{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:28:49Z","timestamp":1782246529067,"version":"3.54.5"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T00:00:00Z","timestamp":1107993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T00:00:00Z","timestamp":1107993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2005,4,1]]},"DOI":"10.1038\/sj.jp.7211259","type":"journal-article","created":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T10:25:43Z","timestamp":1108031143000},"page":"245-250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Combination of Early Perinatal Factors to Identify Near-Term and Term Neonates for Neuroprotection"],"prefix":"10.1038","volume":"25","author":[{"given":"Ajay J","family":"Talati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Yolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon B","family":"Korones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrietta S","family":"Bada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,2,10]]},"reference":[{"key":"BF7211259_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/00008480-199704000-00002","volume":"9","author":"J Patel","year":"1997","unstructured":"Patel J, Edwards AD . Prediction of outcome after perinatal asphyxia. Opin Pediatr 1997;9:128\u2013132.","journal-title":"Opin Pediatr"},{"key":"BF7211259_CR2","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1542\/peds.99.6.851","volume":"99","author":"JM Perlman","year":"1997","unstructured":"Perlman JM . Intrapartum hypoxic\u2013ischemic cerebral injury and subsequent cerebral palsy: medico-legal issues. Pediatrics 1997;99:851\u2013859.","journal-title":"Pediatrics"},{"key":"BF7211259_CR3","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/j.1469-8749.1992.tb11479.x","volume":"34","author":"L Mutch","year":"1992","unstructured":"Mutch L, Alberman E, Hagberg B, Kodoma K, Perat M . Cerebral palsy epidemiology: where are we now and where are we going? Dev Med Child Neurol 1992;34:547\u2013555.","journal-title":"Dev Med Child Neurol"},{"key":"BF7211259_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.100.6.1004","volume":"100","author":"RC Vannucci","year":"1997","unstructured":"Vannucci RC, Perlman JM . Interventions of perinatal hypoxic\u2013ischemic encephalopathy. Pediatrics 1997;100:1\u201311.","journal-title":"Pediatrics"},{"key":"BF7211259_CR5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1542\/peds.101.2.185","volume":"101","author":"F Van Bel","year":"1998","unstructured":"Van Bel F, Shadid M, Moison RMW, et al. Effects of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity. Pediatrics 1998;101:185\u2013193.","journal-title":"Pediatrics"},{"key":"BF7211259_CR6","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0022-3476(98)70458-5","volume":"132","author":"RT Hall","year":"1998","unstructured":"Hall RT, Hal FK, Daily DK . High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized prospective study with a three-year follow-up. J Pediatr 1998;132:345\u2013348.","journal-title":"J Pediatr"},{"key":"BF7211259_CR7","doi-asserted-by":"publisher","first-page":"F174","DOI":"10.1136\/fn.73.3.F174","volume":"73","author":"M Levene","year":"1995","unstructured":"Levene M, Blennow M, Whitelaw A, Hanko E, Fellman V, Hartley R . Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia. Arch Dis Child 1995;73:F174\u2013F177.","journal-title":"Arch Dis Child"},{"key":"BF7211259_CR8","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/S0022-3476(98)70350-6","volume":"132","author":"TA King","year":"1998","unstructured":"King TA, Jackson GL, Jossey S, et al. The effect of profound umbilical artery acidemia in term neonates admitted to a newborn nursery. J Pediatr 1998;132:624\u2013629.","journal-title":"J Pediatr"},{"key":"BF7211259_CR9","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/S0002-9378(96)70021-2","volume":"175","author":"PP Van den Berg","year":"1996","unstructured":"Van den Berg PP, Nelen W, Jongsma HW, et al. Neonatal complications in newborns with umbilical artery pH<7.00. Am J Obstet Gynecol 1996;175:1152\u20131157.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211259_CR10","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/S0002-9378(94)70101-6","volume":"17","author":"JA Low","year":"1994","unstructured":"Low JA, Panagiotopoulos C, Derrick JE . Newborn complications after intrapartum asphyxia with metabolic acidosis in the term fetus. Am J Obstet Gynecol 1994;17:1081\u20131087.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211259_CR11","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/0002-9378(90)91014-4","volume":"162","author":"SC Fee","year":"1990","unstructured":"Fee SC, Malee K, Deddish R, Minogue JP, Socol ML . Severe acidosis and subsequent neurologic status. Am J Obstet Gynecol 1990;162:802\u2013806.