3476(79)80673-3","volume":"95","author":"RA Cockington","year":"1979","unstructured":"Cockington RA . A guide to the use of phototherapy in the management of neonatal hyperbilirubinemia. J Pediatr 1979;95:281\u2013285.","journal-title":"J Pediatr"},{"key":"BF7211258_CR13","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics: Practice parameter: Management of hyperbilirubinemia in the healthy term newborn. Pediatrics 1994;94:558\u2013565.","DOI":"10.1542\/peds.94.4.558"},{"key":"BF7211258_CR14","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1542\/peds.103.1.6","volume":"103","author":"VK Bhutani","year":"1999","unstructured":"Bhutani VK, Johnson L, Sivieri EM . Predictive ability of a pre-discharge hour specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near term newborns. Pediatrics 1999;103:6\u201314.","journal-title":"Pediatrics"},{"key":"BF7211258_CR15","doi-asserted-by":"publisher","first-page":"12128","DOI":"10.1073\/pnas.94.22.12128","volume":"94","author":"M Kaplan","year":"1997","unstructured":"Kaplan M, Renbaum P, Levy-Lahad E, Hammerman C, Lahad A, Beutler E . Gilbert syndrome and glucose-6-phosphate deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia. Proc Natl Acad Sci 1997;94:12128\u201312132.","journal-title":"Proc Natl Acad Sci"},{"key":"BF7211258_CR16","first-page":"99","volume":"84","author":"A Iolascon","year":"1999","unstructured":"Iolascon A, Faienza MF, Perrotta S, Meloni GF, Ruggiu G, del Giudice EM . Gilbert's syndrome and jaundice in glucose-6-phosphate dehydrogenase deficient neonates. Haematologica 1999;84:99\u2013102.","journal-title":"Haematologica"},{"key":"BF7211258_CR17","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","volume":"84","author":"E Beutler","year":"1994","unstructured":"Beutler E . G6PD deficiency. Blood 1994;84:3613\u20133636.","journal-title":"Blood"},{"key":"BF7211258_CR18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/BF02724295","volume":"71","author":"D Mohanty","year":"2004","unstructured":"Mohanty D, Mukherjee MB, Colah RB . Glucose-6-phosphate dehydrogenase deficiency in India. Indian J Pediatr 2004;71:525\u2013529.","journal-title":"Indian J Pediatr"},{"key":"BF7211258_CR19","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1542\/peds.108.4.956","volume":"108","author":"M Kaplan","year":"2001","unstructured":"Kaplan M, Algur N, Hammerman C . Onset of jaundice in glucose 6 phosphate dehydrogenase deficient neonates. Pediatrics 2001;108:956\u2013959.","journal-title":"Pediatrics"},{"key":"BF7211258_CR20","first-page":"945","volume":"39","author":"R Kumar","year":"2002","unstructured":"Kumar R, Narang A, Kumar P, Garewal G . Study of postnatal phenobarbitone prophylaxis for neonatal jaundice in babies with birth weight 1000\u20131499 grams. Indian Pediatr 2002;39:945\u2013951.","journal-title":"Indian Pediatr"},{"key":"BF7211258_CR21","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1651-2227.1974.tb04363.x","volume":"63","author":"S Cuuntilo","year":"1974","unstructured":"Cuuntilo S, Meloni T, Dore A . Effect of orotic acid upon serum bilirubin in newborn infants with erythrocyte G6PD deficiency. Acta Paediatr Scand 1974;63:143\u2013146.","journal-title":"Acta Paediatr Scand"},{"key":"BF7211258_CR22","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1542\/peds.108.1.25","volume":"108","author":"A Kappas","year":"2001","unstructured":"Kappas A, Drummond GS, Valaes T . A single dose of Sn-Mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase deficient newborns. Pediatrics 2001;108:25\u201330.","journal-title":"Pediatrics"},{"key":"BF7211258_CR23","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1365-2141.1983.tb02017.x","volume":"53","author":"T Meloni","year":"1983","unstructured":"Meloni T, Forteleoni G, Dore A, Cutillo S . Neonatal hyperbilirubinemia in heterozygous glucose-6-phosphate dehydrogenase deficient females. Br J Haematol 1983;53:241\u2013246.","journal-title":"Br J Haematol"},{"key":"BF7211258_CR24","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0378-3782(03)00002-1","volume":"71","author":"YH Weng","year":"2003","unstructured":"Weng YH, Chou YH, Lien RI . Hyperbilirubinemia in healthy neonates with glucose-6-phosphate dehydrogenase deficiency. Early Hum Dev 2003;71:129\u2013136.","journal-title":"Early Hum Dev"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7211258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211258","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T16:43:19Z","timestamp":1647621799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7211258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,17]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5,1]]}},"alternative-id":["BF7211258"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7211258","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,17]]},"assertion":[{"value":"17 February 2005","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}