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211259_CR12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1542\/peds.68.1.36","volume":"68","author":"KB Nelson","year":"1981","unstructured":"Nelson KB, Ellenberg JH . Apgar scores as predictors of chronic neurologic disability. Pediatrics 1981;68:36\u201344.","journal-title":"Pediatrics"},{"key":"BF7211259_CR13","first-page":"331","volume":"66","author":"F Silverman","year":"1985","unstructured":"Silverman F, Suidan J, Wassermann J, Antoine C, Young BK . The Apgar score: is it enough? Obstet Gynecol 1985;66:331\u2013336.","journal-title":"Obstet Gynecol"},{"key":"BF7211259_CR14","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/0002-9378(95)90002-0","volume":"172","author":"JA Low","year":"1995","unstructured":"Low JA, Simpson LL, Tonni G, Chamberlain S . Limitations in the clinical prediction of intrapartum fetal asphyxia. Am J Obstet Gynecol 1995;172:801\u2013804.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211259_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0029-7844(94)00375-N","volume":"85","author":"JM Lein","year":"1995","unstructured":"Lein JM, Towers CV, Quilligan EJ, Veciana M, Toohey JS, Morgan MA . Term early-onset neonatal seizures: obstetric characteristics, etiologic classifications, and perinatal care. Obstet Gynecol 1995;85:163\u2013169.","journal-title":"Obstet Gynecol"},{"key":"BF7211259_CR16","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/0002-9378(95)90620-7","volume":"173","author":"JP Phelan","year":"1995","unstructured":"Phelan JP, Ahn MO, Korst LM, Martin GI . Nucleated red blood cells: a marker for fetal asphyxia? Am J Obstet Gynecol 1995;173:1380\u20131384.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211259_CR17","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/S0022-3476(88)80024-6","volume":"113","author":"V Ruth","year":"1988","unstructured":"Ruth V, Autti-Ramo I, Granstorm M, Korkman M, Raivio KO . Prediction of perinatal brain damage by cord plasma vasopressin, erythropoetin, and hypoxanthine values. J Pediatr 1988;113:880\u2013885.","journal-title":"J Pediatr"},{"key":"BF7211259_CR18","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0002-9378(87)80068-6","volume":"157","author":"DI Hollander","year":"1987","unstructured":"Hollander DI, Wright L, Nagey DA, Wright JN, Pupkin MJ, Koch T . Indicators of perinatal asphyxia. Am J Obstet Gynecol 1987;157:839\u2013843.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211259_CR19","doi-asserted-by":"publisher","first-page":"F34","DOI":"10.1136\/fn.72.1.F34","volume":"72","author":"L Westas-Hellstrom","year":"1995","unstructured":"Westas-Hellstrom L, Rosen I, Svenningsen NW . Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants. Arch Dis Child 1995;72:F34\u2013F38.","journal-title":"Arch Dis Child"},{"key":"BF7211259_CR20","doi-asserted-by":"publisher","first-page":"F75","DOI":"10.1136\/fn.73.2.F75","volume":"73","author":"P Eken","year":"1995","unstructured":"Eken P, Toet MC, Groenendaal F, De Vries LS . Predictive value of early neuroimaging, pulsed Doppler and neurophysiology in full term infants with hypoxic\u2013ischemic encephalopathy. Arch Dis Child 1995;73:F75\u2013F80.","journal-title":"Arch Dis Child"},{"key":"BF7211259_CR21","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/0002-9378(90)90844-W","volume":"162","author":"RJ Portman","year":"1990","unstructured":"Portman RJ, Carter BS, Gaylord MS, Murphy MG, Theime RE, Merenstein GB . Predicting neonatal morbidity after perinatal asphyxia: a scoring system. Am J Obstet Gynecol 1990;162:174\u2013182.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211259_CR22","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0022-3476(98)70349-X","volume":"132","author":"BS Carter","year":"1998","unstructured":"Carter BS, McNabb F, Merenstein GB . Prospective validation of a scoring system for predicting neonatal morbidity after acute perinatal asphyxia. J Pediatr 1998;132:619\u2013623.","journal-title":"J Pediatr"},{"key":"BF7211259_CR23","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1203\/00006450-199909000-00005","volume":"46","author":"AJ Gunn","year":"1999","unstructured":"Gunn AJ, Bennet L, Gunning MI, Gluckman PD, Gunn TR . Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res 1999;46(3):274\u2013280.","journal-title":"Pediatr Res"},{"key":"BF7211259_CR24","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1172\/JCI119153","volume":"99","author":"AJ Gunn","year":"1997","unstructured":"Gunn AJ, Gunn TR, de Hann HH, Williams CE, Gluckman PD . Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest 1997;99(2):248\u2013256.","journal-title":"J Clin Invest"},{"key":"BF7211259_CR25","unstructured":"American Academy of Pediatrics, American College of Obstetricians and Gynecologists. Relationships between perinatal factors and neurologic outcome. In: Hauth JC, Merenstein GB, editors. Guidelines for Perinatal Care. 4th edn. Elk Grove Village, IL: American Academy of Pediatrics; 1997. p 122\u2013123."},{"key":"BF7211259_CR26","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","volume":"33","author":"HB Sarnat","year":"1976","unstructured":"Sarnat HB, Sarnat MS . Neonatal encephalopathy following fetal distress. Arch Neurol 1976;33:696\u2013705.","journal-title":"Arch Neurol"},{"key":"BF7211259_CR27","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1001\/archpedi.1985.02140110094038","volume":"139","author":"AJ Capute","year":"1985","unstructured":"Capute AJ, Shapiro BK . The motor quotient. A method for the early detection of motor delay. Am J Dis Child 1985;139:940\u2013942.","journal-title":"Am J Dis Child"},{"key":"BF7211259_CR28","first-page":"1","volume":"1","author":"PA Blasco","year":"1992","unstructured":"Blasco PA . Normal and abnormal development. Pediatr Rounds 1992;1:1\u20136.","journal-title":"Pediatr Rounds"},{"key":"BF7211259_CR29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-1-4757-2719-7_14","volume-title":"Modern Applied Statistics with S-plus","author":"WN Venables","year":"1997","unstructured":"Venables WN, Ripley BD, editors. Modern Applied Statistics with S-plus, 2nd ed. New York: Springer Verlag, Inc.; 1997. p. 413\u2013430."},{"key":"BF7211259_CR30","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1469-8749.1985.tb04571.x","volume":"27","author":"C Robertson","year":"1985","unstructured":"Robertson C, Finer N . Term infants with hypoxic\u2013ischemic encephalopathy: outcome at 3.5 years. Dev Med Child Neurol. 1985;27:473\u2013484.","journal-title":"Dev Med Child Neurol."},{"key":"BF7211259_CR31","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0378-3782(91)90191-5","volume":"25","author":"S Shankaran","year":"1991","unstructured":"Shankaran S, Woldt E, Koepke T, Bedard MP, Nandayal R . Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev 1991;25:135\u2013148.","journal-title":"Early Hum Dev"},{"key":"BF7211259_CR32","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0022-3476(97)70072-6","volume":"131","author":"P Ekert","year":"1997","unstructured":"Ekert P, Perlman M, Steinlin M, Hao Y . Predicting the outcome of post-asphyxial hypoxic\u2013ischemic encephalopathy within 4 hours of birth. J Pediatr 1997;131:613\u2013617.","journal-title":"J Pediatr"},{"key":"BF7211259_CR33","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/S0022-3476(95)70174-5","volume":"127","author":"A Martin-Ancel","year":"1995","unstructured":"Martin-Ancel A, Alix-Garcia A, Gaya F, Cabanas F, Burgueros M, Quero J . Multi-organ involvement in perinatal asphyxia. J Pediatr 1995;127:786\u2013793.","journal-title":"J Pediatr"},{"key":"BF7211259_CR34","first-page":"617","volume":"143","author":"JM Perlman","year":"1989","unstructured":"Perlman JM, Tack ED, Martin T, Shackelford G, Amon E . Acute systemic organ injury in term infants after asphyxia. Am J Dis Child 1989;143:617\u2013620.","journal-title":"Am J Dis Child"},{"key":"BF7211259_CR35","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0022-3476(88)80023-4","volume":"113","author":"JM Perlman","year":"1988","unstructured":"Perlman JM, Tack ED . Renal injury in the asphyxiated newborn infant: relationship to neurologic outcome. J Pediatr 1988;113:875\u2013879.","journal-title":"J Pediatr"},{"key":"BF7211259_CR36","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1542\/peds.97.4.456","volume":"97","author":"JM Perlman","year":"1996","unstructured":"Perlman JM, Risser R . Can asphyxiated infants at high risk for neonatal seizures be rapidly identified by current high-risk markers? Pediatrics 1996;97:456\u2013462.","journal-title":"Pediatrics"},{"key":"BF7211259_CR37","first-page":"143","volume":"19","author":"AJ Barkovich","year":"1998","unstructured":"Barkovich AJ, Hajnal BL, Vigneron D, et al. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. Am J Neuroradiol R 1998;19:143\u2013149.","journal-title":"Am J Neuroradiol R"},{"key":"BF7211259_CR38","first-page":"628","volume":"102","author":"GD Hankins","year":"2003","unstructured":"Hankins GD, Speer M . Defining the pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy. Obstet Gynecol 2003;102:628\u2013636.","journal-title":"Obstet Gynecol"},{"key":"BF7211259_CR39","unstructured":"American College of Obstetricians and Gynecologists' Task Force Report on Neonatal Encephalopathy and Cerebral Palsy, American College of Obstetrics and Gynecologists, American Academy of Pediatrics. Neonatal Encephalopathy and Cerebral Palsy: Defining Pathogenesis and Pathophysiology. 2003."}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7211259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211259","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T16:42:41Z","timestamp":1647621761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7211259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,10]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4,1]]}},"alternative-id":["BF7211259"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7211259","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,10]]},"assertion":[{"value":"10 February 2005","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}